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Cancerous cell viability affected by synergism between electric pulses and a low dose of silver nanoparticle:An adaptive neuro-fuzzy inference system

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Medicine in Novel Technology and Devices 2024年第1期21卷 45-52页

作者： Salim mirshahi Behzad Vahedi Kiarash Aryana Ameneh Sazgarnia Department of Mechanical Engineering Sharif University of TechnologyTehranIran Medical Physics Research Center Mashhad University of Medical SciencesMashhadIran Functional Neurosurgery Research Center Shohada Tajrish Comprehensive Neurosurgical Center of ExcellenceShahid Beheshti University of Medical SciencesTehranIran Department of Mechanical Engineering Ferdowsi University of MashhadMashhadIran

In the current study,applying simultaneously electroporation and silver nanoparticles(SNPs)are ***,one restriction normally assigned to such nanoparticles is their side effects on the vital organs of the *** mitigate such deleterious effects,it is better to use lower dosages of ***,this can result in a decline in the technique's *** compensate for the lower dose of SNPs,one can use secondary method like electroporation to deliver SNPs directly into the cells and reinforces the effect of electric pulses due to the high electrical conductivity of SNPs while having a minimal cytotoxicity effect on normal cells that are not treated with *** the present study,synergism effects of both procedures(SNPs and electroporation)experimentally and theoretically are considered to investigate the property of each technique in increasing the performance with respect to both procedures'*** investigate more,adaptive neuro-fuzzy inference system(ANFIS)is used to predict the percent cell viability of cancerous cells affected by both procedures by considering amplitude and duration as inputs affecting on change of cell viability as an *** results obtained from both experimental and simulation procedures showed that the maximum synergism between nanoparticles and electric pulses was recorded at 700V/cm strength and 100μs ***,Results indicated high correlation between observed and predicted data(r2=0.88).Moreover,the calculated root mean square error for the results of the ANFIS model was equal to *** implies that the model has practical value and can estimate the percent cell viability of cancerous cells influenced by both procedures with varying electric field amplitude and *** method can be proposed for other biophysical or drug delivery applications to save time and resources by utilizing the previous experimental data rather than performing more experiments.

关键词： Electroporation Cancer cell Adaptive neuro-fuzzy inference system Nanoparticle Drug delivery

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酞咪哌啶酮对多发性骨髓瘤细胞系血管新生抑制作用的研究

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中华血液学杂志 2002年第10期23卷 520-523页

作者：陈文明朱嘉芷 F mirshahi J Soria M mirshahi C Soria 首都医科大学附属北京朝阳医院 100020 LabortoireDIFEMA UFRdeMedecineetPhamaciedeRouenfrance76183 INSREMEMI9912 HopitaldeHotelDieufrance75181

目的　研究多发性骨髓瘤 (MM)细胞系培养上清液对人骨髓来源的内皮细胞系(HBMEC)的增殖、迁移、血管新生的促进作用及酞咪哌啶酮对其抑制作用。方法　用MM细胞系 (IM9、XG1、U2 6 6和MOLP 5 )培养上清液培养HBMEC ,检测其对HBMEC的增殖... 详细信息

目的　研究多发性骨髓瘤 (MM)细胞系培养上清液对人骨髓来源的内皮细胞系(HBMEC)的增殖、迁移、血管新生的促进作用及酞咪哌啶酮对其抑制作用。方法　用MM细胞系 (IM9、XG1、U2 6 6和MOLP 5 )培养上清液培养HBMEC ,检测其对HBMEC的增殖、迁移作用。在纤维蛋白胶及基质胶 (matrigel)中观察此上清液对血管新生的影响 ,并研究酞咪哌啶酮对这些作用的抑制。用酶联免疫吸附实验 (ELISA)测定此上清液中血管内皮生长因子 (VEGF)含量。结果　MM培养上清液明显促进HBMEC的增殖及迁移。在纤维蛋白胶及基质胶 (matrigel)中 ,促进微血管的生长。这些作用均可被酞咪哌啶酮抑制。所有这些作用与MM细胞系产生的VEGF无相关性。结论　MM细胞系通过分泌VEGF或其他某些细胞因子促进HBMEC的增殖、迁移及微血管形成 ;酞咪哌啶酮可抑制这些作用。

关键词：多发性骨髓瘤血管新生血管内皮生长因子酞咪哌啶酮治疗

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Oncologic Trogocytosis Protects Tumour Stromal Cells from γδ Cell Cytotoxicity

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Journal of Life Sciences 2011年第12期5卷 986-995页

作者： Emilie Decaup Pej man mirshahi Arash Rafii Massoud mirshahi Jean-Jacques Foumie Mary Poupot INSERM UMR1037-Cancer Research Center of Toulouse CNRS ERL CHU Purpan Toulouse 31024 France University of Toulouse 3 Toulouse 31000 France UMRS 872 INSERA/L University of Pierre et Marie Curie-Paris 6 and University of Paris Descartes Team 18 CRC 15 Rue del ＇Ecole de Mddecine Paris Cedex 06 75270 France Department of Genetic Medecine and Obstetrics and Gynecology WCMC-Qatar Doha Qatar

Tumours progressively develop chemoresistance and immunoescape abilities thanks to support from their stromal microenvironment. In ovarian carcinomas, for instance, tumour-associated mesenchymal stem cells （TAMC） can transfer multi-drug-resistant proteins to develop metastases. However, since the microenvironment of such carcinomas is frequently infiltrated by both TAMC and γδ T lymphocytes, the consequences of interactions between these cell types were unclear. Here, we report that whilst γδ T lymphocytes were not activated when co-incubated in vitro with TAMC, their cell membranes were trogocytosed by the TAMC. Since TAMC constitutively express a low level of HLA class I, which is increased by trogocytosis of γδ cell-derived HLA class I, the interaction increased the expression of HLA class-I molecules on TAMC. In addition, γδ T lymphocytes are HLA-unrestricted cytolytic cells and their activity is regulated by inhibitory receptors （KIR） for self-HLA class I. Hence, although the lytic activity of γδ T lymphocytes for unrelated target cells was unaffected by trogocytosis, it spared the TAMC. Therefore, interactions between TAMC and cytolytic γδ T cells avoided the killing of these stromal cells due to an active transfer of their protective HLA class-I molecules. These results suggest that trogocytosis contributes to the maintenance of cancer-associated stromal cells.

关键词： Membrane transfer tumour microenvironment stromal cells HLA-class I molecules

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多发性骨髓瘤血管新生的体外研究

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中国实验血液学杂志 2002年第4期10卷 310-314页

作者：陈文明吴垠朱嘉芷 Jeannette Soria Massoud mirshahi 首都医科大学附属北京朝阳医院血液科北京100020 巴黎Hotel-Dieu医院

探讨多发性骨髓瘤细胞系培养上清液对人骨髓来源内皮细胞系(HBMEC)的增殖、迁移及血管新生的作用。用含2％胎牛血清(FBS)的RPMI 1640培养液培养骨髓瘤细胞系获得上清液,将此培养液培养HBMEC,研究其时HBMEC的增殖及迁移的影响,并将此液... 详细信息

探讨多发性骨髓瘤细胞系培养上清液对人骨髓来源内皮细胞系(HBMEC)的增殖、迁移及血管新生的作用。用含2％胎牛血清(FBS)的RPMI 1640培养液培养骨髓瘤细胞系获得上清液,将此培养液培养HBMEC,研究其时HBMEC的增殖及迁移的影响,并将此液放入含有携带HBMEC微珠的三维纤维蛋白中,研究其对血管新生的影响。结果表明,与含2％FBS的RPMI 1640培养液比较,骨髓瘤细胞系培养液对HBMEC的增殖有明显促进作用(P<0.001),并促进HBMEC的迁移,诱导毛细血管管腔的形成(长度及宽度)(P<0.001)。结论:骨髓瘤细胞系可能通过分泌某些细胞因子促进HBMEC增殖、迁移及血管新生。

关键词：多发性骨髓瘤多发性骨髓瘤细胞系骨髓来源内皮细胞系血管新生 MM

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LASIK术中角膜微切器的吸引作用对眼结构的影响

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世界核心医学期刊文摘（眼科学分册） 2005年第11期1卷 50-51页

作者： mirshahi a. Kohnen T. 张少娟 Department of Ophthalmology Johann Wolf gang Goethe University Theodor-Stern-Kai 7 60590 Frankfurt amMain Germany Dr.

Purpose: To study the effect of microkeratome suction on ocular structures dur ing LASIK. Design: Observational, prospective case series. Participants: Twenty -one eyes of 11 patients with myopia or astigmatic myopia (8 females, 3 males) were included. The mean patient age was 36.3 years (median, 37 years; range, 24 -48 years), and the mean spherical equivalent was-5.03 diopters(D) (median,-4 .63 D; range,-2.38 to -8.38 D). Methods: We performed preoperative and intraop erative A-scan ultrasonography during applicat ion of suction using the Hansatome microkeratome (Bausch &Lomb Surgical,Munich, Germany) to create corneal flaps during LASIK. We also performed preoperative a nd postoperative B-scan ultrasonography of the posterior ocular segment with sp ecial attention to the presence and size of posterior vitreous detachment (PVD). Main Outcome Measures: We measured changes in the axial length, anterior chambe r depth, lens thickness, and vitreous distance (distance from the posterior lens capsule to the posterior pole) during application of the microkeratome suction ring and recorded new occurrences of or increases in the size of the PVD after s urgery. Results: The lens thickness decreased (mean change,-0.20 mm; P=0.001; 9 5%confidence interval [CI],-0.11 to-0.30) in 18 eyes during application of th e suction ring. The vitreous distance increased (mean change, 0.20 mm; P=0.004; 95%CI, 0.08-0.32) in 16 eyes. No statistically significant changes were found in the anterior chamber depth (P=0.75) or axial length (P=0.51). After surgery, 3 of 14 eyes (21.4%) experienced PVD that did not have echographic signs of PVD before surgery. Of 7 eyes with preoperative PVD, the PVD enlarged in 1 eye (14. 3%). Conclusions: During application of microkeratome suction, the lens thickne ss decreases, whereas the vitreous distance increases, suggesting anterior tract ion on the posterior segment. The relationship between the observed PVD and LASI K merits further investigation.

关键词： LASIK术近视性散光吸引作用晶体厚度眼轴长度前房深度后囊器制病例研究观察性

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光动力治疗后的黄斑转位1例报道

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世界核心医学期刊文摘(眼科学分册) 2006年第2期 51-52页

作者： mirshahi a Schreyger F Baatz H Scharioth G.B. 白芳 Augenzentr um Recklinghausen Erlbruch 34- 36 45657 Recklinghausen Germany Dr.

Background: Photodynamic therapy (PDT) and surgical macular translocation are concurrent treatment options for exudative age-related macular degeneration (ARMD). PDT is currently favoured because of positive study results and the non invasive technique. We report a case of macular translocation with 360° retinotomy after unsuccessful previous PDT for treatment of ARMD. Case Report: PDT with verteporfin was performed in the left eye of a 79- year-old patient with exudative ARMD and predominantly classic juxtafoveal choroidal neovascularisation (CNV). Because of continuing visual loss and deteriorating angiographic signs three months after PDT, a surgical macular translocationwith 360° retinotomy was performed successfully. During the surgery increased adhesion between the CNV and the retina was observed in contrast to patients without previous PDT. In a second step three months later, counter-rotation of the ocular globe was achieved by muscle surgery and the silicone oil was removed in the same session. The best spectacle corrected visual acuity improved from 0.1 before the surgery to 0.4 nine months thereafter (six Snellen lines). No CNV recurrence was observed. Patient satisfaction with the surgery outcome is high. Conclusions: Macular translocation may be considered in cases of continuing deterioration after a previous PDT for treatment of exudative ARMD. Possible complications must be discussed with the patient. Intraoperatively, increased adhesion of CNV to the retina was observed, which might increase the risk of inadvertent damage to the retina during surgery.

关键词：黄斑 PDT 手术视网膜转位作曲法 CNV

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维生素D3对血管抑制新生作用的研究

维生素D3对血管抑制新生作用的研究

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第三届全国血液免疫学学术大会

作者：陈文明朱嘉芷 Soria J mirshahi M 首都医科大学附属北京朝阳医院法国巴黎Hotel-Dieu医院

目的:研究1,25-二羟维生素D3[1,25(OH)D3]对血管内皮生长因子(VEGF)诱导的人骨髓来源的内皮细胞系(HBME-1)的增殖、迁移、微血管形成的抑制作用。方法:在含2%胎牛血清(FBS)的RPMI1640中,先加入20ng/ml的VEGF,经24-48小时培养后,分别检测... 详细信息

目的:研究1,25-二羟维生素D3[1,25(OH)D3]对血管内皮生长因子(VEGF)诱导的人骨髓来源的内皮细胞系(HBME-1)的增殖、迁移、微血管形成的抑制作用。方法:在含2%胎牛血清(FBS)的RPMI1640中,先加入20ng/ml的VEGF,经24-48小时培养后,分别检测VEGF对HBME-1的增殖、迁移和微血管形成的

关键词：血管新生血管内皮生长因子 1,25-二羟维生素D3

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激光原位角膜磨镶术后玻璃体后脱离的发病率研究

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世界核心医学期刊文摘（眼科学分册） 2006年第8期2卷 36-37页

作者： mirshahi a. Schpfer D. Gerhardt D. T. Kohnen 刘瑛 Department of Ophthalmology Johann Wolfgang Goethe UniversityTheodor-Stern-Kai 760590 Frankfurt amMain Germany

Background: Vitreoretinal complications are rare in laser in situ keratomileusis (LASIK). Increase in intraocular pressure caused by intraoperative suction with subsequent deforming of the ocular globe and excimer laser shock during the ablation have been discussed as possible causes. The purpose of this study was to determine the effect of LASIK on the vitreous body. Patients and methods: In a prospective study we performed ocular ultrasonography (B scan) immediately before and 1 week after LASIK procedure in 103 myopic or myopic astigmatic eyes (53 patients, mean age 36.3 years, 32 women, 21 men). In particular, the prevalence, localization, and extent of posterior vitreous detachment (PVD) were determined. Results: The mean spherical equivalent was- 4.85 D (range- 1.25 to- 8.38) and the mean anteroposterior ocular globe length was 25.13 mm (range 23.31- 27.65). Ninety-five eyes (92.2% ) had no PVD preoperatively. Nine eyes out of this group (seven patients, 9.5% ) developed incomplete PVD as assessed 1 week postoperatively. Eight eyes (7.8% ) had a partial PVD preoperatively and in only one eye was an extension of vitreous detachment observed after the surgery. None of the preoperatively measured parameters could predict the occurrence of PVD by LASIK. Conclusions: LASIK may in rare cases lead to new occurrence of PVD or extension of a previously existing partial PVD.

关键词：玻璃体后脱离近视散光准分子激光玻璃体视网膜眼压增高前后径不完全性

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HIV-associated neurocognitive disorder(HAND):a review

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Life Research 2023年第1期6卷 11-16页

作者： Pedram Bolbolizade Fatemeh Zahra Seyed-Kolbadi Nasrin Davari-Dolatabadi Fatemeh Zamani Faezeh mirshahi Student Research Committee Faculty of Para MedicineHormozgan University of Medical SciencesBandar Abass 79166-13885Iran Evidence Based Medicine Study Center Hormozgan University of Medical SciencesBandar Abass 79166-13885Iran Health Information Management Department of Health Information TechnologyBandar Abass 79166-13885Iran

Objective:According to the World Health Organization,the number of infected people with human immunodeficiency virus(HIV)in 2019 was about 38 *** combinational antiretroviral therapy in recent years has increased life expectancy in these people and HIV has been changed from a deadly disease to a chronic ***-associated neurological disorders(HAND)include asymptomatic neurological disorders,Motor neurological disorders,and HIV-associated ***:We searched 3 databases(PubMed,Science Direct and Scopus databases)from January 2015 to March 2021 for the keywords;HIV associated with a neurocognitive disorder,HAND and combinational antiretroviral therapy to provide careful consideration of various aspects of these disorders,including;risk factors,their diagnostic methods,their epidemiology,and finally the treatment of ***:In the initial search,we came across 1351 *** authors did the title-abstract screening,and 270 articles were entered into full-text screening from the previous *** authors did the full-text screening,and the screening outcome was 21 *** categorized the results of our study into sub-categories,including:risk factors,pathogenicity,clinical manifestations,diagnosis,and epidemiology of ***:Although the HAND subheading has made great strides,many questions about the disease remain unanswered,and many of the diagnosing established methods are not 100%accurate and as a result of that,this epidemy can’t be fully endured *** hope to find and apply further advances and more definitive solutions in the coming decades.

关键词： HIV-associated neurocognitive disorder HIV epidemiology treatment risk factors diagnosis

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采用Zyoptix3.1系统的波前导LASIK术对近视及复合近视性散光矫正的1年随访研究:临床预后及高阶像差的改变

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世界核心医学期刊文摘（眼科学分册） 2005年第3期1卷 60-60页

作者： Kohnen T. Bühren J. Kühne C. mirshahi a. 张少娟

To assess safety, efficacy, predictability, stability, and change in aberratio ns after wavefront-guided LASIK for myopia and myopic astigmatism. Prospective, nonrandomized, self-controlled trial. Wavefront-guided LASIK was performed in 97 eyes in a 1-year trial. Treated eyes had a mean subjective manifest spheric al equivalent (SE) of -5.22±2.07 diopters (D), with a range of -0.25 to -9.0 0 D of myopia and 0 to -3.25 D of astigmatism. After a microkeratome cut, a wav efront-based excimer ablation (Zyoptix 3.1) was performed. The full treatment t o achieve emmetropia of an early nomogram provided by the system manufacturer wa s used in all procedures. Safety, efficacy, predictability, and stability were e valuated at 1, 3, and 12 months postoperatively. Wavefront changes of higher ord er aberrations (HOAs) at 1 year were determined for pupil sizes of 3.5 and 6 mm. At 1 year postoperatively, uncorrected visual acuity (VA) was 20/20 or better i n 83%of the eyes, and 20/40 or better in 98%. The mean subjective manifest SE at 1 year was -0.25±0.43 D; it was within 0.50 D in 77%and within 1.0 D in 95 %. No eye lost < 2 lines of best spectacle corrected VA (BSCVA) at 1 year post operatively; 40 eyes gained 1 line of BSCVA, and 5 eyes gained 2 lines. The tota l HOA root meansquare (RMS) increased on average by a factor of 1.23±0.57 with a 3.5-mm pupil; for the 6 mm pupil, the increase factor was 1.52±0.36. No chan ge or reduction in the total HOA RMS was observed in 45.5%of the eyes for a 3.5 -mm pupil and in 20.6%for a 6-mm pupil. There was a significant increase of p rimary spherical aberration (Z 4,0) by a factor of 4.11±10.17 for 3.5-mm pupil s and 4.31±6.76 for 6-mm pupils. Wavefront-guided LASIK using Zyoptix 3.1 is an effective and safe procedure for the treatment of myopia and myopic astigmati sm. Although in close to half of the eyes HOAs could be reduced, there was still undercorrection and induction of HOAs with the algorithm employed.

关键词：近视性散光 LASIK术 Zyoptix3.1 高阶像差随访研究未矫正视力瞳孔大小波前手术系统正视眼

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