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Diagnostic usefulness of selected proteases and acute phase factors in patients with colorectal adenocarcinoma

World Journal of Gastroenterology 2021年第39期27卷 6673-6688页

作者： Tadeusz Sebzda Jan Gnus Barbara Dziadkowiec miroslaw latka Jakub Gburek Department of Pathophysiology Wroclaw Medical UniversityWroclaw 50-368Poland Department of Physiotherapy Wroclaw Medical UniversityWroclaw 50-355Poland Department of Biomedical Engineering Wroclaw University of Science and TechnologyWroclaw 50-370Poland Department of Pharmaceutical Biochemistry Wroclaw Medical UniversityWroclaw 50-556Poland

BACKGROUND Uncontrolled growth and loss of control over basic metabolic functions,leading to invasive proliferation and metastases,are the salient traits of malignant tumors in general and colorectal cancer in *** and metastases hinder effective tumor *** surgical techniques and radiotherapy can be used to remove tumor focus,only chemotherapy can eliminate dispersed neoplastic ***,the efficacy of the latter method is limited in the advanced stages of the ***,recognition of the mechanisms involved in neoplastic cell spreading is indispensable for developing effective *** To use a number of biomarkers involved in cancer progression and identify a panel that could be used for effective early *** We recruited 185 patients with colorectal adenocarcinoma(98 men,87 women with median age 63).Thirty-five healthy controls were sex and ***’staging was as follows:A=22,B=52,C=72,D=*** analyzed patients'blood serum before *** determined:(1)Cathepsin B(CB)with Barrett's method(fluorogenic substrate);(2)Leukocytic elastase(LE)in a complex with alpha 1 trypsin inhibitor(AAT)using the immunoenzymatic MERCK test;(3)Total sialic acid(TSA)with the colorimetric periodate-resorcinol method;(4)Lipid-bound sialic acid(LASA)with the colorimetric Taut's method;and(5)The antitrypsin activity(ATA)employing the colorimetric *** In patients,the values of the five biochemical parameters were as follows:CB=16.1±8.8 mU/L,LE=875±598μg/L,TSA=99±31 mg%,LASA=0.68±0.33 mg%,and ATA=3211±1504 U/*** for LASA,they were significantly greater than those of controls:CB=11.4±6.5 mU/L,LE=379±187μg/L,TSA=71.4±15.1 mg%,LASA=0.69±0.28 mg%,and ATA=2016±690 U/*** CB and LASA,the differences between the four Dukes’stages and controls were not statistically *** inter-stage differences for CB and LASA were also *** receiver operating characteristic(ROC)analysis revealed the potential dia

关键词： Colorectal cancer Cathepsin B Acute phase reactants Colorectal adenocarcinoma Acute phase factor

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