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Mesenchymal stem cell-derived exosomes:Shaping the next era of stroke treatment

Neuroprotection 2023年第2期1卷 99-116页

作者： Arshi Waseem Saudamini Rizwanul Haque miroslaw janowski Syed S.Raza Laboratory for Stem Cell&Restorative Neurology Department of BiotechnologyEra's Lucknow Medical College HospitalEra UniversitySarfarazganjLucknowIndia Department of Biotechnology Central University of South BiharGayaIndia Center for Advanced Imaging Research Department of Diagnostic Radiology and Nuclear MedicineUniversity of MarylandBaltimoreMarylandUSA Department of Stem Cell Biology and Regenerative Medicine Era's Lucknow Medical College HospitalEra UniversitySarfarazganjLucknowIndia

Exosome-based treatments are gaining traction as a viable approach to addressing the various issues faced by an ischemic *** extracellular vesicles,mainly produced by mesenchymal stem cells,exhibit many properties with substantial therapeutic *** are particularly appealing for stroke therapy because of their low immunogenicity,effective cargo transport,and ability to cross the blood–brain *** diverse effects include neuroprotection,angiogenesis stimulation,inflammatory response modulation,and cell death pathway attenuation,synergistically promoting neuronal survival,tissue regeneration,and functional *** also show potential as diagnostic indicators for early stroke identification and customized treatment *** these promising qualities,current exosome-based therapeutics have some *** heterogeneity of exosome release among cell types,difficulty in standardization and isolation techniques,and complications linked to dosage and targeted administration necessitates extensive *** is critical to thoroughly understand exosomal processes and their complicated interactions within the cellular *** improve the practicality and efficacy of exosome-based medicines,research efforts must focus on improving production processes,developing robust evaluation criteria,and developing large-scale isolation ***,exosomes’multifunctional properties offer a new route for transforming stroke treatment and significantly improving patient outcomes.

关键词： exosomes inflammatory stress ischemic stroke mesenchymal stem cells middle cerebral artery occlusion oxidative stress

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3D printing-based frugal manufacturing of glass pipettes for minimally invasive delivery of therapeutics to the brain

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Neuroprotection 2023年第1期1卷 58-65页

作者： Guanda Qiao David Gulisashvili Anna Jablonska Guiling Zhao miroslaw janowski Piotr Walczak Yajie Liang Department of Diagnostic Radiology and Nuclear Medicine University of Maryland School of MedicineBaltimoreMarylandUSA Laboratory of Molecular Cardiology Department of PhysiologyCenter for Biomedical Engineering and TechnologyUniversity of Maryland School of MedicineBaltimoreMarylandUSA

Objective:Intracerebral delivery of agents in liquid form is usually achieved through commercially available and durable metal ***,their size and texture may contribute to mechanical brain *** pipettes with a thin tip may significantly reduce injection-associated brain damage but require access to prohibitively expensive programmable pipette *** study is to remove the economic barrier to the application of minimally invasive delivery of therapeutics to the brain,such as chemical compounds,viral vectors,and ***:We took advantage of the rapid development of free educational online resources and emerging low-cost 3D printers by designing an affordable pipette puller(APP)to remove the cost ***:We showed that our APP could produce glass pipettes with a sharp tip opening down to 20μm or less,which is sufficiently thin for the delivery of therapeutics into the brain.A pipeline from pipette pulling to brain injection using low-cost and open-source equipment was established to facilitate the application of the ***:In the spirit of frugal science,our device may democratize glass pipette-puling and substantially promote the application of minimally invasive and precisely controlled delivery of therapeutics to the brain for finding more effective therapies of brain diseases.

关键词： 3D-printable brain injection frugal science glass pipette pulling

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