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Plastic and Aesthetic Research 2022年第1期9卷 628-639页

作者： Marta R.Bizic Borko Stojanovic Marko Bencic Ivana Joksic miroslav l.djordjevic Department of Urology University Children’s HospitalFaculty of MedicineUniversity of BelgradeBelgrade 11000Serbia Department of Urology Belgrade Center for Urogenital Reconstructive SurgeryBelgrade 11000Serbia Department of Genetics Gynecology and Obstetrics Clinic“Narodni Front”Belgrade 11000Serbia Department of Urology Icahn School for Medicine at Mount SinaiNew YorkNY 10075USA

Aim:This paper presents the latest surgical approaches for epispadias treatment in the pediatric population,as well as those for adolescent and adult populations after initial failed repair in ***:The retrospective study was conducted between March 2005 and May 2020 and included 18 patients with the mean age of 21 months(range 11-48 months)(Group A),who underwent primary epispadias repair and 15 patients with the mean age of 18 years(range 13-29 years)(Group B),who underwent redo surgery after failed epispadias repair in *** Group A,the surgery was performed as a one-stage procedure using complete penile disassembly technique,while,in Group B,the surgery was done as a two-stage procedure and included complete straightening and lengthening of the penis,followed by urethral *** straightening and lengthening were achieved by tunica albuginea incision and *** Group A,the urethral plate was mobilized,transposed ventrally,and tubularized and augmented with vascularized preputial skin flap where *** Group B,the urethra was reconstructed either using the buccal mucosa graft and genital skin flaps or with tubularization of genital skin *** treatment was defined as a functional and esthetically acceptable penis without ***:The mean follow-up was 88 months(range 15-197 months).Satisfactory results were achieved in 26/33 *** fistula occurred in 4/18 patients from Group A and in 3/15 patients in Group B and was surgically repaired after four *** dehiscence occurred in eight patients,five from Group A and three from Group *** penile curvature was observed in 2/18 patients from Group A and required surgical correction and in 2/15 patients from Group B and was mild and did not need surgical *** patients from Group B who filled out the International Index for Erectile Function reported satisfying erectile function,sexual desire,intercourse,and overall satisfa

关键词： Epispadias primary repair penile disassembly urethroplasty buccal mucosa graft genital reconstruction failed epispadias

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Penile prosthesis implantation and tunica albuginea incision without grafting in the treatment of Peyronie＇s disease with erectile dysfunction

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Asian Journal of Andrology 2013年第3期15卷 391-394页

作者： miroslav l djordjevic Vladimir Kojovic School of Medicine University of Belgrade Belgrade 11000 Serbia

We evaluated penile prosthesis implantation with tunica albuginea-relaxing incisions without grafting in the treatment of Peyronie＇s disease associated with erectile dysfunction. Between April 2005 and June 2011, 62 patients underwent surgery due to severe Peyronie＇s disease associated with erectile dysfunction. Malleable and inflatable penile prostheses were inserted in 49 and 13 cases, respectively. Penile prostheses were inserted into the corpora cavernosa using the standard ventral approach. After lifting the neurovascular bundle, the tunica albuginea was incised and opened at the plaque region to correct the deformities and to lengthen the penis. Subsequently, the wide neurovascular bundle was replaced, and all incisions of the tunica albuginea were covered to prevent corporal grafting. In the median follow-up of 35 months （range 14-82 months）, the penis was completely straightened in 59 （95%） patients. Numbness of the glans, which the patients found initially upsetting, decreased or disappeared spontaneously 3-6 months later. Penile prosthesis implantation with tunica albuginea incisions is a viable alternative in the treatment of Peyronie＇s disease because the extensive dissection of the neurovascular bundle allows a good approach to the plaque and provides excellent covering of the incised tunica albuginea without additional grafting.

关键词： erectile dysfunction neurovascular bundle penile prosthesis Peyronie's disease tunica albuginea

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Repeated penile girth enhancement with biodegradable scaffolds： microscopic ultrastructural analysis and surgical benefits

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Asian Journal of Andrology 2018年第5期20卷 488-492页

作者： miroslav l djordjevic Uros Bumbasirevic Borko Stojanovic Tamara Kravic Stevovic Tamara Martinovic Marta Bizic Vladimir Kojovic School of Medicine University of Belgrade Belgrade 11000 Serbia University Children's Hospital Belgrade 11000 Serbia Institute for Urology Clinical Center ofSerbia Belgrade 11000 Serbia

Autologous tissue engineering using biodegradable scaffolds as a carrier is a well-known procedure for penile girth enhancement. We evaluated a group of previously treated patients with the aim to analyze histomorphometric changes after tissue remodeling and to estimate the benefits of repeated procedure. Between February 2012 and December 2016, a group of 21 patients, aged 22-37 （mean 28.0） years, underwent a repeated penile girth enhancement procedure with biodegradable scaffolds. Procedure included insertion of two poly-lactic-co-glycolic acid scaffolds seeded with laboratory-prepared fibroblasts from scrotal tissue specimens. During this procedure, biopsy specimens of tissue formed after the first surgery were taken for microscopic analysis. The mean follow-up was 38 months. Connective tissue with an abundance of connective tissue fibers, small blood vessels, and inflammatory cells were observed in all analyzed surgically removed tissue. Ultrastructural analysis of these tissue samples discovered the presence of large quantities of collagen fibrils running parallel to each other, forming bundles, with a few widely spread fibroblasts. In total, the mean values of flaccid and erect gain in girth after the second surgery were 1.1 ± 0.4 （range： 0.6- 1.7） cm and 1.0±0.3 （range： 0.6-1.5） cm, respectively. Microscopic evaluation of newly formed tissue, induced by autologous tissue engineering using biodegradable scaffolds, showed the presence of vascularized loose connective tissue with an abundance of collagen fibers, fibroblasts, and inflammatory cells, indicating active neovascularization and fibrinogenesis. The benefit of the repeated enhancement procedure was statistically significant.

关键词： biodegradable scaffolds microscopy penile enhancement tissue engineering

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Sc元素添加对双辊铸轧Al−Cu−li−Mg−Zr基合金热处理的影响

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Transactions of Nonferrous Metals Society of China 2024年第6期34卷 1759-1773页

作者： Rostislav KRÁlÍK Barbora KŘIVSKÁ lucia BAJTOŠOVÁ Mykhailo STOlBCHENKO Mirko SCHAPER Olexandr GRYDIN miroslav CIESlAR Department of Physics of Materials Faculty of Mathematics and PhysicsCharles UniversityKe Karlovu 512116PragueCzech Republic Department of Materials Science Faculty of Mechanical EngineeringUniversity of PaderbornWarburger Straße 10033098PaderbornGermany

提出制备含Sc的Al−Cu−li−Mg−Zr基合金带材的工艺方案。即先采用双辊铸轧技术制备近净形状的3 mm厚带材,再对其进行均匀化/固溶处理。研究两种Al−Cu−li−Mg−Zr基双辊铸轧合金,其中一种添加质量分数为0.17%的Sc,另一种未添加Sc。两种合金... 详细信息

提出制备含Sc的Al−Cu−li−Mg−Zr基合金带材的工艺方案。即先采用双辊铸轧技术制备近净形状的3 mm厚带材,再对其进行均匀化/固溶处理。研究两种Al−Cu−li−Mg−Zr基双辊铸轧合金,其中一种添加质量分数为0.17%的Sc,另一种未添加Sc。两种合金均先在300℃下退火30 min,然后在450℃下退火30 min以及530℃下退火30 min,随后进行室温水淬。前两段退火后组织中生成了细小、弥散的Al_(3)Zr/Al_(3)(Sc,Zr)颗粒。最后的退火步骤起到了均匀化/固溶处理的作用。双辊铸轧材料的细小晶粒结构使含有主要合金元素的原始颗粒在较短的退火时间内溶解。缩短保温时间可以限制表面层中li的耗尽和Al_(3)Zr/Al_(3)(Sc,Zr)弥散相的明显粗化。铸态含Sc材料已经具有明显细小的晶粒结构,而经均匀化/固溶处理后生成的Al_(3)(Sc,Zr)弥散相抑制了晶粒在高温下发生粗化。在后续180℃下时效处理后,形成了θʹ(Al_(2)Cu)、T1(Al_(2)Culi)和S'(Al_(2)CuMg)强化相。在峰值时效状态下,屈服强度提高了200 MPa,这一数值与类似直接冷却铸造材料的相当,从而证实了所提方案的合理性。

关键词：显微组织力学性能 Al−Cu−li基合金 Sc合金化双辊铸轧

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Photometric and Spectroscopic Study of Ten low Mass Ratio Contact Binary Systems: Orbital Stability, O'Connell Effect and Infrared Calcium line Filling

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Research in Astronomy and Astrophysics 2024年第8期24卷 214-224页

作者： Surjit S.Wadhwa Adam Popowicz Raúl Michel Petar Kosti? Oliver Vince Nick F.H.Tothill Ain Y.De Horta miroslav D.Filipovi? School of Science Western Sydney University Department of Electronics Electrical Engineering and MicroelectronicsSilesian University of Technology Instituto de Astronomía Astronomical Observatory

low mass ratio contact binary systems are more likely to have unstable orbits and potentially *** addition,such systems exhibit characteristics such as starspots and high energy emissions (UV) suggestive of chromospheric and magnetic *** curve modeling of ten contact binary systems is *** were found to be of extreme low mass ratio ranging from 0.122 to 0.24 and three were found to be potentially unstable and possible merger *** of the infrared calcium absorption lines is a marker of increased chromospheric *** use the available large Sky Area Multi-Object Fiber Spectroscopic Telescope spectra along with matched standard spectra (broadened for rotation) to measure the excess filling of the central core depression flux of the two main infrared calcium absorption linesλ8542 andλ*** find that all reported contact binaries have excess filling of the core flux in the infrared calcium *** of the systems reported were also observed by the Galaxy Evolution Explorer mission and we find that all three have features of excess ultraviolet emissions further adding evidence for increased chromospheric activity in low mass ratio contact *** of both orbital stability and absorption line filling is dependent on the determination of geometric and absolute parameters from light curve *** an insignificant number of contact binary light curves exhibit the O’Connell effect,usually attributed to *** discuss the inclusion of starspots in light curve solutions and how they influence the geometric and absolute parameters.

关键词： (stars:) binaries: eclipsing techniques: photometric stars: chromospheres lIGHT-CURVE SOlUTION TRIPlET EXPlANATION UNIQUENESS

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(+)-柠檬烯和1-甲氧基-2-丙醇对云杉八齿小蠹虫对信息素混合物反映的影响(英文)

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Journal of Forestry Research 2009年第1期20卷 37-44+92页

作者： miroslav Blazenec Rastislav Jaku Institute of Forest Ecology Slovak Academy of Sciences

对利用信息素诱捕云杉八齿小蠹的策略进行了对比分析,尤其是雄性小蠹的诱捕。第一种策略是障碍法,在林分的周围密集的布置捕捉陷阱,使用交互式信息素分别诱捕雄性小蠹和雌性小蠹。第二种策略是单一诱捕法,广阔使用投有相同诱饵诱捕陷阱... 详细信息

对利用信息素诱捕云杉八齿小蠹的策略进行了对比分析,尤其是雄性小蠹的诱捕。第一种策略是障碍法,在林分的周围密集的布置捕捉陷阱,使用交互式信息素分别诱捕雄性小蠹和雌性小蠹。第二种策略是单一诱捕法,广阔使用投有相同诱饵诱捕陷阱,以捕捉最大数量的雄性小蠹为目的,而不包含雌性小蠹的捕捉。在带有低含量的(4S)一反式马鞭草烯醇诱饵混合物中,用0%,1%,10%,35%,60%and90%的(+)-柠檬烯逐步取代α-蒎烯。这种替换对雄性小蠹的反映数量没有影响,但对雄性小蠹的捕捉量稍有影响。在有高含量(4S)-反式马鞭草烯醇捕捉雌性小蠹的引诱剂混合物中,用1-甲氧基-2-丙醇取代2-甲基-3-丁烯-2-醇,对雌性小蠹的捕捉率没有影响。因而,在具有反式马鞭草烯醇和(4县)-2-甲基-6-甲基-2,7-辛-4-醇的混合物中使用1-甲氧基-2-丙醇,捕捉效果没有明显的变化。在单一捕捉的引诱剂混合物中,用(+)-柠檬烯取代α-蒎烯,用1-甲氧基-2-丙醇取代2-甲基-3-丁烯-2-醇,α-蒎烯被代替后对雄性小蠹的捕捉率轻微的影响,但2-甲基-3-丁烯-2-醇被代替后,将不会没有明显地降低捕捉效果。

关键词：信息素诱捕障单一诱捕 (4S)-反式马鞭草烯醇 2-甲基-3-丁烯-2-醇 (一)-α-蒎烯

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Oxidation state specific analysis of arsenic species in tissues of wild-type and arsenic(+3 oxidation state)methyltransferase-knockout mice

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Journal of Environmental Sciences 2016年第11期28卷 104-112页

作者： Jenna M.Currier Christelle Douillet Zuzana Drobná miroslav Styblo Curriculum in Toxicology University of North Carolina at Chapel Hill Department of Nutrition Gillings School of Global Public Health University of North Carolina at Chapel Hill

Arsenic methyltransferase（As3mt） catalyzes the conversion of inorganic arsenic（i As） to its methylated metabolites, including toxic methylarsonite（MAs~Ⅲ） and dimethylarsinite（DMAs~Ⅲ）. Knockout（KO） of As3 mt was shown to reduce the capacity to methylate i As in mice. However, no data are available on the oxidation states of As species in tissues of these mice. Here, we compare the oxidation states of As species in tissues of male C57Bl/6 As3mt-KO and wild-type（WT） mice exposed to arsenite（iA s~Ⅲ） in drinking water. WT mice were exposed to50 mg/l As and As3mt-KO mice that cannot tolerate 50 mg/l As were exposed to 0, 15, 20, 25 or30 mg/l As. iA s~Ⅲaccounted for 53% to 74% of total As in liver, pancreas, adipose, lung, heart, and kidney of As3mt-KO mice; tri- and pentavalent methylated arsenicals did not exceed 10% of total As. Tissues of WT mice retained iA s and methylated arsenicals： iA s~Ⅲ, MAs~Ⅲand DMAs~Ⅲ represented 55%‐68% of the total As in the liver, pancreas, and brain. High levels of methylated species, particularly MAs~Ⅲ, were found in the intestine of WT, but not As3mt-KO mice,suggesting that intestinal bacteria are not a major source of methylated As. Blood of WT mice contained significantly higher levels of As than blood of As3mt-KO mice. This study is the first to determine oxidation states of As species in tissues of As3mt-KO mice. Results will help to design studies using WT and As3mt-KO mice to examine the role of iA s methylation in adverse effects of iA s exposure.

关键词： Arsenic speciation analysis Hydride generation-cryotrapping-atomic absorption spectrometry Arsenic(+ 3 oxidation state) methyltransferase As3mt knockout mice

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Zinc deficiency in patients with chronic pancreatitis

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World Journal of Gastroenterology 2019年第5期25卷 600-607页

作者： miroslav Vujasinovic AleksANDra Hedstr?m Patrick Maisonneuve Roberto Valente Henrik von Horn J-Matthias l?hr Stephan l Haas Department for Digestive Diseases Karolinska University Hospital Division of Epidemiology and Biostatistics IEO European Institute of Oncology IRCCS Department for Digestive Diseases Sapienza University of Rome Division of Clinical Chemistry Department of Molecular Medicine and Surgery Karolinska Institutet Karolinska University Hospital Department of Clinical Science Intervention and Technology (CLINTEC)Karolinska Institute

BACKGROUND Zinc is a key element in numerous proteins and plays an important role in essential cell functions such as defense against free radicals and DNA damage repair. Chronic pancreatitis(CP) is a chronic inflammation with progressive fibrosis of pancreas ultimately resulting in pancreatic exocrine insufficiency(PEI),which is associated with malnutrition. Studies analyzing zinc levels in patients with CP are sparse and lead to conflicting *** To investigate serum zinc levels in patients with CP of various *** Between October 2015 and March 2018, patients with a diagnosis of CP were identified and recruited from the Pancreatic Outpatient Clinic at the Karolinska University Hospital in Stockholm, Sweden. Demographic, clinical and laboratory data were analyzed. Etiology of CP was determined according to the MANNHEIM classification system into the following etiological subcategories:alcohol consumption, nicotine consumption, hereditary factors, efferent pancreatic duct factors and immunological factors. Pancreatic exocrine function was defined as normal(fecal elastase 1 > 200 μg/g), mildly reduced(100-200μg/g) and severely reduced(fecal elastase 1 lTS A total of 150 patients were included in the analysis. Zinc deficiency(l/l) was present in 39(26.0%) of patients: 22 females and 17 males. In the group of patients with zinc deficiency, 76.7% of patients had an exocrine pancreatic insufficiency(FE-1 lder age was significantly associated with low zinc levels. Following a univariate analysis, patients aged 60-69 and patients ≥ 70 years of age had a significantly higher prevalence of zinc deficiencies compared to patients 0.002]. Smoking and number of packyears were additionally associated with low zinc levels. The risk of zinc deficiency in current smokers and smokers with ≥ 20 pack-years was approximately three times higher

关键词： Zinc Pancreas Pancreatic exocrine insufficiency Chronic pancreatitis Malnutrition

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High-speed identification of suspended carbon nanotubes using Raman spectroscopy and deep learning

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Microsystems & Nanoengineering 2022年第1期8卷 259-267页

作者： Jian Zhang Mickael l.Perrin luis Barba Jan Overbeck Seoho Jung Brock Grassy Aryan Agal Rico Muff Rolf Brönnimann miroslav Haluska Cosmin Roman Christofer Hierold Martin Jaggi Michel Calame laboratory for Transport at Nanoscale Interfaces EmpaSwiss Federal Laboratories for Materials Science and TechnologyCH-8600 DübendorfSwitzerland Machine learning and Optimization laboratory School of Computer and Communication SciencesEPFLCH-1015 LausanneSwitzerland Department of Physics and Swiss Nanoscience Institute University of BaselCH-4056 BaselSwitzerland Micro-and Nanosystems Department of Mechanical and Process EngineeringETH ZurichCH-8092 ZurichSwitzerland

The identification of nanomaterials with the properties required for energy-efficient electronic systems is usually a tedious human task.A workflow to rapidly localize and characterize nanomaterials at the various stages of their integration into large-scale fabrication processes is essential for quality control and,ultimately,their industrial *** this work,we develop a high-throughput approach to rapidly identify suspended carbon nanotubes(CNTs)by using high-speed Raman imaging and deep learning *** for Raman spectra with extremely low signal-to-noise ratios(SNRs)of 0.9,we achieve a classification accuracy that exceeds 90%,while it reaches 98%for an SNR of *** applying a threshold on the output of the softmax layer of an optimized convolutional neural network(CNN),we further increase the accuracy of the ***,we propose an optimized Raman scanning strategy to minimize the acquisition time while simultaneously identifying the position,amount,and metallicity of CNTs on each *** approach can readily be extended to other types of nanomaterials and has the potential to be integrated into a production line to monitor the quality and properties of nanomaterials during fabrication.

关键词： carbon suspended speed

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钼催化剂结构对其催化气相丙烯环氧化反应选择性的影响（英文）

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Chinese Journal of Catalysis 2015年第11期36卷 1900-1909页

作者： Martin Sustek Blazej Horvath Ivo Vavra miroslav Gal Edmund Dobrocka Milan Hronec 斯洛伐克理工大学化学与食品技术学院 Radlinskeho 981237斯洛伐克布拉迪斯拉发斯洛伐克科学院电气工程研究院 Dubravskecesta 284104斯洛伐克布拉迪斯拉发 VSB-俄斯特拉发工业大学纳米技术中心 17.listopadu15捷克共和国俄斯特拉发70800

考察了Mo基催化剂上空气气相氧化丙烯反应.从无机的和有机金属Mo前驱体出发,采用浸渍法和物理气相沉积法(PVD)制备了不同类型的SiO2负载氧化钼和Mo-Bi复合氧化物催化剂.透射电镜结果证实,所制催化剂上环氧化反应活性与其纳米结构直接有... 详细信息

考察了Mo基催化剂上空气气相氧化丙烯反应.从无机的和有机金属Mo前驱体出发,采用浸渍法和物理气相沉积法(PVD)制备了不同类型的SiO2负载氧化钼和Mo-Bi复合氧化物催化剂.透射电镜结果证实,所制催化剂上环氧化反应活性与其纳米结构直接有关.催化剂中出现部分或完全结晶的氧化钼相,它们与载体SiO2的相互作用较弱,使得反应生成环氧丙烷的选择性低于10%,而锚合在SiO2上的非结晶的八配位Mo物种上的环氧丙烷选择性达55%以上,此时丙烯转化率约为11%.不同形貌氧化钼的电化学表征结果证实了结构缺陷的重要性.另外,还讨论了Bi对氧化钼催化环氧化活性的直接促进效应.

关键词：环氧丙烷环氧化氧化钼光学特性电化学性质

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