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Biochemical and cellular evidence of the benefit of a combination of cerium oxide nanoparticles and selenium to diabetic rats

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World Journal of Diabetes 2011年第11期2卷 204-210页

作者： Nazila Pourkhalili Asieh hosseini Amir Nili-Ahmadabadi Shokoufeh Hassani Mohsen Pakzad Maryam Baeeri Azadeh Mohammadirad Mohammad Abdollahi Faculty of Pharmacy Pharmaceutical Sciences Research Center Tehran University of Medical sciences Razi Institute for Drug Research Faculty of Med- icine Tehran University of Medical Sciences

AIM: To study the combinative effects of nanocerium and selenium in a murine model of diabetes. METHODS: Cerium oxide (CeO2) nanoparticles (60 mg/kg per day) and sodium selenite (5 μmol/kg per day) aloneor in combination, or the metal form of CeO2 (60 mg/kg) were administered for 2 wk by intraperitoneal injection to streptozotocin-induced diabetic rats. At the end of treatment blood was collected, liver tissue dissected and then oxidative stress markers, extent of energy depletion and lipid prof ile were ***: Antioxidant enzymes and high density lipoprotein decreased whereas oxidative stress, adenosine diphosphate/adenosine triphospahte levels, cholesterol, triglyceride and low density lipoprotein increased on induction of diabetes. All were improved by a combination of nanocerium and sodium selenite. There was a relative amelioration by CeO2 nanoparticles or sodium selenite alone, but the metal form of CeO2 showed no signif icant improvement. CONCLUSION: The combination of nanocerium and sodium selenite is more effective than either alone in improving diabetes-induced oxidative stress.

关键词： Diabetes Oxidative stress Cerium oxide nanoparticles Sodium selenite Nanotoxicology Nano- technology

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视网膜脱离手术后LASIK

世界核心医学期刊文摘（眼科学分册） 2006年第9期2卷 58-58页

作者： Farvardin M. hosseini H. 宋虎平(译) Department of Ophthalmology Khalili Hospital Shiraz University of Medical Sciences Shiraz 71934 Iran 不详

Purpose:To compare,in the same individuals,the safety and efficacy of laser in situ keratomileusis(LASIK)in eyes with and without previous retinal detachment ***:In a prospective clinical trial,seven myopic patients who had previously undergone scleral buckling surgery in one eye underwent conventional LASIK surgery in both *** visual acuity(UCVA),best corrected visual acuity(BCVA),refraction,Orbscan topography and pachymetry were recorded before and 1,3,6 and 12 months after *** eyes were divided into two groups:group 1 consisted of eyes that had undergone previous surgery for retinal detachment,and group 2 consisted of the fellow eyes of the same patients,which had not undergone any previous ocular ***’ s t-test for match-paired data was used to evaluate the significance of ***:LASIK was performed successfully in all *** UCVA improved in all eyes in both *** mean change in the spherical equivalent between 1 and 12 months after LASIK surgery was 1.7± 1.1 and 0.6± 0.5 diopter in groups 1 and 2,respectively(p=0.019).Conclusion:LASIK may be considered for treatment of myopia in eyes that have had previous surgery for retinal ***,the risk of regression may be higher in such eyes than in eyes with no previous scleral buckling surgery.

关键词： LASIK 视网膜脱离手术后

Pregnancy and inflammatory bowel diseases: Current perspectives, risks and patient management

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World Journal of Gastrointestinal Pharmacology and Therapeutics 2015年第4期6卷 156-171页

作者： Pegah hosseini-Carroll Monica Mutyala Abhishek Seth Shaheen Nageeb Demiana Soliman Moheb Boktor Ankur Sheth Jonathon Chapman James Morris Paul Jordan Kenneth Manas Felix Becker Jonathan Steven Alexander Department of Medicine Section of Gastroenterology and Hepatology Louisiana State University Health Sciences Center Department of Molecular and Cellular Physiology Louisiana State University Health Sciences Center Digestive Health Center of Louisiana Department of General and Visceral Surgery

Inflammatory bowel diseases(IBD) are chronic idiopathic inflammatory conditions characterized by relapsing and remitting episodes of inflammation which can affect several different regions of the gastrointestinal tract, but also shows extra-intestinal manifestations. IBD is most frequently diagnosed during peak female reproductive years, with 25% of women with IBD conceiving after their diagnosis. While IBD therapy has improved dramatically with enhanced surveillance and more abundant and powerful treatment options, IBD disease can have important effects on pregnancy and presents several challenges for maintaining optimal outcomes for mothers with IBD and the developing fetus/neonate. Women with IBD, the medical team treating them(both gastroenterologists and obstetricians/gynecologists) must often make highly complicated choices regarding conception, pregnancy, and post-natal care(particularly breastfeeding) related to their choice of treatment options at different phases of pregnancy as well as post-partum. This current review discusses current concerns and recommendations for pregnancy duringIBD and is intended for gastroenterologists, general practitioners and IBD patients intending to become,(or already) pregnant, and their families. We have addressed patterns of IBD inheritance, effects of IBD on fertility and conception(in both men and women), the effects of IBD disease activity on maintenance of pregnancy and outcomes, risks of diagnostic procedures during pregnancy and potential risks and complications associated with different classes of IBD therapeutics. We also have evaluated the clinical experience using "top-down" care with biologics, which is currently the standard care at our institution. Post-partum care and breastfeeding recommendations are also addressed.

关键词： Inflammatory bowel diseases Pregnancy Biologics Br

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追风筝的人(节选)

时代英语（高一版） 2019年第2期 5-5页

作者：卡勒德·胡赛尼不详

微笑。斜斜的。几乎看不见。但就在那儿。在我们后面,孩子们在飞奔,追风筝的人不断尖叫,乱成一团,追逐那只在树顶高高之上飘摇的断线风筝。我眨眼,微笑不见了。但它在那儿出现过,我看见了。'你想要我追那只风筝给你吗?'他的喉结吞咽着... 详细信息

微笑。斜斜的。几乎看不见。但就在那儿。在我们后面,孩子们在飞奔,追风筝的人不断尖叫,乱成一团,追逐那只在树顶高高之上飘摇的断线风筝。我眨眼,微笑不见了。但它在那儿出现过,我看见了。'你想要我追那只风筝给你吗?'他的喉结吞咽着上下蠕动。风掠起他的头发。

关键词：断线风筝树顶微笑喉结风筝

儿科日间手术中超重（或肥胖症）与胃液特性的关系：在禁食指南和误吸风险评估方面的意义

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麻醉与镇痛 2010年第6期6卷 38-49页

作者： Scott D. Cook-Sather Paul R. Gallagher Lydia E. Kruge Jonathan M. Beus Brian P. Ciampa Kevin Conor Welch Sina Shah-hosseini Jieun S. Choi Reshma Pachikara Kim Minger Ronald S. Litman Mark S. Schreiner 周洁(译) 李士通(校) Departments of Anesthesiology and Critical Care Medicine Departments of Biostatistics and Epidemiology Nursing The Children's Hospital of Philadelphia The University of Pennsylvania School of Medicine Philadelphia Pennsylvania 不详

背景超重或肥胖的日间手术儿科患者手术前2小时禁水的安全性尚未得到证实。健康的儿童和肥胖的成人在手术前禁水2小时后残留胃液量（GFVs）并不多，因此认为误吸风险并不高。因此我们将测算日间手术患者中超重症或肥胖症的患病率，并假... 详细信息

背景超重或肥胖的日间手术儿科患者手术前2小时禁水的安全性尚未得到证实。健康的儿童和肥胖的成人在手术前禁水2小时后残留胃液量（GFVs）并不多，因此认为误吸风险并不高。因此我们将测算日间手术患者中超重症或肥胖症的患病率，并假设不管是体重指数还是禁食时间均不会对GFV或胃液pH值产生显著的影响。所有受试儿童均于手术前禁清水2小时，并假设超重或肥胖患儿的GFV不会多于偏瘦或正常体重患儿，而呕吐或误吸的风险也很低。方法本研究中连续纳入了1000例2－12岁行日间手术的患儿，记录人口统计学资料、病史、身高和体重。另外纳入1000例需全麻插管的日间手术患儿（2。12岁）进行研究。气管插管后，经口插入一根14—18F的胃管，抽空胃内容物。用药情况、禁食时间、GFV、pH值和呕吐事件均被详细记录。采用疾病预防及控制中心的生长图表（2000）评定理想体重（IBW=第50个百分位数），并对患儿进行分层：偏瘦或正常体重（BMI在第25—75个百分位数）、超重（第95个百分位数〈BMI≥第85个百分位数）、肥胖（BMI≥第95个百分位数）。结果在所有的日间手术患儿中有14％属于超重，13．3％属于肥胖。肥胖儿按公斤体重算出的GFV较低（P〈0．001）。当我们用IBW进行校正后，所有BMI组中GFV（mw校正后）的容量都相等（均值为0．96ml／kg，SD为0．71；中位数为0．86ml／kg，IQR为0．96）。手术前使用对乙酰氨基酚和咪达唑仑均导致GFV（1BW校正后）增加（P=0．025和P=0．001）。而ASA11I级（P=0．024）、男性（P=0．012）、胃食管反流性疾病（P=0．049）和使用质子泵抑制剂（P=0．018）患儿的GFV（mw校正后）较低。GFV（IBw校正后）与禁食时间和年龄无关。胃液酸度较低与年龄较小（P=0．005）、BMI较高（P=0．036）和美国非洲裔（P=0．033）患儿等因素相关。有8例患儿在全麻诱导时发生了呕吐（其中50％有肥胖症，P=0．052，75％患有阻塞性睡眠呼吸暂停症，P=0．061）。呕吐与ASA分级较高有关，但却与禁食时间的长短无关。研究中没有出现误吸事件。结论27％的儿科日闻手术患儿属超重或肥胖儿童。无论进食时间长短或BMI如何，GFV（IBw校正后）均为1ml／kg，因此这些患儿均可以在手术前2小时饮清水。在此研究群体中，罕见的呕吐事件与禁食时间的缩短并无相关性。

关键词：禁食时间儿科患者风险评估肥胖症超重症胃液量误吸阻塞性睡眠呼吸暂停症

无名动脉闭锁与原发性抗磷脂综合征的联系:血管成形术的治疗(法国)

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世界核心医学期刊文摘（神经病学分册） 2005年第4期1卷 53-53页

作者： Dumurgier J. Desgranges P. Chapoy E H. hosseini 王晓琳 Service de Neurologie CHU Henri Mondor 94010 Cré teil Cedex France

Introduction. Antiphospholipid syndrome may be associated with stroke. Case report. We report a case of a symptomatic occlusion of the innominate artery in a 37- year- old patient, who developed primary anti- phospholipid syndrome. This association, to our knowledge, has not been reported in the literature. Occlusion of the innominate artery was treated by angioplastystenting. Effective oral anticoagulation was given to prevent a new thrombotic event. Conclusion. Systematic search for antiphospholipid antibodies is needed as part of the etiology work- up in young stroke victims.

关键词：动脉闭锁抗磷脂综合征血管成形术脑梗死病文献报道抗凝剂

脂肪提取技术对脂肪细胞的活性和脂肪来源干细胞数量的影响

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中国美容整形外科杂志 2015年第10期26卷 I0015-I0015页

作者： Ava hosseini Brian Mailey Jennifer Bakert Zeni Alfonso Paula Strasser Kevin Hicok Steven Cohen Amanda Gosman Marek Dobke Anne Wallace 叶美辰高景恒张晨袁继龙美国加利福尼亚州圣地亚哥加利福尼亚大学 CytoriTherapeutics公司《中国美容整形外科杂志》编辑部大连大学附属新华医院整形外科辽宁省人民医院整形外科

目的在脂肪抽吸物中活性脂肪来源干细胞（ADSC）的提取对自体脂肪移植的长期效果起决定性的作用。然而，提取方法是否会改变脂肪提取物的性质尚不得知。我们对3种提取技术进行测评，以明确其是否会对脂肪细胞的活性和基质血管细胞群（SV... 详细信息

目的在脂肪抽吸物中活性脂肪来源干细胞（ADSC）的提取对自体脂肪移植的长期效果起决定性的作用。然而，提取方法是否会改变脂肪提取物的性质尚不得知。我们对3种提取技术进行测评，以明确其是否会对脂肪细胞的活性和基质血管细胞群（SVF）的细胞特性产生影响。方法我们对采用3种不同提取脂肪方法的隆乳患者数据进行前瞻性分析。收集每例患者脂肪提取物的样本，并用细胞核计数（NucleoCounter）对细胞的数量和活性进行分析。用流式细胞仪测定SVF细胞表面标记物的表达，并分成4种不同的成分。根据结果对3种脂肪提取方法进行比较。结果本组共2l例患者。对7例患者采用手动操作注射器吸脂，7例采用水动力辅助吸脂，7例采用传统设备吸脂。每种方法的细胞活性、CFU数量和每克脂肪组织提取物的细胞数量均无差异。各组间根据细胞荧光的特征明确细胞成分的数量基本相同。3种提取方法中，SVF中CD34＋／CD31-／CD45-的比例基本无差异（27．3％，27．5％，27．5％）。结论ADSC细胞的数量、活性、形成单元细胞团（CFU）、或SVF成分的比例不受传统脂肪提取方法的影响。需要进一步研究洗涤和净化脂肪提取物是否会对试验和临床结果产生影响。

关键词：组织提取物干细胞数量脂肪细胞细胞活性注射器吸脂脂肪来源干细胞自体脂肪移植细胞成分