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SARS-CoV-2-specific T cell responses wane profoundly in convalescent individuals 10 months after primary infection

Virologica Sinica 2023年第4期38卷 606-619页

作者： Ziwei Li Tiandan Xiang Boyun Liang Jing Liu Hui Deng Xuecheng Yang Hua Wang Xuemei Feng Gennadiy Zelinskyy mirko trilling Kathrin Sutter Mengji Lu Ulf Dittmer Baoju Wang Dongliang Yang Xin Zheng Jia Liu Department of Infectious Diseases Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430022China Institute for Virology University Hospital of EssenUniversity of Duisburg-EssenEssen45147Germany Joint International Laboratory of Infection and Immunity Huazhong University of Science and TechnologyWuhan430022China

A key question in the coronavirus disease 2019(COVID-19)pandemic is the duration of specific T cell responses against the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)post primary infection,which is difficult to address due to the large-scale COVID-19 vaccination and re-exposure to the virus.Here,we conducted an analysis of the long-term SARS-CoV-2-specific T cell responses in a unique cohort of convalescent individuals(CIs)that were among the first to be infected worldwide and without any possible antigen re-exposure since then.The magnitude and breadth of SARS-CoV-2-specific T cell responses correlated inversely with the time that had elapsed from disease onset and the age of those CIs.The mean magnitude of SARS-CoV-2-specific CD4 and CD8 T cell responses decreased about 82%and 76%,respectively,over the time period of ten months after infection.Accordingly,the longitudinal analysis also demonstrated that SARS-CoV-2-specific T cell responses waned significantly in 75%of CIs during the follow-up.Collectively,we provide a comprehensive characterization of the long-term memory T cell response in CIs,suggesting that robust SARS-CoV-2-specific T cell immunity post primary infection may be less durable than previously expected.

关键词： COVID-19 SARS-CoV-2 T cell response Convalescence

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A Crowned Killer’s Ré sumeé: Genome, Structure, Receptors, and Origin of SARS-CoV-2

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Virologica Sinica 2020年第6期35卷 673-684页

作者： Shichuan Wang mirko trilling Kathrin Sutter Ulf Dittmer Mengji Lu Xin Zheng Dongliang Yang Jia Liu Department of Infectious Diseases Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Institute for Virology University Hospital of EssenUniversity of Duisburg-EssenEssen 45147Germany Joint International Laboratory of Infection and Immunity Huazhong University of Science and TechnologyWuhan 430022China

The recent emergence and rapid global spread of the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2) pose an unprecedented medical and socioeconomic crisis, and the disease caused by it, Coronavirus disease 2019(COVID-19),was declared a pandemic by the World Health Organization(WHO) on March 11, 2020. Chinese scientists and physicians rapidly identified the causative pathogen, which turned out to be a novel betacoronavirus with high sequence similarities to bat and pangolin coronaviruses. The scientific community has ignited tremendous efforts to unravel the biological underpinning of SARS-CoV-2, which constitutes the foundation for therapy and vaccine development strategies. Here, we summarize the current state of knowledge on the genome, structure, receptor, and origin of SARS-CoV-2.

关键词： Coronavirus Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2) Coronavirus disease 2019(COVID-19) Genome Structure Receptor Origin

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