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Color Doppler sonography and angioscintigraphy in hepatic Hodgkin's lymphoma

World Journal of Gastroenterology 2009年第26期15卷 3269-3275页

作者： mirjana v stojkovi vera M Artiko Irena B Radoman Slavko J Knezevi Snezana M Luki Mirko D Kerkez Nebojsa S Leki Andrija A Anti Marinko M Zuvela vitomir I Rankovi Milorad N Petrovi Dragana P obi vladimir B Obradovi Institute for Digestive Diseases Clinical Center of Serbia Institute for Nuclear Medicine Clinical Center of Serbia Gastroenterology Department Clinical Center Podgorica Gastroenterology Department Clinical Center Kragujevac

AIM： To estimate the characteristics of Color Doppler findings and the results of hepatic radionuclide angiography （HRA） in secondary Hodgkin＇s hepatic lymphoma. METHODS： The research included patients with a diagnosis of Hodgkin＇s lymphoma with metastatic focal lesions in the liver and controls. Morphologic characteristics of focal liver lesions and hemodynamic parameters were examined by pulsed and Color Doppler in the portal, hepatic and splenic veins were examined. Hepatic perfusion index （HPI） estimated by HRA was calculated. was observed. Lesions were mostly hypoechoic and mixed, solitary or multiple. Some of the patients presented with dilated splenic veins and hepatofugal blood flow. A pulse wave was registered in the centre and at the margins of lymphoma. The average velocity of the pulse wave was higher at the margins （P 〉 0.05）. A continuous venous wave was found only at the margins of lymphoma. There was no linear correlation between lymphoma size and velocity of pulse and continuous wave （r = 390, P 〈 0.01）. HPI was significantly lower in patients with lymphomas than in controls （P 〈 0.05）, pointing out increased arterial perfusion in comparison to portal perfusion. CONCLUSION： Color Doppler ultrasonography is a sensitive method for the detection of neovascularization in Hodgkin＇s hepatic lymphoma and estimation of its intensity. Hepatic radionuclide angiography can additionally help in the assesment of vascularisation of liver lesions.

关键词： Color Doppler ultrasonography Hodgkin's disease Lymphoma Liver Radionuclide angiography velocity Hepatic artery Portal vein Blood flow Splenomegaly

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SARS-Cov Genome Polymorphism: A Bioinformatics Study

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Genomics, Proteomics & Bioinformatics 2005年第1期3卷 18-35页

作者： Gordana M. Pavlovi-La■eti Nenad S. Miti Andrija M. Tomovi mirjana D. Pavlovi Milo v.Beljanski Faculty of Mathematics University of Belgrade 11001 Belgrade Serbia and Montenegro Faculty of Mathematics University of Belgrade 11001 Belgrade Serbia and MontenegroFriedrich MiescherInstitute for Biomedical Research CH-4058 Basel Switzerland Institute of General and Physical Chemistry11001 Belgrade Serbia and Montenegro.Institute of General and Physical Chemistry11001 Belgrade Serbia and Montenegro.

A dataset of 103 SARS-Cov isolates （101 human patients and 2 palm civets） was investigated on different aspects of genome polymorphism and isolate classification. The number and the distribution of single nucleotide variations （SNvs） and insertions and deletions, with respect to a “profile”, were determined and discussed （“profile” being a sequence containing the most represented letter per position）. Distribution of substitution categories per codon positions, as well as synonymous and non-synonymous substitutions in coding regions of annotated isolates, was determined, along with amino acid （a.a.） property changes. Similar analysis was performed for the spike （S） protein in all the isolates （55 of them being predicted for the first time）. The ratio Ka/Ks confirmed that the S gene was subjected to the Darwinian selection during virus transmission from animals to humans. Isolates from the dataset were classified according to genome polymorphism and genotypes. Genome polymorphism yields to two groups, one with a small number of SNvs and another with a large number of SNvs, with up to four subgroups with respect to insertions and deletions. We identified three basic nine-locus genotypes： TTTT/TTCGG, CGCC/TTCAT, and TGCC/TTCGT, with four subgenotypes. Both classifications proposed are in accordance with the new insights into possible epidemiological spread, both in space and time.

关键词： SARS Coronavirus single nucleotide polymorphism insertions deletions spike protein phylogenesis

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Copper,zinc,and iron bioleaching from polymetallic sulphide concentrate

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Transactions of Nonferrous Metals Society of China 2014年第11期24卷 3688-3695页

作者： vesna T.CONIC mirjana M.RAJCIC vUJASINOvIC vlastimir K.TRUJIC vladimir B.CvETKOvSKI Laboratory for Bioleaching and Solvent Extraction Mining and Metallurgy Institute BorBor 19210Serbia Technical Faculty in Bor University of BelgradeBor 19210Serbia

Bioleaching of low-grade complex Cu–Zn–Pb–Fe–Ag–Au sulphide concentrate (of Majdanpek ore body, RTB Bor, Serbia) was carried out in an aerated bioleach reactor in the presence of mesophilic mixed bacterial culture of Acidithiobacillus ferrooxidans, Acidithiobacillus thiooxidans, and Leptospirillum ferrooxidans. A mesophilic acidophiles culture was isolated from the acidic solution of the underground copper mine of Bor, Serbia. The nutrient medium was 9K at pH 1.6. 87% of the particles were v). Bioleaching efficiencies of 89% for zinc, 83% for copper, and 68% for iron can be achieved in the examined conditions. Kinetic analysis shows that the change in leaching corresponds to the Spencer-Topley kinetic model for diffusion-controlled topochemical reactions.

关键词： bioleaching polymetallic sulphide concentrate mesophiles Acidithiobacillus ferrooxidans

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