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国外计量 1991年第3期 45-45,48页

作者： borg.,AF 袁凤

Acute and Sub-Acute Toxicity of Ethanolic Leaf Extracts of <i>Rumex abyssinica</i>Jacq. (Polygonaceae) and <i>Mentha spicata</i>L. (Lamiaceae)

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Pharmacology & Pharmacy 2014年第3期5卷 309-318页

作者： Maud Kamatenesi Mugisha James Gakunga Ndukui Agnes Namutembi Paul Waako Ann-Karl borg Karlson Patrick Vudriko Department of Biological Sciences School of Biosciences College of Natural Sciences Makerere University Kampala Uganda Department of Chemistry KTH Stockholm Sweden Department of Food Technology and Nutrition College of Agriculture and Environmental Sciences Makerere University Kampala Uganda Department of Pharmacology and Therapeutics College of Health Sciences Makerere University Kampala Uganda Department of Veterinary Pharmacy Clinics and Comparative Medicine College of Veterinary Medicine Animal Resources and Biosecurity Makerere University Kampala Uganda Department of Veterinary Pharmacy Clinics and Comparative Medicine College of Veterinary Medicine Animal Resources and Biosecurity Makerere Uni-versity Kampala Uganda

Rumex abyssinica Jacq. (Polygonaceae) is locally used in management of allergies and female reproductive healthcare;whereas Mentha spicata L. (Lamiaceae) is used to treat gastrointestinal and respiratory distress, dandruff, halitosis and malaria in Uganda. Owing to the paucity of data on their safety profiles, this study evaluated the acute and sub-acute toxicities of 70% ethanolic leaf extracts of both plants in mice and Wistar albino rats. The oral acute toxicity of both plants was evaluated in Swiss mice of 7-8 weeks old (16-22 g) body weight and LD50 determined. Sub-acute toxicity was evaluated in Wistar albino rats (6 per group) at dose rates of 500, 1000 and 1500 mg/kg for 28 days. The LD50 of R. abyssinica and M. spicata in mice was 7727 mg/kg and 13,606 mg/kg body weight, respectively. General signs of toxicity due to large doses of both plants extract included hyperurination, abdominal muscle twitches and convulsions. In the sub-acute toxicity test, rats treated with both extracts did not exhibit any clinical signs of toxicity;no mortality and changes in body weight were observed. R. abyssinica did not cause significant changes in haematological indices, except a significant increase in HCT (p 0.05). However, a dose dependant significant decrease in HCT (p 0.05) and a significant increase (p 0.05) in the levels of WBC, LMY and MCHC were observed in rats treated with M. spicata extract. Biochemical test showed that both extracts caused a significant dose dependent increase (p 0.05) in levels of ALT and ALP. Marked increase in the levels of AST was also observed in rats treated with M. spicata extract. Of the two extracts, only rats treated with

关键词： Histopathology Mentha spicata Rumex abyssinica Toxicity

Managing Tourism Development in the Dutch City of Utrecht using a Linear Programming Model of the Tourist Carrying Capacity

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全球城市研究（中英文） 2021年第3期2卷 13-26,F0002,186,187页

作者：让·范·德·博格比利时鲁汶大学地球与环境学院威尼斯大学城市学院威尼斯大学欧洲城市比较研究院欧洲城市联盟(Eurocities) 比利时法兰德斯省旅游局战略发展委员会

As one part of the Landstad International Metropolitan Area,Utrecht has become known as one of the best tourist destinations in recent years,with the rapid growth of worldwide travel *** this paper,through the adaption of the linear programming model,the paper intends to not only quantify the optimum number of visitors to Utrecht but also formulate a number of policy recommendations based on the reconstruction of this *** paper draws the following conclusions:(1) tourist carrying capacity of Utrecht is not yet exceeded;(2) restrictive accommodation policy does not currently seem necessary;(3) the cultural-historical attractions are not yet optimally used;(4) investing in strategic provisions is currently not *** from the conclusion,the paper further puts forward the following suggestions on the city’s tourism development strategy:(1) to identify "tourist flood plains";(2) to encourage the tourist disclosure of these alternatives;(3) to invest even more explicitly in residential tourism and,where possible,curb day tourism;(4) to introduce a new business model.

关键词： Utrecht Tourism Carrying Capacity Linear Programming Model Sustainable Development of Tourism

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相位差／电位变换器

国外计量 1990年第2期 44-46页

作者： borg.,AF 袁风

COVID-19 patient experiences in prehospital pathways:a processual approach using life-events calendar method and state sequence analysis shows detrimental delays

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Family Medicine and Community Health 2024年第1期12卷 45-56页

作者： Romain Lutaud Sebastien Cortaredona Lea Delorme Patrick Peretti-watel Juliette Mirouse Manon borg Lucie Cattaneo Didier Thery Gaetan Gentile Christian Pradier Touitou Irit Philippe Brouqui Sophie Tardieu Michel Carles Stéphanie Gentile Department of General Practice Aix-Marseille UniversityMarseilleFrance ADES MarseilleFrance Institut de Recherche pour le Développement(IRD) MarseilleFrance Assistance Publique-Hôpitaux de Marseille(AP-HM) MarseilleFrance INSERM MarseilleFrance Department of Public Health Archet University HospitalNiceFrance MEPHI MarseilleFrance CEReSS-Health Service Research and Quality of life Center MarseilleFrance Department of Infectious Diseases Centre Hospitalier Universitaire de NiceNiceFrance

Objectives To our best knowledge,no study in France has comprehensively investigated the prehospital history of patients admitted for severe cases of COVID-19.‘Patients’voice is an excellent means to capture data on primary care *** aimed to identify clusters of COVID-19 hospitalised patients with similar prehospital symptom sequences,and to test whether these clusters were associated with a higher risk of poor clinical *** Cross-sectional online survey using life-event *** All patients hospitalised for COVID-19 between September 2020 and May 2021 in the Infectious Disease Departments in Nice and in Marseilles in *** 312 patients responded to the *** outcome measures From the day of symptom onset to the day of hospitalisation,we defined a symptom sequence as the time-ordered vector of the successive symptom grades(grade 1,grade 2,grade 3).State sequence analysis with optimal matching was used to identify clusters of patients with similar symptom *** logistic regressions were performed to test whether these clusters were associated with admission to intensive care unit(ICU)and COVID-19 sequelae after *** Three clusters of symptom sequences were identified among 312 complete prehospital pathways.A specific group of patients(29%)experienced extended symptoms of severe COVID-19,persisting for an average duration of 7.5 days before *** group had a significantly higher probability of being admitted to ICU(adjusted OR 2.01).They were less likely to know a loved one who was a healthcare worker,and more likely to have a lower level of ***,this group of patients,who were more likely to have previously visited the emergency room without exhibiting severe symptoms at that time,may have been inclined to postpone reassessment when their health *** relatives played a decisive role in their *** and relevance This study h

关键词： admitted likely life

FOLFOXIRI vs FOLFIRINOX as first-line chemotherapy in patients with advanced pancreatic cancer: A population-based cohort study

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World Journal of Gastrointestinal Oncology 2020年第3期12卷 332-346页

作者： Angélique Vienot Hortense Chevalier Clément Bolognini Elisabeta Gherga Elodie Klajer Aurélia Meurisse Marine Jary Stefano Kim Christelle d’Engremont Thierry Nguyen Fabien Calcagno Hamadi Almotlak Francine Fein Meher Nasri Syrine Abdeljaoued Anthony Turpin Christophe borg Dewi Vernerey Department of Medical Oncology Besançon University HospitalBesançon F-25030France University Bourgogne Franche-Comté INSERMEFS BFCUMR1098Interactions Hôte-Greffon-Tumeur/Ingénierie Cellulaire et GéniqueBesançon F-25000France INSERM CIC-1431 Clinical Investigation Center in BiotherapyBesançon University HospitalBesançon F-25030France Department of Medical Oncology Lille University HospitalLille F-59000France Department of Medical Oncology Nord Franche-ComtéHospitalMontbéliard F-25020France Methodological and Quality of Life in Oncology Unit Besançon University HospitalBesançon F-25030France Department of Gastroenterology Besançon University HospitalBesançon F-25030France

BACKGROUND FOLFIRINOX regimen is the first-line reference chemotherapy(L1)in advanced pancreatic ductal adenocarcinoma(aPDAC).FOLFOXIRI,a schedule with a lower dose of irinotecan and no bolus 5-fluorouracil,has demonstrated efficacy and feasibility in colorectal *** To investigate the potential clinical value of FOLFOXIRI in patients with aPDAC in routine clinical *** Analyses were derived from all consecutive aPDAC patients treated in L1 between January 2011 and December 2017 in two French institutions,with either FOLFOXIRI(n=165)or FOLFIRINOX(n=124)*** consisted of irinotecan(165 mg/m2),oxaliplatin(85 mg/m2),leucovorin(200 mg/m2)and 5-fluorouracil(3200 mg/m2 as a 48-h continuous infusion)every 2 ***-six pairs of patients were selected through propensity score matching,and clinical outcomes of the two treatment regimens were *** Median overall survival was 11.1 mo in the FOLFOXIRI and 11.6 mo in the FOLFIRINOX cohorts,*** propensity score matching,survival rates remained similar between the two regimens in terms of overall survival(hazard ratio=1.22;P=0.219)and progression-free survival(hazard ratio=1.27;P=0.120).The objective response rate was 37.1%in the FOLFOXIRI group vs 47.8%in the FOLFIRINOX group(P=0.187).Grade 3/4 toxicities occurred in 28.7%of patients in the FOLFOXIRI cohort vs 19.5%in the FOLFIRINOX cohort(P=0.079).FOLFOXIRI was associated with a higher incidence of grade 3/4 digestive adverse *** growth factors were used after each chemotherapy cycle and the low hematological toxicity rates were below 5%with both *** FOLFOXIRI is feasible in L1 in patients with aPDAC but does not confer any therapeutic benefit as compared with *** low hematological toxicity rates strengthened the relevance of primary prophylaxis with hematopoietic growth factors.

关键词： Advanced pancreatic cancer First-line chemotherapy FOLFOXIRI FOLFIRINOX Propensity score Cohort study

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在开采急倾斜矿脉时矿石损失和贫化的测定

国外锡工业 1989年第1期17卷 1-4页

作者： borg.,VG 陈逸明

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卧轴风力机静,动态不平衡效应

大中型风力发电技术 2000年第1期 191-193页

作者： borg,JP 尹继红

文中论述了风力机转子静、动态平衡间的差异。本文从每种平均型式的定义入手，论证了尽管卧轴风力机转子处于静平衡状态，但它仍存在动态不平衡。动态不平衡可引起传放／或摇摆，从而产生扭矩。当惯性主轴与角速度矢量一致时，风力机转... 详细信息

文中论述了风力机转子静、动态平衡间的差异。本文从每种平均型式的定义入手，论证了尽管卧轴风力机转子处于静平衡状态，但它仍存在动态不平衡。动态不平衡可引起传放／或摇摆，从而产生扭矩。当惯性主轴与角速度矢量一致时，风力机转子就处于动平衡状态。这种判别标准可用一个点的质量模型来表示。

关键词：卧轴风力机静态不平衡动态不平衡

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美国空军采用路辗压的混凝土道面的抉择模式

机场工程 1989年第2期 34-41页

作者： borg.,SK 沈其均

CD8^(+)CD226^(high)T cells in liver metastases dictate the prognosis of colorectal cancer patients treated with chemotherapy and radical surgery

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Cellular & Molecular Immunology 2023年第4期20卷 365-378页

作者： Julien Viot Syrine Abdeljaoued Angélique Vienot Evan Seffar Laurie Spehner Adeline Bouard Kamal Asgarov Jean-RenéPallandre Elodie Renaude Elodie Klajer ChloéMolimard Franck Monnien Frederic Bibeau Celia Turco Bruno Heyd Paul Peixoto Eric Hervouet Romain Loyon Alexandre Doussot Christophe borg Marie Kroemer Department of Medical Oncology Biotechnology and Immuno-Oncology PlatformUniversity Hospital of BesançonBesançonFrance INSERM EFS BFCUMR1098RIGHTUniversity of Franche-ComtéInteractions Greffon-Hôte-Tumeur/Ingénierie Cellulaire et GéniqueBesançonFrance Department of Pathology University Hospital of BesançonBesançonFrance Department of Surgery University Hospital of BesançonBesançonFrance EPIGENEXP platform University of Bourgogne Franche-ComtéBesançonFrance Department of Pharmacy University Hospital of BesançonBesançonFrance

CD226 has been reported to participate in the rescue of CD8^(+)T cell *** this study,we aimed to assess the prognostic value of CD226 in tumor-inﬁltrating lymphocytes(TILs)derived from colorectal cancer(CRC)liver metastases treated with chemotherapy and radical *** from 43 metastases were isolated and analyzed ex vivo usingﬂow ***155 and CD3 levels in the tumor microenvironment were assessed by *** and validation of biological processes highlighted in this study were performed by bioinformatics analysis of bulk RNA-seq results for 28 CRC liver metastases pretreated with chemotherapy as well as public gene expression ***226 expression contributes to the deﬁnition of the immune context in CRC liver metastases and primary ***226 on CD8^(+)T cells was not speciﬁcally coexpressed with other immune checkpoints,such as PD1,TIGIT,and TIM3,in liver *** Cox regression analysis revealed CD226 expression on CD8^(+)T cells to be an independent prognostic factor(p=0.003),along with CD3 density at invasion margins(p=0.003)and TIGIT expression on CD4^(+)T cells(p=0.019).CD155 was not associated with the prognostic value of *** expression analysis in a validation dataset conﬁrmed the prognostic value of CD226 in CRC liver metastases but not in primary *** of CD226 on CD8^(+)TILs in the liver microenvironment was restored by IL15 ***,CD226 expression on liver metastasis-inﬁltrating CD8^(+)T cells selectively contributes to immune surveillance of CRC liver metastases and has prognostic value for patients undergoing radical surgery.

关键词： CD226 antigen Colorectal Neoplasms Liver metastasis Lymphocytes Tumor-Inﬁltrating