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Journal of Modern Transportation 2018年第2期26卷 147-161页

作者： miriam F.Bongo Lanndon A.Ocampo Department of Mechanical and Manufacturing Engineering University of San Carlos Department of Industrial Engineering Cebu Technological University

The constant growth of air travel in the Philippines has brought about significant consequences to air traffic congestion. Given limited resources, major airports seek to address this issue while considering various attributes generally affecting air transportation. This paper adopts fuzzy decision-making trial and evaluation laboratory-analytic network process （DEMATEL-ANP） to identify the most critical attributes in the commercial aviation industry. A case study participated by key experts of Ninoy Aquino International Airport was conducted to illustrate the proposed approach. The fuzzy DEMATELANP model performed satisfactorily as it was able to extract the global priority vectors of attributes under a fuzzy environment. The results showed that aviation safety is most prioritized, as can also be seen from the significant influence it brings on other attributes. Following next to safety in terms of priority axe attributes that address the general air transportation system such as economic value, environmental value, social value, equitable treatment of competing airline, customer goodwill, and utilization of runway and terminal. Then, attributes relating to passenger cost, fuel cost, extra crew cost, landing/take-off fee, and cost of using flight routes axe of last priority. Given the order of priorities and criticality of each attribute, shortterm and long-term policies can be framed accordingly to propose air traffic flow management actions that can best address the issue on congestion.

关键词： Air traffic congestion ANP Fuzzy DEMATEL MCDM

Current concepts and trends in the treatment of bone metastases in patients with advanced prostate cancer

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Asian Journal of Andrology 2019年第1期21卷 12-18页

作者： miriam Hegemann Moritz Maas Steffen Rausch Simon Walz lens Bedke Arnulf Stenzl Tilman Todenhofer Department of Urology University Hospital TuebingenTuebingen 72076Germany.

Bone metastases have a major impact on quality of life and survival of patients with advanced prostate cancer,in the last decade,the development and approval of substances inhibiting the vicious cycle of bone metastases have enabled the reduction of complications caused by bone metastases in patients with castration-resistant prostate *** drugs have raised awareness of the importance of skeletal-related events which in the meantime represent an important end point also in trials using agents not specifically designed for bone ***-generation antihormona]drugs such as enzalutamide or abiraterone have been shown to have a positive impact on the incidence of skeletal complications and therefore provide an important tool in the armamentarium used for treating bone *** such as radium-223 dichloride([^223Ra])have been demonstrated not only to reduce skeletal-related events and bone-related pain,but also to prolong overall survival,thereby being the first bone-targeting agent showing a survival *** previous studies have not provided an obvious benefit of bone-targeted lesions in castration-sensitive disease,the use of these agents is not *** oligometastatic prostate cancer,the role of local treatment of metastases using stereotactic radiation or radiosurgery is a matter of intense debates and may play an increasing role in the future.

关键词： bone metastases bone-targeting agents denosumab hormonal therapy prostate cancer radium-223 dichloride zoledronic acid

Ancient Egyptian literature

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Ancient Egyptian literature

Effect of aging on behaviour of mesenchymal stem cells

作者： edited by miriam Lichtheim.

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World Journal of Stem Cells 2019年第6期11卷 337-346页

作者： Juan Antonio Fafián-Labora miriam Morente-López María C Arufe Grupo de Terapia Celular y Medicina Regenerativa Departamento de Fisioterapia Ciencias Biomédicas y MedicinaUniversidade da Coru?a

Organs whose source is the mesoderm lineage contain a subpopulation of stem cells that are able to differentiate among mesodermal derivatives (chondrocytes, osteocytes, adipocytes). This subpopulation of adult stem cells, called “mesenchymal stem cells” or “mesenchymal stromal cells (MSCs)”, contributes directly to the homeostatic maintenance of their organs;hence, their senescence could be very deleterious for human bodily functions. MSCs are easily isolated and amenable their expansion in vitro because of the research demanding to test them in many diverse clinical indications. All of these works are shown by the rapidly expanding literature that includes many in vivo animal models. We do not have an in-depth understanding of mechanisms that induce cellular senescence, and to further clarify the consequences of the senescence process in MSCs, some hints may be derived from the study of cellular behaviour in vivo and in vitro, autophagy, mitochondrial stress and exosomal activity. In this particular work, we decided to review these biological features in the literature on MSC senescence over the last three years.

关键词： Mesenchymal stem cells Aging Autophagy Mitochondrial stress Extracellular vesicles

Secured Cyber Security Algorithm for Healthcare System Using Blockchain Technology

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Intelligent Automation & Soft Computing 2023年第2期35卷 1889-1906页

作者： D.Doreen Hephzibah miriam Deepak Dahiya Nitin C.R.Rene Robin Computational Intelligence Research Foundation(CIRF) Chennai600023TamilnaduIndia College of Computer and Information Sciences Majmaah UniversityMajmaah11952Saudi Arabia Department of Electrical Engineering and Computer Science College of Engineering and Applied ScienceUniversity of CincinnatiCincinnati45221OHUnited States Department of Computer Science and Engineering Sri Sairam Engineering CollegeChennai600044TamilnaduIndia

Blockchain technology is critical in cyber *** most recent cryptographic strategies may be hacked as efforts are made to build massive elec-tronic *** of the ethical and legal implications of a patient’s medical data,cyber security is a critical and challenging problem in *** image secrecy is highly vulnerable to various types of *** a result,designing a cyber security model for healthcare applications necessitates extra caution in terms of data *** resolve this issue,this paper proposes a Lionized Golden Eagle based Homomorphic Elapid Security(LGE-HES)algorithm for the cybersecurity of blockchain in healthcare *** blockchain algorithm preserves the security of the medical image by performing hash *** execution of this research is carried out by MATLAB *** suggested fra-mework was tested utilizing Computed Tumor(CT)pictures and MRI image data-sets,and the simulation results revealed the proposed model’s profound *** the simulation,94.9%of malicious communications were recognized and identiﬁed effectively,according to the total outcomes *** suggested model’s performance is also compared to that of standard approaches in terms of Root Mean Square Error(RMSE),Peak Signal to Noise Ratio(PSNR),Mean Square Error(MSE),time complexity,and other factors.

关键词： Healthcare system cybersecurity security data sharing blockchain

Recycled materials in railroad substructure: an energy perspective

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Railway Engineering Science 2022年第3期30卷 304-322页

作者： Buddhima Indraratna Yujie Qi Rakesh Sai Malisetty Sinniah KNavaratnarajah Fatima Mehmood miriam Tawk Transport Research Centre School of Civil and Environmental EngineeringFaculty of Engineering and Information TechnologyUniversity of Technology SydneySydneyNSW 2007Australia Department of Civil Engineering Faculty of EngineeringUniversity of PeradeniyaPeradeniyaSri Lanka School of Civil Mining and Environmental EngineeringUniversity of WollongongWollongongNSW 2522Australia College of Engineering and Technology American University of the Middle EastEgailaKuwait

Given that the current ballasted tracks in Australia may not be able to support faster and significantly heavier freight trains as planned for the future,the imminent need for innovative and sustainable ballasted tracks for transport infrastructure is *** the past two decades,a number of studies have been conducted by the researchers of Transport Research Centre(TRC)at the University of Technology Sydney(UTS)to investigate the ability of recycled rubber mats,as well as waste tyre cells and granulated rubber to improve the stability of track substructure including ballast and subballast *** paper reviews four applications of these novel methods,including using recycled rubber products such as CWRC mixtures(i.e.,mixtures of coal wash(CW)and rubber crumbs(RC))and SEAL mixtures(i.e.,mixtures of steel furnace slag,CW and RC)to replace subballast/capping materials,tyre cells reinforcements for subballast/capping layer and under ballast mats;and investigates the energy dissipation capacity for each application based on smallscale cyclic triaxial tests and large-scale track model *** has been found that the inclusion of these rubber products increases the energy dissipation effect of the track,hence reducing the ballast degradation efficiently and increasing the track ***,a rheological model is also proposed to investigate the effect of different rubber inclusions on their efficiency to reduce the transient motion of rail track under dynamic *** outcomes elucidated in this paper will lead to a better understanding of the performance of ballast tracks upgraded with resilient rubber products,while promoting environmentally sustainable and more affordable ballasted tracks for greater passenger comfort and increased safety.

关键词： Ballast degradation Recycled rubber Energy dissipation Laboratory testing Rheological model

Recent advancements in the analysis of bone microstructure: new dimensions in forensic anthropology

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Forensic Sciences Research 2018年第4期3卷 294-309页

作者： Janna M.Andronowski Christian Crowder miriam Soto Martinez Department of Biology The University of AkronAkronOHUSA Harris County Institute of Forensic Sciences HoustonTXUSA

Bone is a mechanically active,three-dimensionally(3D)complex,and dynamic tissue that changes in structure over the human *** tissue exists and remodels in 3D and changes over time,introducing a fourth *** products of the remodelling process,secondary and fragmentary osteons,have been studied substantially using traditional two-dimensional(2D)*** a result,much has been learned regarding the biological information encrypted in the histomorphology of bone,yielding a wealth of information relating to skeletal structure and ***-dimensional imaging modalities,however,hold the potential to provide a much more comprehensive understanding of bone *** visualization and analysis of bone using high-resolution 3D imaging will improve current understandings of bone biology and have numerous applications in both biological anthropology and *** recent technological advancements,we can hone current anthropological applications of the analysis of bone microstructure and accelerate research into the third and fourth dimensional *** review will explore the methodological approaches used historically by anthropologists to assess cortical bone microstructure,spanning from histology to current ex vivo imaging modalities,discuss the growing capabilities of in vivo imaging,and conclude with an introduction of novel nonhistological modalities for investigating bone quality.

关键词： Forensic science forensic anthropology cortical bone synchrotron micro-CT in vivo ex vivo histological age estimation bone quality

Modified mesenchymal stem cells in cancer therapy: A smart weapon requiring upgrades for wider clinical applications

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World Journal of Stem Cells 2022年第1期14卷 54-75页

作者： Carla Vicinanza Elisabetta Lombardi Francesco Da Ros miriam Marangon Cristina Durante Mario Mazzucato Francesco Agostini Stem Cell Unit Centro di Riferimento Oncologico di AvianoIRCCSAviano 33081Italy

Mesenchymal stem stromal cells(MSC)are characterized by the intriguing capacity to home toward cancer cells after systemic ***,MSC can be harnessed as targeted delivery vehicles of cytotoxic agents against *** cancer patients,MSC based advanced cellular therapies were shown to be safe but their clinical efficacy was ***,the amount of systemically infused MSC actually homing to human cancer masses is insufficient to reduce tumor ***,induction of an unequivocal anticancer cytotoxic phenotype in expanded MSC is necessary to achieve significant therapeutic *** vivo cell modifications are,thus,required to improve anti-cancer properties of *** based cellular therapy products must be handled in compliance with good manufacturing practice(GMP)*** the present review we include MSCimproving manipulation approaches that,even though actually tested at preclinical level,could be compatible with GMP *** particular,we describe possible approaches to improve MSC homing on cancer,including genetic engineering,membrane modification and cytokine ***,we discuss appropriate modalities aimed at inducing a marked cytotoxic phenotype in expanded MSC by direct chemotherapeutic drug loading or by genetic *** conclusion,we suggest that,to configure MSC as a powerful weapon against cancer,combinations of clinical grade compatible modification protocols that are currently selected,should be introduced in the final *** standardized cancer clinical trials are required to test the efficacy of ameliorated MSC based cell therapies.

关键词： Cancer Mesenchymal stem stromal cells Good manufacturing practice Homing Targeted therapy Ex vivo cell modification

Effect of climate and altitude on plant community composition and richness in Brazilian inselbergs

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Journal of Mountain Science 2020年第8期17卷 1931-1941页

作者： Herval Vieira PINTO-JUNIOR Pedro Manuel VILLA Luis Fernando Tavares de MENEZES miriam Cristina Alvarez PEREIRA Universidade Federal de Vigosa Department of Plant BiologyLaboratory of Ecology and Evolution of Plants36570-900Vicosa-MGBrazil Universidade Federal de Vigosa Department of Forest EngineeringLaboratory of Forest Restoration36570-900Vicosa-MGBrazil Universidade Federal do Espirito Santo Department of Agrarian and Biological SciencesLaboratory of Ecology of Restinga and Mata Atlantica29932-900Sao Mateus-ESBrazil Universidade Federal do Espirito Santo Department of Biology29500-000Alegre-ESBrazil

Plant communities are shaped by multiple factors along environmental gradients;however,studies are limited on how environmental filtering drives community composition and species richness on tropical *** evaluate the influence of altitude and climatic variables related to temperature and precipitation on plant community composition and species richness on Brazilian *** assume as a premise that both climate and altitude would induce changes on plant community composition and species richness at the local *** used plant inventory data from 370 sampling units across four inselberg sites in the Atlantic Forest of Espírito Santo State,south-eastern *** tested the univariate and multivariate effects of altitude and climate variables on community composition and species richness with multiple *** in species richness between inselbergs were evaluated using sample-based data to estimate rarefaction and extrapolation *** addition,differences in species composition and taxonomic beta diversity were examined via novel frequency-based metrics.A contrasting climate pattern was observed between the inselberg sites,with south sites being wet compared to the dry conditions found in northern *** richness by rarefaction showed a similar pattern within regional sites;however,there were marked differences between *** richness and beta diversity showed significant differences among sites,with higher values in southern sites than in northern *** a multi-model comparison between inselberg sites,altitude significantly influenced community composition and species richness and explained more variance than climate *** finding suggested that climate could act to some extent on these tropical inselbergs;however,altitude was a better predictor of plant community composition and species richness at the local level.

关键词： Atlantic Forest Biome Beta diversity Abiotic filtering Climate models Environmental filtering Latitudinal gradient

Preparation and Compaction Behaviour of Poly(methyl methacrylate) Coated Iron Microparticles

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Journal of Materials Science & Technology 2010年第5期26卷 454-460页

作者： Daniela Kladeková Renáta Orináková Annamária Krajníková miriam Kupková Margita Kabátová Kveta Markuová Institute of Chemistry Faculty of ScienceP.J.afárik University in Koice Institute of Materials Research of the Slovak Academy of Sciences in Koice

The poly（methyl methacrylate）（PMMA） coatings onto surface of iron particles were electrochemically prepared and the effect on both surface structure and internal structure of the resulted material after compaction was carried *** electrochemical polymerization treatment was performed in a fluidized bed electrolyzer using sulphuric acid solution containing potassium persulphate and methyl methacrylate（MMA）.The surface topography and the microstructure of the samples were observed by scanning electron microscopy（SEM） and optical microscopy（OM）.It was found that the PMMA layer coated onto iron particles results in improvement of their compressibility compared with uncoated powders,and classical lubricants are not necessary for compacting particles coated.

关键词： Cathodic electropolymerization Poly(methyl methacrylate) coating Surface appearance Microstructure Compaction process