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Insulin-mimetic compound hexaquis(benzylammonium) decavanadate is antilipolytic in human fat cells

World Journal of Diabetes 2017年第4期8卷 143-153页

作者： Christian Carpéné Silvia Garcia-Vicente Marta Serrano Luc Marti ChloéBelles miriam Royo Jean Galitzky Antonio Zorzano Xavier Testar Institut des Maladies Métaboliques et Cardiovasculaires I2MCINSERM U1048Institut.National de la Santé et de la Recherche Médicale &Université Paul Sabatier Genmedica Therapeutics S.L. Esplugues de Llobregat Combinatorial Chemistry Unit Barcelona Science ParkUniversity of Barcelona CIBER-BBN Networking Centre on BioengineeringBiomaterials and Nanomedicine Departament de Bioquimica i Biomedicina Molecular Facultat de BiologiaUniversitat de Barcelona CIBER de Diabetes y Enfermedades Metabólicas Asociadas(CIBERDEM) Instituto de Salud Carlos Ⅲ Institute for Research in Biomedicine(IRB Barcelona) the Barcelona Institute of Science and Technology

AIM To assess in rodent and human adipocytes the antilipolytic capacity of hexaquis(benzylammonium) decavanadate(B6V10), previously shown to exert antidiabetic effects in rodent models, such as lowering free fatty acids(FFA) and glucose circulating *** Adipose tissue(AT) samples were obtained after informed consent from overweight women undergoing plastic surgery. Comparison of the effects of B6V10 and reference antilipolytic agents(insulin,benzylamine,vanadate) on the lipolytic activity was performed on adipocytes freshly isolated from rat, mouse and human AT. Glycerol release was measured using colorimetric assay as an index of lipolytic activity. The influence of B6V10 and reference agents on glucose transport into human fat cells was determined using the radiolabelled 2-deoxyglucose uptake *** In all the species studied, B6V10 exhibited a dosedependent inhibition of adipocyte lipolysis when triglyceride breakdown was moderately enhanced by β-adrenergic receptor stimulation. B6V10 exerted on human adipocyte a maximal lipolysis inhibition of glycerol release that was stronger than that elicited by insulin. However, B6V10 did not inhibit basal and maximally stimulated lipolysis. When incubated at dose ≥ 10 μmol/L, B6V10 stimulated by twofold the glucose uptake in human fat cells, but-similarly to benzylamine-without reaching the maximal effect of insulin, while it reproduced one-half of the insulin-stimulation of lipogenesis in mouse fat cells. CONCLUSION B6V10 exerts insulin-like actions in adipocytes, including lipolysis inhibition and glucose transport activation. B6V10 may be useful in limiting lipotoxicity related to obesity and insulin resistance.

关键词： Adipocyte Lipolysis Amine oxidases Insulin resistance Obesity Hydrogen peroxide Vanadium Antidiabetics

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大规模学生评估的影响力与重要性:德国视角

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复旦教育论坛 2010年第4期8卷 19-26页

作者： Wilfried Bos miriam M.Gebauer 俞可德国多特蒙德理工大学学校发展研究所上海师范大学现代校长研修中心/中德教育研究与协作中心/国际与比较教育研究中心上海200234

二十年来,大规模学生评估对教育研究、学校体系和教育政策产生了深远影响。"国际中学生评估项目"(PISA)、"国际学生数学与科学能力动态项目"(TIMSS)和"国际学生阅读能力进步研究项目"(PIRLS)使各个国家学生成绩值具有一定可比性,由此,... 详细信息

二十年来,大规模学生评估对教育研究、学校体系和教育政策产生了深远影响。"国际中学生评估项目"(PISA)、"国际学生数学与科学能力动态项目"(TIMSS)和"国际学生阅读能力进步研究项目"(PIRLS)使各个国家学生成绩值具有一定可比性,由此,人们能更细致地从学校内部来观察不同国家学校工作的差异度。大规模学生评估还为学校发展、教育领导以及学生成绩的改进提供必要数据。本文以PIRLS为例,旨在从德国视角为中国今后开展大规模国际学生评估提供借鉴。

关键词：大规模学生评估国际比较研究德国教育领导学校发展

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GDF-15 Level Correlates with CMKLR1 and VEGF-A in Tumor-free Margin in Colorectal Cancer

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Current Medical Science 2021年第3期41卷 522-528页

作者： Sylwia Mielcarska Kamila Stopifnska miriam Dawidowicz Agnieszka Kula Pawel Kicamer Alicja Prawdric Senkowska Ewa Nowakowska Zajde Katarzyna Walkiewicz Dariusz Waniczek Elzbieta Swietochowska Department of Medical and Molecular Biology Faculry of Medical Sciences in ZabrceMedical University of SilesicaZabrce41-808.Polard Department and Chair of Pathomorphology.Faculty of Medical Sciences in Zabrze Medical University of SilesiaZabrce 41-800Polardl Department of Nutrition Related Disease Prevention Department of Metabolic Disease PreventionSschool of Public Heath inByron.Medical Universiry of SilesiaByrom 41-902Polandd Department of Surgical Nursing cand Ssurgery Propedeutics.Chair of General.Colorectal and Trauma Surgery SHS in Katowice.Medical Universiry of SilesiaBytom 41-902Poland

Colorectal cancer(CRC)is the third most frequently diagnosed cancer worldwide,responsible for over 880000 deaths each ***/differentiation factor 15(GDF-15)is reported to be a promising diagnostic and prognostic factor in *** induces pleiotropic effects in tumor cells:proliferation,sternness,invasion and *** studies indicate that GDF-15 may stimulate angiogenesis in malignant ***,it has not been investigated in CRC *** aim of our study was to determine the level of GDF-15 and the concentrations of hypoxia-inducible factor-la(HIF-1α),VEGF-A and chemokine-like receptor 1(CMKLR1)in tumor and margin specimens of CRC in relation to histological grade and TNM *** study comprised 33 samples of tumor and margin tissues obtained from CRC *** assess the concentration of GDF-15,HIF-1α,VEGF-A and CMKLR1,commercially available enzyme-linked immunosorbent assay(ELISA)kits were *** found significantly increased levels of GDF-15 and CMKLR1 in tumor tissue compared to margin tissue and higher concentrations of HIF-1α and VEGF-A in margin tissue than in tumor *** levels of GDF-15 and HIF-1α were significantly correlated with VEGF-A and CMKLR1 in margin *** CRC,the increased level of GDF-15 might stimulate angiogenesis through upregulation of HIF-1α,VEGF A and CMKLR1 *** study is the first one to reveal the correlation between the levels of GDF-15 and CMKLR1 in *** elevated levels of HIF-1α and VEGF-A in tumor-free margin tissues suggest that noncancer cells in the tumor microenvironment are an important source of proangiogenic factors.

关键词： colorectal cancer growth/differentiation factor 15(GDF-15) chemokine-like receptor 1(CMKLR1) VEGF-A angiogenesis

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Dual role of lipids for genome stability and pluripotency facilitates full potency of mouse embryonic stem cells

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蛋白质与细胞:英文版 2023年第8期14卷 591-602页

作者： Liangwen Zhong miriam Gordillo Xingyi Wang Yiren Qin Yuanyuan Huang Alexey Soshnev Ritu Kumar Gouri Nanjangud Daylon James C.David Allis Todd Evans Bryce Carey Duancheng Wen Department of Reproductive Medicine Ronald O.Perelman and Claudia Cohen Center for Reproductive MedicineWeill Cornell MedicineNew YorkNY 10065USA Department of Surgery Weill Cornell Medical College1300 York AvenueNew YorkNY 10065USA Laboratory of Chromatin Biology and Epigenetics The Rockefeller UniversityNew YorkNY 10065USA Cold Spring Harbor Laboratory Cold Spring HarborNY 11724USA Molecular Cytogenetics Core.Memorial Sloan Kettering Cancer Center New YorkNY 10065USA Department of Neuroscience Developmental and Regenerative BiologyUniversity of Texas at San AntonioOne UTSA CircleSan AntonioTX 78249USA Gladstone Institutes 1650 Owens StSan FranciscoCA94158USA

While Mek1/2 and Gsk3βinhibition("2i")supports the maintenance of murine embryonic stem cells(EsCs)in a homogenous naive state,prolonged culture in 2i results in aneuploidy and DNA hypomethylation that impairs developmental ***,2i fails to support derivation and culture of fully potent female *** we find that mouse ESCs cultured in 2i/LIF supplemented with lipid-rich albumin(AlbuMAx)undergo pluripotency transition yet maintain genomic stability and full potency over long-term ***,lipids in AlbuMAx impact intracellular metabolism including nucleotide biosynthesis,lipid biogenesis,and TCA cycle intermediates,with enhanced expression of DNMT3s that prevent DNA *** induce a formative-like pluripotent state through direct stimulation of Erk2 phosphorylation,which also alleviates X chromosome loss in female ***,both male and female"all-ESc"mice can be generated from de novo derived ESCs using AlbuMAXbased *** findings underscore the importance of lipids to pluripotency and link nutrient cues to genome integrity in early development.

关键词： mouse pluripotent stem cells lipids pluripotency transition genomic stability developmental potency nucleotide pool depletion 2i medium X chromosome loss femaleall-EsC mice

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流体剖面上溶解硫酸盐的含量能否反映原地甲烷通量

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海洋地质动态 2009年第2期25卷 24-24,28页

作者： miriam kastner 成海燕

在天然气水合物稳定带中,受生物地球化学因素制约的甲烷通量是控制天然气水合物分布和含量的关键.我们将通过非保压岩心和保压岩心数据进行说明,这些数据分别来自孟加拉海两个海盆:克里希纳河-哥达瓦里河盆地(K-G)和印度东南部近海的Mah... 详细信息

在天然气水合物稳定带中,受生物地球化学因素制约的甲烷通量是控制天然气水合物分布和含量的关键.我们将通过非保压岩心和保压岩心数据进行说明,这些数据分别来自孟加拉海两个海盆:克里希纳河-哥达瓦里河盆地(K-G)和印度东南部近海的Mahanadi盆地(水深900～1 170 m),以及位于安达曼海 (水深1 600 m) 的1个站位和卡斯卡底古陆(水深890 m) 的水合物脊上的2个站位.以上所有站位都发现了天然气水合物存在的证据,但每个站位水合物的含量、分布和含水合物沉积物的结构各不相同.数据表明,主要以HCO-13形式存在的溶解无机碳 (DIC),其碳同位素在缺氧沉积物中是推断碳源、有机质成岩过程和海底表层烃通量的关键.

关键词：甲烷通量硫酸盐水合物稳定带天然气水合物含水合物沉积物溶解剖面流体

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Effects of Continuous Vertical Soil Pores on Root and Shoot Growth of Winter Wheat: A Microcosm Study

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Agricultural Sciences 2018年第6期9卷 750-764页

作者： Tim Dresemann miriam Athmann Lukas Heringer Timo Kautz INRES-Agroecology and Organic Farming University of Bonn Bonn Germany Experimental Farm Wiesengut Hennef Germany INRES Soil Science University of Bonn Bonn Germany

Round shaped, continuous vertical pores (CVPs) in the soil are typically created by roots and earthworms. CVPs with diameters > 2 mm are abundant in many agricultural soils. We hypothesized that potential effects of CVPs on shoot growth of winter wheat (Triticum aestivum L.) increase with: 1) decreasing availability of water and 2) decreasing availability of nutrients in the topsoil. We conducted a microcosm experiment with different irrigation regimes (Irr+/Irr-) and P concentrations (P+/P-), with or without artificially created continuous vertical pores (CVP+/CVP-). Winter wheat was cultivated for 16 weeks. In the bulk soil, presence of CVPs resulted in decreased root length in 20 - 40 cm but increased root length in 40 - 60 cm soil depth. In general, total root length of winter wheat in 20 - 60 cm soil depth was higher when CVPs were present or when P concentrations in the topsoil were elevated. Presence of CVPs generally had a positive effect on shoot dry matter and N uptake of wheat. In columns with high phosphorous concentrations but low soil moisture in the topsoil, presence of CVPs increased shoot dry matter by 66%;in contrast, the beneficial effect of CVPs on shoot dry matter was only 39% in columns with high nutrient concentrations and high soil moisture in the topsoil. In total numbers, however, the effect of CVPs on P uptake into the shoot was more pronounced when P concentrations in the topsoil were elevated. We conclude that CVPs can promote the exploration of the solid soil phase by high root-length densities, but adequate nutrient supply in the topsoil is essential.

关键词： Subsoil Mechanical Resistance Drought Stress P Supply Nutrient Acquisition

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A Fatigue Analysis of a Hydraulic Francis Turbine Runner

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World Journal of Mechanics 2012年第1期2卷 28-34页

作者： miriam Flores Gustavo Urquiza José María Rodríguez Centro de Investigación en Ingeniería y Ciencias Aplicadas CIICAp Universidad Autónoma del Estado de Morelos Cuernavaca México

In this work, the estimation of crack initiation life of a hydraulic Francis turbine runner is presented. The life prediction is based on the local strain approach to predict the initiation life. First, the analysis is carried out in air and in water condition and the runner’s natural frequencies were calculated using the finite element (FE) method. The analysis in air is compared with experimental analysis in order to have a representative model of real runner and subsequently the numerical analysis was perform in water. In the case of the runner immersed in water, the added mass effect due to the fluid structure interaction (FSI) is considered. Second, the static and dynamic stresses were calculated according to life estimation. For the calculation of static stresses, the pressure distribution of water and the centrifugal forces were applied to the runner. The dynamic stresses were estimated for interactions between the guide vane and the runner. Lastly, the estimation of the crack initiation life of the runner was obtained.

关键词： Hydraulic Francis Turbine Crack Finite Element Modal Analysis Fluid-Structure Interaction

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Accumulation of the betaine and ectoine in osmotic stress adaptation of biocontrol agents against <i>Fusarium verticillioides</i>in maize

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Agricultural Sciences 2012年第1期3卷 83-89页

作者： Melina Sartori Andrea Nesci Naresh Magan miriam Etcheverry Applied Micology Group Cranfield Health Vincent Building Cranfield University Cranfield UK Laboratorio de Ecología Microbiana Departamento de Microbiología e Inmunología Facultad de Ciencias Exactas Físico Químicas y Naturales Universidad Nacional de Río Cuarto Río Cuarto Argentina

The aims of this study was to examine the effect of the osmotic (NaCl) water stress on, growth and accumulation of endogenous compatible solutes of Bacillus amyloliquefaciens and Microbacterium oleovorans, biocontrol agents against Fusarium verticillioides. Triptic soya broth media were modified ionically to 0.99;0.98;0.97 and 0.96 aw with NaCl. The endogenous contents of the intracellular compatible solutes glycine-betaine and ectoine were quantified. Cells grown under ionic solute stress showed accumulation of significant amounts of both amino acids in all treatments. The growth rate of F. verticillioides was decreased significantly by interaction with B. amyloliquefaciens and M. oleovorans physiologically adapted at 0.96 aw. This study have demonstrated the ability to synthesize betaine and ectoine under high-osmolality conditions of B. amyloliquefaciens and M. oleovorans cells. Such ecophysiological manipulation, especially to water stress, may increase the potential for biological control of F. verticillioides at field under wider aw conditions.

关键词： Biological Control Osmotic Adaptation Solute Compatible Fusarium verticillioides Maize

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An insight into artisanal leather making in Ghana

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Journal of Leather Science and Engineering 2020年第1期2卷 307-320页

作者： miriam Appiah-Brempong Helen M.K.Essandoh Nana Yaw Asiedu Samuel Kwame Dadzie Francis Warings Yao Momade RWESCK Department of Civil EngineeringCollege of EngineeringKwame Nkrumah University of Science and TechnologyKumasiGhana Department of Chemical Engineering College of EngineeringKwame Nkrumah University of Science and TechnologyKumasiGhana Department of Materials Engineering College of EngineeringKwame Nkrumah University of Science and TechnologyKumasiGhana

The production of leather from animal skins and hides through tanning processes began in the pre-historic *** the origination of new leather making techniques such as chrome tanning which is being employed extensively today,the traditional method of leather production primarily through vegetable tanning is still being practised mostly in artisanal tanneries in developing nations including *** leather making,thus,contributes beneficially to rural ***,the growth of this sector has been stifled by the lack of innovative technologies to enhance *** challenge could be partly linked to the knowledge gap on the scientific principles governing artisanal leather production *** study,therefore,elaborates on various process steps and materials employed in traditional leather making in Ghana and the scientific principles underlying each of the *** also makes a comparison between traditional and modern leather manufacturing processes and identifies knowledge and technological gaps which would inspire in-depth scientific research into artisanal leather making.

关键词： Artisanal leather making processes Modern-day leather manufacturing Animal skin/hide Tannery Pre-tanning Tanning Post-tanning

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Mapping What They Know: Concept Maps as an Effective Tool for Assessing Students’ Systems Thinking

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American Journal of Operations Research 2013年第1期3卷 245-258页

作者： Jaklin Tripto Orit Ben-Zvi Assaraf miriam Amit Department of Science and Technology Education Ben Gurion University of the Negev Beer Sheva Israel

In 2006 anew biology curriculum called “Human Biology: Emphasizing the Role of Homeostasis” was introduced into the Israeli high school system. Complex systems like those that make up the human body have become increasingly important as a focus of high school education. This study examines the effectiveness of the concept map as a assessment tool for students’ systems thinking, a tool that provides researchers with a detailed picture of the systems thinking development taking place within individual students. The content of the students’ concept maps was translated into information about students’ system thinking using the Systems Thinking Hierarchy (STH) model, a model in which system thinking is categorized according to eight hierarchical characteristics or abilities. The goal was to use the maps to characterize Israeli high school students’ understanding of the body’s systemic nature. To do this, we identified the extent to which the students understand three central elements of systems, namely hierarchy, homeostasis, and dynamism, and then analyzed this understanding according to its place within the hierarchical stages of the STH model. The extensive qualitative data analysis of 48 concept maps made by 11th grade biology majors suggest that the strength of the concept map is in its ability to describe the first two levels of system thinking (analysis and synthesis). However, it proved less successful in eliciting evidence of the third and highest level, particularly of students’ understanding of patterns, of homeostasis and their capacity for temporal thinking.

关键词： Human Body System Systems Thinking Concept Map

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