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International Journal of Nursing Sciences 2023年第2期10卷 199-205页

作者： Daniel M.Nzengya Albanus K.Mutisya miriam c.a.wagoro Molly Secor-Turner Joan Edwards Research and Innovation St.Paul’s UniversityLimuruKenya School of Nursing Jomo Kenyatta University of Agriculture&TechnologyNairobiKenya Department of Nursing Sciences University of NairobiNairobiKenya Mark and Robyn Jones college of Nursing Montana State UniversityBozemanMTUSA Nelda c.Stark college of Nursing Texas Woman's UniversityHoustonTXUSA

Objective To assess the level of participation of nurses and midwives in health-related research,determine the status of utilization of research to inform nursing and midwifery practice in Kenya,and explore perspectives of nurses and midwives about strategies to empower nurses/midwives to engage in health research in *** Data were extracted from online survey responses of 156 nurse and midwife educators,practitioners,and managers/*** version 26 was used to analyze quantitative data;qualitative data were analyzed using Excel to organize data into *** Over one-third of participants reported ever publishing research(37.2%,58/156).Participants reported using knowledge gained in nursing school to guide practice most frequently(n=148).Utilization of research findings to guide practice was reported by 80.3%(110/137)of *** to enhance participation in the research included research training,research forums,policy reforms,and emphasis on research in *** There is need to intensify and prioritize proposed strategies to empower nurses/midwives to engage in health research.

关键词： Evidence-based practice Kenya Midwifery Nurses Research

Impact of STAT-signaling pathway on cancer-associated fibroblasts in colorectal cancer and its role in immunosuppression

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World Journal of Gastrointestinal Oncology 2024年第5期16卷 1705-1724页

作者： Damián Sánchez-Ramírez Mónica G Mendoza-Rodríguez Omar R Alemán Fernando A candanedo-González miriam Rodríguez-Sosa Juan JoséMontesinos-Montesinos Mauricio Salcedo Ismael Brito-Toledo Felipe Vaca-Paniagua Luis I Terrazas Unidad de Investigacion en Biomedicina Facultad de Estudios Superiores IztacalaUniversidad Nacional Autonoma de MexicoTlalnepantla 54090Estado de MexicoMexico Department of Biology Facultad de QuimicaUniversidad Nacional Autonoma de MexicoCiudad UniversitariaMexico City 04510Mexico Department of Pathology National Medical Center Century XXIInstituto Mexicano del Seguro SocialMexico City 06720Mexico Laboratorio de células Troncales Mesenquimales Unidad de Investigación Médica en Enfermedades OncológicasHospital de Oncología Centro Medico Nacional Siglo XXIInstituto Mexicano del Seguro SocialMexico City 06720Mexico Unidad de Investigacion en Biomedicina y Oncologia Genomica Instituto Mexciano del Seguro SocialMexico City 07300Mexico Servicio de colon y Recto Hospital de Oncología Centro Medico Nacional Siglo XXIInstituto Mexicano del Seguro SocialMexico City 06720Mexico Laboratorio Nacional en Salud Facultad de Estudios Superiores IztacalaUniversidad Nacional Autónoma de MéxicoTlalnepantla 54090Estado de MexicoMexico

colorectal cancer(cRc)remains one of the most commonly diagnosed and deadliest types of cancer *** displays a desmoplastic reaction(DR)that has been inversely associated with poor prognosis;less DR is associated with a better *** reaction generates excessive connective tissue,in which cancer-associated fibroblasts(cAFs)are critical cells that form a part of the tumor *** are directly involved in tumorigenesis through different ***,their role in immunosuppression in cRc is not well understood,and the precise role of signal transducers and activators of transcription(STATs)in mediating cAF activity in cRc remains *** the myriad chemical and biological factors that affect cAFs,different cytokines mediate their function by activating STAT signaling ***,the harmful effects of cAFs in favoring tumor growth and invasion may be modulated using STAT ***,we analyze the impact of different STATs on cAF activity and their immunoregulatory role.

关键词： cancer-associated fibroblasts Signal transducer and activator of transcription signaling colorectal cancer Immunity Immunosuppression

Recognition of Human Actions through Speech or Voice Using Machine Learning Techniques

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computers, Materials & continua 2023年第11期77卷 1873-1891页

作者： Oscar Peña-cáceres Henry Silva-Marchan Manuela Albert miriam Gil Professional School of Systems Engineering Universidad César VallejoPiura20009Perú Escola Tècnica Superior d’Enginyeria Departament d’InformàticaUniversitat de ValènciaBurjassotValencia46100Spain Department of Mathematics Statistics and InformaticsUniversidad Nacional de TumbesTumbes24000Perú Valencian Research Institute for Artificial Intelligence Universitat Politècnica de ValènciaValencia46022Spain

The development of artificial intelligence(AI)and smart home technologies has driven the need for speech recognition-based *** demand stems from the quest for more intuitive and natural interaction between users and smart devices in their *** recognition allows users to control devices and perform everyday actions through spoken commands,eliminating the need for physical interfaces or touch screens and enabling specific tasks such as turning on or off the light,heating,or lowering the *** purpose of this study is to develop a speech-based classification model for recognizing human actions in the smart *** seeks to demonstrate the effectiveness and feasibility of using machine learning techniques in predicting categories,subcategories,and actions from sentences.A dataset labeled with relevant information about categories,subcategories,and actions related to human actions in the smart home is *** methodology uses machine learning techniques implemented in Python,extracting features using countVectorizer to convert sentences into numerical *** results show that the classification model is able to accurately predict categories,subcategories,and actions based on sentences,with 82.99%accuracy for category,76.19%accuracy for subcategory,and 90.28%accuracy for *** study concludes that using machine learning techniques is effective for recognizing and classifying human actions in the smart home,supporting its feasibility in various scenarios and opening new possibilities for advanced natural language processing systems in the field of AI and smart homes.

关键词： AI machine learning smart home human action recognition

Epidemiology of hepatitis c virus infection

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World Journal of Gastroenterology 2007年第17期13卷 2436-2441页

作者： miriam J Alter Institute for Human Infections and Immunity University of Texas Medical Branch Galveston Texas USA 77555 United States

Globally, hepatitis c virus (HcV) has infected an estimated 130 million people, most of whom are chronically infected. HcV-infected people serve as a reservoir for transmission to others and are at risk for developing chronic liver disease, cirrhosis, and primary hepatocellular carcinoma (Hcc). It has been estimated that HcV accounts for 27% of cirrhosis and 25% of Hcc worldwide. HcV infection has likely been endemic in many populations for centuries. However, the wave of increased HcV-related morbidity and mortality that we are now facing is the result of an unprecedented increase in the spread of HcV during the 20th century. Two 20th century events appear to be responsible for this increase; the widespread availability of injectable therapies and the illicit use of injectable drugs.

关键词： Hepatitis c virus Global epidemiology Incidence Prevalence Transmission Natural history

Biomarkers of Human Exposure to carcinogens: An Overview

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Biomedical and Environmental Sciences 1991年第1期4卷 69-72页

作者： FREDERIcK A.BELAND miriam c.POIRIER National center for Toxicological Research JeffersonNational Cancer Institute Bethesda Arkansas 72079-9502 Maryland 20892

Environmental, occupational, or dietary exposure to certain chemicals has been shown to be associated with carcinogenesis in humans. In the 18th century, for example, Percival Pott (1775) noted a high incidence of scrotal cancer in chimney sweeps, which he attributed to their exposure to soot and a concomitant lack of bathing. Subsequent epidemiological studies have identified a number of additional carcinogenic agents, including aromatic amine-based dyes (case et al., 1954), cigarette smoke (Wynder and Graham, 1950), asbestos (Doll, 1955), vinyl chloride (creech and

关键词： An Overview Biomarkers of Human Exposure to carcinogens

New transcriptomic insights in two RNAi wheat lines with the gliadins strongly down-regulated by two endosperm specific promoters

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The crop Journal 2022年第1期10卷 194-203页

作者： miriam Marín-Sanz Julio cMasaru Iehisa Francisco Barro Department of Plant Breeding Institute of Sustainable Agriculture(IAS)Spanish Council for Scientific Research(CSIC)14004 CórdobaSpain Department of Biotechnology Faculty of Chemical SciencesNational University of Asunción111421 San LorenzoParaguay

The gluten proteins of wheat grain are responsible for visco-elastic properties of flour,but they also trigger the immune-response of celiac *** this work,two low-gliadin RNA interference(RNAi)wheat lines that differ for the promoter driving the silencing(D-hordein andγ-gliadin promoters for D783 and D793 lines,respectively),were characterized at transcriptomic,and protein fraction levels in the *** of gliadins provides a readjustment in the grain protein fractions that also affects to the nongluten proteins(NGP),which were increased in both RNAi *** of wheat gluten by means of the R5 monoclonal antibody also showed a strong reduction in the content of gluten in both RNAi ***,fructans,an oligosaccharide linked with the development of non-celiac wheat sensitivity(NcWS)were also significantly decreased in RNAi *** down-regulation of gliadins fractions also impacts to other metabolic processes,particularly on carbohydrate metabolism,enzyme regulator activity and response to *** and transcription factors regulated by ABA were up-regulated,which could suggest the implication of this phytohormone on the stress response observed in the RNAi lines.

关键词： celiac disease Gliadin Protein compensation RNAi lines Triticum aestivum

An Ontology Based cyclone Tracks classification Using SWRL Reasoning and SVM

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computer Systems Science & Engineering 2023年第3期44卷 2323-2336页

作者： N.Vanitha c.R.Rene Robin D.Doreen Hephzibah miriam Sri Sai Ram Engineering college Chennai600044TamilnaduIndia Director of computational Intelligence Research Foundation Chennai600023TamilnaduIndia

Tropical cyclones(Tc)are often associated with severe weather conditions which cause great losses to lives and *** precise classification of cyclone tracks is significantly important in thefield of weather *** this paper we propose a novel hybrid model that integrates ontology and Support Vector Machine(SVM)to classify the tropical cyclone tracks into four types of classes namely straight,quasi-straight,curving and sinuous based on the track *** cyclone TRacks Ontology(TcTRO)described in this paper is a knowledge base which comprises of classes,objects and data properties that represent the interaction among the Tc characteristics.A set of SWRL(Semantic Web Rule Language)rules are directly inserted to the TcTRO ontology for reasoning and inferring new knowledge from ***,we propose a learning algorithm which utilizes the inferred knowledge for optimizing the feature *** to experiments on the IBTrAcS dataset,the proposed ontology based SVM classifier achieves an accuracy of 98.3%with reduced classification error rates.

关键词： Tropical cyclones classification support vector machine ontology SWRL reasoning SVM classification

Effect of aging on behaviour of mesenchymal stem cells

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World Journal of Stem cells 2019年第6期11卷 337-346页

作者： Juan Antonio Fafián-Labora miriam Morente-López María c Arufe Grupo de Terapia celular y Medicina Regenerativa Departamento de Fisioterapia Ciencias Biomédicas y MedicinaUniversidade da Coru?a

Organs whose source is the mesoderm lineage contain a subpopulation of stem cells that are able to differentiate among mesodermal derivatives (chondrocytes, osteocytes, adipocytes). This subpopulation of adult stem cells, called “mesenchymal stem cells” or “mesenchymal stromal cells (MScs)”, contributes directly to the homeostatic maintenance of their organs;hence, their senescence could be very deleterious for human bodily functions. MScs are easily isolated and amenable their expansion in vitro because of the research demanding to test them in many diverse clinical indications. All of these works are shown by the rapidly expanding literature that includes many in vivo animal models. We do not have an in-depth understanding of mechanisms that induce cellular senescence, and to further clarify the consequences of the senescence process in MScs, some hints may be derived from the study of cellular behaviour in vivo and in vitro, autophagy, mitochondrial stress and exosomal activity. In this particular work, we decided to review these biological features in the literature on MSc senescence over the last three years.

关键词： Mesenchymal stem cells Aging Autophagy Mitochondrial stress Extracellular vesicles

Secured cyber Security Algorithm for Healthcare System Using Blockchain Technology

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Intelligent Automation & Soft computing 2023年第2期35卷 1889-1906页

作者： D.Doreen Hephzibah miriam Deepak Dahiya Nitin c.R.Rene Robin computational Intelligence Research Foundation(cIRF) Chennai600023TamilnaduIndia college of computer and Information Sciences Majmaah UniversityMajmaah11952Saudi Arabia Department of Electrical Engineering and computer Science College of Engineering and Applied ScienceUniversity of CincinnatiCincinnati45221OHUnited States Department of computer Science and Engineering Sri Sairam Engineering CollegeChennai600044TamilnaduIndia

Blockchain technology is critical in cyber *** most recent cryptographic strategies may be hacked as efforts are made to build massive elec-tronic *** of the ethical and legal implications of a patient’s medical data,cyber security is a critical and challenging problem in *** image secrecy is highly vulnerable to various types of *** a result,designing a cyber security model for healthcare applications necessitates extra caution in terms of data *** resolve this issue,this paper proposes a Lionized Golden Eagle based Homomorphic Elapid Security(LGE-HES)algorithm for the cybersecurity of blockchain in healthcare *** blockchain algorithm preserves the security of the medical image by performing hash *** execution of this research is carried out by MATLAB *** suggested fra-mework was tested utilizing computed Tumor(cT)pictures and MRI image data-sets,and the simulation results revealed the proposed model’s profound *** the simulation,94.9%of malicious communications were recognized and identiﬁed effectively,according to the total outcomes *** suggested model’s performance is also compared to that of standard approaches in terms of Root Mean Square Error(RMSE),Peak Signal to Noise Ratio(PSNR),Mean Square Error(MSE),time complexity,and other factors.

关键词： Healthcare system cybersecurity security data sharing blockchain

The Synaptonemal complex of Basal Metazoan Hydra:More Similarities to Vertebrate than Invertebrate Meiosis Model Organisms

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Journal of Genetics and Genomics 2014年第3期41卷 107-115页

作者： Johanna Fraune miriam Wiesner Ricardo Benavente Department of cell and Developmental Biology BiocenterUniversity of Würzburg

The synaptonemal complex （Sc） is an evolutionarily well-conserved structure that mediates chromosome synapsis during prophase of the first meiotic division. Although its structure is conserved, the characterized protein components in the current metazoan meiosis model systems （Drosophila melanogaster, caenorhabditis elegans, and Mus musculus） show no sequence homology, challenging the question of a single evolutionary origin of the Sc. However, our recent studies revealed the monophyletic origin of the mammalian Sc protein components. Many of them being ancient in Metazoa and already present in the cnidarian Hydra. Remarkably, a comparison between different model systems disclosed a great similarity between the Sc components of Hydra and mammals while the proteins of the ecdysozoan systems （D. rnelanogaster and c. elegans） differ significantly. In this review, we introduce the basal-branching metazoan species Hydra as a potential novel invertebrate model system for meiosis research and particularly for the investigation of Sc evolution, function and assembly. Also, available methods for Sc research in Hydra are summarized.

关键词： Meiosis Synaptonemal complex Hydra Evolution