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Old-fashioned and newly discovered biomarkers:the future of NAFLD-related HCC screening and monitoring

Hepatoma Research 2022年第1期8卷 415-434页

作者： Roberto Piciotti miriam Longo Adele Agresta Erika Paolini Annalisa Cespiati Marica Meroni Paola Dongiovanni General Medicine and Metabolic Diseases Fondazione IRCCS Ca’Granda Ospedale Maggiore PoliclinicoMilan 20122Italy Department of Pathophysiology and Transplantation Universitàdegli Studi di MilanoMilano 20122Italy Department of Clinical Sciences and Community Health Universitàdegli Studi di MilanoMilano 20122Italy Department of Pharmacological and Biomolecular Sciences Universitàdegli Studi di MilanoMilano 20133Italy

Nonalcoholic fatty liver disease(NAFLD)is the major contributor to the global burden of chronic liver diseases and ranges from simple and reversible steatosis to nonalcoholic steatohepatitis(NASH),which may progress into cirrhosis and hepatocellular carcinoma(HCC).HCC represents the most common liver cancer,and it is a leading cause of death worldwide with an increasing trend for the *** to late diagnosis,non-responsiveness to systemic therapy,and high cancer heterogeneity,the treatment of this malignancy is *** date,liver biopsy and ultrasound(US)are the gold standard procedures for HCC diagnosis and surveillance,although they are not suitable for mass ***,it is impelling to find new,less invasive diagnostic strategies able to detect HCC at an early stage as well as monitor tumor progression and *** and rare inherited variations that boost the switching from NASH to liver cancer may help to predict tumor ***,epigenetic changes which reflect intertumoral heterogeneity occur early in tumorigenesis and are highly stable under pathologic *** severity of hepatic injuries can be detected through the analysis of cell circulating tumor DNAs(ctDNAs),microRNAs(miRNAs),and noncoding RNAs(ncRNAs),which are involved in several pathological processes that feature cancer,including cell growth,survival,and differentiation,thus representing appealing biomarkers for ***,this review discusses the current options for HCC surveillance,focusing on the role of genetic and epigenetic biomarkers as new strategies to refine HCC management.

关键词： NAFLD-HCC screening genetic biomarkers ncRNAs epigenetics early HCC detection

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新型微晶玻璃在电子领域的应用（英文）

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中国材料进展 2015年第7期34卷 558-564页

作者： Roland Langfeld miriam Kunze Martin Letz 肖特公司

硅酸锂铝微晶玻璃材料作为零膨胀材料在光学领域,以及作为耐高温材料在壁炉和烤炉方面的应用都极为广泛。介绍了通过熔化陶瓷化法生产的以Li7La3Zr2O12(LLZO)为主,并以Li SICon结构为主的两种新型微晶玻璃的最新进展,这两种微晶玻璃在... 详细信息

硅酸锂铝微晶玻璃材料作为零膨胀材料在光学领域,以及作为耐高温材料在壁炉和烤炉方面的应用都极为广泛。介绍了通过熔化陶瓷化法生产的以Li7La3Zr2O12(LLZO)为主,并以Li SICon结构为主的两种新型微晶玻璃的最新进展,这两种微晶玻璃在室温下10-3S/cm范围内都显示出了良好的Li离子导电性能。此外,还介绍了含纳米晶铁电体或顺电晶相的微晶玻璃,这种微晶玻璃应用于高性能电容器所用新型介电材料上。

关键词：玻璃微晶玻璃介电性能电容器离子导电性固态电解质锂离子电池

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Infrared fluorescence imaging of infarcted hearts with A@S nanodots

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Nano Research 2019年第4期12卷 749-757页

作者： Dirk H. Ortgies Angel Luis Garcia-Villalon miriam Granado Sara Amor Emma Martin Rodriguez Harrisson DA Santos Jingke Yao Jorge Rubio-Retama Daniel Jaque Nanobiology Group Instituto Ramon y Cajal de Investigacion Sanitaria IRYCIS Ctra. Colmenar km. 9.100 Madrid 28034 Spain Fluorescence Imaging Group Departamento de Fisica de Materiales - Facultad de Ciencias Universidad Autonoma de Madrid C/ Francisco Tomas y Valiente 7 Madrid 28049 Spain Fluorescence Imaging Group Departamento de Fisiologia - Facultad de Medicina Avda. Arzobispo Morcillo 2 Universidad Autonoma de Madrid Madrid 28029 Spain Fluorescence Imaging Group Departamento de Fisica Aplicada - Facultad de Ciencias Universidad Autonoma de Madrid C/ Francisco Tomas y Valiente 7 Madrid 28049 Spain Grupo de Nano-Fotonica e Imagens Instituto de Fisica Universidade Federal de Alagoas Maceio-AL 57072-900 Brazil Departamento de Quimica Fisica en Ciencias Farmaceuticas Facultad de Farmacia Plaza de Ramon y Cajal s/n Universidad Complutense de Madrid Madrid 28040 Spain

Ag2S nano dots have already bee n dem onstrated as promisi ng n ear-i nfrared (NIR-II, 1.0-1.45 pm) emitting nan oprobes with low toxicity, high penetration and high resolution for in vivo imaging of, for example, tumors and vasculature. In this work, we have systematically investigated the pote ntial applicati on of function alized Ag2S nano dots for accurate imaging of damaged myocardium tissues after a myocardial in farction in duced by either partial or global ischemia. Ag2S nano dots surface-function alized with the an giote nsin II peptide (ATI I) have show n over 10-fold enhanced binding efficiency to damaged tissues than non-specifically (PEG) functionalized Ag2S nanodots due to their interaction with the upregulated angiotensin II receptor type I (AT1R). It is demonstrated how the NIR-II images generated by ATII-functionalized Ag2S nanodots contain valuable information about the location and extension of damaged tissue in the myocardium allowing for a proper identification of the occluded artery as well as an in direct evaluati on of the damage level. The pote ntial applicati on of Ag2S nano dots in the n ear future for in vivo imaging of myocardial infarction was also corroborated by performing proof of concept whole body imaging experiments.

关键词： infrared imaging myocardial infarct Ag2S nanodots biological windows Langendorff heart

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Excision margins in squamous cell carcinoma of the tongue: A retrospective audit and review of the literature

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Open Journal of Stomatology 2013年第1期3卷 70-74页

作者： miriam Thake Athanasis Kalantzis Maxillofacial Surgery Oxford Radcliffe Hospitals Oxford UK Oxford University Medical School Oxford Radcliffe Hospitals Oxford University Oxford UK

The incidence of close and involved tongue resection margins for squamous cell carcinoma (SCC) were reviewed with the aim to identify any possible need for change in the surgical approach to glossectomies. The histopathological reports of 101 partial glossectomies for SCC between 2006 and 2012 were retrospectively reviewed. Results: Overall 52 (51.5%) patients had one or more close or involved margin and 9 (8.9%) had both close and involved margins. 42 (41.5%) patients had close margins and 11 (10.9%) had involved margins. The inferior/lateral muscoal margin was most frequently close/involved (32%) followed by deep margin (27%). The anterior margin was least close/involved (5%). The posterior and superior/medical margins were close/involved in 12% and 11% of cases respectively. Conclusions: 52.5% of patients had close or involved margins following surgery, potentially requiring further treatment to avoid an increased risk of tumour recurrence and the associated increase in morbidity and mortality. The inferior/lateral and deep margins were most frequently involved possible due to the anatomical difficulties visualising and dissecting these margins. The potential explanations for these disparities and possible solutions are discussed.

关键词： Squamous Cell Carcinoma Tongue Cancer Partial Glossectomy Excision Margins

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Transcatheter aortic valve implantation operators-get involved in imaging!

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World Journal of Cardiology 2017年第12期9卷 853-857页

作者： miriam Brinkert Stefan Toggweiler Heart Center Lucerne Luzerner KantonsspitalLucerne 6000Switzerland

Pre-procedural planning is the key element of trans-catheter aortic valve implantation(TAVI).Multislice computed tomography of the chest,abdomen and pelvis with the ability to perform a 3-dimensional reconstruction has become the cornerstone of pre-procedural *** would like to encourage TAVI operators(interventional cardiologist and surgeons) to get involved in *** TAVI operators should know how to assess the annulus,the annular root,and the iliofemoral *** strongly believe that this will improve outcomes of this evolving procedure.

关键词： Aortic stenosis Transcatheter aortic valve implantation Transcatheter aortic valve replacement Imaging Computed tomography

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Medical treatment for gastro-entero-pancreatic neuroendocrine tumours

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World Journal of Gastrointestinal Oncology 2016年第4期8卷 389-401页

作者： Rossana Berardi Francesca Morgese Mariangela Torniai Agnese Savini Stefano Partelli Silvia Rinaldi miriam Caramanti Consuelo Ferrini Massimo Falconi Stefano Cascinu Department of Medical Oncology Università Politecnica delle Marche Chirurgia del Pancreas Ospedale San Raffaele IRCCS Università Vita e Salute

Gastro-entero-pancreatic neuroendocrine neoplasms(GEPNENs) represents a various family of rare tumours. Surgery is the first choice in GEP-NENs patients with localized disease whilst in the metastatic setting many other treatment options are available. Somatostatin analogues are indicated for symptoms control in functioning tumours. Furthermore they may be effective to inhibit tumour progression. GEP-NENs pathogenesis has been extensively studied in the last years therefore several driver mutations pathway genes have been identified as crucial factors in their tumourigenesis. GEP-NENs can over-express vascular endothelial growth factor(VEGF), basic-fibroblastic growth factor, transforming growth factor(TGF-α and-β), platelet derived growth factor(PDGF), insulin-like growth factor-1(IGF-1) and their receptors PDGF receptor, IGF-1 receptor, epidermal growth factor receptor, VEGF receptor, and c-kit(stem cell factor receptor) that can be considered as potential targets. The availability of new targeted agents, such as everolimus and sunitinib that are effective in advanced and metastatic pancreatic neuroendocrine tumours, has provided new treatment opportunities. Many trials combing new drugs are ongoing.

关键词： Neuroendocrine neoplasms of the gastro-entero-pancreatic system Chemotherapy Targeted agents Somatostatin analogues Everolimus Sunitinib

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Retinal and Choroidal Alterations in Migraine Patients Compared to Normal Healthy Controls

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Journal of Behavioral and Brain Science 2023年第10期13卷 185-197页

作者： miriam L. Conway Irene Ctori Department of Optometry and Visual Science City University of London London UK

Purpose: Migraine is an incapacitating neurovascular disorder that primarily affects the working-age population. Researchers have postulated that the transient vascular alterations during each migraine attack lead to ischemic damage in the eye which can be measured via optical coherence tomography. Methods: We recruited 29 volunteers: 13 migraineurs (mean age 28 ± 8.8 years;12 female and 1 male) and 16 age-matched controls (mean age 26.6 ± 6.9;9 female and 7 male). All individuals underwent a detailed ophthalmic examination by a qualified optometrist and a Migraine Disability Assessment. The investigators were blind to the migraine diagnosis. Retinal Nerve Fiber Layer (RNFL) thickness, Retinal Thickness (RT), Ganglion Cell Complex (GCL), ranging from the inner-limiting membrane to the inner plexiform layer, and Choroidal Thickness (CT) were measured using the 3D OCT-1Maestro, Topcon, a Spectral Domain OCT (SD-OCT) device. Results: In the migraine population average RNFL was lower for several parameters. However, results did not reach statistical significance. A significant decrease in the right eye inferior parafoveal ganglion cell layer in the migraine group of patients (mean = 25.15, SD = 4.08) compared to normal healthy controls (mean = 28.81, SD = 4.85;t = (27) = 2.17, p = 0.039) was documented. No other ganglion cell layer or choroidal thickness reached significance. No significant relationship between ocular thickness parameters and MIDAS score, parameters and either MIDAS score or frequency of headaches was found. Conclusion: A significant decrease in the right inferior parafoveal ganglion cell layer for migraine patients was reported. All other parameters did not reach significance. .

关键词： Retinal Choroidal Migraine

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SIRT1-dependent modulation of methylation and acetylation of histone H3 on lysine 9(H3K9)in the zygotic pronuclei improves porcine embryo development

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Journal of Animal Science and Biotechnology 2018年第2期9卷 339-350页

作者： Katerina Adamkova Young-Joo Yi Jaroslav Petr Tereza Zalmanova Kristyna Hoskova Pavla Jelinkova Jiri Moravec Milena Kralickova miriam Sutovsky Peter Sutovsky Jan Nevoral Department of Veterinary Sciences Faculty of AgricultureFood and Natural ResourcesCzech University of Life Sciences Prague6-SuchdolPragueCzech Republic Division of Biotechnology SafetyEnvironment and Life Science InstituteCollege of Environmental and Bioresource SciencesChonbuk National UniversityIksan 54596South Korea Institute of Animal Science 10-UhrinevesPragueCzech Republic Proteomic Laboratory Biomedical Center of Faculty of Medicine in PilsenCharles UniversityPilsenCzech Republic Laboratory of Reproductive Medicine of Biomedical Center Charles UniversityPilsenCzech Republic Department of Histology and Embryology Faculty of Medicine in PilsenCharles UniversityPilsenCzech Republic Division of Animal Science University of MissouriColumbiaMOUSA Departments of Obstetrics Gynecology and Women’s HealthUniversity of MissouriColumbiaMOUSA

Background: The histone code is an established epigenetic regulator of early embryonic development in *** lysine residue K9 of histone H3(H3 K9) is a prime target of SIRT1, a member of NAD+-dependent histone deacetylase family of enzymes targeting both histone and non-histone substrates. At present, little is known about SIRT1-modulation of H3 K9 in zygotic pronuclei and its association with the success of preimplantation embryo development. Therefore, we evaluated the effect of SIRT1 activity on H3 K9 methylation and acetylation in porcine zygotes and the significance of H3 K9 modifications for early embryonic ***: Our results show that SIRT1 activators resveratrol and BML-278 increased H3 K9 methylation and suppressed H3 K9 acetylation in both the paternal and maternal pronucleus. Inversely, SIRT1 inhibitors nicotinamide and sirtinol suppressed methylation and increased acetylation of pronuclear H3 K9. Evaluation of early embryonic development confirmed positive effect of selective SIRT1 activation on blastocyst formation rate(5.2 ± 2.9% versus 32.9 ± 8.1% in vehicle control and BML-278 group, respectively; P ≤ 0.05). Stimulation of SIRT1 activity coincided with fluorometric signal intensity of ooplasmic ubiquitin ligase MDM2, a known substrate of SIRT1 and known limiting factor of epigenome ***: We conclude that SIRT1 modulates zygotic histone code, obviously through direct deacetylation and via non-histone targets resulting in increased H3 K9 me3. These changes in zygotes lead to more successful pre-implantation embryonic development and, indeed, the specific SIRT1 activation due to BML-278 is beneficial for in vitro embryo production and blastocyst achievement.

关键词： Embryonic development Epigenetics H3K9 methylation SIRT1 Sirtuin

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Event-based hydrology and sedimentation in paired watersheds under commercial eucalyptus and grasslands in the Brazilian Pampa biome

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International Soil and Water Conservation Research 2021年第2期9卷 180-194页

作者： Ederson Diniz Ebling Jose Miguel Reichert Jhon Jairo Zuluaga Pelaez miriam Fernanda Rodrigues Mirian Lago Valente Rosane Barbosa Lopes Cavalcante Paolo Reggiani Raghavan Srinivasan Soils Department Universidade Federal de Santa MariaAvenida Roraima1000 Bairro CamobiSanta MariaRS97105-900Brazil Corporacion Colombiana de Investigacion Agropecuaria(AGROSAVIA) Centro de Investigacion NataimaEspinalColombia CMPC Celulose Riograndense Rua Sao Geraldo1680GuaibaRS92500-000Brazil Department of Civil Engineering University of SiegenPaul Bonatz Strasse 9-11Siegen D57068Germany Department of Ecology and Conservation Biology Texas A&M University(TAMU)534 John Kimbrough Blvd.Room 305College StationTX77843-2120USA Current address:Instituto Tecnologico Vale.Rua Boaventura da Silva 955UmarizalBelemPABrazil.

Ecological and hydrological impacts are expected when watersheds are under commercial *** this study we evaluated event-based hydrology and sedimentation in paired watersheds under commercial eucalyptus and grasslands ***,suspended sediment concentration,and sediment production were measured and simulated with the Limburg Soil Erosion Model(LISEM)in paired hydrographic watersheds located in southern Brazil;one occupied with 7-years old Eucalyptus saligna plantation(forest watershed-FW;0.83 km^(2))and another Pampa biome with native and exotic grasses used for beef cattle production(grassland watershed-GW;1.10 km^(2)).The effect of rainfall on hydrological and sedimentological variables was more evident in GW compared with *** shape of the hydrograph was steepest in GW,with rapid,marked increase and decrease in flow during *** parameters changed for model calibration in FW and GW were soil saturated hydraulic conductivity,initial soil moisture,and Manning roughness coefficient,whereby the statistical performance was classified as good(NSE>0.75).Fourteen events different from those used in the calibration process were validated for FW and GW,with NSE index classified as“good”and“very good”for *** study shows limitations of LISEM in calibrating and validating the sediment yield for individual events due to the spatial variability of factors controlling soil *** validated modeling results of this study may be applied in simulating soil and crop scenarios in watersheds cultivated with commercial forest and grassland for grazing.

关键词： Southern grasslands Paired watersheds Runoff Erosion LISEM

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《脱盐》文摘

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水处理技术 1992年第1期 71-76页

作者： miriam Balaban ,陈益棠

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