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Carpobrotus edulis(L.) ***. extract as a skin preserving agent: From traditional medicine to scientific validation

Journal of Integrative Medicine 2021年第6期19卷 526-536页

作者： miriam Bazzicalupo Laura Cornara Bruno Burlando Alberta Cascini Marcella Denaro Antonella Smeriglio Domenico Trombetta3 Department for the Earth Environment and Life Sciences(DiSTAV)University of GenovaGenova 16132Italy Department of Pharmacy University of GenovaGenova 16132Italy Department of Chemical BiologicalPharmaceutical and Environmental SciencesUniversity of MessinaMessina 98166Italy

Objective:Carpobrotus edulis(L.)*** a succulent perennial plant native to South Africa and grows invasively in the Mediterranean *** is commonly used for the treatment of various diseases,including skin wound healing and regeneration,for which experimental validation is *** therefore evaluated the skin healing properties by testing a *** aqueous leaf extract(CAE)on cell cultures and in enzymatic ***:Micro-morphological analysis of leaves was carried out using scanning electron microscopy and light *** features and antioxidant activity of CAE were evaluated by reversed-phase liquid chromatography coupled with diode array detection and electrospray ion trap mass spectrometry(RP-LC-DAD-ESI-MS),and in vitro cell-free *** activities were evaluated using keratinocytes and fibroblasts,as well as elastase,collagenase,and ***:CAE showed high carbohydrates(28.59%±0.68%),total phenols([101.9±6.0]g gallic acid equivalents/kg dry extract[DE]),and flavonoids([545.9±26.0]g rutin equivalents/kg DE).RP-LC-DAD-ESI-MS revealed the predominant presence of hydroxycinnamic acids(51.96%),followed by tannins(14.82%)and flavonols(11.32%).The extract was not cytotoxic,had a strong and dose-dependent antioxidant activity,and inhibited collagenase(>90%at 500 mg/m L)and hyaluronidase(100%at 1000 mg/m L).In cell culture experiments,CAE increased wound closure and collagen production,which was consistent with its high polyphenol ***:Our data support the use of the *** for skin care and the treatment of skin ***,use of *** for skin care purposes could be an eco-friendly solution to reduce its invasiveness in the environment.

关键词： Traditional medicine Carbohydrates Polyphenols Antioxidant Wound healing

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Status and outlook of hiking trails in the central part of the Low Tatra Mountains in Slovakia between 1980–1981 and 2013–2014

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Journal of Mountain Science 2018年第8期15卷 1615-1632页

作者： HRNCIAROVá Tatiana KENDERESSY Pavol SPULEROVá Jana VLACHOVICOVá miriam PISCOVá Veronika DOBROVODSKá Marta Institute of Landscape Ecology of the Slovak Academy of Sciences Stefanikova 3P.O.Box 254814 99 BratislavaSlovak Republic Institute of Landscape Ecology of the Slovak Academy of Sciences Branch NitraP.O.Box 22Akademicka 2949 01 NitraSlovak Republic

This study presents a methodology for assessment of the condition of hiking trails(HTs) and their impact zones in the central part of the Low Tatra mountain range, based on comparison of two complex data sets gathered in 33 years apart. The first field investigation was performed in 1980 and 1981, and the second in 2013 and 2014. The main goal was to perform a landscape typology in order to assess the susceptibility of landscape complexes to occurrence of anthropogenic and natural destruction processes and to assess the condition and prospects of HTs and their impacts on the adjacent alpine environment. Landscape complexes were characterised by selected abiotic, biotic and technical parameters of HTs and their impact zones. Due to the high variability of these parameters over the length of the HTs, we had to decide on how to map them. This was done using a square grid with 100 m-sized cells. For each cell with HT, the parameters were assigned the typical value within that cell. In total, 26.3 km of HT were studied, stretching over 266 grid cells. On comparison of the two data sets, it was seen that, 64%(171 grid cells) display a generally positive condition, with 54%(143 grid cells) even exhibiting significant improvement or continuously positive state of their condition. 36%(95 grid cells) were in bad condition, including 3%(9 grid cells) whose state had deteriorated, and 2%(6 grid cells) whose state had significantly deteriorated, in the time between the two assessments.

关键词： Hiking trails Degradation Tourist pressure Monitoring hiking trail changes Low Tatras Mountains Slovakia

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Performance of a Double Catalyst Fuel Cell Cathode with a Tubular Oxygen Breathing and Preliminary Reduction Zone

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Journal of Thermal Science 2005年第2期14卷 187-192页

作者： Luís A.Waack BAMBACE miriam NISHIMORI Fernando M.RAMOS Demétrio BASTOS-NETTO Instituto Nacional de Pesquisas Espaciais-INPE Av.Dos Astronautas 1758 S■o José dos CamposSPBrazilCEP 12210-970Instituto Nacional de Pesquisas Espaciais-INPE Av.Dos Astronautas 1758S■o José dos CamposSPBrazilCEP 12210-970Instituto Nacional de Pesquisas Espaciais-INPE Av.Dos Astronautas 1758S■o José dos CamposSPBrazilCEP 12210-970Instituto National de Pesquisas Espaciais-INPE Rod.Presidente Dutra km 40Cachoeira PaulistaSPBrazil CEP12630-000

This paper discusses a mathematical model for a liquid phase reacting flow occurring at the cathode of a patent pending novel fuel cell geometry, where a non homogeneous catalysis carried by gold and Prussian Blue, with the first reducing air O2 and the second the resulting H2O2. The breathing zone is porous walls microtubes, with three different types of pores in its walls. Inside the microtubes there is water solution of sulfuric acid. The microtubes possess an external layer of extremely porous polymer hydrophobic agent. A Prussian Blue thin porous layer is over the selective membrane. Appropriate porous and tubular connecting elements close the fluid loop. The asymmetry induces proper current and electric potential profiles, which leads to a mainly electrocapillary electrokinetic flow, which enhances the oxygen transport and assures the H2O2 flow to its reduction layer.

关键词： non homogeneous catalysis fuel cell cathode electrokinetic convection breathing area.

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Unusually strong lateral interaction in the CO overlayer in phosphorene-based systems

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Nano Research 2016年第9期9卷 2598-2605页

作者： Antonio Politano miriam Serena Vitiello Leonardo Viti Jin Hu Zhiqiang Mao Jiang Wei Gennaro Chiarello Department of Physics University of Calabriavia ponte Bucci31/C87036 Rende(CS)Italy NEST Istituto Nanoscienze-CNR and Scuola Normale Superiore Piazza San Silvestro 12Pisa 1-56127Italy Department of Physics and Engineering Physics Tulane UniversityNew OrleansLA 70118USA

By means of vibrational spectroscopy and density functional theory (DFT), we investigate CO adsorption on phosphorene-based systems. We find stable CO adsorption at room temperature on both phosphorene and bulk black phosphorus. The adsorption energy and vibrational spectrum are calculated for several possible configurations of the CO overlayer. We find that the vibrational spectrum is characterized by two different C–O stretching energies. The experimental data are in good agreement with the prediction of the DFT model and reveal the unusual C–O vibrational band at 165–180 meV, activated by the lateral interactions in the CO overlayer. [Figure not available: see fulltext.] © 2016, Tsinghua University Press and Springer-Verlag Berlin Heidelberg.

关键词： phosphorene vibrational spectroscopy density functional theory carbon monoxide

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A Comparative Study of Economic Impact of Tourism on West African Countries

A Comparative Study of Economic Impact of Tourism on West Af...

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作者： Fei miriam Nana Serwa 中南林业科技大学

学位级别：硕士

The tourism sector is an imperative source of economic growth which is a composition of both income per capita,GDP per capita,foreign exchange earnings,and *** factors are assumed to contribute to economic development of the west African *** research focuses on investigating the comparative impact tourism industry has on economic growth and the *** order to realize this goal,we estimate a dynamic panel using the estimator of the systems generalized method of moment’s（GMM）coupled with pooled ordinary least squares（POLS）which we apply to about eight economically viable west African countries for the period *** research is an addition to the incomplete empirical studies on the effect tourism has on economic growth and the contrariwise between west African ***,this research contributes by building on preceding researches by presenting a primal possible factor of economic growth,such as the observation of corruption,and by utilizing significant quadratic and collaborating *** results show that an increase of tourism performance results in a maximum level of economic growth and the west African countries with a high supposed level of corruption have a minimal level of economic *** utilizing the economic growth model,we also observe a substantial positive influence of the tourism industry on economic growth of the west African ***,the results of econometric analysis for the tourists’ arrival model show that economic growth is very important for the progression of the tourism *** F-test,which measures the joint significance of the independent variables,is highly significant（0.0000 P-value）implying good performance of the specified *** is positive and highly significant which supports the second hypothesis of the study that economic growth is relevant for the development of the tourism *** further determine the stationarity of the variables,the research employs the u

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The ability of sperm selection techniques to remove single- or double-strand DNA damage

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Asian Journal of Andrology 2011年第5期13卷 764-768页

作者： Maria Enciso miriam Iglesias Isabel Galan Jonas Sarasa Antonio Gosalvez Jaime Gosalvez Unidad de Genetica Departamento de Biologia Universidad Aut6noma de Madrid Madrid 28049 Spain Unidad de Reproducci6n Asistida Hospital Quir6n Madrid Madrid 28223 Spain

A wide variety of techniques for the preparation of sperm are currently available, of which the most commonly employed are densitygradient centrifugation （DGC） and swim-up （SUP）. To date, these methods appear to be effective in selecting functional sperm for assisted reproduction techniques （ART）, but they may have negative effects on sperm DNA. In this study, the ability of these semen processing techniques to eliminate spermatozoa containing single- and double-strand DNA damage was assessed by the two-tailed comet assay and the sperm chromatin dispersion test in 157 semen samples from patients seeking assisted reproduction treatment. Our results indicated that SUP and DGC are equally efficient in eliminating spermatozoa containing double-strand DNA damage and sperm with highly damaged （degraded） DNA, as characterized by the presence of both single- and double-strand DNA breaks. However, DGC is more efficient than SUP in selecting spermatozoa that are free from single-strand DNA damage. Future studies should characterise the importance of the various types of DNA damage and examine the sperm processing protocols used in each laboratory to determine their ability to eliminate DNA damage and hence, prevent the potential transmission of genetic mutations via ART.

关键词： density-gradient centrifugation male factor sperm chromatin dispersion sperm DNA fragmentation swim-up

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Dissecting the Heat Stress Response in Chlamydomonas by Pharmaceutical and RNAi Approaches Reveals Conserved and Novel Aspects

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Molecular Plant 2013年第6期6卷 1795-1813页

作者： Stefan Schmollinger miriam Schulz-Raffelt Daniela Strenkert Daniel Veyel Olivier Vallon Michael Schroda Molekulare Biotechnologie und Systembiologie TU Kaiserslautern PauI-Ehrlich-Str. 23 D-67663 Kaiserslautern Germany Max-Planck-lnstitut for Ilolekulare Pflanzenphysiologie Am MQhlenberg 1 D-14476 Potsdam-Golm Germany CEA-CNRS-Universite Aix Marseille Institut de Biolog~e Environnementale et Biotechnologie UMR 7265 CEA (:adarache F-13108 Saint-Paul-lez-DuranceFrance Institut de Biologie Physico-Chimique UMR 7141 CNRS/Universite Pierre et Marie Curie F-75005 Paris France

To study how conserved fundamental concepts of the heat stress response （HSR） are in photosynthetic eukaryotes, we applied pharmaceutical and antisense/amiRNA approaches to the unicellular green alga Chlamydomonas reinhardtii. The Chlamydomonas HSR appears to be triggered by the accumulation of unfolded proteins, as it was induced at ambient temperatures by feeding cells with the arginine analog canavanine. The protein kinase inhibitor staurosporine strongly retarded the HSR, demonstrating the importance of phosphorylation during activation of the HSR also in Chlamydomonas. While the removal of extracellular calcium by the application of EGTA and BAPTA inhibited the HSR in moss and higher plants, only the addition of BAPTA, but not of EGTA, retarded the HSR and impaired thermotoler- ance in Chlamydomonas. The addition of cycloheximide, an inhibitor of cytosolic protein synthesis, abolished the attenu- ation of the HSR, indicating that protein synthesis is necessary to restore proteostasis. HSP90 inhibitors induced a stress response when added at ambient conditions and retarded attenuation of the HSR at elevated temperatures. In addition, we detected a direct physical interaction between cytosolic HSP90A/HSP70A and heat shock factor 1, but surprisingly this interaction persisted after the onset of stress. Finally, the expression of antisense constructs targeting chloroplast HSP70B resulted in a delay of the cell＇s entire HSR, thus suggesting the existence of a retrograde stress signaling cascade that is desensitized in HSP7OB-antisense strains.

关键词： heat shock factor unfolded protein response heat stress response inhibitor feeding Chlamydomonas rein-hardtii HSP90 HSP70 protein folding calcium geldanamycin canavanine.

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An Ontology Based Cyclone Tracks Classification Using SWRL Reasoning and SVM

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Computer Systems Science & Engineering 2023年第3期44卷 2323-2336页

作者： N.Vanitha C.R.Rene Robin D.Doreen Hephzibah miriam Sri Sai Ram Engineering College Chennai600044TamilnaduIndia Director of Computational Intelligence Research Foundation Chennai600023TamilnaduIndia

Tropical cyclones(TC)are often associated with severe weather conditions which cause great losses to lives and *** precise classification of cyclone tracks is significantly important in thefield of weather *** this paper we propose a novel hybrid model that integrates ontology and Support Vector Machine(SVM)to classify the tropical cyclone tracks into four types of classes namely straight,quasi-straight,curving and sinuous based on the track *** Cyclone TRacks Ontology(TCTRO)described in this paper is a knowledge base which comprises of classes,objects and data properties that represent the interaction among the TC characteristics.A set of SWRL(Semantic Web Rule Language)rules are directly inserted to the TCTRO ontology for reasoning and inferring new knowledge from ***,we propose a learning algorithm which utilizes the inferred knowledge for optimizing the feature *** to experiments on the IBTrACS dataset,the proposed ontology based SVM classifier achieves an accuracy of 98.3%with reduced classification error rates.

关键词： Tropical cyclones classification support vector machine ontology SWRL reasoning SVM classification

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A Coupled Approach for Fluid Dynamic Problems Using the PDE Framework Peano

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Communications in Computational Physics 2012年第6期12卷 65-84页

作者： Philipp Neumann Hans-Joachim Bungartz miriam Mehl Tobias Neckel Tobias Weinzierl Chair of Scientific Computing Faculty of InformaticsTechnische Universitat MunchenBoltzmannstr.381545 GarchingGermany

We couple different flow models,i.e.a finite element solver for the Navier-Stokes equations and a Lattice Boltzmann automaton,using the framework Peano as a common *** new coupling strategy between the meso-and macroscopic solver is presented and validated in a 2D channel flow *** results are in good agreement with theory and results obtained in similar works by Latt et *** addition,the test scenarios show an improved stability of the coupledmethod compared to pure Lattice Boltzmann simulations.

关键词： Spatial coupling Lattice Boltzmann Navier-Stokes Peano

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The mRNA Binding Proteome of Proliferating and Differentiated Muscle Cells

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Genomics, Proteomics & Bioinformatics 2020年第4期18卷 384-396页

作者： Monika Hiller miriam Geissler George Janssen Peter van Veelen Annemieke Aartsma-Rus Pietro Spitali Department of Human Genetics Leiden University Medical CenterLeiden 2333 ZCthe Netherlands Center for Proteomics and Metabolomics Leiden University Medical CenterLeiden 2333 ZCthe Netherlands

Muscle formation is a coordinated process driven by extensive gene expression changes where single cells fuse together to form multinucleated muscle fibers. Newly synthesized m RNAs are then regulated by RNA binding proteins(RBPs), affecting post-transcriptional transcript metabolism. Here, we determined how large-scale gene expression changes affect the catalog of RBPs by studying proliferating and differentiated muscle cells in healthy and dystrophic conditions. Transcriptomic analysis showed that the expression of more than 7000 genes was affected during myogenesis. We identified 769 RBPs, of which 294 were muscle-specific and 49 were uniquely shared with cardiomyocytes. A subset of 32 RBPs(half of which were muscle-specific) was found to be preferentially associated with target mRNAs in either myoblasts(MBs) or myotubes(MTs). A large proportion of catalytic proteins were bound to mRNAs even though they lack classical RNA binding domains. Finally, we showed how the identification of cell-specific RBPs enabled the identification of biomarkers that can separate healthy individuals from dystrophic patients. Our data show how interactome data can shed light on new basic RNA biology as well as provide cell-specific data that can be used for diagnostic purposes.

关键词： RNA binding protein Interactome Duchenne muscular dystrophy Proteomics Skeletal muscle

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