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Metastatic pancreatic and lung cancer patient in complete remission following immunotherapy: A case report and review of literature

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World Journal of Gastrointestinal Oncology 2024年第5期16卷 2233-2240页

作者： Joaquina Martínez-Galán Cristina Jiménez-luna Isabel Rodriguez Elisabeth Maza Carlos García-Collado Antonio Rodríguez-Fernández Javier luis lópez-Hidalgo Octavio Caba Department of Medical Oncology Virgen de las Nieves University HospitalGranada 18014Spain Instituto de Investigación Biosanitaria Ibs.GranadaGranada 18012Spain Institute of Biopathology and Regenerative Medicine(IBIMER) University of GranadaGranada 18016Spain Pharmacogenetics Unit Virgen de las Nieves University HospitalGranada 18014Spain Department of Medicina Nuclear Virgen de las Nieves University HospitalGranada 18014Spain Department of Anatomía Patológica Virgen de las Nieves University HospitalGranada 18014Spain

BACKGROUND Metastatic pancreatic ductal adenocarcinoma(PDAC)is a lethal malignancy with dispiriting survival *** is a promising approach to many cancer types,but achieves poor outcomes in advanced PDAC due to its immunosuppressive tumor *** describe a case of metastatic PDAC effectively treated with *** SUMMARY We report the case of a 67-year-old woman with unresectable locally advanced PDAC,treated with gemcitabine plus nab-paclitaxel followed by radiotherapy plus *** nine months,pancreatic tumor progression was observed at the level of the hepatic hilum with the appearance of a new pulmonary nodule suggestive of a second primary,confirmed by left lung *** immunotherapy was then initiated with pembrolizumab,an immune checkpoint inhibitor targeting programmed cell death protein-1 that covers the two tumor *** patient showed a complete metabolic response that was maintained throughout the *** patient continues to be disease-free at 5.6 years since the start of *** These results suggest that the administration of pembrolizumab after chemoradiotherapy has a beneficial effect in patients with metastatic *** our knowledge,this is the first reported case of a patient with metastatic PDAC and metastatic lung cancer showing such a long-lasting complete response after pembrolizumab treatment without curative *** studies are required to determine biomarkers that identify PDAC patients most likely to benefit from this immunotherapy.

关键词： Pancreatic ductal adenocarcinoma lung cancer Immunotherapy Pembrolizumab Programmed cell death protein-1 Case report

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中国户籍登记系统漏登合成估计方法研究

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系统科学与数学 2024年

作者：黄艳华 lópez-carr David 胡桂华重庆工商大学成渝地区双城经济圈建设研究院 University of California Santa Barbara Department of Geography 重庆工商大学数学与统计学院统计智能计算与监测重庆市重点实验室

中国户籍登记系统存在漏登人口问题,但政府部门尚未开展户籍漏登估计工作.联合国统计司建议各国采用的单重漏登估计量未覆盖全部漏登人口,低估漏登率.本文提出用合成漏登估计量替代单重漏登估计量,并通过案例研究,比较了合成漏登估计量... 详细信息

中国户籍登记系统存在漏登人口问题,但政府部门尚未开展户籍漏登估计工作.联合国统计司建议各国采用的单重漏登估计量未覆盖全部漏登人口,低估漏登率.本文提出用合成漏登估计量替代单重漏登估计量,并通过案例研究,比较了合成漏登估计量与单重漏登估计量.实证研究结果表明:四种合成漏登估计量估计的漏登率均高于单重漏登估计量;除其中一种合成漏登估计量估计的漏登率的抽样标准差略高于单重漏登估计量外,其他三种合成漏登估计量估计结果的抽样标准差均小于单重漏登估计量.研究结果为统计局和公安部未来制定户籍登记系统漏登估计方案提供重要参考,提高方案的科学性和可操作性.

关键词：抽样调查事后分层三系统估计量刀切法

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Management of lateral pelvic lymph nodes in rectal cancer:Is it time to reach an Agreement?

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World Journal of Clinical Oncology 2024年第4期15卷 472-477页

作者： Sigfredo E Romero-Zoghbi Fernando lópez-Campos Felipe Couñago Department of Radiation Oncology GenesisCareTalavera de la Reina 45600ToledoSpain Department of Radiation Oncology Hospital Universitario Ramón Y CajalMadrid 28034Spain Department of Radiation Oncology GenesisCare-Hospital Universitario Vithas Madrid La MilagrosaMadrid 28010Spain

In this editorial,we proceed to comment on the article by Chua et al,addressing the management of metastatic lateral pelvic lymph nodes(mllN)in stage II/III rectal cancer patients below the peritoneal *** treatment of this nodal area sparks significant controversy due to the strategic differences followed by Eastern and Western physicians,albeit with a higher degree of convergence in recent *** dissection of lateral pelvic lymph nodes without neoadjuvant therapy is a standard practice in Eastern *** contrast,in the West,preference leans towards opting for neoadjuvant therapy with chemoradiotherapy or radiotherapy,that would cover the treatment of this area without the need to add the dissection of these nodes to the total mesorectal *** the presence of high-risk nodal characteristics for mllN related to radiological imaging and lack of response to neoadjuvant therapy,the risk of lateral local recurrence increases,suggesting the appropriate selection of strategies to reduce the risk of recurrence in each patient *** the heterogeneous and retrospective nature of studies addressing this area,an international consensus is necessary to approach this clinical scenario uniformly.

关键词： Rectal cancer lateral pelvic lymph node metastases Pelvic lymph node dissection Total neoadjuvant therapy Selective management of the lateral pelvic nodes Prophylactic management of the lateral pelvic nodes Chemoradiotherapy Total mesorectal excision

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Impact of device resistances in the performance of graphene‑based terahertz photodetectors

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Frontiers of Optoelectronics 2024年第2期17卷 87-97页

作者： O.Castelló Sofía M.lópez Baptista K.Watanabe T.Taniguchi E.Diez J.E.Velázquez-Pérez Y.M.Meziani J.M.Caridad J.A.Delgado-Notario Department of Applied Physics University of Salamanca37008 SalamancaSpain Unidad de Excelencia en luz y Materia Estructurada(lUMES) University of Salamanca37008 SalamancaSpain Research Center for Electronic and Optical Materials National Institute for Materials Science1-1 NamikiTsukuba 305-0044Japan Research Center for Materials Nanoarchitectonics National Institute for Materials Science1-1 NamikiTsukuba 305-0044Japan Nanotechnology Group USAL-NanolabUniversity of Salamanca37008 SalamancaSpain

In recent years,graphene field-effect-transistors(GFETs)have demonstrated an outstanding potential for terahertz(THz)photodetection due to their fast response and *** features are essential to enable emerging THz applications,including 6G wireless communications,quantum information,bioimaging and ***,the overall performance of these photodetectors may be utterly compromised by the impact of internal resistances presented in the device,so-called access or parasitic *** this work,we provide a detailed study of the influence of internal device resistances in the photoresponse of high-mobility dual-gate GFET *** dual-gate architectures allow us to fine tune(decrease)the internal resistance of the device by an order of magnitude and consequently demonstrate an improved responsivity and noise-equivalent-power values of the photodetector,*** results can be well understood by a series resistance model,as shown by the excellent agreement found between the experimental data and theoretical *** findings are therefore relevant to understand and improve the overall performance of existing high-mobility graphene photodetectors.

关键词： Graphene THz Photodetector Field-effect transistor Plasmonic

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人口统计分析模型与人口普查净误差估计

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系统科学与数学 2024年

作者：余鲁李婷 David lópez-Carr 胡桂华吴笛漆莉重庆工商大学数学与统计学院 Department of Geography America University of California 重庆工商大学统计智能计算与监测重庆市重点实验室

本文旨在引入美国的人口统计分析模型,建立适合于在我国应用的人口统计分析模型.采取文献解读法和概率模型法,研究人口统计分析模型及其相关问题.研究结果表明:人口统计分析模型在我国的研究尚处于起步阶段,建立我国的人口统计分析模型... 详细信息

本文旨在引入美国的人口统计分析模型,建立适合于在我国应用的人口统计分析模型.采取文献解读法和概率模型法,研究人口统计分析模型及其相关问题.研究结果表明:人口统计分析模型在我国的研究尚处于起步阶段,建立我国的人口统计分析模型,不能照搬美国的人口统计分析模型,而应该结合我国实际情况有所改进与创新;建立人口统计分析模型分为两个层次,一是建立基于全面资料的人口统计分析模型,无需计算抽样方差,二是建立基于抽样调查资料的人口统计分析模型,需采用刀切法近似计算其抽样方差;人口统计分析模型的优势是,充分利用了出生、死亡及国际迁移等人口行政记录资料,节约了数据采集成本,与人口普查独立,劣势是,估计结果具有不确定性,尤其是其中的国际净迁移人数的估计结果差异较大.人口统计分析模型有望应用于我国2030年人口普查净误差估计,开创我国在该领域使用人口统计分析模型的先河.

关键词：人口普查人口普查质量评估行政记录抽样调查刀切法

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Genomic selection in plant breeding:Key factors shaping two decades of progress

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Molecular Plant 2024年第4期17卷 552-578页

作者： Admas Alemu Johanna Astrand Osval A.Montesinos-lópez Julio Isidro y Sanchez Javier Fernandez-Gónzalez Wuletaw Tadesse Ramesh R.Vetukuri Anders S.Carlsson Alf Ceplitis JoséCrossa Rodomiro Ortiz Aakash Chawade Department of Plant Breeding Swedish University of Agricultural SciencesAlnarpSweden lantmannen lantbruk SvalövSweden Facultad de Telematica University de ColimaColimaColima 28040Mexico Centro de Biotecnología y Genómica de Plantas(CBGP UPM-INIA)Universidad Politécnica de Madrid(UPM)-Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria(INIA)Campus de Montegancedo-UPM28223 MadridSpain International Center for Agricultural Research in the Dry Areas(ICARDA) RabatMorocco International Maize and Wheat Improvement Center(CIMMYT) Km 45Carretera México-VeracruzTexcocoMéxico 52640Mexico

Genomic selection,the application of genomic prediction(GP)models to select candidate individuals,has significantly advanced in the past two decades,effectively accelerating genetic gains in plant *** article provides a holistic overview of key factors that have influenced GP in plant breeding during this *** delved into the pivotal roles of training population size and genetic diversity,and their relationship with the breeding population,in determining GP *** emphasis was placed on optimizing training population *** explored its benefits and the associated diminishing returns beyond an optimum *** was done while considering the balance between resource allocation and maximizing prediction accuracy through current optimization *** density and distribution of single-nucleotide polymorphisms,level of linkage disequilibrium,genetic complexity,trait heritability,statistical machine-learning methods,and non-additive effects are the other vital *** wheat,maize,and potato as examples,we summarize the effect of these factors on the accuracy of GP for various *** search for high accuracy in GP—theoretically reaching one when using the Pearson’s correlation as a metric—is an active research area as yet far from optimal for various *** hypothesize that with ultra-high sizes of genotypic and phenotypic datasets,effective training population optimization methods and support from other omics approaches(transcriptomics,metabolomics and proteomics)coupled with deep-learning algorithms could overcome the boundaries of current limitations to achieve the highest possible prediction accuracy,making genomic selection an effective tool in plant breeding.

关键词： genomic selection genetic gain genomic prediction optimization deep learning training population optimization

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Neoadjuvant treatment of rectal cancer: Where we are and where we are going

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World Journal of Clinical Oncology 2024年第7期15卷 790-795页

作者： Elísabet González Del Portillo Felipe Couñago Fernando lópez-Campos Department of Radiation Oncología Hospital Universitario La PazMadrid 28046Spain Department of Radiation Oncology GenesisCare MadridMadrid 28010Spain Department of Radiation Oncology Hospital Universitario Ramón Y CajalMadrid 28034Spain

locally advanced rectal cancer requires a multidisciplinary approach based on total neoadjuvant treatment with radiotherapy(RT)and chemotherapy(ChT),followed by deferred ***,alternatives to the standard total neoadjuvant therapy(TNT)are being explored,such as new ChT regimens or the introduction of *** standard TNT,up to a third of patients may achieve a complete pathological response(CPR),potentially avoiding ***,as of now,we lack predictive markers of response that would allow us to define criteria for a conservative organ *** presence of muta-tions,genes,or new imaging tests is helping to define these *** example of this is the diffusion coefficient in the diffusion-weighted sequence of magnetic resonance imaging and the integration of this imaging technique into RT *** allows for the monitoring of the evolution of this coefficient over successive RT sessions,helping to determine which patients will achieve CPR or those who may require intensification of neoadjuvant therapy.

关键词： locally advanced rectal cancer Total neoadyuvant treatment Radiotherapy Biomarker Magnetic resonance imaging Conservative organ strategy Watch and wait

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Overweight/Obesity in University Students from Mexico: Comparison Using Different Indices

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Journal of Biosciences and Medicines 2024年第7期12卷 151-159页

作者： Gabriel Medrano-Donlucas Claudia Carolina Hernández-Peña Ricardo Juárez-lozano Cecilia lópez-lópez Santiago C. Sigrist Flores Rafael Villalobos-Molina Itzell A. Gallardo-Ortíz Instituto de Ciencias Biomdicas Universidad Autnoma de Ciudad Jurez Ciudad Jurez Mxico Facultad de Estudios Superiores Iztacala Universidad Nacional Autnoma de Mxico Tlalnepantla de Baz Mxico

The goal was to compare body mass index (BMI), waist circumference (WC), waist to height ratio (WHtR), and relative fat mas (RFM), to identify the best predictor of overweight and obesity in university students from Mexico. This is a cross-sectional survey with 697 university students from northern and central Mexico (448 women, and 249 men aged 18 - 19 years). Data was collected during 2018. Overweight and obesity were calculated from those indices and for both, female and male students, the order of correlation between a pair of indices were WHtR vs. RFM > WHtR vs. WC > RFM vs. WC > WHtR vs. BMI > BMI vs. WC > RFM vs. BMI. It is concluded to use the WHtR and the RFM to better predict overweight and obesity in young Mexican university students.

关键词： Overweight and Obesity Anthropometry Anthropometry Indices

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living in a Condominium Regime:Neighborhood Conflicts in low-Income Housing,Tijuana,Baja California-A Secondary Publication

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Journal of World Architecture 2024年第2期8卷 96-107页

作者： M.Zárate lópez A.Almejo Ornelas M.Sahagún Valenzuela Autonomous University of Baja California Mexico

This paper analyzes neighborhood conflicts arising from the condominium property regime,under which social housing promoted by Mexican government institutions and private developers is *** regime has facilitated access to housing for the salaried population,but it is far from contributing to the attainment of the right to *** research takes as case studies housing complexes located in the city of Tijuana,Baja California,*** analysis included a mixed ***,similar case studies were analyzed;secondly,a review of the Condominium Property Regime law was carried out in order to understand its *** view of the pandemic situation,a virtual survey was applied to the inhabitants of these areas,as well as interviews with presidents of neighborhood committees of these *** the above,it was found that this form of ownership generates conflicts,reflected in the dissatisfaction of the inhabitants with their housing,disagreements and controversies in their organization and *** inhabitants have to collectively solve the problems they face,related to the maintenance and use of common areas,insecurity,and cleanliness,among *** addition,there is a lack of support from local *** this,it is concluded that although the inhabitants have a space that solves their housing problem,it does not manage to be a space that adequately guarantees their right to housing.

关键词： Neighborhood conflicts Right to housing Condominium property Social interest Affordable housing

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Concentric Centrifugal Figurate Erythema as an Unusual COVID-19 Evanescent Skin Manifestation in a Patient With CD3^(+)/CD45^(+)lymphocyte Infiltration:A Case Report

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International Journal of Dermatology and Venereology 2024年第2期7卷 115-118页

作者： lucía Achell Achell-Nava José luis Zaldivar-Fujigaki Rebeca Pérez-Cabeza de Vaca Ana Maria Espinosa García luis Montiel lópez Dermatology Department National Medical Center 20 de NoviembreISSSTEMexico City 03229Mexico Biomedical Research Department National Medical Center 20 de NoviembreISSSTEMexico City 03100Mexico Clinical Pharmacology Division General Hospital of MexicoMexico City 06720Mexico Internal Medicine Department National Medical Center 20 de NoviembreISSSTEMexico City 03100Mexico

Introduction:Coronavirus disease 2019(COVID-19)may be associated with various skin *** them,figurate erythema(FE)is rare;only a few clinical reports have been ***,we reported an unusual concentric FE lesions and their immunohistochemical profile in a patient with *** presentation:A 52-year-old woman was diagnosed with *** month later,she developed asymptomatic annular erythematous concentric ring lesions on her inner right *** margin of every ring increased in coloration,and the lesions then completely resolved in 2 weeks.A biopsy revealed vasculitis of small vessels,an increase in the fluorescence intensity of CD3 and CD45,and negativity for COVID-19 ***:The results showed an unusual FE that has a clinical mixed type between erythema annulare centrifugum and erythema gyratum repens;the physiopathological mechanism in the FE due to COVID-19 is unknown;one theory involves rapid viral passage into the cutaneous vascular system that triggers an immune and inflammatory *** the results exhibited a negative COVID-19 RNA in the tissue,the CD3^(+)/CD45^(+)lymphocyte infiltration could explain the clinical pattern as a direct inflammatory response in the small vessel or as a delayed immune ***:Our findings suggest an immunohistochemical small vessel vasculitis pattern with an unusual clinical FE that differs from other types of COVID-19-associated FE or erythema reported previously.

关键词： erythema COVID-19 leukocytoclastic vasculitis skin manifestation CD3 complex CD45 antigen

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