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Value of three-dimensional reconstructions in pancreatic carcinoma using multidetector CT:Initial results

World Journal of Gastroenterology 2009年第46期15卷 5827-5832页

作者： miriam klauβ Max Schbinger Ivo Wolf Jens Werner Hans-Peter Meinzer Hans-Ulrich Kauczor Lars Grenacher Department of Diagnostic and Interventional Radiology University of Heidelberg Department of Medical and Biological Informatics German Cancer Research Center(DKFZ) Surgical Clinic University of Heidelberg

AIM:To evaluate the use of three-dimensional imaging of pancreatic carcinoma using multidetector computed tomography(CT)in a prospective ***:Ten patients with suspected pancreatic tumors were examined prospectively using multidetec-tor CT(Somatom Sensation 16,Siemens,Erlangen,Germany).The images were evaluated for the pres-ence of a pancreatic carcinoma and invasion of the peripancreatic vessels and surrounding *** the isotropic CT data sets,a three-dimensional image was created with automatic vascular analysis and semi-automatic segmentation of the organs and pancreatic tumor by a *** CT examinations and the three-dimensional images were presented to the sur-geon directly before and during the patient's operation using the Medical Imaging Interaction Toolkit-based software "ReLiver".Immediately after surgery,the value of the two images was judged by the *** operation and the histological results served as the gold ***:Nine patients had a pancreatic carcinoma(all pT3),and one patient had a serous *** tumor inf iltrated the superior mesenteric *** inf iltration was correctly *** carcinomas were *** comparison to the CT image with axial and coronal reconstructions,the three-dimensional image was judged by the surgeons as better for operation planning and consistently described as ***:A 3D-image of the pancreas repre-sents an invaluable aid to the ***,the 3D-software must be further developed in order to be integrated into daily clinical routine.

关键词： Pancreatic carcinoma 3D-reconstruction Multidetector computed tomography Pancreatic carcinomainvasion Segmentation

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Epidemiology of hepatitis C virus infection

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World Journal of Gastroenterology 2007年第17期13卷 2436-2441页

作者： miriam J Alter Institute for Human Infections and Immunity University of Texas Medical Branch Galveston Texas USA 77555 United States

Globally, hepatitis C virus (HCV) has infected an estimated 130 million people, most of whom are chronically infected. HCV-infected people serve as a reservoir for transmission to others and are at risk for developing chronic liver disease, cirrhosis, and primary hepatocellular carcinoma (HCC). It has been estimated that HCV accounts for 27% of cirrhosis and 25% of HCC worldwide. HCV infection has likely been endemic in many populations for centuries. However, the wave of increased HCV-related morbidity and mortality that we are now facing is the result of an unprecedented increase in the spread of HCV during the 20th century. Two 20th century events appear to be responsible for this increase; the widespread availability of injectable therapies and the illicit use of injectable drugs.

关键词： Hepatitis C virus Global epidemiology Incidence Prevalence Transmission Natural history

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Neuroprotection of the inner retina:Müller cells and lactate

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Neural Regeneration Research 2018年第10期13卷 1741-1742页

作者： Rupali Vohra miriam Kolko Department of Drug Design and Pharmacology University of Copenhagen Department of Ophthalmology Copenhagen University Hospital

Müller cells：The neglected neighbor：Müller cells constitute the majority of retinal glial cells and offer more alternating functions than any other cell of the ***,Müller cells cover the complete thickness of the retina,and their roles therefore differ correspondingly to the retinal segment in which they are *** the inner retina,Müller cells are crucial in taking up toxic molecules,such as excessive.

关键词： In GPR Neuroprotection of the inner retina:M ller cells and lactate

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Method of directly defining the inverse mapping applied to prostate cancer immunotherapy --Mathematical model

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International Journal of Biomathematics 2018年第5期11卷 233-254页

作者： Ophir Nave miriam Elbaz Department of Mathematics Jerusalem College of Technology (JCT) Hava'ad Haleumi 21 Jerusalem Israel

In this paper, we apply the method of directly defining the inverse mapping introduced by Liao and Zhao [On the method of directly defining inverse mapping for nonlinear differential equations, Numer. Algorithms 72（4）（2016） 989-1020] to the problem of prostate cancer immunotherapy. We extend this method in two directions： first, we apply the method to a system of nonlinear ordinary differential equation, and second, we propose a new technique for finding the base functions in the considered algorithm.

关键词： Nonlinear system of differential equations prostate cancer numerical simulations cancer immunotherapy asymptotic analysis.

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The Synaptonemal Complex of Basal Metazoan Hydra:More Similarities to Vertebrate than Invertebrate Meiosis Model Organisms

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Journal of Genetics and Genomics 2014年第3期41卷 107-115页

作者： Johanna Fraune miriam Wiesner Ricardo Benavente Department of Cell and Developmental Biology BiocenterUniversity of Würzburg

The synaptonemal complex （SC） is an evolutionarily well-conserved structure that mediates chromosome synapsis during prophase of the first meiotic division. Although its structure is conserved, the characterized protein components in the current metazoan meiosis model systems （Drosophila melanogaster, Caenorhabditis elegans, and Mus musculus） show no sequence homology, challenging the question of a single evolutionary origin of the SC. However, our recent studies revealed the monophyletic origin of the mammalian SC protein components. Many of them being ancient in Metazoa and already present in the cnidarian Hydra. Remarkably, a comparison between different model systems disclosed a great similarity between the SC components of Hydra and mammals while the proteins of the ecdysozoan systems （D. rnelanogaster and C. elegans） differ significantly. In this review, we introduce the basal-branching metazoan species Hydra as a potential novel invertebrate model system for meiosis research and particularly for the investigation of SC evolution, function and assembly. Also, available methods for SC research in Hydra are summarized.

关键词： Meiosis Synaptonemal complex Hydra Evolution

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Geometric morphometrics of mandibles for dietary differentiation of Bovidae(Mammalia:Artiodactyla)

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Current Zoology 2022年第3期68卷 237-249页

作者： Bian WANG miriam ZELDITCH Catherine BADGLEY Department of Earth and Environmental Sciences University of MichiganAnn ArborMI48109-1005USA Museum of Paleontology University of MichiganAnn ArborMI48109-1085USA Department of Ecology and Evolutionary Biology University of MichiganAnn ArborMI48109-1085USA

The mammalian family Bovidae has been widely studied in ecomorphological research,with important applications to paleoecological and paleohabitat *** studies of bovid craniomandibular features in relation to diet have used linear *** this study,we conduct landmark-based geometric-morphometric analyses to evaluate whether different dietary groups can be distinguished by mandibular *** analysis includes data for 100 species of extant bovids,covering all bovid tribes and 2 dietary *** the first classification with 3 feeding categories,we found that browsers(including frugivores),mixed feeders,and grazers are moderately well separated using mandibular shape.A finer dietary classification(frugivore,browser,browser-grazer intermediate,generalist,variable grazer,and obligate grazer)proved to be more useful for differentiating dietary extremes(frugivores and obligate grazers)but performed equally or less well for other ***,frugivorous bovids,which belong in tribe Cephalophini,have a distinct mandibular shape that is readily distinguished from all other dietary groups,yielding a 100%correct classification rate from jackknife *** main differences in mandibular shape found among dietary groups are related to the functional needs of species during forage prehension and *** with browsers,both frugivores and grazers have mandibles that are adapted for higher biomechanical demand of ***,frugivore mandibles are adapted for selective *** results call for more work on the feeding ecology and functional morphology of frugivores and offer an approach for reconstructing the diet of extinct bovids.

关键词： ecomorphology frugivory geometric morphometrics herbivory paleoecology

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Phytolith evidence for human-plant subsistence in Yahuai Cave(Guangxi, South China) over the past 30000 years

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Science China Earth Sciences 2020年第11期63卷 1745-1757页

作者： Yan WU Guangmao XIE Limi MAO Zhijun ZHAO miriam BELMAKER Key Laboratory of Vertebrate Evolution and Human Origins Institute of Vertebrate Paleontology and PaleoanthropologyChinese Academy of SciencesBeijing 100044China CAS Center for Excellence in Life and Paleoenvironment Beijing 100044China College of History Culture and TourismGuangxi Normal UniversityGuilin 541001China Guangxi Institute of Cultural Relic Protection and Archaeology Nanning 530022China State Key Laboratory of Palaeobiology and Stratigraphy Nanjing Institute of Geology and PalaeontologyChinese Academy of SciencesNanjing 210008China Institute of Archaeology Chinese Academy of Social SciencesBeijing 100710China Department of Anthropology University of TulsaTulsaOklahoma 74104USA

South China preserves a rich archaeological record elucidating the evolution of early modern humans during the Late ***,few studies on plant utilization were conducted in this *** used phytolith analysis from Yahuai Cave,Guangxi,to infer human use of plant resources over the past 30000 *** 14C dating was used to constrain the chronological *** indicate that several economically essential species were present throughout the sequence including Urticineae(*** sp.),which appears in the lower layers of the sequence(Marine Isotope Stage 3 through Heinrich 1);bamboo and palm which appear throughout the sequence,and wild rice which appears in a clear archaeological context dating to 16000 years *** is the earliest record of wild rice in South China and a prerequisite for rice *** unique stone tool assemblages,which resemble those in north China as opposed to South China,point to the possibility that humans,seeking refuge from the colder north,brought their tool kit with them and utilized familiar northern *** South China would have served as a refuge for human populations escaping the cold,harsh climate in the north with more ameliorate conditions in the south.

关键词： Phytolith Wild rice South China Bamboo Late Pleistocene

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Pulmonary artery stent thrombosis and symptomatic pulmonary hypertension following COVID-19 infection in Alagille patient:A case report

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World Journal of Clinical Cases 2025年第9期13卷 24-29页

作者： Shimon Izhakian miriam Korlansky Dror Rosengarten Elchanan Bruckheimer Mordechai Reuven Kramer Pulmonary Institute Rabin Medical CenterPetach Tikva 49100Israel Cardiac Catheterization Laboratory Schneider Children's Medical CenterPetach Tikva 49100Israel

BACKGROUND Alagille syndrome is a multisystem disease that results in various vascular anomalies,commonly involving the cardiac and pulmonary *** the best of our knowledge,there is no literature regarding the cardiovascular outcomes of these patients in association with coronavirus disease 2019(COVID-19).CASE SUMMARY A 34-year-old woman with a history of Alagille syndrome who underwent successful atrial septal defect with partial anomalous pulmonary veins and patent ductus arteriosus repair,as well as left pulmonary artery catheterization and stenting in childhood due to pulmonary *** patient was without any respiratory symptoms and was a dancer prior to contracting *** weeks after her COVID-19 infection,she developed left pulmonary artery stent thrombosis and subsequent symptomatic pulmonary hypertension.A treatment strategy of anticoagulation alongside pharmacological agents for pulmonary hypertension for 3 months followed by balloon pulmonary artery angioplasty to reopen the stenosis was *** In the era of COVID-19,patients with pulmonary vascular malformations and endovascular stents are at an increased risk for chronic thromboembolic *** may benefit from prophylactic antiplatelet or anticoagulation *** thrombosis is a devastating phenomenon and should be treated urgently and aggressively with balloon pulmonary angioplasty,and/or a thrombolytic agent.

关键词： Alagille syndrome Pulmonary artery stent Stent thrombosis COVID-19 Chronic thromboembolic pulmonary hypertension Pulmonary hypertension Case report

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New transcriptomic insights in two RNAi wheat lines with the gliadins strongly down-regulated by two endosperm specific promoters

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The Crop Journal 2022年第1期10卷 194-203页

作者： miriam Marín-Sanz Julio CMasaru Iehisa Francisco Barro Department of Plant Breeding Institute of Sustainable Agriculture(IAS)Spanish Council for Scientific Research(CSIC)14004 CórdobaSpain Department of Biotechnology Faculty of Chemical SciencesNational University of Asunción111421 San LorenzoParaguay

The gluten proteins of wheat grain are responsible for visco-elastic properties of flour,but they also trigger the immune-response of celiac *** this work,two low-gliadin RNA interference(RNAi)wheat lines that differ for the promoter driving the silencing(D-hordein andγ-gliadin promoters for D783 and D793 lines,respectively),were characterized at transcriptomic,and protein fraction levels in the *** of gliadins provides a readjustment in the grain protein fractions that also affects to the nongluten proteins(NGP),which were increased in both RNAi *** of wheat gluten by means of the R5 monoclonal antibody also showed a strong reduction in the content of gluten in both RNAi ***,fructans,an oligosaccharide linked with the development of non-celiac wheat sensitivity(NCWS)were also significantly decreased in RNAi *** down-regulation of gliadins fractions also impacts to other metabolic processes,particularly on carbohydrate metabolism,enzyme regulator activity and response to *** and transcription factors regulated by ABA were up-regulated,which could suggest the implication of this phytohormone on the stress response observed in the RNAi lines.

关键词： Celiac disease Gliadin Protein compensation RNAi lines Triticum aestivum

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Removal and desorption of chromium in synthetic effluent by a mixed culture in a bioreactor with a magnetic field

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Journal of Environmental Sciences 2020年第5期32卷 151-159页

作者： Roseli MDias Jessica GSilva Vicelma LCardoso miriam Mde Resende Faculty of Civil Engineering Federal University of UberlandiaMinas GeraisBrazil Faculty of Chemical Engineering Federal University of UberlandiaMinas GeraisBrazil

Two chromium removal experiments were performed in bioreactors with and without a magnetic field under the same *** release of the chromium present in the biomass was tested in two experiments one with the initial pH of the medium and one with pH *** objective was to remove Cr(Ⅵ)and total Cr from the effluent,this was carried out by placing biological treatments of synthetic effluent contaminated with 100 mg/L of Cr(Ⅵ)in a bioreactor with neodymium magnets that applied a magnetic field(intensity85.4 mT)to the mixed *** removal of Cr(Ⅵ)was approximately 100.0%for the bioreactor with a magnetic field and 93,3%for the bioreactor without a magnetic field for9 hr of recirculation of the synthetic effluent by the *** removal of total Cr was61.6%and 48.4%,with and without a magnetic field,respectively;for 24 *** desorption of Cr(VI)in the synthetic effluent was 0.05 mg/L,which is below the limit established by Brazilian legislation(0.1 mg/L)for the discharge of effluent containing Cr(Ⅵ)into bodies of *** results obtained for the removal of chromium in synthetic effluent suggested that there was no significant influence on the viable cell count of the mixed *** desorption of Cr(Ⅵ)in synthetic effluent after bioadsorption of chromium by the mixed culture in the process of removal of chromium in bioreactors with and without a magnetic field was not significant in either of the experiments with different initial pHs.

关键词： Chromium removal Mixed culture Magnetic field Desorption Effluent treatment

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