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An overview of end-of-life issues in a cardiology department. Is the mode of death worse in the cardiac intensive care unit?

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Journal of Geriatric Cardiology 2019年第6期16卷 482-489页

作者： Lourdes Vicent Vanesa Bruna Carolina Devesa Jorge García-Carreno Iago Sousa-Casasnovas miriam juárez Francisco Fernández-Avilés Manuel Martínez-Sellés Servicio de Cardiología Hospital Universitario Gregorio Maranon CIBERCV Madrid Spain Universidad Complutense de Madrid Madrid Spain Universidad Europea de Madrid Madrid Spain

Introduction Cardiovascular (CV) diseases are the most common causes of death and causes frequent hospital admissions.[1] The increase in life expectancy and the appearance of new treatments,[2] is changing in the clinical profile of CV disease, with a rise in chronic processes and concomitant comorbidities.[ 3] These changes are probably reflected in the current profile of patients admitted to cardiology departments, and in their causes of mortality.

关键词： Cardiovascular death Mortality Withdraw of life-sustaining therapies

Factors associated with early virological response to peginterferon-α-2a/ribavirin in chronic hepatitis C

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World Journal of Gastroenterology 2013年第12期19卷 1943-1952页

作者： Javier García-Samaniego miriam Romero Rafael Granados Remedios Alemán Miguel Jorge juan Dolores Suárez Ramón Pérez Gregorio Castellano Carlos González-Portela Liver Unit Hospital Carlos Ⅲ Centro de Investigación Biómedica en Red de Enfermedades Hepáticas y Digestivas Department of Gastroenterology Hospital Universitario de Gran Canaria Gastroenterology Service Hospital Universitario de Canarias Department of Gastroenterology Hospital Universitario Insular de Gran Canaria Internal Medicine Service Hospital Arquitecto Marcide Gastroenterology Service Hospital Central de Asturias Gastroenterology Service Hospital 12 de Octubre Gastroenterology Service Hospital Policlínico de Vigo

AIM: To evaluate the impact of sociodemographic/clinical factors on early virological response (EVR) to pegin-terferon/ribavirin for chronic hepatitis C (CHC) in clinical practice. METHODS: We conducted a multicenter, cross-sectional, observational study in Hepatology Units of 91 Spanish hospitals. CHC patients treated with peginterferon α-2a plus ribavirin were included. EVR was defined as undetectable hepatitis C virus (HCV)-ribonucleic acid (RNA) or ≥ 2 log HCV-RNA decrease after 12 wk of treatment. A bivariate analysis of sociodemographic and clinical variables associated with EVR was carried out. Independent factors associated with an EVR were analyzed using a multiple regression analysis that included the following baseline demographic and clinical variables: age (≤ 40 years vs > 40 years), gender, race, educational level, marital status and family status, weight, alcohol and tobacco consumption, source of HCV infection, alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels, and gamma glutamyl transpeptidase (GGT) (≤ 85 IU/mL vs > 85 IU/mL), serum ferritin, serum HCV-RNA concentration ( 400 000 IU/mL in 74% of patients. The mean ALT and AST levels were 88.4 ± 69.7 IU/mL and 73.9 ± 64.4 IU/mL, respectively, and mean GGT level was 82 ± 91.6 IU/mL. The mean ferritin level was 266 ± 284.8 μg/L. Only 6.2% of patients presented with cirrhosis. All patients received 180 mg of peginterferon α-2a. The most frequently used ribavirin doses were 1000 mg/d (41%) and 1200 mg/d (41%).

关键词： Antiviral therapy Baseline factors Early virological response Peginterferon α-2a Ribavirin

Epidemiology of hepatitis C virus infection

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World Journal of Gastroenterology 2007年第17期13卷 2436-2441页

作者： miriam J Alter Institute for Human Infections and Immunity University of Texas Medical Branch Galveston Texas USA 77555 United States

Globally, hepatitis C virus (HCV) has infected an estimated 130 million people, most of whom are chronically infected. HCV-infected people serve as a reservoir for transmission to others and are at risk for developing chronic liver disease, cirrhosis, and primary hepatocellular carcinoma (HCC). It has been estimated that HCV accounts for 27% of cirrhosis and 25% of HCC worldwide. HCV infection has likely been endemic in many populations for centuries. However, the wave of increased HCV-related morbidity and mortality that we are now facing is the result of an unprecedented increase in the spread of HCV during the 20th century. Two 20th century events appear to be responsible for this increase; the widespread availability of injectable therapies and the illicit use of injectable drugs.

关键词： Hepatitis C virus Global epidemiology Incidence Prevalence Transmission Natural history

Neuroprotection of the inner retina:Müller cells and lactate

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Neural Regeneration Research 2018年第10期13卷 1741-1742页

作者： Rupali Vohra miriam Kolko Department of Drug Design and Pharmacology University of Copenhagen Department of Ophthalmology Copenhagen University Hospital

Müller cells：The neglected neighbor：Müller cells constitute the majority of retinal glial cells and offer more alternating functions than any other cell of the ***,Müller cells cover the complete thickness of the retina,and their roles therefore differ correspondingly to the retinal segment in which they are *** the inner retina,Müller cells are crucial in taking up toxic molecules,such as excessive.

关键词： In GPR Neuroprotection of the inner retina:M ller cells and lactate

Recent insights into the characteristics and role of peritoneal macrophages from ascites of cirrhotic patients

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World Journal of Gastroenterology 2021年第41期27卷 7014-7024页

作者： Pilar García-Peñarrubia Antonio JoséRuiz-Alcaraz miriam Ruiz-Ballester Tamara Nadira Ramírez-Pávez María Martínez-Esparza Department of Biochemistry and Molecular Biology B and Immunology School of MedicineUniversity of MurciaMurcia 30100Spain

Macrophages are a diverse myeloid cell population involved in innate and adaptive immune responses,embryonic development,wound repair,and regulation of tissue *** cells link the innate and adaptive immunities and are crucial in the development and sustainment of various inflammatory *** are tissue-resident cells in steady-state conditions;however,they are also recruited from blood monocytes after local pathogen invasion or tissue *** macrophages vary based on their cell complexity,phenotype,and functional *** cells regulate inflammation and control bacterial infections in the ascites of decompensated cirrhotic *** recent work reported several phenotypic and functional characteristics of these cells under both healthy and pathological conditions.A direct association between cell size,CD14/CD16 expression,intracellular level of GATA-6,and expression of CD206 and HLA-DR activation/maturation markers,indicate that the large peritoneal macrophage CD14^(high)CD16^(high)subset constitutes the mature phenotype of human resident peritoneal macrophages during ***,elevated expression of CD14/CD16 is related to the phagocytic *** novel large CD14^(high)CD16^(high)peritoneal subpopulation is increased in the ascites of cirrhotic patients and is highly sensitive to lipopolysaccharide(LPS)-induced activation,thereby exhibiting features of inflammatory ***,phosphorylation of ERK1/2,PKB/Akt,and c-jun is remarkably increased in response to LPS in vitro,whereas that of p38 MAPK is reduced compared with the monocyte-derived macrophages from the blood of healthy ***,in vitro activated monocyte-derived macrophages from ascites of cirrhotic patients secreted significantly higher levels of IL-6,IL-10,and TNF-αand lower amounts of IL-1βand IL-12 than the corresponding cells from healthy donor’s *** on these results,other authors have recently reported that the sur

关键词： Cirrhosis Inflammation Peritoneal macrophages Phenotypic markers Activation routes

Method of directly defining the inverse mapping applied to prostate cancer immunotherapy --Mathematical model

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International Journal of Biomathematics 2018年第5期11卷 233-254页

作者： Ophir Nave miriam Elbaz Department of Mathematics Jerusalem College of Technology (JCT) Hava'ad Haleumi 21 Jerusalem Israel

In this paper, we apply the method of directly defining the inverse mapping introduced by Liao and Zhao [On the method of directly defining inverse mapping for nonlinear differential equations, Numer. Algorithms 72（4）（2016） 989-1020] to the problem of prostate cancer immunotherapy. We extend this method in two directions： first, we apply the method to a system of nonlinear ordinary differential equation, and second, we propose a new technique for finding the base functions in the considered algorithm.

关键词： Nonlinear system of differential equations prostate cancer numerical simulations cancer immunotherapy asymptotic analysis.

The Synaptonemal Complex of Basal Metazoan Hydra:More Similarities to Vertebrate than Invertebrate Meiosis Model Organisms

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Journal of Genetics and Genomics 2014年第3期41卷 107-115页

作者： Johanna Fraune miriam Wiesner Ricardo Benavente Department of Cell and Developmental Biology BiocenterUniversity of Würzburg

The synaptonemal complex （SC） is an evolutionarily well-conserved structure that mediates chromosome synapsis during prophase of the first meiotic division. Although its structure is conserved, the characterized protein components in the current metazoan meiosis model systems （Drosophila melanogaster, Caenorhabditis elegans, and Mus musculus） show no sequence homology, challenging the question of a single evolutionary origin of the SC. However, our recent studies revealed the monophyletic origin of the mammalian SC protein components. Many of them being ancient in Metazoa and already present in the cnidarian Hydra. Remarkably, a comparison between different model systems disclosed a great similarity between the SC components of Hydra and mammals while the proteins of the ecdysozoan systems （D. rnelanogaster and C. elegans） differ significantly. In this review, we introduce the basal-branching metazoan species Hydra as a potential novel invertebrate model system for meiosis research and particularly for the investigation of SC evolution, function and assembly. Also, available methods for SC research in Hydra are summarized.

关键词： Meiosis Synaptonemal complex Hydra Evolution

Geometric morphometrics of mandibles for dietary differentiation of Bovidae(Mammalia:Artiodactyla)

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Current Zoology 2022年第3期68卷 237-249页

作者： Bian WANG miriam ZELDITCH Catherine BADGLEY Department of Earth and Environmental Sciences University of MichiganAnn ArborMI48109-1005USA Museum of Paleontology University of MichiganAnn ArborMI48109-1085USA Department of Ecology and Evolutionary Biology University of MichiganAnn ArborMI48109-1085USA

The mammalian family Bovidae has been widely studied in ecomorphological research,with important applications to paleoecological and paleohabitat *** studies of bovid craniomandibular features in relation to diet have used linear *** this study,we conduct landmark-based geometric-morphometric analyses to evaluate whether different dietary groups can be distinguished by mandibular *** analysis includes data for 100 species of extant bovids,covering all bovid tribes and 2 dietary *** the first classification with 3 feeding categories,we found that browsers(including frugivores),mixed feeders,and grazers are moderately well separated using mandibular shape.A finer dietary classification(frugivore,browser,browser-grazer intermediate,generalist,variable grazer,and obligate grazer)proved to be more useful for differentiating dietary extremes(frugivores and obligate grazers)but performed equally or less well for other ***,frugivorous bovids,which belong in tribe Cephalophini,have a distinct mandibular shape that is readily distinguished from all other dietary groups,yielding a 100%correct classification rate from jackknife *** main differences in mandibular shape found among dietary groups are related to the functional needs of species during forage prehension and *** with browsers,both frugivores and grazers have mandibles that are adapted for higher biomechanical demand of ***,frugivore mandibles are adapted for selective *** results call for more work on the feeding ecology and functional morphology of frugivores and offer an approach for reconstructing the diet of extinct bovids.

关键词： ecomorphology frugivory geometric morphometrics herbivory paleoecology

Phytolith evidence for human-plant subsistence in Yahuai Cave(Guangxi, South China) over the past 30000 years

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Science China Earth Sciences 2020年第11期63卷 1745-1757页

作者： Yan WU Guangmao XIE Limi MAO Zhijun ZHAO miriam BELMAKER Key Laboratory of Vertebrate Evolution and Human Origins Institute of Vertebrate Paleontology and PaleoanthropologyChinese Academy of SciencesBeijing 100044China CAS Center for Excellence in Life and Paleoenvironment Beijing 100044China College of History Culture and TourismGuangxi Normal UniversityGuilin 541001China Guangxi Institute of Cultural Relic Protection and Archaeology Nanning 530022China State Key Laboratory of Palaeobiology and Stratigraphy Nanjing Institute of Geology and PalaeontologyChinese Academy of SciencesNanjing 210008China Institute of Archaeology Chinese Academy of Social SciencesBeijing 100710China Department of Anthropology University of TulsaTulsaOklahoma 74104USA

South China preserves a rich archaeological record elucidating the evolution of early modern humans during the Late ***,few studies on plant utilization were conducted in this *** used phytolith analysis from Yahuai Cave,Guangxi,to infer human use of plant resources over the past 30000 *** 14C dating was used to constrain the chronological *** indicate that several economically essential species were present throughout the sequence including Urticineae(*** sp.),which appears in the lower layers of the sequence(Marine Isotope Stage 3 through Heinrich 1);bamboo and palm which appear throughout the sequence,and wild rice which appears in a clear archaeological context dating to 16000 years *** is the earliest record of wild rice in South China and a prerequisite for rice *** unique stone tool assemblages,which resemble those in north China as opposed to South China,point to the possibility that humans,seeking refuge from the colder north,brought their tool kit with them and utilized familiar northern *** South China would have served as a refuge for human populations escaping the cold,harsh climate in the north with more ameliorate conditions in the south.

关键词： Phytolith Wild rice South China Bamboo Late Pleistocene