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KDM6A被发现在小细胞肺癌亚型可塑性的表观遗传调节中起关键作用

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生物医学工程与临床 2023年第5期27卷 655-655页

作者： Duplaquet l

据Duplaquet l 2023年8月17日(Nat Cell Biol,2023,2023 Aug ***:10.1038/s41556-023-01210-z.)报道,美国哈佛大学医学院等机构研究人员通过研究利用CRISPR/cas9技术制造出了一种特殊的小细胞肺癌(SClC)小鼠模型,其可控制KDM6A表达[即KD... 详细信息

关键词：小细胞肺癌小鼠模型表观遗传调节可塑性

First Results of SECRAl at 18GHz for Intense Beam Production of Highly Charged Ions

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Chinese Physics C 2007年第S1期31卷 9-12页

作者：赵红卫孙良亭郭晓虹张雪珍张子民袁平李锦钰冯玉成何伟宋明涛李锡霞曹云王辉马宝华卢旺詹文龙魏宝文 Institute of Modern Physics Chinese Academy of Sciences

A Superconducting ECR ion source with Advanced design in lanzhou (SECRAl) was successfully built to produce intense beams of highly charged ions for Heavy Ion Research Facility in lanzhou (HIRFl).The ion source has been optimized to be operated at 28GHz for its maximum *** superconducting magnet confinement configuration of the ion source consists of three axial solenoid coils and six sextupole coils with a cold iron structure as field booster and *** 28GHz operation,the magnet assembly can produce peak mirror fields on axis 3.6T at injection,2.2T at extraction and a radial sextupole field of 2.0T at plasma chamber wall.A unique feature of SECRAl is that the three axial solenoid coils are located inside of the sextupole bore in order to reduce the interaction forces between the sextupole coils and the solenoid coils. During the ongoing commissioning phase at 18GHz with a stainless steel chamber,tests with various gases and some metals have been conducted with microwave power less than 3.2kW and it turned out the performance is very *** record ion beam intensities have been produced,for instance,810eμA of O^(7+),505eμA of Xe^(20+),306eμA of Xe^(27+),21eμA of Xe^(34+),2.4eμA of Xe^(38+) and so *** reach better results for highly charged ion beams,further modifications such as an aluminium chamber with better cooling,higher microwave power and a movable extraction system will be done,and also emittance measurements are being prepared.

关键词： SECRAl ECR ion source superconducting magnet highly charged ion beams

light meson emissions of selected charmonium-like states within compact tetraquark configurations

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Chinese Physics C 2023年第6期47卷 5-14页

作者：李宁何惠珍梁唯吕齐放陈殿勇董宇兵 Department of Physics Hunan Normal UniversityKey Laboratory of Low-Dimensional Quantum Structures and Quantum Control of Ministry of EducationChangsha 410081China Key laboratory for Matter Microstructure and Function of Hunan Province Hunan Normal UniversityChangsha 410081China School of Physics and Electronics Hunan Key Laboratory of Nanophotonics and DevicesCentral South UniversityChangsha 410083China Research Center for Nuclear Physics(RCNP) IbarakiOsaka 567-0047Japan School of Physics Southeast UniversityNanjing 210094China lanzhou Center for Theoretical Physics Lanzhou UniversityLanzhou 730000China Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Theoretical Physics Center for Science Facilities(TPCSF) Chinese Academy of SciencesBeijing 100049China School of Physical Sciences University of Chinese Academy of SciencesBeijing 101408China

We adopt the quark pair creation model to investigate the light meson emissions of several charmoniumlike *** quark pair creation model is applied to four-body systems,and we calculate the pion/kaon emissions of X(4700),z_(c)(4430),Y(4230),Y(4360),Y(4390),and Y(4660)within compact tetraquark *** find that the pion/kaon decay widths of X(4700)and z_(c)(4430)the resonances Y(4230),Y(4360),Y(4390),and Y(4660)cay behaviors will provide useful information for future experimental searches and theoretical interpretations.

关键词： charmonium-like states light meson emissions compact tetraquarks strong decays quark pair creation model

Cell adhesion mediated by β_2 integrin-ICAM-1 interactions

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医用生物力学 2010年第S1期25卷 14-15页

作者： Changliang Fu,Dongying zhan,Chunfang Tong,Manliu Wang,Shouqin lü,Yan zhang,Mian long(1 Key laboratory of Microgravity,Institute of Mechanics,Chinese Academy of Sciences,2 National Microgravity laboratory and 3 Center of Biomechanics,and Bioengineering,Institute of Mechanics,Chinese Academy of Sciences,Beijing 100190,China.)

Introduction During the inflammatory responses,leukocytes are recruited at the site of high endothelial venule,roll over the endothelium surface,form the firm adhesion to spread out,and finally transmigrate across the... 详细信息

关键词： ICAM PMN

产脲酶菌株Bacillus ***-1矿化特性及其石灰岩裂缝修复性能

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应用与环境生物学报 2023年第3期29卷 742-750页

作者：王秀秀曾勇闫志英杜亚玲田雪平吕青阳刘杨周立宏成都理工大学生态环境学院地质灾害防治与地质环境保护国家重点实验室成都610059 中国科学院成都生物研究所中国科学院环境与应用微生物重点实验室四川省环境与应用微生物重点实验室成都610041 南京大学环境学院污染控制与资源化国家重点实验室南京210023

许多暴露在外界环境的石灰岩易产生裂缝,微生物诱导碳酸钙沉淀(MICP)技术作为一种新兴的裂缝修复技术已受到广泛关注.对一株产脲酶菌株Ml-1进行形态表征、生理生化鉴定和16S rRNA基因鉴定,并探究其修复石灰岩裂缝的性能,以挖掘基于MICP... 详细信息

许多暴露在外界环境的石灰岩易产生裂缝,微生物诱导碳酸钙沉淀(MICP)技术作为一种新兴的裂缝修复技术已受到广泛关注.对一株产脲酶菌株Ml-1进行形态表征、生理生化鉴定和16S rRNA基因鉴定,并探究其修复石灰岩裂缝的性能,以挖掘基于MICP技术修复石质文物的潜能;对Ml-1矿化产物进行FTIR和XRD表征,并通过修复后材料的冻融循环、吸水率和透气率、耐候性以及SEM表征来研究Ml-1诱导碳酸钙沉淀在石灰岩裂缝修复中的作用和添加不同成核剂对矿化产物形貌、尺寸以及修复材料性能的影响.菌株Ml-1经鉴定为芽孢杆菌(Bacillus sp.),其脲酶活性和菌体zeta电势与产脲酶代表性菌株Sporosarcina pasteurii相当.与***相比,Ml-1还具有对数生长期长、生物量大、温度和pH耐受范围广的优点.在0.25 mol/l CaCl_(2)浓度和0.8 mol/l尿素浓度的反应条件下,脲酶活性为1429.28ΔU/ml,碳酸钙沉淀为稳定的方解石晶型,Ca^(2+)沉淀率为99.8%;成核剂柠檬酸钠和蛋清会减小碳酸钙沉淀的尺寸,提高矿化碳酸钙沉淀的性能;石灰岩裂缝经Ml-1修复后可在冻融循环10次后无明显质量损失;耐候性试验证实修复后材料表面紧实,室外放置不会产生菌斑等污渍,矿化沉淀在裂缝表层形成了有效的防护层,可以降低有害环境对石灰岩的损伤.本研究表明基于MICP技术修复的石灰岩裂缝具有良好的性能,为石质文物裂缝修复提供了新的途径,而Ml-1作为MICP功能菌株在石灰岩裂缝修复方面表现出巨大的应用潜力.

关键词： MICP 脲酶菌石灰岩裂缝成核剂形貌

Search for the doubly heavy baryon Ξ_(bc)^(+)→ decaying to J/ψΞ_(c)^(+)

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中国物理C:英文版 2023年第9期47卷 1-13页

作者： R.Aaij A.S.W.Abdelmotteleb C.Abellan Beteta F.Abudinén T.Ackernley B.Adeva M.Adinolfi H.Afsharnia C.Agapopoulou C.A.Aidala S.Aiola z.Ajaltouni S.Akar K.Akiba J.Albrecht F.Alessio M.Alexander A.Alfonso Albero z.Aliouche P.Alvarez Cartelle S.Amato J.l.Amey Y.Amhis l.An l.Anderlini M.Andersson A.Andreianov M.Andreotti D.Andreou D.Ao F.Archilli A.Artamonov M.Artuso E.Aslanides M.Atzeni B.Audurier S.Bachmann M.Bachmayer J.J.Back A.Bailly-reyre P.Baladron Rodriguez V.Balagura W.Baldini J.Baptista de Souza leite M.Barbetti R.J.Barlow S.Barsuk W.Barter M.Bartolini F.Baryshnikov J.M.Basels G.Bassi B.Batsukh A.Battig A.Bay A.Beck M.Becker F.Bedeschi I.B.Bediaga A.Beiter V.Belavin S.Belin V.Bellee K.Belous I.Belov I.Belyaev G.Bencivenni E.Ben-Haim A.Berezhnoy *** D.Berninghoff H.C.Bernstein C.Bertella A.Bertolin C.Betancourt F.Betti Ia.Bezshyiko S.Bhasin J.Bhom l.Bian M.S.Bieker N.V.Biesuz S.Bifani P.Billoir A.Biolchini M.Birch F.C.R.Bishop A.Bitadze A.Bizzeti M.P.Blago T.Blake F.Blanc S.Blusk D.Bobulska J.A.Boelhauve O.Boente Garcia T.Boettcher A.Boldyrev N.Bondar S.Borghi M.Borsato J.T.Borsuk S.A.Bouchiba T.J.V.Bowcock A.Boyer C.Bozzi M.J.Bradley S.Braun A.Brea Rodriguez J.Brodzicka A.Brossa gonzalo D.Brundu A.Buonaura l.Buonincontri A.T.Burke C.Burr A.Bursche A.Butkevich J.S.Butter J.Buytaert W.Byczynski S.Cadeddu H.Cai R.Calabrese l.Calefice S.Cali R.Calladine M.Calvi M.Calvo Gomez P.Camargo Magalhaes P.Campana D.H.Campora Perez A.F.Campoverde Quezada S.Capelli l.Capriotti A.Carbone G.Carboni R.Cardinale A.Cardini I.Carli P.Carniti l.Carus A.casais Vidal R.cas.ary G.casse M.Cattaneo G.Cavallero V.Cavallini S.Celani J.Cerasoli D.Cervenkov A.J.Chadwick M.G.Chapman M.Charles Ph.Charpentier C.A.Chavez Barajas M.Chefdeville C.Chen S.Chen A.Chernov S.Chernyshenko V.Chobanova S.Cholak M.Chrzaszcz A.Chubykin V.Chulikov P.Ciambrone M.F.Cicala X.Cid Vidal G.Ciezarek G.Ciullo P.E.l.Clarke M.Clemencic H.V.Cliff J.Closier J.l.Cobbledick V.Coco J.A.B.Coelho J.Cogan E.Cogneras l.Cojocariu P.Collins T.Colombo l.Congedo A.Contu N.Cooke Centro Brasileiro de Pesquisas Físicas(CBPF) Rio de JaneiroBrazil Universidade Federal do Rio de Janeiro(UFRJ) Rio de JaneiroBrazil Center for High Energy Physics Tsinghua UniversityBeijingChina Institute Of High Energy Physics(IHEP) BeijingChina School of Physics State Key laboratory of Nuclear Physics and Technology Peking UniversityBeijingChina University of Chinese Academy of Sciences BeijingChina Institute of Particle Physics Central China Normal UniversityWuhanHubeiChina Université Savoie Mont Blanc CNRSIN2P3-LAPPAnnecyFrance UniversitéClermont Auvergne CNRS/IN2P3LPCClermont-FerrandFrance Aix Marseille Univ CNRS/IN2P3CPPMMarseilleFrance UniversitéParis-Saclay CNRS/IN2P3IJCLabOrsayFrance laboratoire leprince-Ringuet CNRS/IN2P3Ecole PolytechniqueInstitut Polytechnique de ParisPalaiseauFrance lPNHE Sorbonne UniversitéParis Diderot Sorbonne Paris CitéCNRS/IN2P3ParisFrance I.Physikalisches Institut RWTH Aachen UniversityAachenGermany Fakultät Physik Technische Universität DortmundDortmundGermany Max-Planck-Institut für Kernphysik(MPIK) HeidelbergGermany Physikalisches Institut Ruprecht-Karls-Universität HeidelbergHeidelbergGermany School of Physics University College DublinDublinIreland INFN Sezione di Bari BariItaly INFN Sezione di Bologna BolognaItaly INFN Sezione di Ferrara FerraraItaly INFN Sezione di Firenze FirenzeItaly INFN laboratori Nazionali di Frascati FrascatiItaly INFN Sezione di Genova GenovaItaly INFN Sezione di Milano MilanoItaly INFN Sezione di Milano-Bicocca MilanoItaly INFN Sezione di Cagliari MonserratoItaly Universitàdegli Studi di Padova Universitàe INFNPadovaPadovaItaly INFN Sezione di Pisa PisaItaly INFN Sezione di Roma la Sapienza RomaItaly INFN Sezione di Roma Tor Vergata RomaItaly Nikhef National Institute for Subatomic Physics AmsterdamNetherlands Nikhef National Institute for Subatomic Physics and VU University Amsterdam AmsterdamNetherlands AGH-University of Science and Technology Faculty of Physics and Applied Computer Scienc

A first search for the Ξ_(bc)^(+)J/ψΞ_(c)^(+) decay is performed by the lHCb experiment with a data sample of proton-proton collisions, corresponding to an integrated luminosity of 9 fb−1 recorded at centre-of-mass energies of 7, 8, and 13 TeV. Two peaking structures are seen with a local (global) significance of 4.3(2.8) and 4.1(2.4) standard deviations at masses of 6571 and 6694 MeV/c2, respectively. Upper limits are set on the Ξ+bc baryon production cross-section times the branching fraction relative to that of the B+c→J/ψD+s decay at centre-of-mass energies of 8 and 13 TeV, in the Ξ+bc and in the B+c rapidity and transverse-momentum ranges from 2.0 to 4.5 and 0 to 20GeV/c, respectively. Upper limits are presented as a function of the Ξ+bc mass and lifetime.

关键词： QCD B physics charm physics spectroscopy

射频SOI lDMOS功率放大器设计与仿真

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电讯技术 2009年第3期49卷 43-46页

作者：陈卫军马里剑张海鹏余厉阳吕韶义杭州电子科技大学RF电路与系统省部共建教育部重点实验室杭州310018

简介了改进的绝缘层上硅横向扩散金属氧化物-半导体(SOI lDMOS)电路模型。根据改进的SOI lDMOS电路模型,采用射频仿真软件进行了射频功率放大器的设计与仿真。该射频功率放大器采用两级放大结构,采用了S参数设计方法和负载牵引方法设计... 详细信息

简介了改进的绝缘层上硅横向扩散金属氧化物-半导体(SOI lDMOS)电路模型。根据改进的SOI lDMOS电路模型,采用射频仿真软件进行了射频功率放大器的设计与仿真。该射频功率放大器采用两级放大结构,采用了S参数设计方法和负载牵引方法设计。结果表明放大器的增益达到15dB,输出功率达到25dBm,功率附加效率大于40%。

关键词：射频功率放大器 SOI lDMOS 计算机辅助设计与仿真负载牵引法

大数据驱动多方合作助力可持续发展——“首届中科年货节”总结暨“一带一路”优质地理产品生境保护与可持续发展行动启动大会成功召开

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全球变化数据学报（中英文） 2022年第1期6卷 149-152,I0151-I0154页

作者：诸云强刘闯王振波张国友宋献方曹京华张琪中国科学院地理科学与资源研究所北京100101 中国地理学会北京100101 “一带一路”国际科学组织联盟(ANSO) 北京100101 中国科学院后勤协会

2022年2月16日,中国科学院地理科学与资源研究所(以下简称中科院地理资源所)中国地理学会、“一带一路”国际科学组织联盟(ANSO)、中国科学院后勤协会联合主办,亚洲地理学会、中国自然资源学会、中国生态学会区域生态专业委员会、中国... 详细信息

2022年2月16日,中国科学院地理科学与资源研究所(以下简称中科院地理资源所)中国地理学会、“一带一路”国际科学组织联盟(ANSO)、中国科学院后勤协会联合主办,亚洲地理学会、中国自然资源学会、中国生态学会区域生态专业委员会、中国地理学会文化地理专业委员会等单位联合支持,地理资源所对外合作处、中国地理学会大数据工作委员会、全球变化科学数据出版系统世界数据中心(《全球变化数据学报(中英文)》编辑部)中科生活服务有限公司联合承办的“大数据驱动多方合作助力可持续发展——首届中科年货节’总结暨‘一带一路’优质地理产品生境保护与可持续发展行动启动大会”在北京顺利召开,会议采取线上与线下相结合的方式举行。

关键词：大数据优质地理产品中科年货节可持续发展一带一路

Search for the doubly heavy baryons Ω^(0)_(bc) and E^(0)_(bc) decaying to Λ^(+)_(c)π^(-) and E^(+)_(c)π^(-)

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Chinese Physics C 2021年第9期45卷 10-21页

作者： R.Aaij C.Abelian Beteta T.Ackernley B.Adeva M.Adinolfi H.Afshamia C.A.Aidala S.Aiola z.Ajaltouni S.Aka J.Albrecht F.Alessio M.Alexander A.Alfonso Albero z.Aliouche G.Alkhazov P.Alvarez Cartelie S.Amato Y.Amhis l.An l.Anderlini A.Andreianov M.Andreotti F.Archilli A.Artamonov M.Artuso K.Arzymatov E.Aslanides M.Atzeni B.Audurier S.Bachmann M.Bachmayer J.J.Back P.Baladron Rodriguez V.Balagura W.Baldini J.Baptista leite R.J.Barlow S.Barsuk W.Barter M.Bartolini F.Baryshnikov J.M.Basels G.Bassi B.Batsukh A.Battig A.Bay M.Becker F.Bedeschi I.Bediaga A.Beiter V.Belavin S.Belin V.Bellee K.Belous I.Belov I.Belyaev G.Bencivenni E.Ben-Haim A.Berezhnoy *** D.Beminghoff H.C.Bernstein C.Bertella A.Bertolin C.Betancourt F.Betti Ia.Bezshyiko S.Bhasin J.Bhom l.Bian M.S.Bieker S.Bifani P.Billoir M.Birch F.C.R.Bishop A.Bitadze A.Bizzeti M.Bjorn M.P.Blago T.Blake F.Blanc S.Blusk D.Bobulska J.A.Boelhauve O.Boente Garcia T.Boettcher A.Boldyrev A.Bondar N.Bondar S.Borghi M.Borisyak M.Borsato J.T.Borsuk S.A.Bouchiba T.J.V.Bowcock A.Boyer C.Bozzi M J.Bradley S.Braun A.Brea Rodriguez M.Brodski J.Brodzicka A.Brossa gonzalo D.Brundu A.Buonaura C.Burr A.Bursche A.Butkevich J.S.Butter J.Buytaert W.Byczynski S.Cadeddu H.Cai R.Calabrese l.Calefice l.Calero Diaz S.Cali R.Calladine M.Calvi M.Calvo Gomez P.Camargo Magalhaes A.Camboni P.Campana A.F.Campoverde Quezada S.Capelli l.Capriotti A.Carbone G.Carboni R.Cardinale A.Cardini I.Carli P.Camiti l.Carus K.Carvalho Akiba A.casais Vidal G.casse M.Cattaneo G.Cavallero S.Celani J.Cerasoli A.J.Chadwick M.G.Chapman M.Charles Ph.Charpentier G.Chatzikonstantinidis C.A.Chavez Barajas M.Chefdeville C.Chen S.Chen A.Chernov V.Chobanova S.Cholak M.Chrzaszcz A.Chubykin V.Chulikov P.Ciambrone M.F.Cicala X.Cid Vidal G.Ciezarek P.E.l.Clarke M.Clemencic H.V.Cliff J.Closier J.l.Cobbledick V.Coco J.A.B.Coelho J.Cogan E.Cogneras l.Cojocariu P.Collins T.Colombo l.Congedo A.Contu N.Cooke G.Coombs G.Corti C.M.Costa Sobral B.Couturier D.C.Craik J.Crkovska M.Cruz Torres R.Currie C.l.Da Silva E.Dall'Occo J.Dalseno C.D'Ambrosi Centro Brasileiro de Pesquisas Fisicas(CBPF) Rio de JaneiroBrazil Universidade Federal do Rio de Janeiro(UFRJ) Rio de JaneiroBrazil Center for High Energy Physics Tsinghua UniversityBeijingChina Institute of High Energy Physics(IHEP) BeijingChina School of Physics State Key laboratory of Nuclear Physics and Technology Peking UniversityBeijingChina University ofChinese Academy of Sciences BeijingChina Institute of Particle Physics Central China Normal UniversityWuhanHubeiChina Univ.Savoie Mont Blanc CNRSIN2P3-LAPPAnnecyFrance Universite Clermont Auvergne CNRS/IN2P3LPCClermont-FerrandFrance Aix Marseille Univ CNRS/IN2P3CPPMMarseilleFrance Universite Paris-Saclay CNRS/IN2P3IJCLabOrsayFrance laboratoire leprince-Ringuet CNRS/IN2P3Ecole PolytechniqueInstitut Polytechnique de ParisPalaiseauFrance lPNHE Sorbonne UniversiteParis Diderot Sorbonne Paris CiteCNRS/FN2P3ParisFrance I.Physikalisches Institut RWTH Aachen UniversityAachenGermany Fakultat Physik Technische Universitat DortmundDortmundGermany Max-Planck-Institut für Kemphysik(MPIK) HeidelbergGermany Physikalisches Institut Ruprecht-Karls-Universitat HeidelbergHeidelbergGermany School of Physics University College DublinDublinIreland INFN Sezione di Bari BariItaly INFN Sezione di Bologna BolognaItaly INFN Sezione di Ferrara FerraraItaly INFN Sezione di Firenze FirenzeItaly INFN laboratori Nazionali di Frascati FrascatiItaly INFN Sezione di Genova GenovaItaly INFN Sezione di Milano MilanoItaly INFN Sezione di Milano-Bicocca MilanoItaly INFN Sezione di Cagliari MonserratoItaly Universita degli Studi di Padova Universita e INFNPadovaPadovaItaly INFN Sezione di Pisa PisaItaly INFN Sezione di Roma la Sapienza RomaItaly INFN Sezione di Roma Tor Vergata RomaItaly Nikhef National Institute for Subatomic Physics AmsterdamNetherlands Nikhef National Institute for Subatomic Physics and VU University Amsterdam AmsterdamNetherlands AGH-University of Science and Technology Faculty of Physics and Applied Computer ScienceKr

The first search for the doubly heavyΩ^(0)_(bc)baryon and a search for the E^(0)_(bc)baryon are performed using pp collision data collected via the lHCb experiment from 2016 to 2018 at a centre-of-mass energy of 13 TeV,corresponding to an integrated luminosity of 5.2 fb^(-1).The baryons are reconstructed via their decays to Λ^(+)_(c)π^(-)and E^(+)_(c)π^(-).No significant excess is fbund for invariant masses between 6700 and 7300 MeV/c^(2),in a rapidity range from 2.0 to 4.5 and a transverse momentum range from 2 to 20 MeV/*** limits are set on the ratio of the Ω^(0)_(bc)and E^(0)_(bc)production cross-section times the branching fraction to Λ^(+)_(c)π^(-)(E^(+)_(c)π^(-))relative to that of the Λ^(0)_(b)(E^(0)_(b))baryon,for different lifetime hypotheses,at 95%confidence *** upper limits range from 0.5 x 10^(-4)to 2.5 x 10^(-4)for theΩ^(0)_(bc)→Λ^(+)_(c)π^(-)(E^(0)_(bc)→Λ^(+)_(c)π^(-))decay,and from 1.4x 10^(-3)to 6.9 x 10^(-3)for theΩ^(0)_(bc)→E^(+)_(c)π^(-)(E^(0)_(bc)→E^(+)_(c)π^(-))decay,depending on the considered mass and lifetime of theΩ^(0)_(bc)(E^(0)_(bc))baryon.

关键词： B physics quarkonium spectroscopy heavy quark production