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Effects of immune cells on mesenchymal stem cells during fracture healing

World Journal of Stem Cells 2021年第11期13卷 1667-1695页

作者： Sabrina Ehnert Borna Relja Katharina Schmidt-Bleek Verena Fischer Anita Ignatius Caren Linnemann Helen Rinderknecht Markus Huber-Lang miriam Kalbitz Tina Histing Andreas K Nussler Siegfried Weller Research Institute at the BG Trauma Center Tübingen Department of Trauma and Reconstructive SurgeryUniversity of TübingenTübingen 72076Germany Experimental Radiology Department of Radiology and Nuclear MedicineOttovon-Guericke UniversityMagdeburg 39120Germany Julius Wolff Institute and Berlin Institute of Health Center of Regenerative Therapies Charité-University Medicine BerlinBerlin 13353Germany Institute of Orthopedic Research and Biomechanics Ulm University Medical CenterUlm 89091Germany Institute for Clinical and Experimental Trauma-Immunology(ITI) University Hospital UlmUlm 89091Germany Department of Trauma and Orthopedic Surgery University Hospital Erlangen Friedrich-Alexander University Erlangen-Nürnberg(FAU)Erlangen 91054Germany

In vertebrates,bone is considered an osteoimmune system which encompasses functions of a locomotive organ,a mineral reservoir,a hormonal organ,a stem cell pool and a cradle for immune *** osteoimmune system is based on cooperatively acting bone and immune cells,cohabitating within the bone *** are highly interdependent,a fact that is confounded by shared progenitors,mediators,and signaling *** fracture healing requires the participation of all the precursors,immune and bone cells found in the osteoimmune *** evidence demonstrated that changes of the immune cell composition and function may negatively influence bone *** this review,first the interplay between different immune cell types and osteoprogenitor cells will be elaborated more *** separate paragraphs focus on the specific cell types,starting with the cells of the innate immune response followed by cells of the adaptive immune response,and the complement system as mediator between ***,a brief overview on the challenges of preclinical testing of immunebased therapeutic strategies to support fracture healing will be given.

关键词： Trauma Bones Immune response Mesenchymal stem cells Fracture healing

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This pain drives me crazy:Psychiatric symptoms in women with interstitial cystitis/bladder pain syndrome

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World Journal of Psychiatry 2024年第6期14卷 954-984页

作者： Marianna Mazza Stella Margoni Giuseppe Mandracchia Guglielmo Donofrio Alessia Fischetti Georgios D Kotzalidis Giuseppe Marano Alessio Simonetti Delfina Janiri Lorenzo Moccia Ilaria Marcelli Greta Sfratta Domenico De Berardis Ottavia Ferrara Evelina Bernardi Antonio Restaino Francesco Maria Lisci Antonio Maria D'Onofrio Caterina Brisi Flavia Grisoni Claudia Calderoni Michele Ciliberto Andrea Brugnami Sara Rossi Maria Chiara Spera Valeria De Masi Ester Maria Marzo Francesca Abate Gianluca Boggio Maria Benedetta Anesini Cecilia Falsini Anna Quintano Alberto Torresi miriam Militenda Giovanni Bartolucci Marco Biscosi Sara Ruggiero Luca Lo Giudice Giulia Mastroeni Elisabetta Benini Luca Di Benedetto Romina Caso Francesco Pesaresi Francesco Traccis Luca Onori Luca Chisari Leonardo Monacelli Mariateresa Acanfora Eleonora Gaetani Monia Marturano Sara Barbonetti Elettra Specogna Francesca Bardi Emanuela De Chiara Gianmarco Stella Andrea Zanzarri Flavio Tavoletta Arianna Crupi Giulia Battisti Laura Monti Giovanni Camardese Daniela Chieffo Antonio Gasbarrini Giovanni Scambia Gabriele Sani Department of Neurosciences Fondazione Policlinico Universitario A Gemelli IRCCSUniversita Cattolica del Sacro CuoreRome 00168Italy Department of Psychiatry UniversitàCattolica del Sacro CuoreRome 00168Italy Department of Neurosciences Section of PsychiatryFondazione Policlinico Universitario Agostino Gemelli IRCCSUniversitàCattolica del Sacro CuoreRome 00168Italy Mental Health NHSASL 4 TeramoTeramo 64100Italy Medical and Surgical Sciences UniversitàCattolica del Sacro CuoreRome 00168Italy Division of Gynecologic Oncology UniversitàCattolica del Sacro CuoreRome 00168Italy UOS Psicologia Clinica Governo ClinicoFondazione Policlinico Universitario Agostino Gemelli IRCCSRome 00168Italy CEMAD Digestive Disease Center Fondazione Policlinico Universitario A.Gemelli-IRCCSRome 00168Italy Department of Woman and Child Health Catholic UniversityRome 00168Italy UOC Psichiatria Clinica e d’Urgenza Dipartimento di Scienze Dell’InvecchiamentoNeurologicheOrtopediche e Della Testa-colloFondazione Policlinico Universitario Agostino Gemelli IRCCSRome 00168Italy

BACKGROUND Interstitial cystitis/bladder pain syndrome(IC/BPS)is an at least 6-mo noninfectious bladder inflammation of unknown origin characterized by chronic suprapubic,abdominal,and/or pelvic *** the term cystitis suggests an inflammatory or infectious origin,no definite cause has been *** occurs in both sexes,but women are twice as much *** To systematically review evidence of psychiatric/psychological changes in persons with IC/*** Hypothesizing that particular psychological characteristics could underpin IC/BPS,we investigated in three databases the presence of psychiatric symptoms and/or disorders and/or psychological characteristics in patients with IC/BPS using the following strategy:("interstitial cystitis"OR"bladder pain syndrome")AND("mood disorder"OR depressive OR antidepressant OR depression OR depressed OR hyperthymic OR mania OR manic OR rapid cyclasterisk OR dysthymiasterisk OR dysphoriasterisk).RESULTS On September 27,2023,the PubMed search produced 223 articles,CINAHL 62,and the combined PsycLIT/PsycARTICLES/PsycINFO/Psychology and Behavioral Sciences Collection search *** on *** produced 14 studies,of which none had available *** were peer-reviewed articles reporting psychiatric/psychological symptoms in patients with IC/BPS,i.e.63 articles spanning from 2000 to October *** studies identified depression and anxiety problems in the IC/BPS population,along with sleep problems and the tendency to *** Psychotherapies targeting catastrophizing and life stress emotional awareness and expression reduced perceived pain in women with IC/*** concepts should be considered when implementing treatments aimed at reducing IC/BPS-related pain.

关键词： Interstitial cystitis/bladder pain syndrome Psychiatric symptoms Psychological symptoms Catastrophizing Anxiety Depression

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Trend of <i>Cryptosporidium</i>Infection among Children below 24 Months in an Informal Urban Settlement, Kenya

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Open Journal of Medical Microbiology 2020年第3期10卷 153-161页

作者： Daisy Chepkemoi Mutai Patrick Opiyo Owili miriam Adoyo Muga Department of Public Health School of Health Sciences University of Eastern Africa Baraton Kenya Department of Human Nutrition and Dietetics School of Medicine and Health Sciences Kabarak University Nakuru Kenya

Cryptosporidium infection is estimated to cause 2.9 million diarrheal cases yearly among children aged under 24 months in sub-Saharan Africa. Studies have shown long-term climatic variations can affect infectious diseases. The burden of cryptosporidiosis in rural areas of sub-Saharan Africa is well characterized. However, the trend of Cryptosporidium infection is not known, especially in informal urban settings. This study therefore sought to determine cryptosporidiosis trends, and further explore the association between year and Cryptosporidium infection among children below 24 months in Kibera urban informal settlement in Kenya. Data collected by the Kenya Medical Research Institute longitudinal study in Tabitha clinic in Kibera from 2009 to 2015 were used. At least 3000 children aged , children presenting with diarrhea were eligible for stool sample collection (n = 477), out of which 421 stool samples were tested using TaqMan™ Array Card (TAC) polymerase chain reaction panel that included a target for Cryptosporidium genus. Data for the 421 children were included in the analysis. Logistic regression was used to explore the difference between the seven years and cryp

关键词： Cryptosporidium Infection Informal Urban Settlement Children below 24 Months Trend TaqMan™ Array Card

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Academic listening encounters :

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1999年

作者： Espeseth miriam.

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口腔黏膜早期不典型性增生等位基因缺失的检测

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中华耳鼻咽喉科杂志 2003年第5期38卷 374-378页

作者：王琪 Lewei Zhang miriam P.Rosin 首都医科大学附属北京同仁医院耳鼻咽喉-头颈外科北京100730 Department of Oral Biological and Medical Sciences British Columbia CancerResearch Centre

目的　探索用等位基因缺失检测的方法预测口腔黏膜早期不典型性增生病变的癌变。方法　用组织显微切割法提取组织并获得DNA ,以聚合酶链反应和多态性微卫星标记物分析检测等位基因缺失。 2 1个微卫星标记物对 8条染色体臂 ( 3p、4 q、8p... 详细信息

目的　探索用等位基因缺失检测的方法预测口腔黏膜早期不典型性增生病变的癌变。方法　用组织显微切割法提取组织并获得DNA ,以聚合酶链反应和多态性微卫星标记物分析检测等位基因缺失。 2 1个微卫星标记物对 8条染色体臂 ( 3p、4 q、8p、9p、11q、13q、14q和 17p)进行了检测。比较轻度和中度不典型性增生 ( 5 5例 )与高危不典型性增生 (重度不典型性增生和原位癌 2 3例 ;与癌组织同时存在的轻度和中度不典型增生 4 8例 )的等位基因缺失情况。增生病变 ( 34例 )和癌组织 ( 34例 )为对照。结果　等位基因缺失发生率随着病变恶性程度的增高而增高 ;增生病变仅见单个等位基因缺失 ,而不典型增生和癌组织可见多个等位基因缺失 ;轻度和中度不典型增生标本中 3个或 3个以上臂的等位基因缺失少见 ,而重度不典型增生、原位癌和癌组织 3个或 3个以上臂的等位基因缺失多见 ;轻度和中度不典型增生的等位基因缺失多发生在 3p、9p和 14 q ,而高危不典型增生的等位基因缺失可发生在除此以外的 4 q、8p、11q、13q、17p染色体臂上。结论　早期的不典型增生没有等位基因缺失时癌变危险可能较小 ,而出现多于 3个或 3个以上臂 ,特别是在 8p、11q、13q和 17p上的等位基因缺失。

关键词：口腔黏膜不典型性增生等位基因基因缺失黏膜白斑病

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New era for pancreatic endoscopic ultrasound: From imaging to molecular pathology of pancreatic cancer

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World Journal of Gastrointestinal Oncology 2019年第11期11卷 933-945页

作者： Livia Archibugi Sabrina Gloria Giulia Testoni miriam Redegalli Maria Chiara Petrone Michele Reni Massimo Falconi Claudio Doglioni Gabriele Capurso Paolo Giorgio Arcidiacono Paolo Giorgio Arcidiacono Pancreato-Biliary Endoscopy and EUS DivisionPancreas Translational and Clinical Research CenterIRCCS San Raffaele Scientific InstituteMilan 20132Italy Pathology Department Pancreas Translational and Clinical Research CenterIRCCS San Raffaele Scientific InstituteMilan 20132Italy Department of Medical Oncology Pancreas Translational and Clinical Research CenterIRCCS San Raffaele Scientific InstituteMilan 20132Italy Pancreatic Surgery Department Pancreas Translational and Clinical Research CenterIRCCS San Raffaele Scientific InstituteMilan 20132Italy

With recent advances in molecular pathology and the development of new chemotherapy regimens,the knowledge of the molecular alterations of pancreatic ductal adenocarcinoma(PDAC)is becoming appealing for stratifying patients for prognosis and response to a defined *** formalin-fixed,paraffinembedded samples are a useful source of genomic deoxyribonucleic acid;nevertheless,most studies employed formalin-fixed,paraffin-embedded samples deriving from surgical specimens,which are therefore representative of<20%of PDAC ***,the development of a reliable methodology for endoscopic ultrasound-guided tissue acquisition,stabilization,and analysis is crucial for the development of molecular markers for clinical use in order to achieve“personalized medicine”.With the development of new needles,this technique is able to retrieve a high quantity and quality of PDAC tissue that can be used not only for diagnosis but also for mutational and transcriptome evaluations and for the development of primary cell or tissue *** the present editorial,we discuss the current knowledge regarding the use of endoscopic ultrasound as a tool to obtain samples for molecular analyses,its possible pitfalls,and its use for the development of disease models such as xenografts or organoids.

关键词： Endoscopic ultrasound Pancreatic cancer Ribonucleic acid Deoxyribonucleic acid Mutation Molecular Organoid Profiling Personalized medicine

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Dissecting the Heat Stress Response in Chlamydomonas by Pharmaceutical and RNAi Approaches Reveals Conserved and Novel Aspects

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Molecular Plant 2013年第6期6卷 1795-1813页

作者： Stefan Schmollinger miriam Schulz-Raffelt Daniela Strenkert Daniel Veyel Olivier Vallon Michael Schroda Molekulare Biotechnologie und Systembiologie TU Kaiserslautern PauI-Ehrlich-Str. 23 D-67663 Kaiserslautern Germany Max-Planck-lnstitut for Ilolekulare Pflanzenphysiologie Am MQhlenberg 1 D-14476 Potsdam-Golm Germany CEA-CNRS-Universite Aix Marseille Institut de Biolog~e Environnementale et Biotechnologie UMR 7265 CEA (:adarache F-13108 Saint-Paul-lez-DuranceFrance Institut de Biologie Physico-Chimique UMR 7141 CNRS/Universite Pierre et Marie Curie F-75005 Paris France

To study how conserved fundamental concepts of the heat stress response （HSR） are in photosynthetic eukaryotes, we applied pharmaceutical and antisense/amiRNA approaches to the unicellular green alga Chlamydomonas reinhardtii. The Chlamydomonas HSR appears to be triggered by the accumulation of unfolded proteins, as it was induced at ambient temperatures by feeding cells with the arginine analog canavanine. The protein kinase inhibitor staurosporine strongly retarded the HSR, demonstrating the importance of phosphorylation during activation of the HSR also in Chlamydomonas. While the removal of extracellular calcium by the application of EGTA and BAPTA inhibited the HSR in moss and higher plants, only the addition of BAPTA, but not of EGTA, retarded the HSR and impaired thermotoler- ance in Chlamydomonas. The addition of cycloheximide, an inhibitor of cytosolic protein synthesis, abolished the attenu- ation of the HSR, indicating that protein synthesis is necessary to restore proteostasis. HSP90 inhibitors induced a stress response when added at ambient conditions and retarded attenuation of the HSR at elevated temperatures. In addition, we detected a direct physical interaction between cytosolic HSP90A/HSP70A and heat shock factor 1, but surprisingly this interaction persisted after the onset of stress. Finally, the expression of antisense constructs targeting chloroplast HSP70B resulted in a delay of the cell＇s entire HSR, thus suggesting the existence of a retrograde stress signaling cascade that is desensitized in HSP7OB-antisense strains.

关键词： heat shock factor unfolded protein response heat stress response inhibitor feeding Chlamydomonas rein-hardtii HSP90 HSP70 protein folding calcium geldanamycin canavanine.

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Application of the TTC Concept on Food Packaging Materials

Application of the TTC Concept on Food Packaging Materials

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中国毒理学会第五次全国学术大会

作者： Garry Wiltshire Hollnagel Heli miriam The Dow Chemical Company MIUSA

＜正＞The Threshold of Toxicological Concern（TTC） concept can be used as a tool to help in various day to day challenges in safety *** challenge is the evaluation of food contact substances（FCSs） that are used in the manufacture,holding and packaging of *** include polymers,paper and paperboard, substances used in food manufacturing equipment, and those materials which may contact food or release small quantities of some substances into food.

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Development of Atmospheric Plasma Sprayed Dielectric Ceramic Coatings for High Efficiency Tubular Ozone Generators

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Journal of Water Resource and Protection 2010年第9期2卷 799-808页

作者： Rainer Gadow Christian Friedrich Andreas Killinger miriam Floristán 不详

Oxidative degradation of hazardous materials by ozone treatment like in sterilization of water, dump waste, pulp bleach and chemical processing, is superior to the traditional chlorine chemistry with respect to by-products and environmental protection. For an efficient and cost effective production of ozone for applications in drinking water and wastewater purification, a new concept of tubular composite material components has been developed. A borosilicate glass tube was coated with a layer system consisting of an intermetallic electrode and a dielectric oxide ceramic surface layer. Thermo-mechanical and dielectric properties are investigated with respect to the use of different thermal spray powders as well as the use of a high and a low energetic atmospheric spray gun. The materials and ozone production system of thermal sprayed ozonizer tubes are described and analyzed.

关键词： Ozone Production Water Treatment Thermal Spraying Dielectric Strength and Permittivity

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Factors associated with early virological response to peginterferon-α-2a/ribavirin in chronic hepatitis C

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World Journal of Gastroenterology 2013年第12期19卷 1943-1952页

作者： Javier García-Samaniego miriam Romero Rafael Granados Remedios Alemán Miguel Jorge Juan Dolores Suárez Ramón Pérez Gregorio Castellano Carlos González-Portela Liver Unit Hospital Carlos Ⅲ Centro de Investigación Biómedica en Red de Enfermedades Hepáticas y Digestivas Department of Gastroenterology Hospital Universitario de Gran Canaria Gastroenterology Service Hospital Universitario de Canarias Department of Gastroenterology Hospital Universitario Insular de Gran Canaria Internal Medicine Service Hospital Arquitecto Marcide Gastroenterology Service Hospital Central de Asturias Gastroenterology Service Hospital 12 de Octubre Gastroenterology Service Hospital Policlínico de Vigo

AIM: To evaluate the impact of sociodemographic/clinical factors on early virological response (EVR) to pegin-terferon/ribavirin for chronic hepatitis C (CHC) in clinical practice. METHODS: We conducted a multicenter, cross-sectional, observational study in Hepatology Units of 91 Spanish hospitals. CHC patients treated with peginterferon α-2a plus ribavirin were included. EVR was defined as undetectable hepatitis C virus (HCV)-ribonucleic acid (RNA) or ≥ 2 log HCV-RNA decrease after 12 wk of treatment. A bivariate analysis of sociodemographic and clinical variables associated with EVR was carried out. Independent factors associated with an EVR were analyzed using a multiple regression analysis that included the following baseline demographic and clinical variables: age (≤ 40 years vs > 40 years), gender, race, educational level, marital status and family status, weight, alcohol and tobacco consumption, source of HCV infection, alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels, and gamma glutamyl transpeptidase (GGT) (≤ 85 IU/mL vs > 85 IU/mL), serum ferritin, serum HCV-RNA concentration ( 400 000 IU/mL in 74% of patients. The mean ALT and AST levels were 88.4 ± 69.7 IU/mL and 73.9 ± 64.4 IU/mL, respectively, and mean GGT level was 82 ± 91.6 IU/mL. The mean ferritin level was 266 ± 284.8 μg/L. Only 6.2% of patients presented with cirrhosis. All patients received 180 mg of peginterferon α-2a. The most frequently used ribavirin doses were 1000 mg/d (41%) and 1200 mg/d (41%).

关键词： Antiviral therapy Baseline factors Early virological response Peginterferon α-2a Ribavirin

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