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Role of vitamin B_(12) on methylmalonyl-CoA mutase activity

Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2012年第6期13卷 423-437页

作者： Tóshiko TAKAHASHI-IIGUEZ Enrique GARCíA-HERNANDEZ Roberto ARREGUíN-ESPINOSA María Elena flores Department of Molecular Biology and Biotechnology Institute of Biomedical ResearchNational Autonomous University of MexicoD.F.04510Mexico Department of Chemistry of Biomacromolecules Institute of ChemistryNational Autonomous University of MexicoD.F.04510Mexico

Vitamin B 12 is an organometallic compound with important metabolic derivatives that act as cofactors of certain enzymes,which have been grouped into three subfamilies depending on their *** them,methylmalonyl-CoA mutase (MCM) has been extensively *** enzyme catalyzes the reversible isomerization of L-methylmalonyl-CoA to succinyl-CoA using adenosylcobalamin (AdoCbl) as a cofactor participating in the generation of radicals that allow isomerization of the *** crystal structure of MCM determined in Propionibacterium freudenreichii *** has helped to elucidate the role of this cofactor AdoCbl in the reaction to specify the mechanism by which radicals are generated from the coenzyme and to clarify the interactions between the enzyme,coenzyme,and *** existence of human methylmalonic acidemia (MMA) due to the presence of mutations in MCM shows the importance of its role in *** recent crystallization of the human MCM has shown that despite being similar to the bacterial protein,there are significant differences in the structural organization of the two *** studies have identified the involvement of an accessory protein called MMAA,which interacts with MCM to prevent MCM's inactivation or acts as a chaperone to promote regeneration of inactivated *** interdisciplinary studies using this protein as a model in different organisms have helped to elucidate the mechanism of action of this isomerase,the impact of mutations at a functional level and their repercussion in the development and progression of MMA in *** is still necessary to study the mechanisms involved in more detail using new methods.

关键词： Vitamin B 12 Methylmalonyl-CoA mutase (MCM) MMAA MeaB Methylmalonic academia (MMA) Protectase Reactivase

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road to stemness in hepatocellular carcinoma

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World Journal of Gastroenterology 2017年第37期23卷 6750-6776页

作者： Teresita NJ flores-Téllez Saúl Villa-Trevino Carolina Pina-Vázquez Departam ento de Biología Celular Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional(CINVESTAV-IPN) Av.IPN No.2508 Col

Carcinogenic process has been proposed to relay on the capacity to induce local tissue damage and proliferative repair. Liver has a great regeneration capacity and currently, most studies point towards the dominant role of hepatocytes in regeneration at all levels of liver damage. The most frequent liver cancer is hepatocellular carcinoma(HCC). Historical findings originally led to the idea that the cell of origin of HCC might be a progenitor cell. However, current linage tracing studies put the progenitor hypothesis of HCC origin into question. In agreement with their dominant role in liver regeneration, mature hepatocytes are emerging as the cell of origin of HCC, although, the specific hepatocyte subpopulation of origin is yet to be determined. The relationship between the cancer cell of origin(CCO) and cancer-propagating cells, known as hepatic cancer stem cell(HCSC) is unknown. It has been challenging to identify the definitive phenotypic marker of HCSC, probably due to the existence of different cancer stem cells(CSC) subpopulations with different functions within HCC. There is a dynamic interconversion among different CSCs, and between CSC and non-CSCs. Because of that, CSC-state is currently defined as a description of a highly adaptable and dynamic intrinsic property of tumor cells, instead of a static subpopulation of a tumor. Altered conditions could trigger the gain of stemness, some of them include: EMT-MET, epigenetics, microenvironment and selective stimulus such as chemotherapy. This CSC heterogeneity and dynamism makes them out reach from therapeutic protocols directed to a single target. A further avenue of research in this line will be to uncover mechanisms that trigger this interconversion of cell populations within tumors and target it.

关键词： Cancer stem cell Liver progenitor cell Liver stem progenitor cell Stemness Plasticity Cancer cell of origin Cancer stem cells subpopulations

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Influence of Data Clouds Fusion From 3D RealTime Vision System on Robotic Group Dead Reckoning in Unknown Terrain

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IEEE/CAA Journal of Automatica Sinica 2020年第2期7卷 368-385页

作者： Mykhailo Ivanov Oleg Sergyienko Vera Tyrsa Lars Lindner Wendy flores-Fuentes Julio Cesar Rodriguez-Quinonez Wilmar Hernandez Paolo Mercorelli Universidad Autónoma de Baja California MexicaliB.C.21100Mexico Universidad de Las Américas Quito 170125Equador Leuphana University of Lueneburg Lüneburg 21335Germany

This paper proposes the solution of tasks set required for autonomous robotic group behavior optimization during the mission on a distributed area in a cluttered hazardous *** navigation scheme uses the benefits of the original real-time technical vision system(TVS)based on a dynamic triangulation *** method uses TVS output data with fuzzy logic rules processing for resolution *** on previous researches,the dynamic communication network model is modified to implement the propagation of information with a feedback method for more stable data exchange inside the robotic *** to the comparative analysis of approximation methods,in this paper authors are proposing to use two-steps post-processing path planning aiming to get a smooth and energy-saving *** article provides a wide range of studies and computational experiment results for different scenarios for evaluation of common cloud point influence on robotic motion planning.

关键词： Data transfer group behavior machine vision navigation robotic group(RG) vision system

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Growth retardation and severe anemia in children with Trichuris dysenteric syndrome

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Asian Pacific Journal of Tropical Biomedicine 2015年第7期5卷 581-586页

作者： Rina Girard Kaminsky Renato Valenzuela Castillo Coralia Abrego flores Pediatric Department School of Medicine National Autonomous University of Honduras and Service of Parasitology University Hospital Honduras.P.O.Box 1547Tegucigalpa Honduras Pediatric Department School of Medicine National Autonomous University of Honduras Pediatric Psychology Unit University HospitalHonduras

Objective: To document epidemiologic data, clinical manifestations and treatment in hospitalized children with Trichuris dysenteric syndrome from Honduras during 2010-2012. Methods: Severe trichuriasis cases were identified by routine stool examinations from hospitalized patients(12 years old or less). Relevant epidemiologic, clinical and management data were obtained from review of clinical histories in the ward. Results: Of 122 Trichuris infections diagnosed in 11 528(1.0%) stool samples for all ages, 81(66.4%) were identified in the age group 2-12 years old, 21(25.9%) of which were severe(≥ 100 eggs in 2 mg of feces). Thirteen of those 21 patients collaborated in this study. Patients(9 males and 4 females) were of rural precedence, from large poor or very poor families, chronically parasitized, and between 2 and 12 years old. Dysentery of months duration, severe anemia and stunting were common complaints; clinical characteristics associated with heavy Trichuris infections included egg counts from 232-3 520 eggs per direct smear, hemoglobin from 3.4-10.8 g/d L, eosinophilia up to 43%, severe malnutrition and growth stunting. Orally administered drugs mebendazole, albendazole, metronidazole, nitaxozanide, and piperazine were prescribed at different dosages and duration other than recommended; no cure or egg excretion control was exercised before patient release. A range of 340 to about 10 000 worms were recovered after treatment from 8 patients. Conclusions: This report underlines the need for detailed community studies in trichuriasis morbidity, effective treatment assessment and clinical response in severely malnourished parasitized children.

关键词： Anemia Honduras Stunting Trichuris dysentery syndrome

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Segmentation of thermal infrared images of cucumber leaves using K-means clustering for estimating leaf wetness duration

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International Journal of Agricultural and Biological Engineering 2020年第3期13卷 161-167页

作者： Dongmei Wen Aixin Ren Tao Ji Isabel Maria flores-Parra Xinting Yang Ming Li Beijing Research Center for Information Technology in Agriculture/National Engineering Research Center for Information Technology in Agriculture/National Engineering Laboratory for Agri-product Quality Traceability/National Meteorological Service Center of Urban Agriculture Beijing 100097China College of Plant Protection China Agricultural UniversityBeijing 100193China Department of Sustainable Crop Production UniversitàCattolica del Sacro Cuore29122 PiacenzaItaly Department of Informatics University of AlmeriaAlmeriaCP04120Spain

Leaf wetness duration(LWD)is a critical parameter used to predict plant disease,but its determination under actual field conditions is a major *** this study,a method for determining LWD using thermal infrared imaging was developed and applied to cucumber plants grown in a solar *** images of the plant leaves were captured using an infrared scanning camera,and a leaf wetness area segmentation method consisting of two procedures was ***,a color space conversion was performed automatically by an image-processing ***,the K-means clustering algorithm was applied to enable the segmentation of the wetness area on the thermal ***,to enable overall thermal image analysis,an initial leaf wetness threshold(LWT)of 5%was defined(where wetness values higher than 5%indicated that the leaf was in a wet state).The results of comparative experiments conducted using thermal images of plant leaves captured using an infrared scanning camera and human visual observation indicated that the estimated LWD values were generally higher than the observed LWD values,because slight leaf wetness condensations were overlooked by the human eye but detected by the infrared scanning *** these differences were not found to be statistically significant in this study,the proposed method for determining LWD using thermal infrared imaging may provide a new LWD detection method for cucumber and other plants grown in solar greenhouses.

关键词： thermal imaging K-means clustering algorithm leaf wetness duration cucumber

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Innovative strategies and nutritional perspectives for fortifying pumpkin tissue and other vegetable matrices with iron

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Food Science and Human Wellness 2020年第2期9卷 103-111页

作者： Marina F.de Escalada Pla Silvia K.flores Carolina E.Genevois Universidad de Buenos Aires Facultad de Ciencias Exactas y NaturalesDepartamento de IndustriasBuenos AiresArgentina CONICET-Universidad de Buenos Aires Instituto de Tecnologia de Alimentos y Procesos Quimicos(ITAPROQ)Buenos AiresArgentina Universidad Nacional de Entre Rios(UNER) Facultad de BromatologiaGualeguaychuEntre RiosArgentina CONICET Buenos AiresArgentina

The present review article focuses on different technological strategies and nutritional perspectives having added advantage to human health in fortifying vegetables matrices with *** introduction to the main aspects related to iron deficiency consequences is resumed in order to understand the importance of developing new strategies for improving iron *** this sense,the tendencies and alternatives will also be *** technologies like impregnation or dry infusion are presented as sustainable options for obtaining structured fortified vegetables.A review about the usefulness of edible covers for stabilizing micronutrients and/or probiotic microorganisms in fortified matrices is also *** iron deficiency still continue to be a worldwide health issue,innovating in food fortification remains a challenge for researchers and food manufactures.

关键词： Vegetables Iron Ascorbic acid Probiotics Edible covers

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Can coffee help fighting the drug problem? Preliminary results of a Brazilian youth drug study

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Acta Pharmacologica Sinica 2000年第12期 4-15页

作者： Gladis B flores,Fernanda ANDRADE,Darcy R LIMA Research Coordinator Brazilian Youth Drug Study (BYDS) Research Assistant BYDS General Coordinator BYDS Professor of Clinical Pharmacology at Neurology Institute Federal University of Rio de Janeiro Brazil & Associate Director for Medicinal Plants Studies Institute for Coffee Studies Vanderbilt University Medical Center Nashville TN USA

INTRODUCTION At different times and at different places many plants have been domesticated, and the development of agriculture was an intensification by man of his food extractive process. Simultaneous to the agricultural development, the selection of psychotropic plants has always been one of the most tempting and determined activities of mankind in its history. Behaviorally active drugs have captured and control human behaviour in susceptible individuals. Nowadays the most consumed plants worldwide are legal ones such as coffee and tobacco and illegal ones such as cocaine, opium and cannabis. And little is known about

关键词： coffee caffeine chlorogenic acid al-cohol drinking depression drugs opioid receptors lim-bic system

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Near shore seismic movements induced by seaquakes using the boundary element method

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Earthquake Engineering and Engineering Vibration 2017年第3期16卷 571-585页

作者： Alejandro Rodríguez-Castellanos Manuel Carbajal-Romero Norberto flores-Guzmán J.Efraín Rodríguez-Sánchez Andriy Kryvko instituto mexicano del petróleo eje central lázaro cárdenas 152Gustavo A.MaderoDistrito FederalMéxico escuela superior de ingeniería mecánicay eléctrica instituto politécnico nacionalupalmEdif.5Av.Instituto Politécnico Nacional S/NCol.LindavistaGustavo A.MaderoDistrito FederalMéxico escuela superior de ingeniería mecánicay eléctrica instituto politécnico nacionalunidad profesional azcapotzalcoDistrito FederalMéxico centro de investigación en matemáticas jalisco s/nmineral de valencianaguanajuatoMéxico

This study quantifies seismic amplifications in near-shore arising from seaquakes. Within the Boundary Element Method, boundary elements are used to irradiate waves and force densities obtained for each element. Huygens′ Principle is implemented since the diffracted waves are constructed at the boundary from which they are radiated, which is equivalent to Somigliana′s theorem. Application of boundary conditions leads to a system of integral equations of the Fredholm type of second kind and zero order. Several numerical configurations are analyzed： The first is used to verify the present formulation with ideal sea floor configurations to estimate seismic amplifications. With the formulation verified, simple slope configurations are studied to estimate spectra of seismic motions. It is found that P-waves can produce seismic amplifications from 1.2 to 3.9 times the amplitude of the incident wave. SV-waves can generate seismic amplifications up to 4.5 times the incident wave. Another relevant finding is that the highest amplifications are at the shore compared to the ones at the sea floor.

关键词： seismic amplifications seaquake earthquake elastic waves boundary element method near shore cities

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Silage Feeding with Water Hyacinth in the Tropics: A Research Note

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Agricultural Sciences 2022年第2期13卷 282-289页

作者： Danny Agustin flores Skye Blue Internet Port Coquitlam Canada

Water hyacinth has ecological significance in addition to its agricultural and energy uses. Lower quality silage is defined in this paper as requiring nitrogen supplementation and treatment to improve nutritive value (NV). Ensilage of water hyacinth as a test case centers largely around the process to optimize protein nitrogen retention in silage-based regimens. A previous hypothesis proposed earlier by the author of that of functional amino acid ratios [tyrosine (TYR): large neutral amino acids (LNAA), tyrosine (TYR): phenylalanine (PHE)] were subsequently found to be counter to what the given schemata predicts. And subsequently with another study there was no corroborative evidence for it to support the espoused hypothesis using the same schemata. The role of N status is still the most viable option among factors from studies continuing how amino acids like histidine (HIS) and arginine (ARG) and their growth-related endocrine functions play a role. There are other schemas illustrating non-homeostatic type regulation with protein intake. To focus on molecular-level mechanisms to ruminal protein digestion it is becoming clear what factors in feed and microbial cell fermentation contribute to optimizing microbial cell protein (MCP) synthesis from ATP with organic matter (OM) digestibility and preformed amino acids (PFAA) from peptides and free amino acids in addition to non-protein nitrogen (NPN), the former more efficiently assimilated in MCP than NPN in the rumen. Accordingly, it has been recommended that soluble proteins fed to dairy cows not exceed microbial requirements along with high dietary escape protein fed with a sufficient amino acid profile to meet dairy production.

关键词： Water Hyacinth Lower Quality Silage Functional Amino Acids Nitrogen Status Nutritive Value

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Limited long-distance dispersal success in a Western European fairy shrimp evidenced by nuclear and mitochondrial lineage structuring

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Current Zoology 2020年第3期66卷 227-237页

作者： Paula C.RODRIGUEZ-flores Ernesto RECUERO Yolanda JIMENEZ-RUIZ Mario GARCIA-PARIS Museo Nacional de Ciencias Naturales(MNCN-CSIC) Jose Gutierrez Abascal2Madrid 28006Spain Centre d'Estudis Avanqats de Blanes(CEAB-CSIC) C.d'Acces Cala Sant Francesc 14Blanes 17300Spain

Anostraca are known by their ability for long-distance dispersal,but the existence in several species of deep,geographically structured mtDNA lineages suggests their populations are subjected to allopatric differentiation,isolation,and prevalence of local scale *** stagnalis is one of the most widespread species of Anostraca and previous studies revealed an unclear geographical pattern of mtDNA genetic ***,we analyze populations from the Iberian and Italian Peninsulas,Central Europe,and Scandinavia,with the aim to characterize the patterns of genetic diversity in a spatio-temporal framework using mtDNA and nuclear markers to test gene flow among close *** these aims we built a time-calibrated phylogeny and carried out Bayesian phylogeographic analyses using a continuous diffusion *** results indicated that *** presents a deeply structured genetic diversity,including 7 ancient lineages,some of them even predating the *** Iberian Peninsula harbors high diversity of lineages,with strong isolation and recent absence of gene flow between *** at local scale seems to be the prevailing dispersal mode of ***,which exhibits a pattern of isolation-bydistance in the Iberian *** remark the vulnerability of most of these lineages,given the limited known geographic distribution of some of them,and the high risk of losing important evolutionary potential for the species.

关键词： allopatric fragmentation Anostraca Crustacea nuclear markers Pleistocene phylogeography

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