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Antibacterial, Antioxidant Activities and GC-MS Analysis of Dichrostachys cinera (L.) Ethanolic Leaves Extract

Pharmacology & Pharmacy 2022年第12期13卷 545-557页

作者： Sitelbanat Yassin Mohamed Abubker Anwar Mohamed Selma Omer Salah Humeada Elhadi M. M. Ahmed mirghani abd alrahman Department of Pharmaceutics (Pharmaceutical Microbiology) University of Gezira Wad Madani Sudan Department of Pharmaceutical Chemistry University of Gezira Wad Madani Sudan Central Laboratory University of Gezira Wad Madani Sudan Department of Microbiology Faculty of Medical Laboratory Sciences University of Gezira Wad Madani Sudan Department of Chemistry Faculty of Education West Kordofan University Kordofan Sudan Department of Pharmacognosy University of Gezira Wad Madani Sudan Medicinal and Aromatic Plants Research Center University of Gezira Wad Madani Sudan Department of Clinical Pharmacy and Pharmacy Practice University of Gezira Wad Madani Sudan

Traditional medicinal plants are one of the potential sources of antimicrobial drugs and there is a great concern in the use and development of herbal medicine for the treatment of various infections. This study aimed to evaluate the antibacterial, and antioxidant activities of Dichrostachys cinera ethanolic leaves extract and to determine the components of the crude extract. D. cinera extract was evaluated against Staphylococcus aureus ATCC 25923, Escherichia coli ATCC 25922, and Pseudomonas aeruginosa ATCC 27853. The antibacterial, antioxidant activities and active constituents were determined using standard methods. Antibacterial activity of the crude extract findings showed that all bacterial candidates were susceptible where S. aureus represent MIC at 12.5 mg/ml and MBC at 25 mg/ml, E. coli and P. aeruginosa both showed MIC 25 mg/ml and MBC 50 mg/ml. In the free radical scavenging assay of the extract and the standard quercetin at concentrations of 250 μg/ml, 125 μg/ml, 50 μg/ml, 10 μg/ml, and 5 μg/ml. The radical scavenging activity for the extract was about 92%, 89.6%, 86.8%, 82.8% and 37.8% respectively, compared to quercetin which gave 89.7%, 85.8%, 62.1%, 55.5%, and 45% radical scavenging activity. The GC-Ms analysis of the total constituents demonstrated that 1,6-Anhydro-2,4-dideoxy-.beta.-D-ribo-hexo (21.26%) with different peaks, followed by Glycerin (11.56%), 1,2,3-Cyclopentanetriol (10.18%), 8,11,14-Eicosatrienoic acid, (Z,Z,Z)-(6.18%), 1H-Pyrrole, 1-methyl-(6.08%), Phytol (5.91%) and 7-Bromo-6-(2-diethylaminoethoxy)-2,3-dihyd (5.44%) as major components in the extract. Finally, this study provided useful information on the therapeutic potential of D. cinera as an antibacterial agent and recommended to be evaluated against a wide range of Bacterial and fungal strains using different solvents and different parts from the plant.

关键词： Dichrostachys cinera Antibacterial Activity Antioxidant GC MS Analysis

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Antibacterial, Antioxidant Activities and GC-MS Analysis of Dichrostachys cinera (L.)Ethanolic Leaves Extract

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Pharmacology & Pharmacy（药理与制药） 2022年第12期

作者： Sitelbanat Yassin Mohamed Abubker Anwar Mohamed Selma Omer Salah Humeada Elhadi M. M. Ahmed mirghani abd alrahman

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Integrating Geotechnical Investigation with Hydrological Modeling for Mitigation of Expansive Soil Hazards in Tabuk City, Saudi Arabia

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Open Journal of Modern Hydrology 2017年第1期7卷 11-37页

作者： abd-alrahman Embaby Ayman Abu Halawa Medhat Ramadan Geology Department Faculty of Science Damietta University Damietta Egypt Nuclear Material Authority Cairo Egypt

Due to global climatic changes, flash floods are followed as a yearly disaster with high magnitude of influence. During the years 1981, 1988, 2010, 2012 and in January 2013, Tabuk city, northwest of Saudi Arabia suffered huge flash floods. These are major factors affecting on the swelling behavior of expansive Tabuk shale. The examined geotechnical properties of the surface and subsurface lithology of the sedimentary deposits distinguished Tabuk city into three zones. The expansive zone is spread in the middle and the non-expansive zones are distributed in the east and west of the city. The Watershed Modeling System (WMS) and Hydrologic Engineering Center (HEC-1) models were used to delineate and identify the drainage system and basin morphometry, where flash floods and accumulation of water might take place. Integration between geotechnical distribution maps of the expansion soil and surface hydrological data in terms of runoff maps was done. It has been identified the whereabouts the soils which have expansion characteristics and areas prone to flooding and surface runoff. They are helpful in defining the hazard zones map. Based on this map, it can be avoided constructions on the risk neighborhoods such as Al Qadsiyah, Al Maseif, Arrwdah, Al Nakhil and Al Rajhi. Also, it can suggest that the western side of Tabuk city is suitable for future urban extension. These results will help planners and citizens to create alternative development scenarios and determine their impact on the future urbanization patterns. Moreover, the direction of surface runoff flow or storm water discharge should be away from the expansion soil areas. Therefore, constructing dams on the outlet of the high-risk basins, south of Tabuk city is an important solution to control flash flood events, as well as increase groundwater recharge.

关键词： Expansion Soil Hazards Flash Floods Geotechnical Investigation Saudi Arabia Tabuk City Watershed Modeling System

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Improving Adherence to Prescribed Antidiabetics and Cardiovascular Medications in Primary Health Care Centers in Nyala City, South Darfur State-Sudan

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Pharmacology & Pharmacy 2013年第9期4卷 701-709页

作者： Ahmed Dahab Ahmed Asim Ahmed Elnour mirghani abd Elrahman Yousif Farah Hamad Farah Hasab Alrasoul Akasha Ahmed Osman Abobakr Abasaeed College of Pharmacy and Health Sciences Ajman University of Sciences and Technology Ajman UAE College of Pharmacy Clinical Pharmacy Taif University Taif KSA Consultant Clinical Pharmacist Al Ain Hospital Abu Dhabi Health Services Company (SEHA) Al Ain UAE Department of Pharmacology College of Medicine and Health Sciences UAE University Al Ain UAE Revolving Drug Fund (RDF) Ministry of Health (MOH) Nyala Sudan Department of Pharmaceutics Faculty of Pharmacy Gezira University Medani Sudan Social and Clinical Pharmacy Department Faculty of Pharmacy Charles University Hradec Kralove Czech Republic Registration and Drug Control Department Ministry of Health Abu Dhabi UAE. The Epidemiological Laboratory (Epi-Lab) Khartoum Sudan

Aims: Prospective pharmacist’s interventions aimed to improve patient’s knowledge and behaviors to adhere to medications in patients with type 2 diabetes with or without cardiovascular medical conditions in primary health care (PHCs) centers in Nyala city, South Darfur State, Sudan. Methodology and Materials: 300 patients were enrolled for assessing adherence with the Brief Medication Questionnaire (BMQ) in ten PHCs in Nyala city. We assessed patients’ responses to BMQ pre-and post-interventions plan by: complex interventions, humanitarianism and disease outcomes determined by health-related outcomes (SF-36), glycosylated hemoglobin (HbA1c) and blood pressure. Results: BMQ scores have improved significantly in four screens (pre-and post-interventions): regimen [4.6 ± 0.2 to 1.8 ± 0.1;P = 0.001], belief [1.6 ± 0.3 to 0.3 ± 0.3;P = 0.007], recall [1.7 ± 0.2 to 0.6 ± 0.2;P = 0.043] and access screens [1.8 ± 0.1 to 0.4 ± 0.1;P = 0.005];which have indicated an improved patients’ adherence to medications. Percentage of subjects reaching target of post prandial blood glucose (PPBG) have increased from 28.0% to 49.3%;[P = 0.02] post interventions. PPBG mean values have decreased significantly from [11.1 ± 0.6 mmol/L to 8.1 ± 0.8 mmol/L;

关键词： Adherence Darfur Medications Nyala PHCs Sudan

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硫胺素及其磷酸酯与沙特阿拉伯人心血管代谢危险因素的相关性分析

硫胺素及其磷酸酯与沙特阿拉伯人心血管代谢危险因素的相关性分析

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作者： Nasser M Al-Daghri Omar S Al-Attas Khalid M Alkharfy Majed S Alokail Sherif H abd-alrahman Shaun Sabico 刘庆春胡南摘

目前已表明硫胺素缺乏与几种胰岛素抵抗并发症有关。在本研究中,我们根据修订后的《国家胆固醇教育计划-成人治疗小组III》,随机招募沙特成年志愿者(166名男性和70名女性),并筛选出患有代谢综合征(MetS)的人员。用HPLC分析探讨循环硫胺... 详细信息

目前已表明硫胺素缺乏与几种胰岛素抵抗并发症有关。在本研究中,我们根据修订后的《国家胆固醇教育计划-成人治疗小组III》,随机招募沙特成年志愿者(166名男性和70名女性),并筛选出患有代谢综合征(MetS)的人员。用HPLC分析探讨循环硫胺素水平与心血管代谢相关参数的关系。

关键词：阿拉伯代谢综合征硫胺素

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