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Coarse to Fine: The role of Severe Plastic Deformation in Advancing Titanium-Based Medical implants - A Comprehensive review

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Journal of Wuhan University of Technology(Materials Science) 2025年第1期40卷 295-306页

作者： Dragana r Mihajlović Bojan i Međo ivana Lj Cvijović-Alagić Veljko r Djokić Faculty of Technology and Metallurgy University of BelgradeKarnegijeva 411120 BelgradeSerbia Vinča institute of Nuclear Sci-ences-National institute of the republic of Serbia University of Belgrade11001BeogradSerbia innovation Centre of the Faculty of Technology and Metallurgy Karnegijeva 411120 BelgradeSerbia

This paper describes severe plastic deformation(SPD)procedures,which are utilized to form an ultrafine-grained structure in metallic *** the SPD process,a solid material sample is subjected to very high loads without a significant change in sample *** the present work,the high-pressure torsion(HPT)process,as one of the SPD techniques,which achieves a high degree of deformation and ensures refinement of the microstructure,will be discussed in more *** that grain size control is accepted as a method to obtain materials with desired characteristics,an overview of the properties of ultrafine-grained titanium-based biomaterials to be used in medicine is ***,particular attention is dedicated to the influences of HPT process parameters,primarily hydrostatic pressure,and number of revolutions during torsion,on the grain size and physical and mechanical characteristics(modulus of elasticity,microhardness,and tensile properties),corrosion resistance,and biocompatibility of the titanium-based biomaterials.A review of the literature indicates that titanium-based materials obtained by the SPD process show improved mechanical and physical properties without losing biocompatibility and corrosion resistance,which suggests that these methods of obtaining implants are something that should be further developed in the future.

关键词： high-pressure torsion process ultrafine-grained titanium-based materials electrochemical anodization physical properties mechanical properties

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Arctic sea-ice extent: No record minimum in 2023 or recent years

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Atmospheric and Oceanic Science Letters 2025年第1期18卷 52-55页

作者： Ola M.Johannessen Tor i.Olaussen Nansen Scientific Society BergenNorway Nansen Environmental and remote Sensing Center BergenNorway

Arctic sea-ice extent reaches its minimum each year in September. On 11 September 2023 the minimum was 4.969 million square kilometers(***^(2)). This was not a record low, which occurred in 2012, when the minimum was 4.175 ***^(2), 0.794 ***^(2) less than the minimum in 2023. However, the ice extent had decreased by 0.432 ***^(2) compared with 2022. Nevertheless, the summer melting in 2023 was remarkably less than expected when considering the strong heat waves in the atmosphere and ocean, with record temperatures set around the world. in general, there is a high correlation between the long-term decrease in sea-ice extent and the increasing CO_(2) in the atmosphere, where the increase of CO_(2) in recent decades explains about 80% of the decrease in sea ice in September, while the remainder is caused by natural variability.

关键词： Sea ice Arctic Minimum ice Climate

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Emerging potential of progranulin-dependent SorCS2 signaling in healthy and diseased nervous systems

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Neural regeneration research 2025年第9期20卷 2591-2593页

作者： Alena Salasova Anders Nykjær Danish research institute of Translational Neuroscience DANDriTE-Nordic EMBL Partnership for Molecular Medicine and Centre of Excellence PROMEMODepartment of BiomedicineAarhus UniversityAarhusDenmark

The formation of the mammalian nervous system and its maturation into sensory,motor,cognitive,and behavioral circuits is a complex process that begins during early embryogenesis and lasts until young *** neurodevelopm... 详细信息

关键词： progr jointly CS2

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Comprehensive study on the results of tension leg platform responses in random sea

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2006年第8期7卷 1305-1317页

作者： TABESHPOUr M.r GOLAFSHANi A.A. seif M.S Department of Civil Engineering Sharif University of Technology P.O.Box 11365-9313 Tehran Iran Department of Mechanical Engineering Sharif University of Technology P.O.Box 11365-9313 Tehran Iran

Compliant offshore structures are used for oil exploitation in deep water. Tension leg platform (TLP) is a suitable type for very deep water. The nonlinear dynamic response of TLP under random sea wave load is necessary for determining the maximum deformations and stresses. Accurate and reliable responses are needed for optimum design and control of the structure. in this paper nonlinear dynamic analysis of TLP is carried out in both time and frequency domains. The time history of random wave is generated based on Pierson-Moskowitz spectrum and acts on the structure in arbitrary direction. The hydrodynamic forces are calculated using the modified Morison equation according to Airy’s linear wave theory. The power spectral densities (PSDs) of displacements, velocities and accelerations are calculated from nonlinear responses. The focus of the paper is on the comprehen-sive interpretation of the responses of the structure related to wave excitation and structural characteristics. As an example a case study is investigated and numerical results are discussed.

关键词： Tension leg platform (TLP) Ocean wave Stochastic Nonlinear

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Security Strategy of Digital Medical Contents Based on Blockchain in Generative Ai Model

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Computers, Materials & Continua 2025年第1期82卷 259-278页

作者： Hoon Ko Marek r.Ogiela Division of Computer Science and Engineering Sunmoon UniversityAsan31460Republic of Korea AGH University of Krakow Cryptography and Cognitive Informatics LaboratoryKrakow30-059Poland

This study presents an innovative approach to enhancing the security of visual medical data in the generative Ai environment through the integration of blockchain *** combining the strengths of blockchain and generative Ai,the research team aimed to address the timely challenge of safeguarding visual medical *** participating researchers conducted a comprehensive analysis,examining the vulnerabilities of medical Ai services,personal information protection issues,and overall security *** multi faceted exploration led to an indepth evaluation of the model’s performance and ***,the correlation between accuracy,detection rate,and error rate was *** analysis revealed insights into the model’s strengths and limitations,while the consideration of standard deviation shed light on the model’s stability and performance *** study proposed practical improvements,emphasizing the reduction of false negatives to enhance detection rate and leveraging blockchain technology to ensure visual data integrity in medical *** blockchain to generative Ai-created medical content addresses key personal information protection *** utilizing the distributed ledger system of blockchain,the research team aimed to protect the privacy and integrity of medical data especially medical *** approach not only enhances security but also enables transparent and tamperproof ***,the use of generative Ai models ensures the creation of novel medical content without compromising personal information,further safeguarding patient *** conclusion,this study showcases the potential of blockchain-based solutions in the medical field,particularly in securing sensitive medical data and protecting patient *** proposed approach,combining blockchain and generative Ai,offers a promising direction toward more robust and secure medical content *** research and advancements

关键词： Digitalmedical content medical diagnostic visualization security analysis generativeAi blockchain vulnerability pattern recognition

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Antisense oligonucleotides provide optimism to the therapeutic landscape for tauopathies

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Neural regeneration research 2025年第3期20卷 803-804页

作者： Glenn A.Harris Lauren r.Hirschfeld rainwater Charitable Foundation Fort WorthTXUSA

Tauopathies are a group of neurodegenerative diseases characterized by abnormal metabolism of the misfolded tau protein. Tau is encoded by the microtubule-associated protein tau gene(MAPT) and can be classified as either 3-repeat(3r) or 4-repeat(4r) based on the number of repeat domains from alternative splicing of exon 10 of the MAPT gene.

关键词： tau metabolism diseases

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Multisensory mechanisms of gait and balance in Parkinson’s disease:an integrative review

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Neural regeneration research 2025年第1期20卷 82-92页

作者： Stiven roytman rebecca Paalanen Giulia Carli Uros Marusic Prabesh Kanel Teus van Laar Nico i.Bohnen Department of radiology University of MichiganAnn ArborMIUSA Department of Neurology University of MichiganAnn ArborMIUSA Morris K.Udall Center of Excellence for Parkinson’s Disease research University of MichiganAnn ArborMIUSA institute for Kinesiology research Science and Research Centre KoperKoperSlovenia Department of Health Sciences Alma Mater Europaea–ECMMariborSlovenia Parkinson’s Foundation research Center of Excellence University of MichiganAnn ArborMIUSA Department of Neurology University of GroningenUniversity Medical Center GroningenGroningenThe Netherlands Neurology Service and GrECC VA Ann Arbor Healthcare SystemAnn ArborMIUSA

Understanding the neural underpinning of human gait and balance is one of the most pertinent challenges for 21st-century translational neuroscience due to the profound impact that falls and mobility disturbances have on our aging *** and gait control does not happen automatically,as previously believed,but rather requires continuous involvement of central nervous *** effectively exert control over the body,the brain must integrate multiple streams of sensory information,including visual,vestibular,and somatosensory *** mechanisms which underpin the integration of these multisensory signals are the principal topic of the present *** multisensory integration theories focus on how failure of cognitive processes thought to be involved in multisensory integration leads to falls in older *** emphasis,however,has been placed on specific contributions of individual sensory modalities to multisensory integration processes and cross-modal interactions that occur between the sensory modalities in relation to gait and *** the present work,we review the contributions of somatosensory,visual,and vestibular modalities,along with their multisensory intersections to gait and balance in older adults and patients with Parkinson’s *** also review evidence of vestibular contributions to multisensory temporal binding windows,previously shown to be highly pertinent to fall risk in older ***,we relate multisensory vestibular mechanisms to potential neural substrates,both at the level of neurobiology(concerning positron emission tomography imaging)and at the level of electrophysiology(concerning electroencephalography).We hope that this integrative review,drawing influence across multiple subdisciplines of neuroscience,paves the way for novel research directions and therapeutic neuromodulatory approaches,to improve the lives of older adults and patients with neurodegenerative diseases.

关键词： aging balance encephalography functional magnetic resonance imaging gait multisensory integration Parkinson’s disease positron emission tomography somatosensory vestibular visual

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influence of proton-skin thickness on the α decays of heavy nuclei

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Chinese Physics C 2018年第1期42卷 122-134页

作者： W.M.seif A.Abdurrahman Cairo University Faculty of Science Department of Physics Giza Egypt Misr University for Science and Technology (MUST) Faculty of Engineering Department of Physics Giza Egypt

We investigate the effect of proton-skin thickness on the α decay process. We consider 188 neutrondeficient nuclei belonging to the isotopic chains from Te（Z = 52） to Pb（Z = 82）. The calculations of the half-life are carried out in the framework of the preformed cluster model, with the Wentzel-Kramers-Brillouin penetration probability and assault frequency. it is shown that the proton-skin thickness（？p） of the daughter nucleus gives rise to a total α-daughter nucleus interaction potential of relatively wide deep internal pocket and a thinner Coulomb barrier of less height. This increases the penetration probability but decreases the assault frequency. The overall impact of the proton-skin thickness appears as a decrease in the decay half-life. The proton-skin thickness decreases the stability of the nucleus. The half-lives of the proton-skinned isotopes along the isotopic chain decrease exponentially with increasing the proton-skin thickness, whereas the Qα-value increases with ？p. α-decay manifests itself as the second favorite decay mode of neutron-deficient nuclei, next to the β＋-decay and before proton-decay. it is indicated as main, competing, and minor decay mode, at 21%, 7%, and 57%, respectively, of the investigated nuclei.

关键词： alpha decay half-life proton-skin thickness branching ratio

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Apolipoprotein A-i binding protein-mediated neuroprotection in glaucomatous neuroinflammation and neurodegeneration

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Neural regeneration research 2025年第5期20卷 1414-1415页

作者： Sinwoo Hwang Seunghwan Choi Soo-Ho Choi Keun-Young Kim Yury i.Miller Won-Kyu Ju Hamilton Glaucoma Center and Shiley Eye institute The Viterbi Family Department of OphthalmologyUniversity of California San DiegoLa JollaCAUSA Department of Medicine University of California San DiegoLa JollaCAUSA National Center for Microscopy and imaging research Department of NeurosciencesUniversity of California San DiegoLa JollaCAUSA

Glaucoma is a multifactorial eye disorder that can cause vision loss and irreversible blindness,affecting individ uals aged 40 to 80 yea rs *** to the aging population,it is expected that the number of people affected by glaucoma will surpass 111 million by 2040 as the disease becomes more *** primarily contributes to optic nerve axon loss and the progressive degeneration of retinal ganglion cells (rGCs),subsequently leading to vision impairment.

关键词： irreversible pass primarily

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Examining E-participatory Governance in Local Cameroon：Participation,Perceived influence,Satisfaction and Trust in Government

Examining E-participatory Governance in Local Cameroon：Part...

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作者： elna ENANGA ESEMBE 上海财经大学

学位级别：硕士

Participatory governance is a practice of management within public administration which permits a collaboration between a state,its government,and *** the years,the evolution in traditional bureaucratic practise of participatory governance has brought forth what is today termed as electronic *** put,electronic governance is a transfer of tasks and operations from manual methods to automated ***,this study defines electronic participatory（e-participatory）governance as the exploration of internet communication tools used in the process of participatory *** research explores citizenry participation in local governance;encompassing an examination of the elements which build on the existence of electronic participatory governance for local government in *** essence of this research is to harness the knowledge and perception of citizens’ participation from a sample population that establishes certainty towards the development of e-participatory governance in local *** elements researched are participation,satisfaction,and perceived influences as inputs to local and national *** governance is now a global trend for nations,as such,Cameroon needs to adopt such a system to attain local *** ＆ Sigauke（2007）defined participatory governance as “a regular and guaranteed presence of citizens when making binding decisions of representatives for those collectives that will be affected by the policy adopted.” As defined by these authors,this research posits the vitality of citizens’ participation through the process of electronic governance because participatory governance encourages acts of civic engagement in matters of how citizens are ***,in this research,the author explores the role of electronic governance in participation;hence,a description of e-participatory governance.E-participatory governance is a type of participation that is more transparent through governmen

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