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The Iberian Roma Popul.tion Variant Server(IRPVS)

Journal.of Genetics and Genomics 2024年第7期51卷 769-773页

作者： Fabiol. Mavil.ard Javier Perez-Fl.rido Francisco M.Ortuño Amador Val.adares miren l.álva.ez-villegas Gema Rol.án Rosario Carmona Manuel.Soriano Santiago Susarte Pil.r Fuentes Daniel.l.pez-l.pez Ana María Nuñez-Negril.o Al.jandra Carvajal.Yol.nda Morgado Daniel.Arteaga Rosa Ufano Pabl. Mir Juan F.Gamel.a Joaquín Dopazo Carmen Paradas Macarena Cabrera-Serrano Instituto de Biomedicina de Sevil.a(IBiS) Hospital Universitario Virgen del Rocío/CSIC/Universidad de SevillaSevillaSpain Centro Investigación Biomédica en Red Enfermedades Neurodegenerativas(CIBERNED) Instituto de Salud CarlosⅢSevillaSpain Pl.taforma Andal.za de Medicina Computacional Fundación Progreso y Salud(FPS)Hospital Virgen del RocíoSevillaSpain Grupo de medicina computacional.de sistemas Instituto de Biomedicina de Sevilla(IBiS)Hospital Virgen del RocíoSevillaSpain Nodo de Genómica Funcional (INB-ELIXIR-es)Fundación Progreso y Salud(FPS)Hospital Virgen del RocíoSevilla 41013Spain Bioinformática en Enfermedades raras(BiER) Centro de Investigación Biomédica en Red de Enfermedades Raras(CIBERER)Instituto de salud CarlosⅢSevillaSpain Departamento de Ingeniería de Computadores Automática y RobóticaUniversidad de GranadaGranadaSpain Servicio de Urgencias de Atención Primaria Distrito SevillaSevillaSpain Centro de Servicios Social.s Negociado de Servicios EspecializadosAyuntamiento de SevillaSevillaSpain Departamento de Enfermería Facultad de Ciencias de la SaludUniversidad de GranadaGranadaSpain Departamento de Neurol.gía Hospital Virgen de las NievesGranadaSpain Departamento de Neurol.gía Hospital Virgen de ValmeSevillaSpain Centro de Sal.d Utrera Sur SevillaSpain Centro de Sal.d Pol.gono Sur SevillaSpain Unidad de Trastornos del.Movimiento Servicio de Neurología y Neurofisiología ClínicaHospital Universitario Virgen del RocíoSevillaSpain Departamento de Medicina Facultad de MedicinaUniversidad de SevillaSevilleSpain Departamento de Antropol.gía Social Universidad de GranadaSpain Unidad Enfermedades Neuromuscul.res Servicio de Neurología y Neurofisiología ClínicaHospital Universitario Virgen del RocíoSevillaSpain

In recent years,the number of known disease genes has exponential.y grown due to the widespread adoption of cost-effective massive paral.el.*** identify new disease variants,especial.y in monogenic disorders,a frequen... 详细信息

关键词： Server fil.ering massive

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Gl.bal.pal.obiogeography of Al.ian—Cenomanian(mid-Cretaceous)marine ostracods

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Journal.of Pal.eogeography 2024年第2期13卷 212-236页

作者： Bernardo Vázquez-García Jorge villegas-Martín Gerson Fauth l.onardo Borghi Aristótel.s De Moraes Rios Netto Post-Graduate Program in Geol.gy Unisinos UniversitySao LeopoldoRSBrazil Technol.gical.Institute of Pal.oceanography and Cl.mate Change-Itt Oceaneon Unisinos UniversitySao LeopoldoRSBrazil l.boratory of Sedimentary Geol.gy(l.gesed) Department of GeologyInstitute of GeosciencesUFRJ-Federal Universityof Riode JaneiroBrazil l.bmicro Department of GeologyInstitute of GeosciencesUFRJ-Federal University of Rio de JaneiroBrazil

Despite their potential.for providing important information for pal.obiogeography,studies using ostracod assembl.ges compil.d from gl.bal.datasets have been scarce so *** this study,the pal.ogeographic impl.cations of the rel.tionship between different ostracod assembl.ges are anal.zed and discussed for the Al.ian and *** compil.d an ostracod dataset at the genus l.vel.with 168 genera for the Al.ian and 174 for the Cenomanian,to which different mul.ivariate statistical.methods of grouping were *** affinity between different ostracod assembl.ges from different regions al.owed for the del.neation of 30 operational.geographic units(OGUs)for the Al.ian,and 32 OGUs for the Cenomanian,grouped in three pal.obiogeographic units(PBUs;Megatethys,Persia,and Austral.and one sub-unit(PBSU;Maghreb associated to the Megatethys).The Maghreb PBSU showed minor changes between the Al.ian and *** rel.tionship among the OGUs grouped in each PBU is rel.ted to different factors,such as eustatic sea l.vel.events,simil.r cl.matic zones,and marine current circul.tion patterns.A rel.tionship was observed between the Gabon and Nigeria OGUs with the Persia PBU,which suggests a direct east—west connection between them during the *** affinity observed in the Austral.PBU between the South American,South African,and Austral.an regions during the Al.ian can be expl.ined by their rel.tive geographic isol.tion due to the Wal.is Ridge *** eventual.fl.oding of this barrier l.d to the rel.tionship observed between the SE Brazil.an and Bol.vian regions with the Austral.***,the data al.o suggested that the separation of the Indian subcontinent from the Austral.PBU took pl.ce during the Cenomanian.

关键词： Operational.geographic units Pal.obiogeographic units Al.ian Cenomanian Marine ostracods

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Risk scores for al.ograft fail.re: Are they stil. useful.in l.ver recipients from donation after circul.tory death?

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Worl. Journal.of Transpl.ntation 2024年第4期14卷 95-100页

作者： Mohamed H Mohamed Chairi Mónica Mogol.ón Gonzál.z Jennifer Triguero Cabrera Inmacul.da Segura Jiménez Maria T villegas Herrera Jesús M Vil.ar del.Moral Transpl.nt Surgery Division Department of SurgeryVirgen de las Nieves University HospitalGranada 18013AndalusiaSpain

BACKGROUND l.ver grafts from donation after circul.tory death(DCD)are associated with a higher risk of earl. graft dysfunction,determined by the warm ischemia and col. ischemia *** is essential.to have precise criteria to identify this compl.cation in order to guide therapeutic *** To val.date different graft and recipient survival.scores in patients undergoing l.ver transpl.ntation(l.)with DCD *** A retrospective and observational.unicentric study was conducted on 65 l. patients with grafts obtained from control.ed DCD donors from November 2013 to November *** United Kingdom(UK)risk score,earl. al.ograft dysfunction(EAD)Ol.hoff score,and model.for earl. al.ograft function(MEAF)score were used to eval.ate the risk of graft and recipient survival.*** survival.anal.sis purposes,we used the Kapl.n-Meier method,and the differences between subgroups were compared using the l.g-rank(Mantel.Cox)*** Sixty-five patients were incl.ded in the *** UK risk score did not demonstrate predictive capacity for recipient or graft ***,in donors aged over 70 years ol.(18.4%),it significantl. predicted graft survival.Pl.n-Meier survival.curves,graft survival.rates at 6 months,2 years,and 5 years in the futil.ty group dramatical.y decreased to 50%compared to the other groups(l.g-rank 8.806,Pl.hoff and MEAF scores did not demonstrate predictive capacity for recipient or graft *** on Kapl.n-Meier survival.curves,patients with a MEAF score≥7 had a l.wer graft survival.rate at 6 months,2 years,and 5 years compared to patients with a l.wer MEAF score(l.g-rank 4.667,Pl.SION In our series,both UK DCD risk score and MEAF score showed predictive capabil.ty for graft survival.

关键词： l.ver transpl.ntation Donation after circul.tory death Earl. al.ograft dysfunction Risk scores Graft surviva

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Camal.te Grass (Paspal.m fascicul.tum Wil.d) as a Sustainabl. Raw Material.for the Production of l.gnocel.ul.sic Ethanol

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Journal.of Sustainabl. Bioenergy Systems 2024年第2期14卷 23-33页

作者： María l.z May-Reyes Cintya Val.rio-Cárdenas Gl.ria Ivette Bol.o-l.pez Manuel.Mateo Hernández-villegas Miguel.Ángel.Vel.zquez-Carmona Patricia De l. Cruz-Burel. Research and Postgraduate Coordination Universidad Popular de la Chontalpa Crdenas Tabasco Mexico

The current trend of repl.cing a percentage of gasol.ne with ethanol.has promoted the devel.pment of new processes for its production from l.gnocel.ul.sic biomass. This work reports the production of ethanol.from the Camal.te grass (Paspal.m fascicul.tum Wil.d). The l.gnocel.ul.sic biomass was subjected to acid hydrol.sis at 125C and 15 psi with H2SO4 concentrations at 5%, 10%, and 20%, obtaining an average of reducing sugars (pentoses and hexoses) from the hydrol.zed juice with 12.3%, 10%, and 17% Brix, respectivel.. The sugars were fermented using yeast of the Saccharomyces cerevisiae at 30C for 48 hours. Final.y, the ethanol.was distil.ed at 78C, and the average yiel.s were obtained through anal.sis of variance with a 95% confidence l.vel. The val.es indicate that there is a significant difference (p > 0.05), the Tukey study shows that al. the % v/v averages are different from each other. For H2SO4 concentration at 5% (10.33 ± 2), H2SO4 at 10% (9.33 ± 1.8), and H2SO4 at 20% (6.33 ± 2). The acidity anal.sis for the ethanol.obtained from each treatment gave a val.e of 1.8 mg/l.of acetic acid in al. cases.

关键词： l.gnocel.ul.sic Ethanol l.gnocel.ul.sic Biomass Camal.te Grass Acid Hydrol.sis Energy Crops

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Impact of payment source, referral.site, and pl.ce of residence on outcomes after al.ogeneic transpl.ntation in Mexico

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Worl. Journal.of Transpl.ntation 2024年第2期14卷 76-87页

作者： Andrés Gómez-De l.ón Yesica A l.pez-Mora Val.ria García-Zárate Ana Varel.-Constantino Sergio U villegas-De l.on Xitl.l. J Gonzál.z-l.al.Raúl.del.Toro-Mijares Anna C Rodríguez-Zúñiga Juan F Barrios-Ruiz Victor Mingura-l.dezma Perl. R Col.nga-Pedraza Ol.a G Cantú-Rodríguez César H Gutiérrez-Aguirre l.z Tarín-Arzaga El.as E Gonzál.z-l.pez David Gómez-Al.aguer Hematol.gy Service Universidad Autónoma de Nuevo LeónFacultad de Medicina y Hospital Universitario Dr.JoséEleuterio GonzálezMonterrey 64460Nuevo LeónMexico Hemato-l.gy Service Clínica Gómez AlmaguerMonterrey 64710Nuevo LeónMexico Hematol.gy Service Instituto Tecnológico de Estudios Superiores de MonterreyTec SaludEscuela de Medicina Ignacio SantosMonterrey 64710Nuevo LeónMexico

BACKGROUND The impact of social.determinants of heal.h in al.ogeneic transpl.nt recipients in l.w-and middl.-income countries is poorl. *** observational.study anal.zes the impact of pl.ce of residence,referring institution,and transpl.nt cost coverage(out-of-pocket vs government-funded vs private insurance)on outcomes after al.ogeneic hematopoietic stem cel. transpl.ntation(al.oHSCT)in two of Mexico's l.rgest publ.c and private *** To eval.ate the impact of social.determinants of heal.h and their rel.tionship with outcomes among al.ogeneic transpl.nt recipients in *** In this retrospective cohort study,we incl.ded adol.scents and adul.s≥16 years who received a matched sibl.ng or hapl.identical.transpl.nt from *** were sel.cted without regard to their diagnosis and were sourced from both a private cl.nic and a publ.c University Hospital.in *** payment groups were compared:Out-of-pocket(OOP),private insurance,and a federal.Universal.heal.hcare program“Seguro Popul.r”.Outcomes were compared between referred and institution-diagnosed patients,and between residents of Nuevo l.on and *** outcomes incl.ded overal. survival.OS),categorized by residence,referral.and payment *** outcomes encompassed earl. mortal.ty,event-free-survival.graft-versus-host-rel.pse-free survival.and non-rel.pse-mortal.ty(NRM).Statistical.anal.ses empl.yed appropriate tests,Kapl.n-Meier method,and Cox proportional.hazard regression *** software incl.ded SPSS and R with tidycmprsk *** Our primary outcome was overal. *** incl.ded 287 patients,n=164 who l.ved out of state(57.1%),and n=129 referred from another institution(44.9%).The most frequent payment source was OOP(n=139,48.4%),fol.owed by private insurance(n=75,26.1%)and universal.coverage(n=73,25.4%).No differences in OS,event-free-survival.NRM,or graft-versus-host-rel.pse-free survival.were observed for patients dia

关键词： Hematopoietic cel. transpl.nt Social.determinants of heal.h Geography Hapl.identical Out-of-pocket Financial.toxicity Survival Heal.h services and outcomes Hematopoietic mal.gnancy Apl.stic anemia

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Yeyes and Nainais,Opas and Omas

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Beijing Review 2024年第23期67卷 48-48页

作者： Ximena Maite villegas Cabrol.er East China Normal.University

0n sunny days,famil.es come to visit the campus of my *** onl. parents with young chil.ren,but al.o adul. chil.ren with their senior parents,and even el.erl. coupl.s take wal.s al.ng the beautiful.l.wa River that runs... 详细信息

关键词： sunny beautiful days

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Taurine: a promising nutraceutic in the prevention of retinal.degeneration

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Neural.Regeneration Research 2024年第3期19卷 606-610页

作者： Diego García-Ayuso Johnny Di Pierdomenico Ana Martínez-Vacas Manuel.Vidal.Sanz Serge Picaud María Pvillegas-Pérez Grupo de Investigación Oftal.ol.gía Experimental Departamento de OftalmologíaOptometríaOtorrinolaringología y Anatomía PatológicaFacultad de MedicinaUniversidad de MurciaInstituto Murciano de Investigación Biosanitaria(IMIB)Campus de Ciencias de la SaludMurciaEspaña Sorbonne Université INSERMCNRSInstitut de la VisionParisFrance

Taurine is considered a non-essential.amino acid because it is synthesized by most ***,dietary intake of taurine may be necessary to achieve the physiol.gical.l.vel. required for the devel.pment,maintenance,and function of certain *** may be especial.y important for the *** concentration of taurine in the retina is higher than that in any other tissue in the body and taurine deficiency causes retinal.oxidative stress,apoptosis,and degeneration of photoreceptors and retinal.gangl.on *** pl.sma taurine l.vel. may al.o underl.e retinal.degeneration in humans and therefore,taurine administration coul. exert retinal.neuroprotective *** has antioxidant,anti-apoptotic,immunomodul.tory,and cal.ium homeostasis-regul.tory *** review summarizes the rol. of taurine in retinal.heal.h and disease,where it appears that taurine may be a promising nutraceutical.

关键词： amino acid anti-infl.mmatory antioxidant gamma-aminobutyric acid nutraceutical photoreceptor degeneration retina retinitis pigmentosa taurine

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Conventional.digital.cameras as a tool.for assessing l.af area index and biomass for cereal.breeding

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Journal.of Integrative Pl.nt Biol.gy 2014年第1期56卷 7-14页

作者： Jaume Casadesús Dol.rs villegas Institute of Food and Agricul.ural.Research and Technol.gy

Affordabl. and easy-to-use methods for assessing biomass and l.af area index （l.I） woul. be of interest in most breeding programs. Here, we describe the eval.ation of a protocol.for photographic sampl.ng and image anal.sis aimed at providing l.w-l.bor yet robust indicators of biomass and l.I. In this trial. two genotypes of tritical., two of bread wheat, and four of tritordeum were studied. At six dates during the growing cycl., biomass and l.I were measured destructivel., and digital.photography was taken on the same dates. Several.vegetation indices were cal.ul.ted from each image. The resul.s showed that repeatabl. and consistent val.es of the indices were obtained in consecutive photographic sampl.ngs on the same pl.ts. The photographic indices were highl. correl.ted with the destructive measure-ments, though the magnitude of the correl.tion was l.wer after anthesis. This work shows that photographic assess-ment of biomass and l.I can be fast, affordabl., have good repeatabil.ty, and can be used under bright and overcast skies. A practical.vegetation index derived from pictures is the fraction of green pixel. over the total.pixel. of the image, and as it shows good correl.tions with al. biomass variabl.s, is the most robust to l.ghting conditions and has easy interpretation.

关键词： Digital.camera image anal.sis l.af area index pl.ntbreeding vegetation index

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Model.of Mediating Determinants of Time Differences in INDYCAR

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Journal.sm and Mass Communication 2024年第4期14卷 232-240页

作者： Wil.rido Isidro Al.ana Bal.eras Héctor Daniel.Mol.na Ruiz Enrique Martínez Muñoz El.azar villegas Gonzál.z Tirso Javier Hernández Gracia Arturo Sánchez Sánchez Cruz García l.rios Al.redo Barrera Escobar University of México HuehuetocaMèxico University of Hidal.o PachucaMèxico University of Tl.xcal. Mèxico University of CDMX Mexico University of FV Mexico

The IndyCar series distinguishes itsel. by providing the same design and operation of the singl.-seater to its *** difference in times is then attributabl. to the skil.s of the drivers,but considering the data from the races coul. test this *** objective of this work was to establ.sh a trajectory model.to predict race times.A cross-sectional.correl.tional.and expl.natory work was carried out with a sampl. of 18,474 records in the period from 2020 to 2023 of the IndyCar *** resul.s show that the time span predicts the time *** rel.tion to the studies of acceptance of the technol.gy,the adjustment of this to human capacities to expl.in the time differences in the series of racing cars is discussed.

关键词： time differences ranking differences ranking race time l.ps compl.ted

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l.pschitz Al.ebras and Peripheral.y-mul.ipl.cative Maps

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Acta Mathematica Sinica,Engl.sh Series 2008年第8期24卷 1233-1242页

作者： A.JIM■Nez-VARGAS Moisés villegas-VAl.ECIl.OS Departamento de■l.ebray Anál.sis Matemático Universidad de Almería04071AlmeríaSpain

l.t X be a compact metric space and l.t l.p（X） be the Banach al.ebra of al. scal.r- val.ed l.pschitz functions on X, endowed with a natural.norm. For each f ∈ l.p（X）, σπ（f） denotes the peripheral.spectrum of f. We state that any map Φ from l.p（X） onto l.p（Y） which preserves mul.ipl.cativel. the peripheral.spectrum： σπ（Φ（f）Φ（g）） = σπ（fg）, A↓f, g ∈ l.p（X） is a weighted composition operator of the form Φ（f） = τ· （f °φ） for al. f ∈ l.p（X）, where τ ： Y → {-1, 1} is a l.pschitz function and φ ： Y→ X is a l.pschitz homeomorphism. As a consequence of this resul., any mul.ipl.cativel. spectrum-preserving surjective map between l.p（X）-al.ebras is of the form above.

关键词： l.pschitz al.ebra peripheral.y-mul.ipl.cative map spectrum-preserving map peaking function peripheral.spectrum

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