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皮肤自发荧光、戊糖素与主动脉僵硬度相关:Maastricht研究

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中华高血压杂志 2016年第9期24卷 899-899页

作者： van Eupen MG Schram MT van Sloten TT Scheijen J Sep SJ van der Kallen CJ Dagnelie PC Koster A Schaper N henry RM Kroon AA Smit AJ Stehouwer CD Schalkwijk CG 刘莉叶鹏

以颈股动脉脉搏波传导速度（carotid-femoralpulse-wavevelocity，cfPWV）或脉压增加为特征的动脉硬化可增加心血管病发生风险，尤其是在2型糖尿病的个体。

关键词： Maastricht 主动脉僵硬度自发荧光脉搏波传导速度皮肤糖素 2型糖尿病发生风险

西罗莫司洗脱支架与裸金属支架在急性心肌梗死应用中的比较

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世界核心医学期刊文摘（心脏病学分册） 2007年第2期3卷 14-14页

作者： Spaulding C. henry P. Teiger E. 韩瑞娟 Cochin Hospital 27 rue du Faubourg St. Jacques 75014 Paris France.Dr

背景:与裸金属支架相比,西罗莫司洗脱支架降低了再狭窄和再介入的发生率。关于应用这两种支架行直接经皮冠状动脉介入(PCI)治疗ST段抬高型急性心肌梗死的安全性和有效性的资料有限。方法:进行了一项单盲、多中心、前瞻性、随机化试验,... 详细信息

背景:与裸金属支架相比,西罗莫司洗脱支架降低了再狭窄和再介入的发生率。关于应用这两种支架行直接经皮冠状动脉介入(PCI)治疗ST段抬高型急性心肌梗死的安全性和有效性的资料有限。方法:进行了一项单盲、多中心、前瞻性、随机化试验,以比较西罗莫司洗脱支架与裸金属支架用于对ST段抬高型急性心肌梗死患者行直接PCI的效果。

关键词：裸金属支架急性心肌梗死再狭窄单盲再梗死靶血管随机化亚组血管造影内膜增殖

Race and colorectal cancer screening compliance among persons with a family history of cancer

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World Journal of Gastrointestinal Endoscopy 2015年第18期7卷 1300-1305页

作者： Adeyinka O Laiyemo Nicole Thompson Carla D Williams Kolapo A Idowu Kathy Bull-henry Zaki A Sherif Edward L Lee Hassan Brim Hassan Ashktorab Elizabeth A Platz Duane T Smoot Division of Gastro-enterology Department of Medicine Howard University College of Medicine Howard University Cancer Center Department of Medicine Georgetown Univer-sity Department of Biochemistry and Molecular Biology Howard University College of Medicine Department of Pathology Howard University Department of Epidemiology Johns Hopkins Bloomberg School of Public Health the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins Department of Medicine Meharry Medical Center

AIM: To determine compliance to colorectal cancer(CRC) screening guidelines among persons with a family history of any type of cancer and investigate racial differences in screening ***: We used the 2007 Health Information National Trends Survey and identified 1094(27.4%)respondents(weighted population size = 21959672) without a family history of cancer and 3138(72.6%) respondents(weighted population size = 58201479) with a family history of cancer who were 50 years and older. We defined compliance with CRC screening as the use of fecal occult blood testing within 1 year, sigmoidoscopy within 5 years, or colonoscopy within 10 years. We compared compliance with CRC screening among those with and without a family member with a history of cancer. RESULTS: Overall, those with a family member with cancer were more likely to be compliant with CRC screening(64.9% vs 55.1%; OR = 1.45; 95%CI: 1.20-1.74). The absolute increase in screening rates associated with family history of cancer was 8.2% among whites. Hispanics had lowest screening rates among those without family history of cancer 41.9% but had highest absolute increase(14.7%) in CRC screening rate when they have a family member with cancer. Blacks had the lowest absolute increase in CRC screening(5.3%) when a family member has a known history of cancer. However, the noted increase in screening rates among blacks and Hispanics when they have a family member with cancer were not higher than whites without a family history of cancer:(54.5% vs 58.7%; OR = 1.16; 95%CI: 0.72-1.88) for blacks and(56.7% vs 58.7%; OR = 1.25; 95%CI: 0.72-2.18) for ***: While adults with a family history of any cancer were more likely to be compliant with CRC screening guidelines irrespective of race/ethnicity, blacks and Hispanics with a family history of cancer were less likely to be compliant than whites without a family history. Increased burden from CRC among blacks may be related to poor uptake of screening

关键词： Colon cancer Health disparities Screening Fecal bl

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温和的季节

时代英语（高二版） 2020年第5期 1-1页

作者：亨利·霍华德不详

心血管风险与环氧化酶抑制：选择性环氧化酶2抑制剂和非选择性环氧化酶2抑制剂观察研究之系统综述

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美国医学会杂志（中文版） 2007年第3期26卷 175-175页

作者： Patricia McGettigan, MD, FRACP David henry, MB, ChB, FRCP 陈立敏（译）

背景：有证据表明，罗非考昔（rofecoxib）可增加心肌梗死的患病风险，为此人们开始慎重对待其他非甾体类抗炎药物（nonsteroidal anti—inflammatory drugs，NSAIDs）。当前，医药管理部门已就传统的非选择性NSAIDs所带来的心血管患病... 详细信息

背景：有证据表明，罗非考昔（rofecoxib）可增加心肌梗死的患病风险，为此人们开始慎重对待其他非甾体类抗炎药物（nonsteroidal anti—inflammatory drugs，NSAIDs）。当前，医药管理部门已就传统的非选择性NSAIDs所带来的心血管患病风险给出了各种各样的建议。

关键词：选择性环氧化酶2抑制剂心血管风险环氧化酶抑制系统综述 inflammatory 非甾体类抗炎药物 NSAIDs 患病风险

Combined antiviral activity of interferon-α and RNA interference directed against hepatitis C without affecting vector delivery and gene silencing

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世界最新医学信息文摘 2017年第30期 281-281页

作者： Qiuwei Pan Scot D.henry Herold J.Metselaar Bob Scholte Jaap Kwekkeboom Hugo W.Tilanus Harry L.A.Janssen Luc J.W.van der Laan

The current standard interferon-alpha(IFN-α)-based therapy for chronic hepatitis C virus(HCV) infection is only effective in approximately half of the patients,prompting the need for alternative *** interference(RNAi)represents novel approach to combat HCV by sequence-specific targeting of viral or host factors involved in *** of RNAi,however,may lead to therapeutic resistance by mutational escape of the ***,we proposed that combining lentiviral vector-mediated RNAi and IFN-a could be more effective and avoid therapeutic *** this study,we found that IFN-α treatment did not interfere with RNAi-mediated gene *** and IFN-α act independently on HCV replication showing combined antiviral activity when used simultaneously or *** ofmouse hepatocytes in vivo and in vitro was not effected by IFN-α *** conclusion,RNAi and IFN-a can be effectively combined without crossinterference and may represent a promising combinational strategy for the treatment of hepatitis C.

关键词： RNAi IFN-α Gene therapy Lentiviral vector HCV

Combined antiviral activity of interferon-α and RNA interference directed against hepatitis C without affecting vector delivery and gene silencing

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世界最新医学信息文摘 2016年第11期 8-8页

作者： Qiuwei Pan Scot D.henry Herold J.Metselaar Bob Scholte Jaap Kwekkeboom Hugo W.Tilanus Harry L.A.Janssen Auc J.W.van der Laan

The current standard interferon-alpha(IFN-α)-based therapy for chronic hepatitis C virus(HCV) infection is only effective in approximately half of the patients, prompting the need for alternative treatments. RNA interference(RNAi) represents novel approach to combat HCV by sequence-specific targeting of viral or host factors involved in infection. Monotherapy of RNAi, however, may lead to therapeutic resistance by mutational escape of the virus. Here, we proposed that combining lentiviral vector-mediated RNAi and IFN-α could be more effective and avoid therapeutic resistance. In this study, we found that IFN-α treatment did not interfere with RNAi-mediated gene silencing. RNAi and IFN-α act independently on HCV replication showing combined antiviral activity when used simultaneously or sequentially. Transduction ofmouse hepatocytes in vivo and in vitro was not effected by IFN-α treatment. In conclusion, RNAi and IFN-α can be effectively combined without crossinterference and may represent a promising combinational strategy for the treatment of hepatitis c.

关键词： RNAi IFN-α Gene therapy Lentiviral vector HCV

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错误成功学

环球科学 2010年第5期 70-73页

作者：亨利·L·罗迪格三世（henry L.Roediger III）布里奇德·芬恩（Bridgid Finn）冯泽君（翻译）美国华盛顿大学圣路易斯分校华盛顿大学不详

新的研究认为，学校里的难题测验有助于学生们更好地掌握新知识；这项研究还提出了一种适用于任何人的独特学习策略。

关键词：成功学学习策略学生学校

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手术治疗肺动脉狭窄症的评价

中华医学杂志 1957年第11期43卷 912-912页

作者： henry T.Bahnson Merril W.Brown 王一山

肺动脉狭窄症可大别为两类型:①有室间隔缺陷者(法乐氏四联症是标准的代表);②室间隔虽完整,但常有间隔缺陷或未闭的卵圆孔存在(如单纯性肺动脉狭窄症)。对肺动脉狭窄症的治疗,有三种不同的手术方法可以施行: (1) Blalock氏(1944)所倡...

肺动脉狭窄症可大别为两类型:①有室间隔缺陷者(法乐氏四联症是标准的代表);②室间隔虽完整,但常有间隔缺陷或未闭的卵圆孔存在(如单纯性肺动脉狭窄症)。对肺动脉狭窄症的治疗,有三种不同的手术方法可以施行: (1) Blalock氏(1944)所倡用的锁骨下动脉与肺动脉的吻合与Potts,Smith及Gibson等氏(1946)所倡用的主动脉与肺动脉的吻合,均为捷径手术,主要用来增加肺部血循环,改善发绀。手术仅限于心脏

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