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Metabolic characterization of selected probiotic consortia during gluten and wheat bread simulated digestion

Food Science and Human Wellness 2024年

作者： mirco vacca Giuseppe Celano Olga Nikoloudaki Bodo Speckmann Francesco Maria Calabrese Marco Gobbetti Maria de Angelis Faculty of Science and Technology， Free University of Bozen Evonik Operations GmbH Department of Soil Plant and Food Sciences， University of Bari Aldo Moro

While exerting their metabolic activities in the gastrointestinal milieu， probiotics impact the host well-being by boosting immunity， treating metabolic disorders， and modulating microbiota and metabolome. Due to the high incidence of gluten-based disorders， the present work aims to deeply explore the metabolism of two selected microbial consortia (MCs) during gluten digestion under simulated gastrointestinal conditions. Featured by high protease and peptidase activity， both MCs accounted for different lactic acid bacteria and Bacillus strains that were combined with two commercial protease enzymes. Gluten substrates were used as purified extracts， white and whole wheat breads. Control samples， instead， relied onto the microbial enzyme lack. Twenty-four hours of simulated digestion were sufficient to completely hydrolyze gluten in one of the two MC-containing experimental sets， and the relative 48 h-digested extract did not alter the cytokine expression in duodenal biopsies from celiac disease (CeD) patients. When digested samples were assayed for antioxidant and phytase activities， microbial enzymes demonstrated to significantly improve both ABTS and DPPH values and to decrease the phytic acid concentration. The inspection of the free amino acid profiles allowed for distinguishing the two MCs， whereas the detection of a heterogeneous panel of volatile organic compounds supported the presence/activity of microbial enzymes without statistically significant differences between MCs. As functional contribution， digested extracts with MCs also proved to reduce the inflammatory cytokine concentrations in cell lines exposed to lipopolysaccharide trigger. Therefore， in line with studies exploring novel adjuvant therapies， the present innovative probiotic consortium featured by high gluten-hydrolyzing metabolism also showed the capability to improve various parameters usually found to be altered in patients affected by gluten-based disorders or CeD.

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Chronic Ankle Instability: Therapeutic Exercise and Data Analysis

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Open Journal of Orthopedics 2024年第5期14卷 201-217页

作者： Rosa Grazia Bellomo Giulia Barletta mirco Brunetti Claudia Barbato Department of Biomolecular Sciences University of Study of Urbino Carlo Bo Urbino Italy

Background and Objectives: Ankle injuries are the most common type of injury in healthy active individuals. If not treated properly, recurrent sprains can lead to a condition of chronic ankle instability (CAI). The present paper examines some subjects with a previous history of acute inversion ankle sprain who have developed a subsequent condition of instability, grouping them according to inclusion criteria and analyzing them through four field tests considered objective by the scientific literature: SEBT test, BEES test, TIBT test, SHT test. The data obtained were stored in order to compare them following a re-education protocol aimed at improving proprioception, balance, walking and strengthening the extrinsic and intrinsic muscles of the foot. per year. The subjects were then divided into two categories: subjects with CAI > 1 year and subjects with CAI ≤ 1 year. A protocol lasting 6 weeks was administered to both groups, trying to work on improving balance in single stance, improving static and dynamic stability, strengthening the gluteus medius and maximus (pelvis stabilizers) and strengthening of the intrinsic muscles of the foot. At the end of the protocol the subjects were all re-evaluated with the same field tests used previously and the data obtained were compared both with the pre-protocol data and with the data measured by the control subjects.

关键词： Ankle Instability Ankle Sprain Ankle Injuries Exercise

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REALISTIC AND CORRECT MODELS OF IMPRESSED SOURCES FOR TIME-HARMONIC ELECTROMAGNETIC BOUNDARY VALUE PROBLEMS INVOLVING METAMATERIALS

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International Journal of Modeling, Simulation, and Scientific Computing 2013年第3期4卷 97-148页

作者： PAOLO FERNANDES mirco RAFFETTO Istituto di Matematica Applicata e Tecnologie Informatiche del Consiglio Nazionale delle Ricerche Via De Marini 6 I-16149 GenoaItaly Department of Biophysical and Electronic Engineering University of Genoa Via Opera Pia 11a I-16145GenoaItaly

The aim of this work is to analyze the role of the impressed sources in determining the well or ill-posedness of time harmonic electromagnetic boundary value problems involving isotropic effective *** is shown,in particular,that,even if all interfaces are regular,the class of ill-posed problems can be very large in the presence of general square-integrable impressed ***,when a simple and realistic constraint is enforced on these sources,requiring that the support of the sources does not include any interface between a traditional medium and a metamaterial,among the problems here considered just those involving an interface between complementary materials remain *** considerations have a very significant impact also on the approximability of the solution of well-posed problems since the numerical noise can introduce small fictitious sources even where the sources to be simulated are not *** effects on finite element simulators are fully ***,we propose an algorithm that allows to obtain much better approximations of the solutions of the most critical wellposed problems.

关键词： Time-harmonic electromagnetic boundary value problems electromagnetic modeling of composite media waveguide discontinuity problems ill-posedness metamaterials electromagnetic simulators finite element methods.

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地拉那金字塔

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世界建筑导报 2024年第4期39卷 121-125页

作者： Ronald Hoogeveen Stavros Gargaretas Guido Boeters Angel Sanchez Navarro Boris Tikvarski Jasper van der Ven mirco Facchinelli Manuel Magnaguagno Leo Stuckardt MVRDV

地拉那金字塔是一个新型的文化中心,位于阿尔巴尼亚首都的中心地带。地拉那金字塔最初是作为纪念共产主义者恩维尔·霍查(EnverHoxha)而建的博物馆,MVRDV对其进行了巨大的改造,现在的地拉那金字塔重新使用了混凝土结构,已经成为了一个... 详细信息

地拉那金字塔是一个新型的文化中心,位于阿尔巴尼亚首都的中心地带。地拉那金字塔最初是作为纪念共产主义者恩维尔·霍查(EnverHoxha)而建的博物馆,MVRDV对其进行了巨大的改造,现在的地拉那金字塔重新使用了混凝土结构,已经成为了一个新公园中的开放式雕塑。公园和雕塑中散布着一个个五颜六色的盒子,这些盒子散落在原来的建筑中及其周围,里面有咖啡馆、工作室、工作坊、创业办公室、孵化器、节庆活动,还有供阿尔巴尼亚青年免费学习各种技术和知识的教室。建筑倾斜的外墙还增加了台阶,让阿尔巴尼亚人民可以在这位前共产主义者的杰作上漫步。

关键词：工作坊金字塔节庆活动孵化器阿尔巴尼亚咖啡馆工作室混凝土结构

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High-contrast,high-resolution photochromic silicone polymer based on photoswitchable[Ru(bpy)_(2)OSO]PF_(6)building blocks

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Photonics Research 2013年第4期1卷 197-201页

作者： Kristin Springfeld Volker Dieckmann mirco Imlau Department of Physics Osnabrück UniversityBarbarastraße 749076 OsnabrückGermany

The implementation of photoinduced linkage isomerism in molecular-based optical materials represents a promising approach for the synthesis of high-contrast,high-resolution photosensitive materials that are necessary for high-density(holographic)data storage and/or real-three-dimensional(holographic)*** unsolved task of embedding a photofunctional coordination complex into a matrix like polymer polydimethylsiloxane(PDMS)with photoinduced isomerism of a SO-bond in the sulfoxide compoundRubpy2OSOPF6 is *** approach allows to preserve the spectral properties within the solid dielectric environment,with an impact of PDMS on population and relaxation *** data are discussed in the framework of photofunctionality,storage,and display applications.

关键词： dynamics. holographic polymer

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Chirp control of femtosecond-pulse scattering from drag-reducing surface-relief gratings

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Photonics Research 2018年第6期6卷 542-548页

作者： JULIANE EGGERT BJOERN BOURDON STEFAN NOLTE JOERG RISCHMUELLER mirco IMLAU School of Physics Osnabrück University

The role of chirp on the light-matter interaction of femto- and pico-second laser pulses with functional structured surfaces is studied using drag-reducing riblets as an example. The three-dimensional, periodic microstructure naturally gives rise to a mutual interplay of （i） reflection, （ii） scattering, and （iii） diffraction phenomena of incident coherent light. Furthermore, for femtosecond pulses, the structure induces （iv） an optical delay equivalent to a consecutive temporal delay of 230 fs in places of the pulse. These features enable studying experimentally and numerically the effect of tuning both pulse duration τ and spectral bandwidth Δω on the features of the wideangle scattering pattern from the riblet structure. As a result, we discovered a significant breakdown of fringes in the scattering pattern with decreasing pulse duration and/or increasing spectral bandwidth. This unique type of chirp control is straightforward/y explained and verified by numerical modeling considering the spectral and temporal interaction between different segments within the scattered, linearly chirped pulse and the particular geometric features of the riblet structure. The visibility of the fringe pattern can be precisely adjusted, and the offstate is achieved using τ 〈 230 fs or Δω〉 2.85 × 10^13 rad/s.

关键词： Optical inspection Surface measurements figure Linear and nonlinear lightscattering from surfaces Optical sensing and sensors Chirping Femtosecond phenomena

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Biomechanics of the anterior cruciate ligament:Physiology,rupture and reconstruction techniques

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World Journal of Orthopedics 2016年第2期7卷 82-93页

作者： Christoph Domnick Michael J Raschke mirco Herbort Department of Trauma Hand and Reconstructive SurgeryWestphalian Wilhelms University Muenster

The influences and mechanisms of the physiology,rupture and reconstruction of the anterior cruciate ligament(ACL)on kinematics and clinical outcomes have been investigated in many biomechanical and clinical studies over the last several *** knee is a complex joint with shifting contact points,pressures and axes that are affected when a ligament is *** ACL,as one of the intra-articular ligaments,has a strong influence on the resulting ***,other meniscal or ligamentous injuries accompany ACL ruptures and further deteriorate the resulting kinematics and clinical *** the surgical options,anatomic relations and current evidence to restore ACL function and considering the influence of concomitant injuries on resulting kinematics to restore full function can together help to achieve an optimal outcome.

关键词： Biomechanics anterior cruciate ligament joint pressure anterior cruciate ligament rupture graft fixation anterior cruciate ligament reconstruction

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Towards the FAIRification of Scanning Tunneling Microscopy Images

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Data Intelligence 2023年第1期5卷 27-42页

作者： Tommaso Rodani Elda Osmenaj Alberto Cazzaniga mirco Panighel Cristina Africh Stefano Cozzini AREAScience Park Padriciano9934149TriesteItaly CNR-1OM Consiglio Nazionale delle Ricerche-Istituto Officina dei MaterialiS.S.14Km 163.5Basovizza34149TriesteItaly

In this paper,we describe the data management practices and services developed for making FAIR compliant a scientific archive of Scanning Tunneling Microscopy(STM)*** a first step,we extracted the instrument metadata of each image of the dataset to create a structured *** then enriched these metadata with information on the structure and composition of the surface by means of a pipeline that leverages human annotation,machine learning techniques,and instrument metadata *** visually explore both images and metadata,as well as to improve the accessibility and usability of the dataset,we developed"STM explorer"as a web service integrated within the Trieste Advanced Data services(TriDAS)*** top of these data services and tools,we propose an implementation of the W3C PROV standard to describe provenance metadata of STM images.

关键词： Provenance STM images data management FAIR metadata for nanoscience W3C PROV

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On the evaluation of ALD TiO_(2),ZrO_(2) and HfO_(2) coatings on corrosion and cytotoxicity performances

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Journal of Magnesium and Alloys 2021年第5期9卷 1828-1841页

作者： mirco Peron Susanna Cogo Maria Bjelland Abdulla Bin Afif Anup Dadlani Elisa Greggio Filippo Berto Jan Torgersen Department of Industrial and Mechanical Engineering Norwegian University of Science and TechnologyRichard Birkelands vei 2b7034 TrondheimNorway Department of Biology University of PadovaVia Ugo Bassi 58/b35131PadovaItaly

Magnesium alloys have been widely studied as materials for temporary implants,but their use has been limited by their corrosion ***,coatings have been proven to provide an effective *** only little explored in the field,Atomic Layer Deposition(ALD)stands out as a coating technology due to the outstanding film conformality and density ***,we provide first insights into the corrosion behavior and the induced biological response of 100 nm thick ALD TiO_(2),HfO_(2)and ZrO_(2)coatings on AZ31 alloy by means of potentiodynamic polarization curves,electrochemical impedance spectroscopy(EIS),hydrogen evolution and MTS colorimetric assay with L929 *** three coatings improve the corrosion behavior and cytotoxicity of the ***,HfO_(2)coatings were characterized by the highest corrosion resistance and cell viability,slightly higher than those of ZrO_(2)***_(2)was characterized by the lowest corrosion improvements and,though generally considered a biocompatible coating,was found to not meet the demands for cellular applications(it was characterized by grade 3 cytotoxicity after 5 days of culture).These results reveal a strong link between biocompatibility and corrosion resistance and entail the need of taking the latter into consideration in the choice of a biocompatible coating to protect degradable Mg-based alloys.

关键词： Atomic layer deposition(ALD) Coatings Corrosion resistance Cytocompatibility Magnesium

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Chronic Ankle Instability: Therapeutic Exercise and Data Analysis

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Open Journal of Orthopedics（矫形学期刊） 2024年第5期 201页

作者： Rosa Grazia Bellomo Giulia Barletta mirco Brunetti Claudia Barbato

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