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Aero-Acoustics of Modern Transonic Fans—— Fan Noise Reduction from Its Sources

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Journal of Thermal Science 2003年第2期12卷 104-113页

作者： l.xu J.D.Denton Whittle laboratory University of CambridgeUKWhittle LaboratoryUniversity of CambridgeUK

The noise of aerodynamics nature from modern transonic fan is examined from its sources with the perspective of noise reduction through aero-acoustics design using advanced Computational Fluid Dynamics (CFD) tools. In particular the problems associated with the forward propagating noise in the front is addressed. It is identified that the shock wave spillage from the leading edge near the fan tip is the main source of the tone noise. Two different approaches have been studied to reduce the forward arc tone noise and two state-of-art transonic fans are designed using the strategies developed. The following rig tests show that while the fans exhibit other noise problems, the primary goals of noise reduction have been achieved through both fans and the novel noise reduction concept vindicated.

关键词： transonic fan aero-acoustics noise reduction.

Ethical challenges in vascularized composite allotransplantation of the lower extremity:lessons learned from hand transplantation and implications for the future

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Plastic and Aesthetic Research 2022年第1期9卷 196-212页

作者： Amy l.xu Casey Jo Humbyrd Department of Orthopaedic Surgery Johns Hopkins HospitalBaltimoreMD 21287USA Department of Orthopaedic Surgery Hospital of the University of PennsylvaniaPhiladelphiaPA 19106USA

Vascularized composite allotransplantation(VCA)is a novel surgical practice that involves the transplantation of multiple tissue types as a functional unit without the primary purpose of extending *** VCA of the upper extremity is becoming increasingly accepted and performed,VCA of the lower extremity remains largely unexplored despite its acknowledged potential *** are inherent ethical concerns surrounding VCA that are dominated by a conflict between the principles of beneficence and *** primary question is whether the quality-of-life benefits to the patient outweigh the risks associated with long-term immunosuppression for a non-lifesaving *** addition,the ethical conversation involves concerns regarding informed consent,donor autonomy,patient privacy and public disclosure,patient selection,and unique considerations in the pediatric *** extremity VCA has additional ethical issues compared to upper extremity VCA,as current lower limb prostheses provide excellent,near baseline function that upper limb constructs have not yet been able to *** this review,we discuss the ethical challenges of lower extremity VCA using available evidence for the upper *** also compare ethical considerations of VCA of the extremity with other surgical alternatives to limb loss-namely,limb salvage and replantation-and address how the conversation may be altered with further advancements in immunosuppression and prosthetic technology.

关键词： Vascularized composite allotransplantation(VCA) lower extremity ethics limb salvage replantation

Identifying Scientific and Technical“Unicorns”

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Journal of Data and Information Science 2021年第2期6卷 96-115页

作者： lucy l.xu Miao Qi Fred Y.Ye Jiangsu Key laboratory of Data Engineering and Knowledge Service School of Information ManagementNanjing UniversityNanjing 210023China University library Nantong UniversityNantong 226019China

Purpose:Using the metaphor of"unicorn,"we identify the scientific papers and technical patents characterized by the informetric feature of very high citations in the first ten years after publishing,which may provide a new pattern to understand very high impact works in science and ***/methodology/approach:When we set CT as the total citations of papers or patents in the first ten years after publication,with CT≥5,000 for scientific"unicorn"and CT≥500 for technical"unicorn,"we have an absolute standard for identifying scientific and technical"unicorn"***:We identify 165 scientific"unicorns"in 14,301,875 WoS papers and 224 technical"unicorns"in 13,728,950 DII patents during 2001–*** 50%of"unicorns"belong to biomedicine,in which selected cases are individually *** rare"unicorns"increase following linear model,the fitting data show 95%confidence with the RMSE of scientific"unicorn"is 0.2127 while the RMSE of technical"unicorn"is *** limitations:A"unicorn"is a pure quantitative consideration without concerning its quality,and"potential unicorns"as CT≤5,000 for papers and CT≤500 for patents are left in future *** implications:Scientific and technical"unicorns"provide a new pattern to understand high-impact works in science and ***"unicorn"pattern supplies a concise approach to identify very high-impact scientific papers and technical ***/value:The"unicorn"pattern supplies a concise approach to identify very high impact scientific papers and technical patents.

关键词： Unicorn Scientific paper Technical patent Citation analysis Patent analysis

Recombinant chitinase-3-like protein 1 alleviates learning and memory impairments via M2 microglia polarization in postoperative cognitive dysfunction mice

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Neural Regeneration Research 2025年第9期20卷 2727-2736页

作者： Yujia liu xue Han Yan Su Yiming Zhou Minhui xu Jiyan xu Zhengliang Ma Xiaoping Gu Tianjiao Xia Department of Anesthesiology Nanjing Drum Tower HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjingJiangsu ProvinceChina Medical School Nanjing UniversityNanjingJiangsu ProvinceChina Jiangsu Key laboratory of Molecular Medicine Nanjing UniversityNanjingJiangsu ProvinceChina State Key laboratory of Pharmaceutical Biotechnology Nanjing UniversityNanjingJiangsu ProvinceChina Department of Anesthesiology Zhongshan HospitalFudan UniversityShanghaiChina

Postoperative cognitive dysfunction is a seve re complication of the central nervous system that occurs after anesthesia and surgery,and has received attention for its high incidence and effect on the quality of life of *** date,there are no viable treatment options for postoperative cognitive *** identification of postoperative cognitive dysfunction hub genes could provide new research directions and therapeutic targets for future *** identify the signaling mechanisms contributing to postoperative cognitive dysfunction,we first conducted Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses of the Gene Expression Omnibus GSE95426 dataset,which consists of mRNAs and long non-coding RNAs differentially expressed in mouse hippocampus3 days after tibial *** dataset was enriched in genes associated with the biological process"regulation of immune cells,"of which Chill was identified as a hub ***,we investigated the contribution of chitinase-3-like protein 1 protein expression changes to postoperative cognitive dysfunction in the mouse model of tibial fractu re *** were intraperitoneally injected with vehicle or recombinant chitinase-3-like protein 124 hours post-surgery,and the injection groups were compared with untreated control mice for learning and memory capacities using the Y-maze and fear conditioning *** addition,protein expression levels of proinflammatory factors(interleukin-1βand inducible nitric oxide synthase),M2-type macrophage markers(CD206 and arginase-1),and cognition-related proteins(brain-derived neurotropic factor and phosphorylated NMDA receptor subunit NR2B)were measured in hippocampus by western *** with recombinant chitinase-3-like protein 1 prevented surgery-induced cognitive impairment,downregulated interleukin-1βand nducible nitric oxide synthase expression,and upregulated CD206,arginase-1,pNR2B,and brain-derived neurotropic factor expr

关键词： Chil1 hippocampus learning and memory M2 microglia neuroinflammation postoperative cognitive dysfunction(POCD) recombinant CHI3l1

Benign lymph node microenvironment is associated with response to immunotherapy

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Precision Clinical Medicine 2020年第1期3卷 44-53页

作者： Maria I.Toki Deepika Kumar Fahad S.Ahmed David l.Rimm Mina l.xu Department of Pathology Yale University School of MedicineNew HavenCT 06510USA Department of Medicine Yale University School of MedicineNew HavenCT 06510USA

Introduction:Benign lymph nodes have been considered the hubs of immune surveillance in cancer *** microenvironment of these lymphoid tissues can be immune suppressed,hence allowing for tumor *** the spectrum of benign findings in bystander lymph nodes in immune checkpoint blockade therapy could prove to be key to understanding the mechanism and assessing treatment ***:Benign lymph nodes and spleen were evaluated from patients treated with immunotherapy who subsequently received postmortem *** used quantitative immunofluorescence(QIF)to assess tumor infiltrating lymphocytes(TIl)and macrophage marker expression and characterized activation status using a novelmultiplexed QIF assay including CD3,GranzymeB,and *** performedimmunohistochemistry to correlate results of ***:Benign lymph nodes from non-responders to immunotherapy showed significantly higher expression of cytotoxic markers and proliferation index(Ki67)in T cells compared to *** expression of PD-l1 in macrophages was also *** was no significant difference in CD3+expression,but higher levels of CD8+T cells as well as CD20+B cells were seen in lymph nodes of *** significant differences were seen between responder and non-responder splenic *** were supported by traditional immunostaining ***:While most studies in biomarkers for immunotherapy focus on tumor microenvironment,we show that benign lymph node microenvironment may predict response to *** responding patients,bystander lymph nodes appear to have been mobilized,resulting in reduced cytotoxic T ***,patients whose disease progressed on immunotherapy demonstrate higher levels of macrophages that express increased PD-l1,and activated T cells not recruited to the tumor site.

关键词： response to immunotherapy lymph node microenvironment quantitative immunofluorescence

Synaptopathy in CHMP2B frontotemporal dementia highlights the synaptic vesicle cycle as a therapeutic target

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Neural Regeneration Research 2023年第2期18卷 315-316页

作者： miranda Robbins Emma l.Clayton MRC laboratory of Molecular Biology Department of Zoology University of CambridgeCambridgeUK UK Dementia Research Institute at King’s College london Department of Basic and Clinical Neuroscience Institute of PsychiatryPsychology and NeuroscienceKing’s College LondonMaurice Wohl Clinical Neuroscience InstituteLondonUK

Amyotrophic lateral sclerosis(AlS)and frontotemporal dementia(FTD)are both devastating neurodegenerative *** affecting different regions of the nervous system(FTD affecting primarily the frontal and temporal lobes,whilst AlS presents with motor neuron loss),there is significant overlap between these conditions in terms of genetics,pathology,and disease mechanisms,and they are therefore often grouped as a spectrum of symptoms under the heading FTD/AlS(Abramzon et al.,2020).Significantly,there is currently no cure for AlS or ***,recent mechanistic insight points to a novel pathway to target for potential therapeutic intervention.

关键词： therapeutic pathology

Updating of the hierarchical rock mass rating(HRMR) system and a new subsystem developed for weathered granite formations

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International Journal of Mining Science and Technology 2014年第6期24卷 769-775页

作者： miranda Tiago e Sousa l.Ribeiro Tinoco Joaquim ISISE University of Minho Guimar?es 4800-058 Portugal State Key laboratory of Geomechanics and Deep Underground Engineering China University of Mining & Technology University of Porto Porto 4200 Portugal

The RMR system is still very much applied in rock mechanics engineering context. It is based on the evaluation of six weights to obtain a final rating. To obtain the final rating a considerable amount of information is needed concerning the rock mass which can be difficult to obtain in some projects or project stages at least with accuracy. In 2007 an alternative classification scheme based on the RMR, the Hierarchical Rock Mass Rating(HRMR) was presented. The main feature of this system was the adaptation to the level of knowledge existent about the rock mass to obtain the classification of the rock mass since it followed a decision tree approach. However, the HRMR was only valid for hard rock granites with low fracturing degrees. In this work, the database was enlarged with approximately 40% more cases considering other types of granite rock masses including weathered granites and based on this increased database the system was updated. Granite formations existent in the north of Portugal including Porto city are predominantly granites. Some years ago a light rail infrastructure was built in the city of Porto and surrounding municipalities which involved considerable challenges due to the high heterogeneity levels of the granite formations and the difficulties involved in their geomechanical characterization. In this work it is intended to provide also a contribution to improve the characterization of these formations with special emphasis to the weathered horizons. A specific subsystem applicable to the weathered formations was developed. The results of the validation of these systems are presented and show acceptable performances in identifying the correct class using less information than with the RMR system.

关键词： Rock mass classification system Decision tree Weathered granite formations

Risk Models for the Prize Collecting Steiner Tree Problems with Interval Data

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Acta Mathematicae Applicatae Sinica 2014年第1期30卷 1-26页

作者： Eduardo lvarez-miranda Alfredo Candia-Vjar xu-jin CHEN Xiao-dong HU Bi lI Industrial Management Department Universidad de TalcaChile DEI University of BolognaItaly Academy of Mathematics and Systems Science CAS

Given a connected graph G=（V,E）with a nonnegative cost on each edge in E,a nonnegative prize at each vertex in V,and a target set V′V,the Prize Collecting Steiner Tree（PCST）problem is to find a tree T in G interconnecting all vertices of V′such that the total cost on edges in T minus the total prize at vertices in T is *** PCST problem appears frequently in practice of operations *** the problem is NP-hard in general,it is polynomial-time solvable when graphs G are restricted to series-parallel *** this paper,we study the PCST problem with interval costs and prizes,where edge e could be included in T by paying cost xe∈[c e,c＋e]while taking risk（c＋e xe）/（c＋e c e）of malfunction at e,and vertex v could be asked for giving a prize yv∈[p v,p＋v]for its inclusion in T while taking risk（yv p v）/（p＋v p v）of refusal by *** establish two risk models for the PCST problem with interval *** given budget upper bound on constructing tree T,one model aims at minimizing the maximum risk over edges and vertices in T and the other aims at minimizing the sum of risks over edges and vertices in *** propose strongly polynomial-time algorithms solving these problems on series-parallel graphs to *** study shows that the risk models proposed have advantages over the existing robust optimization model,which often yields NP-hard problems even if the original optimization problems are polynomial-time solvable.

关键词： uncertainty modeling prize collecting Steiner tree interval data series-parallel graphs polynomial-time solvability

Preparation of Co/S co-doped carbon catalysts for excellent methylene blue degradation

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 169-181页

作者： Haixu li Haobo He Tiannan Jiang Yunfei Du Zhichen Wu liang xu Xinjie Wang Xiaoguang liu Wanhua Yu Wendong xue School of Materials Science and Engineering University of Science and Technology BeijingBeijing 100083China Beijing Jinyu Tongda Refractory Technologies Co. Ltd.Beijing 100085China

S and Co co-doped carbon catalysts were prepared via pyrolysis of MOF-71 and thiourea mixtures at 800℃at a mass ratio of MOF-71 to thiourea of 1:0.1 to effectively activate peroxymonosulfate(PMS)for methylene blue(MB)*** effects of two different mixing routes were identified on the MB degradation ***,the catalyst obtained by the alcohol solvent evaporation(MOF-AEP)mixing route could degrade 95.60%MB(50 mg/l)within 4 min(degradation rate:K=0.78 min^(-1)),which was faster than that derived from the direct grinding method(MOF-DGP,80.97%,K=0.39 min^(-1)).X-ray photoelectron spectroscopy revealed that the Co-S content of MOF-AEP(43.39at%)was less than that of MOF-DGP(54.73at%),and the proportion of C-S-C in MOF-AEP(13.56at%)was higher than that of MOF-DGP(10.67at%).Density functional theory calculations revealed that the adsorption energy of Co for PMS was -2.94 eV when sulfur was doped as C-S-C on the carbon skeleton,which was higher than that when sulfur was doped next to cobalt in the form of Co-S bond(-2.86 eV).Thus,the C-S-C sites might provide more contributions to activate PMS compared with ***,the degradation parameters,including pH and MOF-AEP dosage,were ***,radical quenching experiments and electron paramagnetic resonance(EPR)measurements revealed that ^(1)O_(2)might be the primary catalytic species,whereas·O~(2-)might be the secondary one in degrading MB.

关键词： advanced oxidation process alcohol solvent evaporation hydrogen bond S and Co co-doped carbon catalysts wastewater remediation