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Management of gastroesophageal reflux disease: Patient and physician communication challenges and shared decision making

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World Journal of Clinical Cases 2018年第15期6卷 892-900页

作者： Scott Klenzak Igor Danelisen Grace D Brannan Melissa A Holland miranda al van tilburg Department of Psychiatry Cape Fear Valley Health System School of Osteopathic Medicine Campbell University College of Pharmacy and Health Sciences Campbell University Division of Gastroenterology and Hepatology School of Medicine University of North Carolina University of Washington

Gastroesophageal reflux disease(GERD) is a common upper esophageal condition and typical symptoms can include heartburn and sensation of regurgitation while atypical symptoms include chronic cough, asthma, hoarseness, dyspepsia and nausea. Typically, diag-nosis is presumptive given the presence of typical and atypical symptoms and is an indication for empiric therapy. Treatment management can include lifestyle modifications and/or medication therapy with proton pump inhibitor(PPI) class being the preferred and most effective. Complete symptom resolution is not always achieved and long-term PPI therapy can put patients at risk for serious side effects and needless expense. The brain-gut connection and hypervigilance plays an important role in symptom resolution and treatment success, especially in the case of non-PPI responders. Hypervigilance is a combination of increased esophageal sensory sensitivity in combination with exaggerated threat perception surrounding esophageal symptoms. Hypervigilance requires a different approach to GERD managements, where continued PPI therapy and surgery are usually not recommended. Rather, helping physicians and patients understand the brain-gut connection can guide and improve *** and reassurance should be the main pillars or treatment. However, it is important not to suggest the symptoms are due to anxiety alone, this often leads to patient dissatisfaction. Patient dissatisfaction with treatment reveals the need for a more patient-centered approach to GERD management and better communication between patients and providers. Shared decision making(SDM) with the incorporation of patient-reported outcomes(PRO) promotes patient adherence and satisfaction. SDM is a joint discussion between clinician and patient in which a mutually shared solution is explored for GERD symptoms. For SDM to work the physician needs to capture patients' perceptions which may not be obtained in the standard interview. This can be done through the

关键词： Gastroesophageal reflux disease Psychosocial Patient-physician communication Shared decision making Patient-reported outcomes Patient satisfaction

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Chronological age when health care transition skills are mastered in adolescents/young adults with inflammatory bowel disease

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World Journal of Gastroenterology 2017年第18期23卷 3349-3355页

作者： Natalie Stollon Yi Zhong Maria Ferris Suneet Bhansali Brian Pitts Eniko Rak Maureen Kelly Sandra Kim miranda al van tilburg School of Social Work University of Washington Department of Economics University of North Carolina Department of Pediatrics University of North CarolinaSchool of Medicine Department of Pediatrics NYU School of Medicine Department of allied Health Sciences University of North CarolinaSchool of Medicine Department of Pediatrics Children's Hospital of Pittsburgh Department of Clinical Research Campbell UniversityCollege of Pharmacy and Health Sciences Department of Gastroenterology and Hepatology the University of North CarolinaSchool of Medicine

To describe the longitudinal course of acquisition of healthcare transition skills among adolescents and young adults with inflammatory bowel *** recruited adolescents and young adults (AYA) with inflammatory bowel diseases (IBD), from the pediatric IBD clinic at the University of North Carolina. Participants completed the TRxANSITION Scale™ at least once during the study period (2006-2015). We used the electronic medical record to extract participants’ clinical and demographic data. We used ordinary least square regressions with robust standard error clustered at patient level to explore the variations in the levels and growths of healthcare transition *** sample (n = 144) ranged in age from 14-22 years. Age was significantly and positively associated with both the level and growth of TRxANSITION Scale™ scores (P althcare transition (HCT) skills were acquired between ages 12 and 14 years, but others were not mastered until after age 18, including self-management *** is one of the first studies to describe the longitudinal course of HCT skill acquisition among AYA with IBD, providing benchmarks for evaluating transition interventions.

关键词： Inflammatory bowel disease Crohn’s disease Ulcerative colitis Pediatrics Healthcare transition

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Psychosocial mechanisms for the transmission of somatic symptoms from parents to children

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World Journal of Gastroenterology 2015年第18期21卷 5532-5541页

作者： miranda al van tilburg Rona L Levy Lynn S Walker Michael Von Korff Lauren D Feld Michelle Garner Andrew D Feld William E Whitehead Center for Functional GI and Motility Disorders University of North Carolina School of Social Work University of Washington Department of Pediatrics Vanderbilt University School of Medicine Nashville TN 37201 United States Group Health Research Institute Mount Sinai School of Medicine Department of Social Work University of Washington Tacoma Group Health Cooperative

AIM: To examine familial aggregation of irritable bowel syndrome(IBS) via parental reinforcement/modeling of symptoms, coping, psychological distress, and exposure to ***:Mothers of children between the ages of8 and 15 years with and without IBS were identified through the Group Health Cooperative of Puget *** completed questionnaires,including the Child Behavior Checklist(child psychological distress),the Family Inventory of Life Events(family exposure to stress),SCL-90R(mother psychological distress),and the Pain Response Inventory(beliefs about pain).Children were interviewed separately from their parents and completed the Pain Beliefs Questionnaire(beliefs about pain),Pain Response Inventory(coping)and Child Symptom Checklist[gastrointestinal(GI)symptoms].In addition,health care utilization data was obtained from the automated database of Group Health *** with IBS(n=207)and their 296 children were compared to 240 control mothers and their 335 children,while controlling for age and ***:Hypothesis 1:reinforcement of expression of GI problems is only related to GI symptoms,but not others(cold symptoms)in *** was no significant correlation between parental reinforcement of symptoms and child expression of GI or other *** 2:modeling of GI symptomsis related to GI but not non-GI symptom reporting in *** of parents with IBS reported more non-GI(8.97 vs 6.70,Palth care visits made by the mother correlated with visits made by the child(rho=0.35,Pales showed weak but significant correlations(stoicism rho=0.13,P<0.05;acceptance rho=0.13,P<0.05).Hypothesis 4:mothers and chi

关键词： Abdominal pain Coping Illness behaviors Psychological distress Social learning Stress

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Scavenger receptor BI: A multi-purpose player in cholesterol and steroid metabolism

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World Journal of Gastroenterology 2010年第47期16卷 591-5924页

作者： Menno Hoekstra Theo JC van Berkel miranda van Eck Division of Biopharmaceutics Leiden/Amsterdam Center for Drug Research Gorlaeus Laboratories

Scavenger receptor class B type Ⅰ (SR-BI) is an important member of the scavenger receptor family of integral membrane glycoproteins. This review highlights studies in SR-BI knockout mice, which concern the role of SR-BI in cholesterol and steroid metabolism. SR-BI in hepatocytes is the sole molecule involved in selective uptake of cholesteryl esters from high-density lipoprotein (HDL). SR-BI plays a physiological role in binding and uptake of native apolipoprotein B (apoB)-containing lipoproteins by hepatocytes, which identif ies SR-BI as a multipurpose player in lipid uptake from the blood circulation into hepatocytes in mice. In adrenocortical cells, SR-BI mediates the selective uptake of HDL-cholesteryl esters, which is eff iciently coupled to the synthesis of glucocorticoids (i.e. corticosterone). SR-BI knockout mice suffer from adrenal glucocorticoid insuff iciency, which suggests that functional SR-BI protein is necessary for optimal adrenal steroidogenesis in mice. SR-BI in macrophages plays a dual role in cholesterol metabolism as it is able to take up cholesterol associated with HDL and apoBcontaining lipoproteins and can possibly facilitate cholesterol efflux to HDL. Absence of SR-BI is associated with thrombocytopenia and altered thrombosis susceptibility, which suggests a novel role for SR-BI in regulating platelet number and function in mice. Transgenic expression of cholesteryl ester transfer protein in humanized SR-BI knockout mice normalizes hepatic delivery of HDL-cholesteryl esters. However, other pathologies associated with SR-BI def iciency, i.e. increased atherosclerosis susceptibility, adrenal glucocorticoid insuffi ciency, and impaired platelet function are not normalized, which suggests an important role for SR-BI in cholesterol and steroid metabolism in man. In conclusion, generation of SR-BI knockout mice has signif icantly contributed to our knowledge of the physiological role of SR-BI. Studies using these mice have identif ied SR-BI as a

关键词： Scavenger receptor class B type Ⅰ Highdensity lipoprotein Cholesterol Lipoprotein metabolism Liver Macrophages Adrenal gland Platelets Steroido- genesis

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CD4^(+)T cells produce IFN-I to license cDC1s for induction of cytotoxic T-cell activity in human tumors

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Cellular & Molecular Immunology 2024年第4期21卷 374-392页

作者： Xin Lei Daniël C.de Groot Marij J.P.Welters Tom de Wit Ellen Schrama Hans van Eenennaam Saskia J.Santegoets Timo Oosenbrug Annemarthe van der Veen Joris L.Vos Charlotte L.Zuur Noel F.C.C.de miranda Heinz Jacobs Sjoerd H.van der Burg Jannie Borst Yanling Xiao Department of Immunology Leiden University Medical CenterLeidenThe Netherlands Oncode Institute Leiden University Medical CenterLeidenThe Netherlands Department of Tumor Biology and Immunology The Netherlands Cancer InstituteAmsterdamThe Netherlands Department of Medical Oncology Oncode InstituteLeiden University Medical CenterLeidenThe Netherlands IMMIOS B.V. OssThe Netherlands Division of Medical Oncology The Netherlands Cancer InstituteAmsterdamThe Netherlands Department of Otorhinolaryngology Leiden University Medical Center LeidenThe Netherlands Department of Pathology Leiden University Medical CenterLeidenThe Netherlands

CD4^(+)T cells can"help"or"license" conventional type 1 dendritic cells(cDC1s)to induce CD8^(+)cytotoxic T lymphocyte(CTL)anticancer responses,as proven in mouse *** recently identified cDC1s with a transcriptomic imprint of CD4^(+)T-cell help,specifically in T-cell-infiltrated human cancers,and these cells were associated with a good prognosis and response to PD-1-targeting ***,we delineate the mechanism of cDC1 licensing by CD4^(+)T cells in *** CD4^(+)T cells produce IFNβvia the STING pathway,which promotes MHC-I antigen(cross-)presentation by cDC1s and thereby improves their ability to induce CTL anticancer *** cooperation with CD40 ligand(L),IFNβalso optimizes the costimulatory and other functions of cDC1s required for CTL response ***-I-producing CD4^(+)T cells are present in diverse T-cell-infiltrated cancers and likely deliver“help”signals to CTLs locally,according to their transcriptomic profile and colocalization with“helped/licensed”cDCs and tumor-reactive CD8^(+)T *** agreement with this scenario,the presence of IFN-I-producing CD4^(+)T cells in the TME is associated with overall survival and the response to PD-1 checkpoint blockade in cancer patients.

关键词： CD4^(+)T-cell help cDC1 licensing IFN-I signaling CD40 costimulation (cross-)presentation CTL priming Tumor control

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儿童功能性胃肠病罗马Ⅳ标准

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中华儿科杂志 2017年第1期55卷 4-14页

作者： Marc A. Benninga Samuel Nurko Christophe Faure Paul E. Hyman Ian St. James Roberts Neil L. Schechter Jeffrey S. Hyams Carlo Di Lorenzo Miguel Saps Robert J. Shulman Annamaria Staiano miranda van tilburg Pediatric Gastroenterology Emma Children's HospitalAcademic Medical CenterAmsterdamThe Netherlands Center for Motility and Functional Gastrointestinal Disorders Boston Children' s HospitalBostonMassachusetts Pediatric Gastroenterology Sainte-Justine HospitalMontrealQuebecCanada Pediatric Gastroenterology Children' s HospitalNew OrleansLouisiana Thomas Coram Research Unit University College London Institute of EducationUniversity College LondonLondonUK Pediatric Pain Center Boston Children' s HospitalBostonMassachusetts Division of Digestive Diseases Hepatologyand NutritionConnecticut Children's Medical CenterHartfordConnecticut Division of Digestive Diseases Hepatologyand NutritionNationwide Children' s HospitalColumbus Ohio Baylor College ofMedicine Children's Nutrition Research CenterTexas Children's HospitalHoustonTexas Department ofTranslational Science Section of PediatricsUniversity of NaplesFederico IINaplesItaly Department of Gastroenterology and Hepatology University of North Carolina at ChapelHillChapel HillNorth Carolina

罗马标准是目前关于功能性胃肠病（ FGID）分类最全面且不断更新的标准。罗马Ⅰ、Ⅱ标准分别于1994年、1999年发布。罗马Ⅱ标准开始单列儿童FGID分类。2006年，根据年龄不同，婴幼儿（0-36个月）和儿童（〉36个月） FGID的罗马Ⅲ诊断标... 详细信息

罗马标准是目前关于功能性胃肠病（ FGID）分类最全面且不断更新的标准。罗马Ⅰ、Ⅱ标准分别于1994年、1999年发布。罗马Ⅱ标准开始单列儿童FGID分类。2006年，根据年龄不同，婴幼儿（0-36个月）和儿童（〉36个月） FGID的罗马Ⅲ诊断标准发布，但相关的流行病学、病理生理学、诊断检查、治疗策略以及预后等资料都很少。

关键词：功能性胃肠病罗马标准儿童 FGID 罗马Ⅱ标准病理生理学诊断标准流行病学

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Leukocyte ABC-transporter A1 and LDL receptor play independent roles in atherosclerosis:the potential contribution of T cells

Leukocyte ABC-transporter A1 and LDL receptor play independe...

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第九届全国免疫学学术大会

作者： Ying Zhao Jun Wang Laura Calpe-Berdiel Amanda C.Foks Bart Lammers Johan Kuiper Theo J.C.van Berkel miranda van Eck Department of Pathology and Pathophysiology Soochow University Division of Biopharmaceutics Leiden/Amsterdam Center for Drug ResearchLeiden University Institute of Biology and Medical Sciences Soochow University

Background:LDL receptor(LDLr)and ABC-transporter A1(ABCA1)are two distinct players in cellular cholesterol *** recognizes apoprotein B100 and apoE in lipoproteins to mediate the uptake of cholesterol,while ABCA1 promotes excess cholesterol efttux to apoprotein ***:The present study aims to investigate whether LDLr deficiency influences the atheroprotective effects of leukocyte ABCA1 in *** and Results:LDLr-/-mice were transplanted with bone marrow from LDLr/ABCA1mice,LDLr/ABCA1/-mice,and their respective *** leukocyte ABCA1 deficiency reduced plasma cholesterol levels,after 8weeks of Western-type diet feeding,animals transplanted with LDLr/ABCA1and LDLr/ABCA1bone marrow developed 1.6-fold(palysis also demonstrated that deletion of the leukocyte LDLr reduced lesion development(pally in the absence of leukocyte ***,leukocyte LDLr deficiency did not affect monocytosis,recruitment of moncocytes and macrophage foam cell ***,the deletion of leukocyte ABCA1 did reduce lymphocytosis and recruitment of T cells into the adventitia of lesions,associated with smaller lesion size in LDLr/ABCA1transplanted mice,indicating the potential contribution of lymphocytosis and recruitment ofT cells to ***:Leukocyte LDLr deficiency does not affect the atheroprotective effects of leukocyte ***,suppression of lymphocytosis and recruitment of T cells in the adventitia could contribute to the atheroprotection of Leukocyte LDLr deficiency and ABCA1.

关键词： LDL receptor ABCA1 lymphocytosis T lymphocytes atherosclerosis

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Leukocyte ABCA1 is atheroprotective in absence of ApoAI

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中国病理生理杂志 2012年第11期 2009-2009页

作者： Laura CalPE-BERDIEL Josep JULVE Joan Carles ESCOL-GIL Amanda FOKS Ronald J.van DER SLUIS Johan KUIPER Francisco BLANCO-VACA Theo J.C.van BERKEL Jan-albert KUIVENHOVEN miranda van ECK Department of Pathophysiology School of Biology and Basic Medical SciencesSoochow UniversitySuzhou 215123China IIB Sant Pau and CIBER de Diabetes y Enfermedades Metabólicas Asociadas CIBERDEMBarcelonaSpain 3. Division of BiopharmaceuticsLeiden/Amsterdam Center for Drug ResearchGorlaeus LaboratoriesLeiden UniversityLeidenNetherlands Departament de Bioquímicali Biologia Molecular Universitat Autònoma de BarcelonaBarcelonaSpain Department of Vascular Medicine Academic Medical CenterUniversity of AmsterdamAmsterdamNetherlands

AIM:ABC-transporter A1(ABCA1)facilitates cellular cholesterol efflux to lipid-free/poor apolipoproteins,including apolipoprotein AI(ApoAI).The aim of the present study was to investigate the importance of ApoAI for AB... 详细信息

关键词： Leukocyte ABCA1 is atheroprotective in absence of ApoAI

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Leukocyte ABC-transporter A1 and LDL Receptor Play Independent Roles in Atherosclerosis： the Potential Contribution of T Cells

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中国动脉硬化杂志 2013年第9期21卷 I0075-I0075页

作者： Ying Zhao Jun Wang Laura Calpe-Berdiel Amanda C. Foks Bart Lammers Johan Kuiper Theo J.C. van Berkel miranda van Eck Department of Pathology and Pathophysiology Soochow University Suzhou Jiangsu 215123 China Division of Biopharmaeeutics leiden~Amsterdam Center for Drug Research leiden University leiden 2333 CCThe Netherlands Institute of Biology and Medical Sciences Soochow University Suzhou Jiangsu 215123 China

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Adequate Diagnostic Performance of Combined [¹⁸F]-Fluormethylcholine PET-CT with Diffusion-Weighted MRI in Primary Staging of High Risk Prostate Cancer

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Advances in Molecular Imaging 2016年第1期6卷 1-9页

作者： Pieter L. Jager R. Jorn Beukinga Tjard D. de Haan Martijn F Boomsma Ben E. Laddé miranda van t Veer-ten Kate Ad H. J. Oostdijk Martijn G. Steffens Department of Nuclear Medicine Zwolle Netherlands Department of Urology Zwolle Netherlands Department of Radiology Zwolle Netherlands Department of Pathology Zwolle Netherlands

Introduction: [18F]-fluoro-methylcholine (FCH) PET/CT and MRI with diffusion-weighted MRI (DW-MRI) have insufficient performance in lymph node staging of primary prostate cancer by themselves, but the combination may perform better. We aim to prospectively determine the diagnostic performance of combined FCH PET and MRI for lymph node staging. Methods: This was a single site study of diagnostic accuracy in a well-defined group of 21 consecutive high-risk primary prostate cancer patients (>30% chance of lymph node metastases) in a large community hospital. We performed FCH PET/CT and MRI with DW-MRI prior to endoscopic extended pelvic lymph node dissection (EPLND). PET was fused and interpreted together with various MRI image sets (T1, T2, DWIBS) and was only scored positive when a lymph node seen on MRI coincided with increased focal FCH uptake on PET. Findings were compared with detailed histological evaluation, on a per-patient and per-region level. We calculated sensitivity, specificity, positive and negative predictive value of combined PET-MRI. Results: 14 out of 21 patients had metastatic lymph nodes with 37 out of 164 evaluable regions harboring metastases. On a per-patient analysis, PET-MRI had a sensitivity/specificity of 79/100% with a PPV/NPV of 100/77%. On a per-region analysis (n = 164) these figure were 65/99% and 96/91%, respectively. Conclusions: Combined DW-MRI and FCH PET/CT has a very high positive predictive value in high risk prostate cancer patients. If confirmed in larger series a positive combined scan may safely allow cancellation of surgical staging in selected patients, depending on local protocols in N1 M0 patients.

关键词： Positron Emission Tomography Diffusion-Weighted Imaging Fluor-Methyl-Choline Prostate Cancer Primary Staging

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