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MicroRNA-142-3p and microRNA-142-5p are downregulated in hepatocellular carcinoma and exhibit synergistic effects on cell motility

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Frontiers of Medicine 2015年第3期9卷 331-343页

作者： Felice Ho-Ching tsang Sandy Leung-Kuen Au Lai Wei Dorothy Ngo-Yin Fan Joyce man-Fong Lee Carmen Chak-Lui Wong Irene Oi-Lin Ng Chun-Ming Wong State Key Laboratory for Liver Research and Department of Pathology Li Ka Shing Faculty of Medicine The University of Hong Kong HongKong SAR China

MicroRNAs （mirNAs）, an important class of small non-coding RNAs, regulate gene expression at the post-transcriptional level, mirNAs are involved in a wide range of biological processes and implicated in different diseases, including cancers. In this study, mirNA profiling and qRT-PCR validation revealed that mir-142-3p and mir-142-5p were significantly downregulated in hepatocellular carcinoma （HCC） and their expression levels decreased as the disease progressed. The ectopic expression of mir-142 significantly reduced HCC cell migration and invasion. Overexpression of either mir-142-3p or mir-142-5p suppressed HCC cell migration, and overexpression of both synergistically inhibited cell migration, which indicated that mir-142-3p and mir-142-5p may cooperatively regulate cell movement, mir-142-3p and mir-142-5p, which are mature mirNAs derived from the 3＇- and 5＇-strands of the precursor mir-142, target distinct pools of genes because of their different seed sequences. Pathway enrichment analysis showed a strong association of the putative gene targets of mir-142-3p and mir-142-5p with several cell motility-associated pathways, including those regulating actin cytoskeleton, adherens junctions, and focal adhesion. Importantly, a number of the putative gene targets were also significantly upregulated in human HCC cells. Moreover, overexpression of mir-142 significantly abrogated stress fiber formation in HCC cells and led to cell shrinkage. This study shows that mature mir-142 pairs collaboratively regulate different components of distinct signaling cascades and therefore affects the motility of HCC cells.

关键词： hepatocellular carcinoma microRNA metastasis cytoskeletal reorganization

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High-Q germanium optical nanocavity

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Photonics Research 2018年第9期6卷 925-928页

作者： TING-HUI XIAO ZIQIANG ZHAO WEN ZHOU MITSURU TAKENAKA HON Ki tsang ZHENZHOU CHENG KEISUKE GODA Department of Chemistry The University of TokyoTokyo 113-0033Japan Department of Electrical Engineering and Information Systems The University of TokyoTokyo 113-0033Japan Department of Electronic Engineering The Chinese University of Hong KongShatinHong Kong SARChina Department of Electrical Engineering University of CaliforniaLos AngelesCalifornia 90095USA

Mid-infrared(mir) integrated photonics has attracted broad interest due to its promising applications in biochemical sensing, environmental monitoring, disease diagnosis, and optical communication. Among mir integration platforms, germanium-based platforms hold many excellent properties, such as wide transparency windows, high refractive indices, and high nonlinear coefficients; however, the development of mir germanium photonic devices is still in its infancy. Specifically, mir high-Q germanium resonators with comparable performance to their silicon counterparts remain unprecedented. Here we experimentally demonstrate an mir germanium nanocavity with a Q factor of ~18,000, the highest-to-date of reported nanocavities across mir germanium-based integration platforms. This is achieved through a combination of a feasible theoretical design,Smart-Cut methods for wafer development, and optimized device fabrication processes. Our nanocavity, with its high Q factor and ultrasmall mode volume, opens new avenues for on-chip applications in the mir spectral range.

关键词：薄膜热光性能通讯技术发展现状

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