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A Preliminary Study on Combination Therapy of Artemisinin Dimer Oxime and Topotecan against Nonsmall Cell Lung Cancer in Mice

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World Journal of Traditional Chinese Medicine 2018年第1期4卷 8-14页

作者： Mohammad K.Ashfaq Mohamed Sadek Abdel-Bakky mir tahir maqbool Waseem Gul Mahmoud A.ElSohly National Center for Natural Product Research School of Pharmacy University of Mississippi University Faculty of Pharmacy Al-Azhar University ElSohly Laboratory Incorporation Industrial Drive Oxford Department of Pharmaceutics School of PharmacyUniversity of Mississippi University

Background: Artemisinin dimer oxime – dimer molecule synthesized from artemisinin possesses high bioavailability and marked in vitro anticancer activities against solid tumor?derived cell lines, endothelial cell proliferation, migration, and angiogenic processes. Numerous murine models have been developed to study human cancer. The most widely used models are the human tumor xenograft mouse model. Materials and Methods: In this study, human tumor cells(NCI?H640, 1 × 107 in 100 μL) are implanted subcutaneously, or 1 × 107 in 50 μL in the thoracic cavity, in athymic nude mice(nu/nu). The implanted cells were allowed to grow for 10 days before initiation of drug treatment(dimer oxime and topotecan, ip). Tumor volume and thoracic/body weight ratio were recorded. Results: We successfully established subcutaneous and thoracic xenografts with human nonsmall cell lung cancer cell line xenografts in athymic nude mice in only 10 days. Using these models, we attempted treatment of xenografts with topotecan – a known anticancer drug and artemisinin dimer oxime or combination of these two drugs. Combination therapy showed a significant reduction in tumor volume and tumor/body weight. Treatments with combination of topotecan and dimer oxime resulted in the reduced mortality rates in comparison with untreated mice. Conclusions: Xenograft tumor models are useful for preclinical screening of new pharmacophores. From this preliminary study, it appears that combination of dimer oxime and topotecan may be used as chemotherapeutic agents against nonsmall cell lung cancer. Further studies are needed to evaluate other combination treatment regimens as well as the mechanism(s) of action.

关键词： Artemisinin cancer dimer oxime topotecan xenografts

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Study of pure and semileptonic decays of D_s meson within R-parity violating supersymmetric model

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Chinese Physics C 2014年第12期38卷 1-10页

作者： Farida tahir Azeem mir Shakeel Mahmood COMSATS Institutte of Information Technology Physics Department Islamabad Pakistan COMSATS Institutte of Information Technology Physics Department Lahore Pakistan

We present the comaprative study of semileptonic and leptonic decays of Ds, D±and D0meson（D →M l＋-αl-β, D → l＋αlβ, D → l＋αvα;α,β=e,μ） within the framework of R-parity violating the（ Rp） Minimal Supersymmetric Standard Model（MSSM）. The comparison shows that combination and product couplings,（λβiα λ＊ ij qor λβqkλ＊αj k）contribution to the branching fractions of the said processes（under consideration） is consistent with or comparable to the experimental measurements in most of the cases. However, some cases exist where these contributions are highly suppressed. We identify such cases in our analysis and single out the important ones suitable for exploring in the future and current experiments.

关键词： supersymmtery R-parity violating MSSM leptonic decays pseudo-scalar meson

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Vaccination Approach Toward Monkeypox: An Urgent Call

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Infectious Diseases & Immunity 2023年第1期3卷 1-2页

作者： Minahil Binte Saleem Somina Shaikh Sadia tahir Syeda Lamiya mir Govinda Khatri Department of Internal Medicine Dow University of Health ScienceKarachiPakistan Karachi Medical and Dental College KarachiPakistan.

*** Following the global COVID-19 emergency,another public health emergency was declared by the World Health Organization on July 23,2022:“monkeypox.”Monkeypox virus(MPXV)belongs to the Poxviridae family and causes monkeypox,a disease clinically similar to smallpox.[1,2]Monkeypox was discovered in 1958 after two outbreaks of poxlike disease in research colonies of *** first known human infection was in 1970 in a newborn in the Democratic Republic of Congo.[3]Monkeypox began to reemerge in 2022,and the evolution of the outbreak is worrisome,as it does not seem that the pandemic,which has affected large numbers of people worldwide,is slowing down *** reported more than 57,000 cases and approximately 22 deaths on September 13.[4]Animal-to-human and human-to-human transmissions are two possible routes of transmission for *** to the clinicians,intimate sexual contact was the suspected route of transmission for the MPXV in 95% of *** or bisexual men,as well as other men who have sex with men,have been particularly hard hit by the current *** with smallpox,symptoms are similar but less severe and include pustular skin lesions,fever,headache,myalgia,and *** rash usually begins on the lips and spreads to the face and then to the limbs in a circular pattern.

关键词： belongs monkey circular

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Comparative assessment of clinical profile and outcomes after primary percutaneous coronary intervention in young patients with single vs multivessel disease

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World Journal of Cardiology 2020年第4期12卷 136-143页

作者： Atif Sher Muhammad Tariq Ashraf Ayaz mir Syed Alishan Faiza Farooq Ali Ammar Musa Karim Syed Nadeem Hassan Rizvi tahir Saghir Jawaid Akbar Sial Naveed Ullah Khan Department of Adult Cardiology National Institute of Cardiovascular DiseasesKarachi 75510Pakistan Department of Clinical Research National Institute of Cardiovascular DiseasesKarachi 75510Pakistan

BACKGROUND Even though percutaneous coronary intervention(PCI)improved the survival of patients with acute myocardial infarction,still multivessel coronary artery disease remains an important factor burdening prognosis and it is being associated with a worse prognosis compared to single-vessel disease(SVD).AIM To compare the clinical profile and outcomes after the primary PCI in young patients with SVD vs multivessel disease(MVD).METHODS The retrospective cohort of patients were divided into two groups:SVD and MVD *** study population consisted of both male and female young(≤45 years)patients presented with ST-elevation myocardial infarction(STEMI)at the National Institute of Cardiovascular Disease,Karachi,Pakistan and undergone primary PCI from 1 st July 2017 to 31 st March *** and postprocedure management of the patients was as per the guidelines and institutional *** A total of 571 patients with STEMI,≤45 years were stratified into two groups by the number of vessels involved,342(59.9%)with SVD and 229(40.1%)with *** average age of these patients was 39.04±4.86 years.A lower prevalence of hypertension and diabetes was observed in SVD as compare to MVD group(25.1%vs 38%,P<0.01;11.7%vs 27.5%,P<0.001)***,smoking was more prevalent among the SVD group as compare to MVD group(36.3%vs 28.4%,P=0.05).The high-C Lesion was observed in a significantly higher number of younger patients with MVD as compared to SVD group(48.8%vs 39.2%,P=0.021).Post-procedure thrombolysis in myocardial infarction flow grade was found to be not associated with the number of diseased vessels with a P value of 0.426 and thrombolysis in myocardial infarction flow grade III was observed in 98%vs 96.5%of the patients is SVD vs MVD *** The MVD comprised of around 40%of the young patients presented with ***,this study shows that diabetes and hypertension have a certain role in the pathogenesis of multivessel diseases,therefore,preventive

关键词： Young Multivessel disease Primary percutaneous coronary intervention STelevation myocardial infarction Premature coronary artery diseases Single-vessel disease

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Pattern of rubber bullet injuries in the lower limbs： A report from Kashmir

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Chinese Journal of Traumatology 2016年第3期19卷 129-133页

作者： Shabir Ahmed Dhar tahir Ahmed Dar Sharief Ahmed Wani Saheel Maajid Jawed Ahmed Bhat Naseer Ahmed mir Imtiyaz Hussain Dar Shahid Hussain Department of Orthopaedics SKIMS Medical College/Haspital Bemina Srinagar 190001 Kashmir India Directorate of Health Services Srinagar 190001 Kashmir India Government Hospital for Bone and Joint Surgery Barzulla. Srinogar 190001 Kashmir India

Purpose： Rubber bullets are considered a non-lethal method of crowd control and are being used over the world. However the literature regarding the pattern and management of these injuries is scarce for the forensic pathologist as well as for the traumatologist. The objective of this report was to add our experience to the existing literature. Methods： From June 2008 to August 2010 the Government Hospital for Bone and Joint Surgery Barzulla and the Department of Orthopaedics, SKIMS Medical College/Hospital Bemina Srinagar received 28 patients for management of their orthopaedic injuries caused by rubber bullets. We documented all injuries and also recorded the management issues and complications that we encountered. Results： All patients were males with an age range of 11-32 years and were civilians who had been hit by rubber bullets fired by the police and the paramilitary forces. Among them, 19 patients had injuries of the lower limbs and 9 patients had injuries of the upper limbs. All patients were received within 6 h of being shot. Conclusion： Our findings suggest that these weapons are capable of causing significant injuries including fractures and it is important for the surgeon to be well versed with the management of such injuries especially in areas of unrest, The report is also supportive of the opinion that these weapons are lethal and should hence be reclassified_

关键词： Rubber bulletNon-lethalCrowd control

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