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The role of glutamine in supporting gut health and neuropsychiatric factors

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Food Science and Human Wellness 2021年第2期10卷 149-154页

作者： Brett J.Deters mir saleem Halmos College of Natural Sciences and Oceanography NOVA Southeastern UniversityFort LauderdaleFL 33314 USA

Recent research has shown that the amino acid glutamine can positively affect gut health by supporting the gut microbiome,gut mucosal wall integrity,and by modulating infiammatory *** modulated by the vagus nerve,via the enteric nervous system,the gut-brain connection can impact the brain’s neurochemical *** gut health can disrupt the balance of neurotransmitters,which can result in neuropsychiatric based conditions such as *** supplementation may provide significant adjunctive nutritional support in cases of depression by promoting proper gut health and function.

关键词： Glutamine Gut Neuropsychiatry Enteric nervous system Neurotransmitters Microbiome

The importance of preventative medicine in conjunction with modern day genetic studies

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Genes & Diseases 2018年第2期5卷 107-111页

作者： Sierra Sandler Lauren Alfino mir saleem NOVA Southeastern University United States

Genetic screening in the primary care setting is the future of preventative *** testing is an important medical tool for assessing various inheritable diseases,conditions,and *** ability to diagnose patients before symptoms surface can help lessen the severity of symptoms and promote quality of ***,genetic screening can cause psychological distress from the knowledge of test results,in some cases only serving to increase the risk of developing a condition due to *** testing can be conducted anytime in life,even before *** this review,a compilation of genetic testing’s definitions and boundaries,factors influencing an individual’s test outcomes,and an overview of a wide variety of diseases,conditions and cancers were collected.

关键词： Cancer screening DNA testing Genetic abnormalities Genetic analysis Gene mutation Hereditary disorders Prevention of genetic diseases Primary care

巴基斯坦穆扎法拉巴德市Pattika公园鸟类多样性

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Zoological Research 2007年第6期28卷 634-639页

作者： Muhammad Naeem Awan mir Mohammad saleem Department of Wildlife Azad Jammu and Kashmir Muzaffarabad Azad Kashmir Pakistan

2006年6月-2007年5月年对位于巴基斯坦自由克什米尔省穆扎法拉巴德市帕蒂卡（Pattika）休闲公园（EW：73°34′，纬度：NS：34°27′）内的栖息鸟类进行了调查，共有73种，分属10目35科。其中雀型目占73．55％，非雀型目占45％。其分布... 详细信息

2006年6月-2007年5月年对位于巴基斯坦自由克什米尔省穆扎法拉巴德市帕蒂卡（Pattika）休闲公园（EW：73°34′，纬度：NS：34°27′）内的栖息鸟类进行了调查，共有73种，分属10目35科。其中雀型目占73．55％，非雀型目占45％。其分布的多寡随该地区的季节而变化。大量物种出现在迁移繁殖的雨季。该公园处于人口密集之郊外，其间家畜的放养、灌木的砍伐及生境的干扰等人为因素都会对鸟类的分布和数量造成影响。

关键词：鸟类区系 Pattika休闲公园穆扎法拉巴德巴基斯坦

Is intra-operative cholangiography necessary during laparoscopic cholecystectomy? A multicentre rural experience from a developing world country

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World Journal of Gastroenterology 2007年第33期13卷 4493-4497页

作者： Iqbal saleem mir mir Mohsin Omar Kirmani Tafazul Majid Khurshid Wani Mehmood-ul Hassan Javed Naqshbandi Mohammed Maqbool Minimal Access Surgery Unit Government Gousia Hospital Khanyar Kashmir 190010 India Department of Radiology Government Gousia Hospital Khanyar Kashmir 190010 India Anaesthesia Unit Government Gousia Hospital Khanyar Kashmir 190010 India

AIM: To evaluate the feasibility and safety of performing laparoscopic cholecystectomy (LC) in nonteaching rural hospitals of a developing country without intra-operative cholangiography (IOC). To evaluate the possibility of reduction of costs and hospital stay for patients undergoing ***: A prospective analysis of patients with symptomatic benign diseases of gall bladder undergoing LC in three non-teaching rural hospitals of Kashmir Valley from Jan 2001 to Jan 2007. The cohort represented a sample of patients requiring LC, aged 13 to 78 (mean 47.2) years. Main outcome parameters included mortality, complications, re-operation, conversion to open procedure without resorting to IOC, reduction in costs borne by the hospital, and the duration of hospital ***: Twelve hundred and sixty-seven patients (976 females/291 males) underwent laparoscopic cholecystectomy. Twenty-three cases were converted to open procedures; 12 patients developed port site infection, nobody died because of the procedure. One patient had common bile duct (CBD) injury, 4 patients had biliary leak, and 4 patients had subcutaneous emphysema. One cholecystohepatic duct was detected and managed intraoperatively, 1 patient had retained CBD stones, while 1 patient had retained cystic duct stones. Incidental gallbladder malignancy was detected in 2 cases. No long-term complications were detected up to ***: LC can be performed safely even in non-teaching rural hospitals of a developing country provided proper equipment is available and the surgeons and other team members are well trained in the procedure. It is stressed that IOC is not essential to prevent biliary tract injuries and missed CBD stones. The costs to the patient and the hospital can be minimized by using reusable instruments, intracorporeal sutures, and condoms instead of titanium clips and endobags.

关键词：胆管造影术外科手术治疗方法诊断

An Experience of Short-Term Results of Laparoscopic Inguinal Hernioplasty Using 3D Mesh in a Developing Country

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International Journal of Clinical Medicine 2015年第1期6卷 64-69页

作者： Iqbal saleem mir Alfer Ah Nafae Aijaz Ahmed Malyar Muntakhab Nafae Yawar Watali Mudasir Farooq Shahnawaz Bashir Bhat Sheikh Viqar The Post-Graduate Department of Surgery Govt Medical College Srinagar India

Background: The experience of short term results of laparoscopic inguinal hernia repair using 3D mesh in a developing country is reviewed. Methods: From January 2012 to February 2014, 53 patients underwent laparoscopic inguinal hernioplasty. A retrospective case series of 53 consecutive patients undergoing TEP/TAPP by a single surgical team was followed prospectively with a focused physical examination and interview. 4 out of 53 patients had recurrent hernia following open repairs and 49 had primary hernias. Data collected included operative time, intraoperative bleeding, intraoperative difficulties, immediate postoperative pain, chronic groin pain, recurrence, sensory disturbance, activity or occupational limitation and personal satisfaction. Results: All the patients were male aged 32 to 75 years with a mean age of 53.5 years. Mean operative time was 37.4 minutes;intraoperative dissection, blood loss were less;and immediate postoperative pain was negligible as assessed by VAS. There was no mortality or major morbidity. Mean follow-up was 12 months (2 to 18 months). Follow-up was completed by interview and physical examination. Hernia was not found to recur during the follow up period. Chronic pain occurred in 2 patients (3.7%), which was mild in nature. Ninety-seven percent of patients were satisfied with their repair and would or had recommended TEP/TAPP to others using 3D Mesh. Conclusions: Short-term results of TEP/TAPP hernia repair using 3D mesh demonstrated to be an effective and safe procedure with low prevalence of chronic pain that is generally of a mild, infrequent nature. It was also concurred that there is decrease in operative time. Manipulation of mesh was significantly reduced. Intraoperative bleeding and use of post operative analgesia was reduced considerably. There was no recurrence, however the cost of the mesh increased the overall cost of the procedure acting as a limiting factor in a developing country.

关键词： Inguinal Hernia 3D Prolene Mesh Totally Extra-Peritoneally (TEP) Trans-Abdominal Pre-Peritoneal (TAPP)

Vaccination Approach Toward Monkeypox: An Urgent Call

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Infectious Diseases & Immunity 2023年第1期3卷 1-2页

作者： Minahil Binte saleem Somina Shaikh Sadia Tahir Syeda Lamiya mir Govinda Khatri Department of Internal Medicine Dow University of Health ScienceKarachiPakistan Karachi Medical and Dental College KarachiPakistan.

*** Following the global COVID-19 emergency,another public health emergency was declared by the World Health Organization on July 23,2022:“monkeypox.”Monkeypox virus(MPXV)belongs to the Poxviridae family and causes monkeypox,a disease clinically similar to smallpox.[1,2]Monkeypox was discovered in 1958 after two outbreaks of poxlike disease in research colonies of *** first known human infection was in 1970 in a newborn in the Democratic Republic of Congo.[3]Monkeypox began to reemerge in 2022,and the evolution of the outbreak is worrisome,as it does not seem that the pandemic,which has affected large numbers of people worldwide,is slowing down *** reported more than 57,000 cases and approximately 22 deaths on September 13.[4]Animal-to-human and human-to-human transmissions are two possible routes of transmission for *** to the clinicians,intimate sexual contact was the suspected route of transmission for the MPXV in 95% of *** or bisexual men,as well as other men who have sex with men,have been particularly hard hit by the current *** with smallpox,symptoms are similar but less severe and include pustular skin lesions,fever,headache,myalgia,and *** rash usually begins on the lips and spreads to the face and then to the limbs in a circular pattern.

关键词： belongs monkey circular

Overlap of diabetic ketoacidosis and hyperosmolar hyperglycemic state

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World Journal of Clinical Cases 2022年第32期10卷 11702-11711页

作者： Esraa Mamdouh Hassan Hisham Mushtaq Esraa Elaraby Mahmoud Sherley Chhibber Shoaib saleem Ahmed Issa Jain Nitesh Abbas B Jama Anwar Khedr Sydney Boike Mikael mir Noura Attallah Salim Surani Syed A Khan Critical Care Medicine Mayo Clinic Health SystemMankatoMN 56001United States Medicine St.Vincent's Medical CenterBridgeportCT 06606United States Medicine College of MedicineUniversity of SharjahSharjah 27272United Arab Emirates Medicine Mercy Catholic Medical CenterDarbyPA 19025United States Medicine Mayo HospitalLahore 54000PunjabPakistan Medicine Medical University of the AmericasNevisWest Indies Medicine BronxCare Health SystemBronxNY 10457United States Medicine University of Minnesota Medical SchoolMinneapolisMN 55455United States Medicine&Pharmacology Texas A&M University Health Science CenterCollege StationTX 77843United States Anesthesiolgy Mayo ClinicRochesterMN 55905United States

Diabetic ketoacidosis(DKA)and hyperosmolar hyperglycemia state(HHS)are two life-threatening metabolic complications of diabetes that significantly increase mortality and *** major advances,reaching a uniform consensus regarding the diagnostic criteria and treatment of both conditions has been challenging.A significant overlap between these two extremes of the hyperglycemic crisis spectrum poses an additional *** has well been noted that a complete biochemical and clinical patient evaluation with timely diagnosis and treatment is vital for symptom ***,there is a lack of large-scale studies that help define how hyperglycemic crises should be *** article will provide a comprehensive review of the pathophysiology,diagnosis,and management of DKA-HHS overlap.

关键词： Diabetic ketoacidosis Hyperosmolar Coma Diabetes Metabolic acidosis Hypernatremia Hyperosmolar hyperglycemia state

Structural, Thermal and Optical Studies of Oxypeucedanin Hydrate Monoacetate Micro-Crystals from <i>Prangos pabularia</i>

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American Journal of Analytical Chemistry 2012年第3期3卷 204-209页

作者： Javid Ahmad Banday Feroz Ahmad mir saleem Farooq Mushtaq Ahmad Qurishi Surinder Koul Tej Kishen Razdan Bio-Organic Division Indian Institute of Integrative Medicine (CSIR) Jammu J&K-India Department of Chemistry University of Jammu Jammu J&K-India Department of Chemistry University of Kashmir Srinagar J&K-India Department of Material Science and Condense Matter Physics S.N. Bose National Centre for Basic Sciences Kolkata India

Oxypeucedanin hydrate monoacetate (Mol. Formula = C18H18O7) micro-crystals were obtained by acetylation of oxy-peucedanin hydrate, a furanocoumarin, isolated from the roots of Prangos pabularia. The composition related structural, thermal and optical properties were investigated. All the crystals were found to have triclinic structure. From thermal studies of these crystals, stability, melting point and other relevant informations were obtained. Their blue emission, less absorption in entire visible range and band gap predicts these crystals as good candidate for modern optoelectronic devices.

关键词： Prangos pabularia Oxypeucedanin Hydrate Monoaceate Furanocoumarin Triclinic Non-Linear Optical

Geographic Access to Working Family Planning Centers and Unintended Pregnancies among Married Women: A Community Based Nested Case Control Study

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Open Journal of Epidemiology 2016年第1期6卷 95-108页

作者： Sumera Aziz Ali Sarah saleem Neelofar Sami mir Shabbar Muhammad Ahmed Shafquat Rozi Robert L. Goldenberg Margo S. Harrison Omrana Pasha Department of Community Health Sciences Aga Khan University Karachi Pakistan Willows Foundation Karachi Pakistan Department of Urban and Infrastructure Engineering NED University Karachi Pakistan Department of OB/GYN Columbia University Medical Center New York USA

Background: Unintended pregnancies pose substantial risk to mothers and children. In Pakistan, unintended pregnancies account for 46% of all pregnancies. Lack of geographic access to open and well-supplied family planning (FP) centers may be related to the occurrence of such pregnancies, particularly in rural areas. Objective: The objective of this analysis is to determine if geographic access to family planning centers in the Thatta district of Pakistan is related to unintended pregnancy rates among married women. Methods: We conducted a community-based, nested case-control study of 800 pregnant women identified from the database of an active surveillance system, which registers and follows all pregnant women in the catchment area of Thatta district. Women were enrolled during the first trimester;those that reported their pregnancy to be unintended were selected as cases (n = 200), and those whose pregnancies were intended served as controls (n = 600). We defined geographic access as including both the distance of a family planning center from the woman’s home, and availability of personal transportation. Logistic regression was used for analysis. Results: In the multivariate model, neither distance [OR = 1.0;95% CI (0.95 - 1.05)] nor availability of transportation [OR = 1.14;95% CI (0.78 - 1.67)] were significantly associated with unintended pregnancy. In fact, women with unintended pregnancies were more likely to be aware of family planning [OR = 2.21;95% CI (1.23 - 3.97)] and more likely to have been using a contraceptive method before conceiving their index pregnancy [OR = 3.59;95% CI (1.83 - 7.06)]. Other factors related to unintended pregnancy were older maternal age [OR = 1.13;95% CI (1.08 - 1.17)], having already had at least one son [OR = 3.13;95% CI (1.93 - 5.07)];spousal opposition to contraceptive use, [OR = 3.24;95% CI (1.89 - 5.56)] and low spousal education level [OR = 1.85;95% CI (1.08 - 3.18)] as compared to women with intended pregnancy. Conclusio

关键词： Unintended Pregnancy Geographic Access Family Planning