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Open Journal of Orthopedics 2024年第1期14卷 32-40页

作者： mir sadat-ali Department of Orthopaedic Surgery Haifa Medical Complex Al Khobar Kingdom of Saudi Arabia

Background: The growth and use of Artificial Intelligence (AI) in the medical field is rapidly rising. AI is exhibiting a practical tool in the healthcare industry in patient care. The objective of this current review is to assess and analyze the use of AI and its use in orthopedic practice, as well as its applications, limitations, and pitfalls. Methods: A review of all relevant databases such as EMBASE, Cochrane Database of Systematic Reviews, MEDLINE, Science Citation Index, Scopus, and Web of Science with keywords of AI, orthopedic surgery, applications, and drawbacks. All related articles on AI and orthopaedic practice were reviewed. A total of 3210 articles were included in the review. Results: The data from 351 studies were analyzed where in orthopedic surgery. AI is being used for diagnostic procedures, radiological diagnosis, models of clinical care, and utilization of hospital and bed resources. AI has also taken a chunk of share in assisted robotic orthopaedic surgery. Conclusions: AI has now become part of the orthopedic practice and will further increase its stake in the healthcare industry. Nonetheless, clinicians should remain aware of AI’s serious limitations and pitfalls and consider the drawbacks and errors in its use.

关键词： Artificial Intelligence Healthcare Pitfalls Drawbacks

Artificial Intelligence for Global Health: Difficulties and Challenges: A Narrative Review

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Open Journal of Epidemiology 2024年第1期14卷 122-130页

作者： Nazia S. sadat Maryam S. Shuttari mir sadat-ali Department of Applied Nutrition University of New England Portland USA Department of US Consultancy for Applied Research Lombard USA Department of Haifa Medical Center AlKhobar Saudi Arabia

Global health (GH) aims to improve healthcare for all people on the planet and eradicate all avoidable diseases and deaths. The inception of Artificial Intelligence (AI) is innovating healthcare practices and improving patient outcomes by shuffling enormous volumes of health data—from health records and clinical studies to genetic information analyzing it much faster than humans. AI also helps in the improvement of medical imaging and medical diagnosis. There is an increased optimism regarding the use of applications of AI locally but can these facets be translated globally in the advancement and delivery of healthcare with the help of AI. At present majority of AI developments and applications in health care provide to the needs of developed countries and there is little effort to develop programs which could help to improve healthcare delivery globally. We performed this narrative review to assess the difficulties and discrepancies in implementing AI in global health delivery and find ways to improve.

关键词： Artificial Intelligence Global Health Implementation Pitfalls

Developmental Dysplasia of the Hip (DDH) in Saudi Arabia: Time to Wake up. A Systematic Review (1980-2018)

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Open Journal of Epidemiology 2020年第2期10卷 125-131页

作者： mir sadat-ali Department of Orthopaedic Surgery College of Medicine Imam AbdulRahman Bin Faisal University Dammam and King Fahd Hospital of the University AlKhobar KSA

The objective of this systematic literature review was to assess the incidence of DDH among the Saudi Arabian population. Methods: A systematic review was performed for all the published articles in the English language literature on DDH in Saudi Arabia. Data sources were PubMed Medline (1980-2018) (http://***/pubmed/), Ovid Medline (1980-2018), EMBASE MEDLINE (1980 to May 2018), EMBASE (1991 to May 2018), the Cochrane Central Register of Controlled Trials and Cochrane Database of Systematic Reviews, the Science Citation Index (1966 to May 2018), published data from the Saudi Medical Journal (1985-2018) and Annals of Saudi Medicine (1985-2018). The author independently reviewed articles and abstracted the data. The key words used were Saudi Arabia developmental dysplasia of the hip ORDDH, congenital hip dislocation or congenital subluxation of the hip, and congenital dysplasia of the hip. Results: The authors identified 18 potentially relevant articles published in the last 38 years, and 10 met the inclusion criteria. The 10 studies analyzed included 2037 studies of infants diagnosed with DDH;and they gave an average incidence of 10.46/1000. Two studies (303 subjects) did not report the affected gender;in the remaining 338 were boys and 1396 were girls and one study did not report the side of affection. The majority presented after 12 months of age. The right side was affected in 532 (27.2%) affected, 734 (37.6%) were left side and 687 (35.2%) infants were affected bilaterally. Consanguinity, breech presentation, and family history were found to be the risk factors in 32.9%, 17.3%, and 23.6% of the patients, respectively. Conclusions: There is paucity of available literature on DDH in Saudi Arabia. New strategies have to be developed that include mandatory screening programs in all hospitals (private and public) so that more children can be treated by nonsurgical methods.

关键词： Developmental Dysplasia of the Hip Congenital Hip Dislocation Congenital Subluxation of the Hip Congenital Dysplasia of the Hip Saudi Arabia

Spinal cord injury regeneration using autologous bone marrowderived neurocytes and rat embryonic stem cells:A comparative study in rats

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World Journal of Stem Cells 2020年第12期12卷 1591-1602页

作者： mir sadat-ali Dakheel A Al-Dakheel Ayesha Ahmed Haifa A Al-Turki Abdallah S Al-Omran Sadananda Acharya Methal I Al-Bayat Department of Orthopedic Surgery Imam Abdulrahman Bin Faisal University and King Fahd Hospital of the UniversityDammam 31952Saudi Arabia Department of Orthopedic Surgery Imam Abdulrahman Bin Faisal UniversityAlKhobar 31952Saudi Arabia Department of Pathology Imam Abdulrahman Bin Faisal UniversityDammam 31952Saudi Arabia Department of Obstetrics and Gynecology Imam Abdulrahman Bin Faisal UniversityDammam 31142Saudi Arabia Department of Orthopedic Surgery Imam Abdulrahman Bin Faisal University and King Fahd Hospital of the UniversityAlKhobar 31952Saudi Arabia Department of Public Health College of Public HealthImam Abdulrahman Bin Faisal UniversityDammam 31441Saudi Arabia

BACKGROUND Spinal cord injury(SCI)is an important cause of traumatic paralysis and is mainly due to motor vehicle ***,there is no definite treatment for spinal cord *** To assess the outcome of rat embryonic stem cells(rESC)and autologous bone marrow-derived neurocytes(ABMDN)treatment in iatrogenic SCI created in rats,and to compare the efficacy of the two different cell *** The study comprised 45 male Wistar rats weighing between 250 and 300 g,which were divided into three groups,the control,rESC and ABMDN *** anesthetized animals underwent exposure of the thoracic 8th to lumbar 1st vertebrae.A T10-thoracic 12th vertebrae laminectomy was performed to expose the spinal cord.A drop-weight injury using a 10 g weight from a height of 25 cm onto the exposed spinal cord was *** wound was closed in *** urinary bladder was manually evacuated twice daily and after each evacuation Ringer lactate 5 mL/100 g was administered,twice daily after each bladder evacuation for the first 7 postoperative *** the 10th day,the rats underwent nerve conduction studies and behavioral assessment[Basso,Beattie,Brenham(BBB)]to confirm *** embryonic stem cells,ABMDN and saline were injected on the 10th *** animals were euthanized after 8 wk and the spinal cord was isolated,removed and placed in 2%formalin for histopathological analysis to assess the healing of neural tissues at the axonal *** All the animals tolerated the procedure *** BBB scale scoring showed that at the end of the first week no recovery was observed in the ***-injection,there was a strong and significant improvement in rats receiving rESC and ABMDN as compared to the control group based on the BBB scale,and the Trainof-four-Watch SX acceleromyography device exhibited statistically significant(P<0.0001)regeneration of neural tissue after *** evaluation of the spinal cord showed maximum vacuolization and least gliosis i

关键词： Spinal cord injury Regeneration Embryonic stem cells Autologous bone marrow-derived neurocytes Iatrogenic Stem cells

Can we suppress excessive post-surgical scar formation:A case report

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World Journal of Orthopedics 2023年第3期14卷 166-170页

作者： mir sadat-ali Sulaiman A Al-Mousa Khalid Waleed Al-Tabash Mohamed M Abotaleb Fawaz M Al-Anii Department of Orthopaedic Surgery Imam Abdulrahman Bin Faisal UniversityDammam 31142Saudi Arabia

BACKGROUND Hypertrophic scars(HSs)formation is a complication that occurs after wounds heal with secondary intention and sometimes after clean surgical *** treatments are in vogue now with varying *** the mechanism or mechanisms that cause a HS to form are not clearly understood,one thing that is clear is that once scar tissue matures,any intervention will not be *** this paper,we report on a case where a patient who was known to develop HS was treated with a new combination of ingredients(Phyto-chemicals+Silicone JUMI)to suppress HS *** SUMMARY A 68-year-old female of African descent presented a severe HS post total knee replacement(TKR),which the patient describes as itchy and *** to complications caused by the scar,she was apprehensive about undergoing TKR on her other ***,after the TKR of the contralateral side post-removal of skin clips,JUMI anti-scar cream(JASC)was used to suppress excessive scar *** JASC appears potent and efficacious at suppressing excessive scar *** believe that this warrants further studies on larger patient groups and on different surgical sites.

Vancomycin flushing syndrome in orthopaedic practice:A case report

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World Journal of Orthopedics 2023年第10期14卷 771-775页

作者： Fawaz M Al-Anii mir sadat-ali Khalid Waleed Al-Tabash Ahmad I AlMulhim Sulaiman A AlMousa Abdulaziz M AlHawas Orthopaedic Surgery Imam AbdulRahman Bin Faisal University and King Fahd Hospital of the UniversityAlKhobar 31952Saudi Arabia

BACKGROUND Vancomycin flushing syndrome(VFS),also known as red man syndrome,is an allergic reaction to *** typically presents as a rash on the face,neck,and upper torso after intravenous administration of *** is blamed on rapid intravenous infusion of vancomycin during management and rarely happens after local use.A review of the literature showed that in the last 23 years,4 such cases have been ***,we add another case of VFS developed after slow local absorption of vancomycin in cement *** SUMMARY A 44-year-old male with a known case of hypertension,no history of allergies to medications,and a history of chronic osteomyelitis of the right tibia with discharging sinus over the anterolateral aspect of the *** pus culture grew Staphylococcus aureus,which was sensitive to clindamycin and *** patient underwent irrigation and debridement with the placement of vancomycin cement beads made from 4 g of vancomycin powder and 40 g of polymethyl *** hours postoperatively,the patient developed a pruritic,erythematous,macular rash predominantly on his face,neck,chest,and lower extremities and to a lesser extent his upper extremities.A diagnosis of VFS was made and was successfully treated with cetirizine(10 mg,oral)and methylprednisolone sodium succinate(125 mg,intravenous).The patient continued to have itching with a facial rash for 12 h with gradual improvement.A decision was made to not remove the beads as the patient continued to ***,the rash disappeared after 96 h with no further *** VFS can occur not only after rapid intravenous injection of vancomycin but also with local release,as in our *** orthopaedic surgeons routinely use vancomycin with polymethyl methacrylate in chronic osteomyelitis and revision arthroplasty,they should be aware of such a complication occurring.

关键词： Vancomycin Anaphylactic reactions Red man syndrome Vancomycin flushing syndrome Case report

Hospitalizations for Osteoporosis-Related Fractures: Analysis from Eastern Saudi Arabia

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Open Journal of Orthopedics 2020年第6期10卷 117-123页

作者： mir sadat-ali AbdulAziz H. Al-Shams Zainab R. Al Ghanim Khaleel I. Al Batran Yousef M. Al Jamaan Abrar S. Hashishi Faisal M. Al Anaz Abdul Raheem A. Al Talib Fatima Abdulmohsen Mohamed The Department of Orthopaedic Surgery King Fahd Hospital of the University Imam Abdul Rahman Bin Faisal University Al Khobar KSA

Background and Objectives: Osteoporosis causes fragility fractures which increase the morbidity and mortality in the elderly. Our objective was to look at the hospital admissions due to fragility fractures and site of fractures. Methods: This is a retrospective study of a 2-year period (2017-2018), in which we evaluated all the admissions of fragility fractures at King Fahd Hospital of the University, Al Khobar, Saudi Arabia. A Fragility Fracture is a fracture which occurs in patients with low bone mass due to a fall from a standing height. The data were gathered from the Quadru Med patient care system for patients over the age of 50 years: sex, site of fracture, previous fractures, and treatment meted out. The hospitalization rate for fragility fractures was calculated by taking into consideration of all the adult admissions to the orthopaedic department. Ethical approval was obtained from the Institutional Review Board of the Hospital and the Imam Abdul Rahman Bin Faisal University, Dammam. Results: During the study period 187 patients with fragility fractures were admitted. The mean age was 68.55 ± 12.43 years;fracture femur was the most common with 136 (72.7%), tibia 15 (8%) and spine 14 (7.5%). At the time of discharge based on the T score of spine 50 were osteopenic and 45 were osteoporotic. Overall adult admission for the study period was 1410 patients and 13.26% were patients with fragility fractures. There were 3 (1.6%) deaths within the first 30 days in the hospital. Conclusions: Fracture femur was the most common fragility fracture seen in our study. Orthopaedic surgeons should be ready to treat all fragility fractures and treat osteoporosis appropriately so that a second fracture is prevented.

关键词： Fragility Fractures Saudi Arabia Osteopenia Osteoporosis

Do osteoporosis-related vertebral fractures precede hip fractures?

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World Journal of Orthopedics 2012年第12期3卷 235-238页

作者： mir sadat-ali Abid Hussain Gullenpet Md Quamar Azam Ammar K Al-Omran Department of Orthopaedic Surgery College of Medicine University of Dammam and King Fahd Hospital of the University Al Khobar 31952 Saudi Arabia Department of Radiology College of Medicine University of Dammam and King Fahd Hospital of the University Al Khobar 31952 Saudi Arabia

AIM:To evaluate the relationship between a vertebral fracture and a hip fracture in Saudi Arabians with ***:In this retrospective study,154 Saudi Arabian patients with osteoporosis-related hip fractures were analyzed for the presence of a vertebral *** were retrieved from the IPAC(Image Picture Archiving and Computing)System,an imaging retrieval system,and were reviewed independently by two of the authors,Abid Hussain Gullenpet,and mir sadat-ali,and later reviewed *** admitted with proximal hip fracture who were≥50 years and had undergone Thoraco-lumber imaging and a dual energy X-ray absorptiometry(DEXA)scan were included in the *** with a history of significant trauma to the spine and those with a malignancy or connective tissue disorder were excluded from the ***:Out of 154 patients with hip fractures,78had a fracture of the femoral neck while 76 had an intertrochanteric hip *** the 111 patients whowere finally included in the study,after applying inclusion and exclusion criteria,76 patients with an average age of 67.28±12 years had no fractures of the ***-five patients with an average age of 76.9±14.5years(31.53%)had a total of 49 vertebral *** with vertebral fractures were significantly older than those without fractures P<***,24.7%of these patients had an asymptomatic vertebral *** analysis showed that 11 males(18.96%)and 24 females(45.28%)had suffered a previous asymptomatic vertebral ***,all women who participated in this study and who presented with a femoral neck fracture had experienced a prior asymptomatic vertebral ***:We recommend that all elderly patients who go to the radiology department for a chest X-ray also have a DEXA scan and a lateral thoracic spine radiograph.

关键词： Fragility fracture Osteoporosis Vertebral fractures Hip fractures Saudi Arabia

Redox-sensitive, PEG-shielded carboxymethyl PEI nanogels silencing MicroRNA-21, sensitizes resistant ovarian cancer cells to cisplatin

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Asian Journal of Pharmaceutical Sciences 2020年第1期15卷 69-82页

作者： Sanaz Javanmardi ali Mohammad Tamaddon Mahmoud Reza Aghamaali Ladan Ghahramani Samira sadat Abolmaali Department of Biology Faculty of ScienceUniversity of Guilarij Rasht 64891Iran Center for Nanotechnology in Drug Delivery Shiraz University of Medical SciencesShiraz 71345Iran School of Pharmacy Shiraz University of Medical SciencesShiraz 71345Iran

A series of branched polyethylenimine(PEI) modifications including PEGylation(PEG2 k-PEI) for steric shielding, redox-sensitive crosslinking for synthesis PEG2 k-PEI-ss nanogels and subsequent carboxymethylation(PEG2 k-CMPEI-ss) for modulation of the polymer pk a have been introduced for cellular delivery of Anti-mi R-21. The synthesis was characterized using 1 H NMR, FTIR, TNBS, potentiometric titration, particle size and ζ potential. Loading of Anti-mi R-21 at various N/P ratios was investigated by gel retardation, ethidium bromide dye exclusion, heparin sulfate competition and DNase I digestion experiments. The mi R-21 silencing was measured by stem-loop RT PCR in A2780 ovarian cancer cell lines whether it is sensitive to resistant to cisplatin. It has been shown that PEG2 k-CMPEI-ss was well suited for delivery of Anti-mi R-21 in terms of nucleic acid loading, preservation against extracellular matrix and nucleases and sequence-specific silencing of mi RNA-21 in vitro. Moreover, it has been demonstrated that pre-treating cells with Anti-mi R-21 loaded nanogels can sensitize them to cis-Pt even at non-toxic concentraions. The results indicate that PEG2 k-CMPEIss mediated micro RNA delivery can be considered as a novel strategy for ovarian cancer therapy.

关键词： MicroRNA PEI nanogels Anti-mir-21 Gene delivery Cisplatin resistance

Altered expression of mir-125a and dysregulated cytokines in systemic lupus erythematosus: Unveiling diagnostic and prognostic markers

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World Journal of Experimental Medicine 2023年第5期13卷 102-114页

作者： Tagreed Qassim Alsbihawi Mojtaba Zare Ebrahimabad Fakhri sadat Seyedhosseini Homa Davoodi Nafiseh Abdolahi alireza Nazari Saeed Mohammadi Yaghoub Yazdani Department of Immunology Faculty of MedicineGolestan University of Medical SciencesGorgan 49341-74515Iran Metabolic Disorders Research Center Golestan University of Medical SciencesGorgan 49341-74515Iran Laboratory Sciences Research Center Golestan University of Medical SciencesGorgan 49341-74515Iran Department of Immunology Golestan University of Medical SciencesGorgan ***Iran Golestan Rheumatology Research Center Golestan University of Medical SciencesGorgan 49341-74515Iran Department of Surgery Faculty of MedicineRafsanjan University of Medical SciencesRafsanjan ***Iran Golestan Research Center of Gastroenterology and Hepatology Golestan University of Medical SciencesGorgan 49341-74515Iran

BACKGROUND Systemic lupus erythematosus(SLE)is a chronic autoimmune disorder impacting multiple organs,influenced by genetic factors,especially those related to the immune ***,there is a need for new biomarkers in ***-125a(mir-125a)levels are decreased in T cells,B cells,and dendritic cells of SLE ***-125a plays a regulatory role in controlling the levels of tumor necrosis factor-alpha(TNF-α)and interleukin 12(IL-12),which are crucial pro-inflammatory cytokines in SLE *** To assess the levels of mir-125a,IL-12,and TNF-αin SLE patients’plasma,evaluating their diagnostic and prognostic *** The study included 100 healthy individuals,50 newly diagnosed(ND),and 50 SLE patients undergoing *** patients were monitored for a duration of 24 wk to observe and record instances of ***-125a expression was measured using real-time reverse transcription polymerase chain reaction,while ELISA kits were used to assess IL-12 and TNF-α*** The results showed significantly reduced mir-125a expression in SLE patients compared to healthy individuals,with the lowest levels in ND ***-αand IL-12 expression levels were significantly elevated in SLE patients,especially in the early stages of the *** operating characteristic curve analyses,and Cox-Mantel Log-rank tests indicated mir-125a,TNF-α,and IL-12 as proper diagnostic biomarkers for SLE.A negative correlation was found between plasma mir-125a expression and IL-12/TNF-αlevels in SLE *** Decreased mir-125a levels may be involved in the development of SLE,while elevated levels of IL-12 and TNF-αcontribute to immune *** findings offer new diagnostic and prognostic markers for ***,the negative correlation observed suggests an interaction between mir-125a,TNF-α,and *** research is necessary to uncover the underlying mechanisms that govern these relationships.

关键词： Systemic lupus erythematosus microRNA-125a Interleukin-12 Tumor necrosis factor alpha Biomarker