检索结果-南通市图书馆

Diabetes mellitus, revascularization and outcomes in elderly patients with myocardial infarction-related cardiogenic shock

引用

Journal of Geriatric Cardiology 2020年第10期17卷 604-611页

作者： miquel Gual Albert Ariza-Solé María García Márquez Cristina Fernández JoséL Bernal Francesc Formiga María-Isabel Barrionuevo JoséC Sánchez-Salado Victòria Lorente Júlia Pascual Isaac Llaó Oriol Alegre Angel Cequier Javier Elola Hospital Universitari de Bellvitge L’Hospitalet de LlobregatBarcelonaSpain Fundación Instituto para la Mejora de la Asistencia Sanitaria MadridSpain Hospital Clínico Universitario San Carlos MadridSpain Hospital Universitario 12 de Octubre MadridSpain

Background The prognostic role of diabetes mellitus(DM)in elderly patients with myocardial infarction-related cardiogenic shock(MI-CS)remains *** information exists about the impact of intensive cardiac care unit(ICCU)and revascularization on outcomes of elderly patients with *** aimed to assess the prognostic impact of DM according to age in patients with MI-CS,and to analyze the impact ICCU management and revascularization on in-hospital mortality in MI-CS patients at older *** Discharge episodes with diagnosis of CS associated with MI were selected from the Spanish National Health System’s Basic Data *** were classified according to their availability of *** outcome measured was in-hospital *** A total of 23,590 episodes of MI-CS were identified,of whom 12,447(52.8%)were in patients aged≥75 *** impact of DM on in-hospital mortality was different among age *** in younger patients,DM was associated to a higher mortality risk(0.52 vs.0.47,OR=1.12,95%CI:1.06–1.18,χ^2<0.001),this association became non-significant in older patients(0.76 vs.0.81,χ^2=0.09).Adjusted mortality rate of MI-CS aged≥75 years was lower in patients admitted to hospitals with ICCU(adjusted mortality rate:74.2%vs.77.7%,P<0.001)and in patients undergoing revascularization(74.9%vs.77.3%,P<0.001).Conclusions Prognostic impact of DM in patients with MI-CS was different according to age,with a significantly lower impact at older *** availability of ICCU and revascularization were associated with better outcomes in these complex patients.

关键词： Cardiogenic shock Diabetes mellitus Myocardial infarction Revascularization The elderly

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

激发经济和社会活力复苏的城区更新

引用

城市建筑 2015年第4期12卷 74-75页

作者： miquel Pybus 高远巴塞罗那城市发展局城市战略部

近几十年来人们所经历的技术创新,尤其是与新的信息和通信技术相关的创新,使得知识成为生产过程中的一个关键因素,而以前被视为占主导地位的因素（诸如资金和劳动力等）已退居第二位,对生产过程、组织和产品进行创新的能力则被视为具有... 详细信息

近几十年来人们所经历的技术创新,尤其是与新的信息和通信技术相关的创新,使得知识成为生产过程中的一个关键因素,而以前被视为占主导地位的因素（诸如资金和劳动力等）已退居第二位,对生产过程、组织和产品进行创新的能力则被视为具有竞争优势的最可靠的价值之一。后工业社会正见证着这些新技术如何演变为未来发展的要素。

关键词：社会活力知识型社会劳动市场整体框架技术创新生产过程居第通信技术城市发展 innovative

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

为什么要同步发情

引用

国外畜牧学（猪与禽） 2014年第10期34卷 29-31页

作者：毛慧 miquel Collell 美国默沙东动物保健猪科学事务处

这篇文章的标题中蕴含着一个简单的问题,而1篇2页文章就可以轻松解答。发情时又究竟会发生什么?什么是同期发情且所有的养殖场都适用吗?

关键词：同步发情定时授精黄体期卵泡期

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

巴塞罗那波布雷诺旧工业区更新策略探析

引用

住区 2013年第3期 138-145页

作者：周婷 miquel Vidal Pla 清华大学建筑学院巴塞罗那加泰罗理大学建筑学院

2000年,巴塞罗那推出22@计划,将波布雷诺旧工业区改造为高新知识经济区。本文在分析该地区更新背景的基础上,介绍了波布雷诺工业区的更新策略。从复合功能重构、基础设施升级、公共空间优化、建筑保护改造四个方面,深入探析了巴塞罗那22... 详细信息

2000年,巴塞罗那推出22@计划,将波布雷诺旧工业区改造为高新知识经济区。本文在分析该地区更新背景的基础上,介绍了波布雷诺工业区的更新策略。从复合功能重构、基础设施升级、公共空间优化、建筑保护改造四个方面,深入探析了巴塞罗那22@计划整体性的规划战略和以人为本的城市理念。

关键词：波布雷诺旧工业区更新策略

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Analysis of single nucleotide polymorphisms in the region of CLDN2-MORC4 in relation to inflammatory bowel disease

引用

World Journal of Gastroenterology 2013年第30期19卷 4935-4943页

作者： Jan Sderman Elisabeth Norén Malin Christiansson Hanna Bragde Raphaele Thiébaut Jean-Pierre Hugot Curt Tysk Colm A O'Morain miquel Gassull Yigael Finkel Jean-Frédéric Colombel Marc Lémann Sven Almer Division of Medical Diagnostics Ryhov County Hospital55185 JnkpingSweden Department of Clinical and Experimental Medicine Linkping University58183 LinkpingSweden INSERM U843Université Paris DiderotHpital Robert Debré75019 ParisFrance Université ParisDiderot Sorbonne Paris-Cité UMR84375018 ParisFrance Assistance Publique-Hopitaux de Paris Hopital Robert Debré75019 ParisFrance Division of Gastroenterology Department of MedicineUniversity HospitalSchool of Health and Medical Sciencesrebro University70185 rebroSweden School of Health and Medical Sciences rebro University70185 rebroSweden Department of Gastroenterology Adelaide and Meath HospitalTallaghtDublin 24Ireland Trinity College Dublin College GreenDublin 2Ireland Health Sciences Research Institute Germans Trias i Pujol08916 BadalonaSpain Department of Gastroenterology Sachs' Children's HospitalSdersjukhuset11861 StockholmSweden EPIMAD group Registre EPIMADService d'Epidémiologie et de Santé PubliqueHpital CalmetteCentre Hospitalier Universitaire de Lille59037 LilleFrance Icahn School of Medicine at Mount Sinai New YorkNY 10029United States GETAID group Groupe d'Etude Thérapeutiques des Affections Inflammatoires DigestivesService de gastroentérologieHpital Saint Louis75010 ParisFrance Department of Gastroenterology UHL County Council of stergtland58185 Link pingSweden Division of Gastroenterology Karolinska InstitutetDepartment of Gastroenterology and HepatologyKarolinska university hospital14186 StockholmSweden

AIM:To investigate a possible genetic influence of claudin(CLDN)1,CLDN2 and CLDN4 in the etiology of inflammatory bowel ***:Allelic association between genetic regions of CLDN1,CLDN2 or CLDN4 and patients with inflammatory bowel disease,Crohn's disease(CD)or ulcerative colitis were investigated using both a casecontrol study approach(one case randomly selected from each of 191 Swedish inflammatory bowel disease families and 333 controls)and a family-based study(463 non-Swedish European inflammatory bowel disease-families).A nonsynonymous coding single nucleotide polymorphism in MORC4,located on the same linkage block as CLDN2,was investigated for association,as were two novel CLDN2 single nucleotide polymorphism markers,identified by ***:A single nucleotide polymorphism marker(rs12014762)located in the genetic region of CLDN2 was significantly associated to CD(case-control allelic OR = 1.98,95%CI:1.17-3.35,P = 0.007).MORC4 was present on the same linkage block as this CD *** the case-control approach,a significant association(case control allelic OR = 1.61,95%CI:1.08-2.41,P = 0.018)was found between CD and a nonsynonymous coding single nucleotide polymorphism(rs6622126)in *** association between the CLDN2 marker and CD was not replicated in the familybased *** colitis was not associated to any of the single nucleotide polymorphism ***:These findings suggest that a variant of the CLDN2-MORC4 region predisposes to CD in a Swedish population.

关键词： Crohn’s disease Genetic predisposition Inflammatory bowel disease Single nucleotide polymorphism Tight junctions

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Costimulatory molecule programmed death-1 in the cytotoxic response during chronic hepatitis C

引用

World Journal of Gastroenterology 2009年第41期15卷 5129-5140页

作者： Juan Ramón Larrubia Selma Benito-Martínez Joaquín miquel Miryam Calvino Eduardo Sanz-de-Villalobos Trinidad Parra-Cid Translational Hepatology Unit Guadalajara University Hospital University of Alcalá

Hepatitis C virus（HCV）-specific CD8^＋ T cells play an important role in the resolution of HCV infection. Nevertheless, during chronic hepatitis C these cells lack their effector functions and fail to control the virus. HCV has developed several mechanisms to escape immune control. One of these strategies is the upregulation of negative co-stimulatory molecules such us programmed death-1 （PD-1）. This molecule is upregulated on intrahepatic and peripheral HCV-specific cytotoxic T cells during acute and chronic phases of the disease, whereas PD-1 expression is low in resolved infection. PD-1 expressing HCV-specific CD8^＋ T cells are exhausted with impairment of several effector mechanisms, such as： type-1 cytokine production, expansion ability after antigen encounter and cytotoxic ability. However, PD-1 associated exhaustion can be restored by blocking the interaction between PD-1 and its ligand （PD-L1）. After this blockade, HCV-specific CD8^＋ T cells reacquire their functionality. Nevertheless, functional restoration depends on PD-1 expression level. High PD-l-expressing intrahepatic HCV-specific CD8^＋ T cells do not restore their effector abilities after PD-1/ PD-L1 blockade. The mechanisms by which HCV is able to induce PD-1 up-regulation to escape immune control are unknown. Persistent TCR stimulation by a high level of HCV antigens could favour early PD-1 induction, but the interaction between HCV core protein and gClq receptor could also participate in this process. The PD-1/PD-L1 pathway modulation could be a therapeutic strategy, in conjunction with the regulation of others co-stimulatory pathways, in order to restore immune response aclainst HCV to succeed in clearing the infection.

关键词： Chronic hepatitis Exhaustion Hepatitis C virus core Hepatitis C virus Programmed death-1 Programmed death-1 ligand

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Current trends in access to treatment for hepatitis B in immigrants vs non-immigrants

引用

Gastroenterology Report 2020年第5期8卷 362-366,I0002页

作者： Mireia miquel Albert Pardo Montse Forné Gemma Martínez-Alpin AdriàRodríguez-Castellano Meritxell Casas MercèRosinach MercèRoget Blai Dalmau Rocío Temiño Joan Carlos Quer Jordi Sanchez-Delgado Jordi Ortiz Mercedes Vergara Liver Unit Gastroenterology DepartmentParc TaulíUniversity HospitalInstitut d’Investigacio i InnovacióParc TaulíI3PTAutonomous University of BarcelonaSabadellSpain Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas(CIBERehd) Instituto de Salud Carlos IIIMadridSpain Gastroenterology Department University Hospital Joan XXIIITarragonaSpain Liver Unit Gastroenterology DepartmentUniversity Hospital Mútua TerrassaBarcelonaSpain Liver Unit Gastroenterology DepartmentConsorci Sanitari de TerrassaTerrassaSpainó

Background:Universal vaccination for hepatitis B virus(HBV)and migratory movements have changed the demographic characteristics of this disease in Spain and in ***,we evaluated the characteristics of the disease and the possible differences according to origin(immigrants vs non-immigrants)and access to ***:This is a multicenter cross-sectional study(June 2014 to May 2015)in which outpatients with a positive HBsAg were seen and followed in four Hepatology *** and clinical data and indication and access to treatment were collected in two different regions of Catalonia(Spain)where there are no barriers to treatment due to a comprehensive coverage under the National Health ***:A total of 951 patients were evaluated(48.1%men).Of these,46.6%were immigrants(58.7%of them were born in Africa)and were significantly younger compared to *** proportions of patients with alcohol consumption,being overweight,and other indicators of metabolic co-morbidities were significantly higher in *** the 937 patients receiving HBeAg examination,91.7%were *** HBeAg-positive infection was significantly higher in immigrants(3.9%vs 0.6%,P=0.001)and chronic HBeAg-negative hepatitis was higher non-immigrants(31.7%vs 21.4%,P<0.001).Not only was the proportion of patients who met treatment criteria significantly higher among nonimmigrants(38.4%vs 29.2%,P=0.003),but also the proportion of those with indication of effectively receiving therapy at the time of data collection(83.2%vs 57.8%,P<0.001).Conclusions:The immigrant population with HBV is younger and has a lower prevalence of metabolic co-morbidities and a higher frequency of chronic HBeAg *** having access to care and an indication for treatment,some do not get adequately treated due to several factors including local adaptation that precludes access to treatment.

关键词： hepatitis B prevalence immigration access to treatment

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

ChipIdea多种高性能高速USB解决方案

引用

中国集成电路 2004年第5期13卷 65-70页

作者：曲艳燕 Luis miquel Sampaio ChipIdea Microelectronics SA(***) ChipIdea Digital Technology Center

USB是一种近几年迅速发展起来的灵活多样,简单易用,价格适中的标准的高速接口技术。市场信息指出,仅在2002年,配有USB的设备就已达到375百万台。到2007年这个数目将会增到863百万。这个迅速发展起来的大市场,吸引了成百上千的半导体厂... 详细信息

USB是一种近几年迅速发展起来的灵活多样,简单易用,价格适中的标准的高速接口技术。市场信息指出,仅在2002年,配有USB的设备就已达到375百万台。到2007年这个数目将会增到863百万。这个迅速发展起来的大市场,吸引了成百上千的半导体厂商投资于USB设计以便增加其产品的竟争力。但是,USB的设计,测试及最终验证比其他接口技术复杂困难:Chipldea公司于2002年开始跻身于USB AFE,USBPHY设计行列。现在,Chipldea已拥有30多种USB PHY。其设计技术跨越于0.25微米,0.18微米,0.13微米及90纳米。本文将主要介绍Chipldea新近开发的USB解决方案。其中包括USB2.0 PHY,USB 2.0 On-The-Go PHY,USB 2.0 LPI PHY。

关键词： USB ChipIdea公司通用串行总线 USB-IF USB2.0PHY

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Establishing the Tolerability to Turkeys of Nonanoic Acid at Practical Levels of Use as a Feed Flavoring

引用

Open Journal of Animal Sciences 2021年第3期11卷 422-439页

作者： Maria H. L. Bento Elizabeth A. Lewis miquel Nofrarias Borja Vilà Philip McGuire Kurt Richardson NutraSteward Pembroke Dock UK CReSA—Animal Health IRTA Bellaterra Spain Animal Nutrition IRTA Constantí Spain Anitox Wellingborough UK

Objective: Nonanoic acid (NA) is one of a series of straight-chain aliphatic alcohols, aldehydes, acids and their derivatives with a well-documented history of use as a synthetic flavoring in human food. As part of a safety evaluation of NA for use as a flavoring in animal feed, an experiment was conducted to evaluate the ability of turkeys to tolerate NA at levels relevant to practical feeding practices. Materials and Methods: A total of 594-day-old BUT Premium turkeys (300 males and 294 females) were allocated at random to 40 floor pens containing either 15 males or 13 to 15 females. Poults were fed one of 4 treatment diets in crumble (0 to 14 days) or pellet (15 to 59 days) form containing 0 (control), 100, 300 or 1000 mg NA/kg complete feed for 59 days. General health and performance were monitored for the duration of the study. At days 57 and 59 of age, blood samples were taken and birds were sacrificed and necropsied for histopathological examination of the digestive tract. Significant differences were considered at P ≤ 0.05 and near-significant trends at P ≤ 0.10. <

关键词： Turkey Flavoring Nonanoic Acid Safety

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

后备母猪管理1：批次管理和同步发情

引用

国外畜牧学（猪与禽） 2017年第7期37卷 48-49页

作者：高和坤 miquel Collell

人们经常说猪的生产周期从繁育母猪开始,但是同时也能经常听到人们说后备母猪是猪场的未来。因此,后备母猪会成为猪场更大的群体,同时也是最难管理的猪群。

关键词：批次管理后备母猪同步发情月龄日龄公猪

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：