检索结果-南通市图书馆

Protein glycation:a wolf in sweet sheep’s clothing behind neurodegeneration

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2024年第5期19卷 975-976页

作者： Ana B.Uceda Francisco Leal-Pérez miquel adrover Institut Universitari d’Investigacióen Ciències de la Salut(IUNICS) Institut d’InvestigacióSanitària Illes Balears(IdISBa) Departament de Química Universitat de les Illes BalearsCtraPalma de MallorcaSpain

At the beginning of the 16th century,Paracelsus coined the maxim:“the dose makes the poison”.This principle can be applied to all living organisms,including organs and *** brain and its glial and neuronal cells are ... 详细信息

关键词： organs sheep sweet

Low field microwave absorption and magnetization process in CoFeNi electroplated wires

在线全文

学校读者我要写书评

暂无评论

Chinese Physics B 2008年第4期17卷 1430-1435页

作者： H.García-miquel G.V.Kurlyandskay E.T.S.I.Telecomunicación Dpto.Ing.ElectrónicaUniversidad Politcnica de ValenciaCamino de Vera s/nValencia 46022Spain Universidad del País Vasco UPV-EHU Dept.Electricidad y ElectrónicaApdo.644Bilbao 48080Spain Department of Physics Ferromagnetic Resonance GroupUniversity of MarylandCollege ParkMaryland 20742-4111USA

Ferromagnetic resonance （FMR）, Ferromagnetic antirresonance （FMAR） and low field magnetoimpedance （MI） are the characteristic features of high frequency losses in applied fields. While some results on FMR and FMAR in CoFeNi electroplated wires were reported earlier, here we present microwave absorption in CuBe wires electroplated by 1 μm FeCoNi magnetic layer at very low fields. These data are comparatively analysed together with longitudinal hysteresis loops in order to reveal the correlation between power absorption and magnetization processes. Microwave studies are made by using the cavity perturbation method at 9.65 GHz for a DC field parallel to the sample axis, and with microwave magnetic field hrf parallel or perpendicular to the wire axis. Two peaks have been observed in all samples, one is due to FMR, and the other is, at very low fields, related to MI. The MI peaks represent minima in power absorption. By comparing with the hysteresis loop we remark the close correspondence between the MI phenomena in the axial mode and the concomitant magnetization process.

关键词： microwave absorption magnetoimpedance electroplated wires

Depressive symptoms in neurodegenerative diseases

在线全文

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2015年第8期3卷 682-693页

作者： miquel Baquero Nuria Martín Servei de Neurologia Hospital Universitari i Politècnic La Fe

Depressive symptoms are very common in chronic conditions. This is true so for neurodegenerative diseases. A number of patients with cognitive decline and dementia due to Alzheimer's disease and related conditions like Parkinson's disease, Lewy body disease, vascular dementia, frontotemporal degeneration amongst other entities, experience depressive symptoms in greater or lesser grade at some point during the course of the illness. Depressive symptoms have aparticular significance in neurological disorders, specially in neurodegenerative diseases, because brain, mind, behavior and mood relationship. A number of patients may develop depressive symptoms in early stages of the neurologic disease, occurring without clear presence of cognitive decline with only mild cognitive deterioration. Classically, depression constitutes a reliable diagnostic challenge in this setting. However, actually we can recognize and evaluate depressive, cognitive or motor symptoms of neurodegenerative disease in order to establish their clinical significance and to plan some therapeutic strategies. Depressive symptoms can appear also lately, when the neurodegenerative disease is fully developed. The presence of depression and other neuropsychiatric symptoms have a negative impact on the quality-of-life of patients and caregivers. Besides, patients with depressive symptoms also tend to further decrease function and reduce cognitive abilities and also uses to present more affected clinical status, compared with patients without depression. Depressive symptoms are treatable. Early detection of depressive symptoms is very important in patients with neurodegenerative disorders, in order to initiate the most adequate treatment. We review in this paper the main neurodegenerative diseases, focusing in depressive symptoms of each other entities and current recommendations of management and treatment.

关键词： Neurodegenerative diseases Alzheimer Depressive symptoms Frontotemporal degeneration Vascular dementia Lewy body disease Depression Dementia

Multi-agent system simulation for urban policy design:open space land use change problem

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Modeling, Simulation, and Scientific Computing 2016年第2期7卷 20-37页

作者： Roman Buil miquel Angel Piera Egils Ginters Logistics and Aeronautics Unit Universitat Autonoma de Barcelona c.Emprius2 Sabadell 08202Spain Vidzeme University of Applied Sciences Cesu Street 4 Valmiera LV-4201Latvia

Multi-agent system(MAS)models have been increasingly applied to the simulation of complex phenomena in different areas,providing successful and credible *** behavior related to a specific urban activity(i.e.,recreation activities in a park,using bicycle for mobility purposes)can be modeled as an agent(actor)with several affinities and preferences which are dependent on aspects that affect the activity.A particular application of a MAS approach is in area of urban policy design,in which policies should be designed considering citizens needs,preferences and *** an open space in a city is available(i.e.,an industry is moved to an industrial area),a land use policy should contribute to identify the new use for the urban *** are different land use policies that can be applied depending on which services or facilities must be empowered in the *** is important to identify the correct policy in order to satisfy present citizens needs but considering also the future needs in a social changing context.A socio-technological simulation model has been developed to allow citizens to get a better understanding of the urban problem,its dynamics and explore the sustainability of the different solutions.,enhancing citizens to participate in the urban decisions through new technologies(i.e.,e-participation).This paper illustrates an open space MAS simulation model for land use design policies in which citizens can check their opinion and get a better understanding of the different choices and its acceptability by the community considering not only present neighborhood profiles,but also future neighborhood *** is the first step before the development of the final software including a user friendly interface to let citizens with different cultural profiles to perform simulations as an essential and neutral tool to reach consensus during the decision-making process in urban policy design.

关键词： Agent simulation,urban policy open space e-governance e-participation

Developing spatially and thematically detailed backdated maps for land cover studies

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Digital Earth 2017年第2期10卷 175-206页

作者： Juan JoséVidal-Macua Alaitz Zabala miquel Ninyerola Xavier Pons Dep Geografia Grumets Research GroupUniversitat Autònoma de BarcelonaBellaterraCataloniaSpain Dep Biologia Animal Vegetal i EcologiaGrumets Research GroupUniversitat Autònoma de BarcelonaBellaterraCataloniaSpain

Global or regional land cover change on a decadal time scale can be studied at a high level of detail using the availability of remote sensing data such as that provided by ***,there are three main technical challenges in this ***,the generation of land cover maps without reference data is problematic(backdating).Second,it is important to maintain high accuracies in land cover change map products,requiring a reasonably rich legend within each ***,a high level of automation is necessary to aid the management of large volumes of *** paper describes a robust methodology for processing time series of satellite data over large spatial *** methodology includes a retrospective analysis used for the generation of training and test data for historical periods lacking reference *** methodology was developed in the context of research on global change in the Iberian *** this study we selected two scenes covering geographic regions that are representative of the Iberian *** each scene,we present the results of two classifications(1985-1989 and 2000-2004 quinquennia),each with a legend of 13 *** overall accuracy of over 92%was obtained for all 4 maps.

关键词： Land cover mapping Landsat statistical classifiers backdating Iberian Peninsula

Modeling shoreline sand waves on the coasts of Namibia and Angola

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Sediment Research 2013年第3期28卷 338-348页

作者： Francesca RIBAS Albert FALQUES Niels VAN DEN BERG miquel CABALLERIA Department of Applied Physics Universitat Politecnica de CatalunyaSpain

The southwestern（SW） coast of Africa（Namibia and Angola） features long sandy beaches and a wave climate dominated by energetic swells from the Southsouthwest（SSW）,therefore approaching the coast with a very high *** images reveal that along that coast there are many shoreline sand waves with wavelengths ranging from 2 to 8 km.A more detailed study,including a Fourier analysis of the shoreline position,yields the wavelengths（among this range） with the highest spectral density ***,it becomes apparent that at least some of the sand waves are dynamically active rather than being controlled by the geological setting.A morphodynamic model is used to test the hypothesis that these sand waves could emerge as free morphodynamic instabilities of the coastline due to the obliquity in wave *** is found that the period of the incident water waves,T;,is crucial to establish the tendency to stability or instability,instability increasing for decreasing period,whilst there is some discrepancy in the observed *** results for T;= 7-8 s clearly show the tendency for the coast to develop free sand waves at about 4 km wavelength within a few years,which migrate to the north at rates of 0.2-0.6 km yr;.For larger T;or steeper profiles,the coast is stable but sand waves originated by other mechanisms can propagate downdrift with little decay.

关键词： Shoreline evolution Shoreline sand waves High angle wave instability Longshore sediment transport

A coupled fluid FEM-DEM technique for predicting blasting operations in tunnels

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Underground Space 2018年第4期3卷 310-316页

作者： Francisco Zarate Jose M.Gonzalez Juan miquel Rainald Lohner Eugenio Onate Centre Internacional de Metodes Numerics en Enginyeria(CIMNE) Spain Universitat Politecnica de Catalunya(UPC) Gran Capitan s/nCampus Nord08034 BarcelonaSpain George Mason University USA1

We present recent developments in the coupling of the finite element method(FEM)and the discrete element method(DEM)for the analysis of rock blasting operations in *** coupled FEM-DEM technique has been proven to be an efficient procedure for pre-dicting the multiple fractures of rock induced by the loads generated in *** coupled FEM-DEM procedure is applied in tunnel construction,as well as to gas pressure blasting pyrotechnics to break rocks for the excavation of the tunnel *** the latter case,the effect of gas explosion is modeled by solving the equations of gas dynamics in the analysis domain using *** effect of gas forces in the underlying rock mass is modeled via an embedded fluid-structure interaction *** efficiency of the coupled FEM-DEM tech-nique is demonstrated in several examples of fracture tests and rock blasting problems related to tunnel *** examples pre-sented indicate that the combination of the DEM with simple three-node linear triangular elements(for two-dimensional problems)captures the onset of fractures and their evolution accurately,accounting for the penetration of gas in the failure domain(Zarate&Onate,2015;Zarate,Cornejo,&Onate,2018).

关键词： Discrete elements Finite elements Fracture mechanics FEM-DEM Gas dynamics

Using classification assignment rules to assess land-use change impacts on forest biodiversity at local-to-national scales

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Forest Ecosystems 2018年第2期5卷 162-176页

作者： Kathrin Affeld Susan K. Wiser Ian J. Payton miquel DeCaceres Manaaki Whenua - Landcare Research PO Box 69040 Lincoln 7640 New Zealand Lincoln University PO Box 85084 Lincoln 7647 New Zealand Forest Science Centre of Catalonia Ctra. Sant Llorenc km.2 E-25280 Solsona Spain

Background： Ecosystem representation is one key component in assessing the biodiversity impacts of land-use changes that will irrevocably alter natural ecosystems. We show how detailed vegetation plot data can be used to assess the potential impact of inundation by a proposed hydroelectricity dam in the Mokihinui gorge, New Zealand, on representation of natural forests. Specifically we ask： 1） How well are the types of forest represented Locally, regionally, and nationally; and 2） How does the number of distinct communities （i.e. beta diversity） in the target catchment compare with other catchments nationally？ Methods： For local and regional comparisons plant species composition was recorded on 45 objectively located 400 m2 vegetation plots established in each of three gorges, with one being the proposed inundation area of the Mokihinui lower gorge. The fuzzy classification framework of noise clustering was used to assign these plots to a specific alliance and association of a pre-existing national-scale classification. NationaLly, we examined the relationship between the number of alliances and associations in a catchment and either catchment size or the number of plots per catchment by fitting Generalised Additive Models. Results： The four alliances and five associations that were observed in the Mokihinui lower gorge arepresent in the region but limited locally. One association was narrowly distributed nationally, but is the mostfrequent association in the Mokihinui lower gorge; inundation may have consequences of national importance to its long-term persistence. That the Mokihinui lower gorge area had nearly twice as many plots that could not be assigned to pre- existing alliances and associations than either the Mokihinui upper or the Karamea lower gorges and proportionally more than the national dataset emphasises the compositional distinctiveness of this gorge. These outlier plots in the Mokihinui lower gorge may be unsorted assemblages of species or reflect

关键词： Beta-diversity Biodiversity conservation Environmental impacts Ecosystem representation Hydroelectricity dams Land-use change National vegetation classification Noise clustering New Zealand NVS databank Plant community composition

Genetic variants of innate immune receptors and infections after liver transplantation

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2014年第32期20卷 11116-11130页

作者： Gemma Sanclemente Asuncion Moreno miquel Navasa Francisco Lozano Carlos Cervera Department of Infectious Diseases Hospital Clinic of BarcelonaIDIBAPS University of Barcelona Liver Transplant Unit Hospital Clinic of Barcelona IDIBAPS University of Barcelona Immunology Hospital Clinic of BarcelonaIDIBAPS University of Barcelona

Infection is the leading cause of complication after liver transplantation, causing morbidity and mortality in the first months after surgery. Allograft rejection is mediated through adaptive immunological responses, and thus immunosuppressive therapy is necessary after transplantation. In this setting, the presence of genetic variants of innate immunity receptors may increase the risk of post-transplant infection, in comparison with patients carrying wild-type alleles. Numerous studies have investigated the role of genetic variants of innate immune receptors and the risk of complication after liver transplantation, but their results are discordant. Tolllike receptors and mannose-binding lectin are arguably the most important studied molecules; however, many other receptors could increase the risk of infection after transplantation. In this article, we review the published studies analyzing the impact of genetic variants in the innate immune system on the development of infectious complications after liver transplantation.

关键词： Innate immunity Genetic variants Single nucleotide polymorphisms Liver transplantation Post-transplant infections Toll-like receptors Mannose-binding lectin