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The beginning of acupuncture in Washington,*** Maryland:an interview with ***-chong Chan

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Journal of Integrative Medicine 2013年第3期11卷 220-228页

作者： arthur Yin Fan Zivi Fan McLean Center for Complementary and Alternative Medicine PLC.ViennaVA 22182USA

Dr. Yeh-chong Chan （Y.C. Chan） is one of the earliest acupuncturists in the United States （US）. He served for seven years in the first acupuncture center in the US, which was established in Washington, D.C. in 1972. In 1979, he moved the clinic to Rockville, Maryland and continued to practice acupuncture there for over 30 years. He is a well-known licensed acupuncturist （LAc）, one of the developers of the acupuncture profession, and a scholar of acupuncture and traditional Chinese medicine （TCM）. He has treated two US Governors （In the US, the title Governor refers to the chief executive of each state or insular territory and the political and ceremonial head of the state.） and many sports stars. He is the author of books entitled Acupuncture Practice in the United States,

关键词： acupuncture the United States Maryland Washington DC interview as topic history of medicine Dr. Yeh-chong Chan (Y.C. Chan)

NumericalModeling of ElasticWave Propagation in a Fluid-Filled Borehole

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Communications in Computational Physics 2008年第1期3卷 33-51页

作者： arthur C.H.Cheng Joakim O.Blanch Cambridge GeoSciences 14090 Southwest FreewaySuite 300Sugar LandTX 77478USA Nexus GeoSciences 14090 Southwest FreewaySuite 240Sugar LandTX 77478USA previously at SensorWise Inc.2908 RodgerdaleHoustonTX 77042USA.

We review the methods of simulating elastic wave propagation in a *** considered two different approaches: a quasi-analytic approach using theDiscreteWavenumber SummationMethod, and the purely numerical Finite DifferenceMethod. We consider the special geometry of the borehole and discuss the problem incylindrical coordinates. We point out some numerical difficulties that are particularlyunique to this problem in cylindrical coordinates.

关键词： Acoustic borehole numerical modeling.

SimTCM: A human patient simulator with application to diagnostic accuracy studies of Chinese medicine

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Journal of Integrative Medicine 2015年第1期13卷 9-19页

作者： arthur de Sá Ferreira Antonio Guilherme Pacheco Postgraduation Program in Rehabilitation Science Augusto Motta University Center Program of Scientific Computing

OBJECTIVE： The aim of this work is to develop and implement the SimTCM, an advanced computationa model that incorporates relevant aspects from traditional Chinese medicine （TCM） theory as well as advanced statistical and epidemiological techniques for simulation and analysis of human patients. METHODS： SimTCM presents five major attributes for simulation： representation of true and false profiles for any single pattern; variable count of manifestations for each manifestation profile; empirical distributions of patterns and manifestations in a disease-specific population; incorporation of uncertainty in clinical data; and the combination of the four examinations. The proposed model is strengthened by following international standards for reporting diagnostic accuracy studies, and incorporates these standards in its treatment of study population, sample size calculation, data collection of manifestation profiles, exclusion criteria and missing data handling, reference standards, randomization and blinding and test reproducibility. RESULTS： Simulations using data from patients diagnosed with hypertension and post-stroke sensory- motor impairments yielded no significant differences between expected and simulated frequencies of patterns （P = 0.22 or higher）. Time for convergence of simulations varied from 9.90 s （9.80, 10.27） to 28.31 s （26.33, 29.52）. The ratio iteration profile necessary for convergence varied between 1：1 and 5：1. CONCLUSION： This model is directly connected to forthcoming models in a large project to design and implement the Suite TCM： ProntTCM, SciTCM, DiagTCM, StudentTCM, Research TCM, HerbsTCM, AcuTCM, and DataTCM. It is expected that the continuity of the SuiteTCM project enhances the evidence-based practice of Chinese medicine.

关键词： medicine, Chinese traditional evidence-based medicine computer-assisted decision making rehabilitation medicine (TCM)

Qualitative and quantitative analyses of the bifidobacterial microbiota in the colonic mucosa of patients with colorectal cancer, diverticulitis and inflammatory bowel disease

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World Journal of Gastroenterology 2007年第29期13卷 3985-3989页

作者： Miguel Gueimonde arthur Ouwehand Heikki Huhtinen Eeva Salminen Seppo Salminen Functional Food Forum Department of Biochemistry and Food Chemistry University of Turku Turku Finland and Instituto de Productos Lácteos de Asturias (IPLA- CSIC) Villaviciosa Asturias Spain Functional Food Forum Department of Biochemistry and Food Chemistry University of Turku Turku Finland and Health and Nutrition Danisco Kantvik Finland Department of Surgery Turku University Hospital Turku Finland Department of Oncology Turku University Hospital Turku Finland Functional Food Forum Department of Biochemistry and Food Chemistry University of Turku Turku Finland

AIM： To characterize the bifidobacterial microbiota of the colonic mucosa in patients with colon cancer, inflammatory bowel disease or diverticulitis. METHODS： A sample of the distal colonic mucosa was taken during surgery from a total of 34 patients, twenty-one with diagnosed colorectal cancer, nine with diverticulitis and four with inflammatory bowel disease, requiring surgery for their condition. Bacterial DNA was extracted from the resected mucosal samples and bifidobacterial mucosa-associated microbiota was qualitatively and quantitatively determined by means of qualitative and quantitative PCR. RESULTS： Bifidobacteria were found in 100% of the samples from patients with diverticulitis or IBD and a 76% of those suffering colon cancer. The species B. Iongum and B. bifidum were the most widely found, followed by B. animalis, B. catenulatum and B. adolescentis. B. breve, B. dentium and B. angulatum were not detected in any sample. A significantly higher occurrence of B. Iongum was observed in patients with diverticulitis than in those with colon cancer or IBD （100%, 62% and 75%, respectively, P 〈 0.05）. Similar results were obtained for B, animalis （56%, 0% and 25%, P 〈 0.05）, while B. adolescentis was only found in the mucosa from patients with colon cancer （5 out of 21, 24%）. At the quantitative level, patients with colon cancer or IBD showed lower counts of total Bifidobacterium （4.94 and 5.91 vs 6.96 log Cells/sample, respectively, P 〈 0.05） and of the species B. longum （4.05 and 4.79 vs 6.76, P 〈 0.05） than those with diverticulitis.CONCLUSION： Aberrancies in mucosa associated microbiota are present in different intestinal diseases. This may indicate a role of the microbiota in the pathogenesis of these diseases.

关键词： Bifidobacterium Colonic mucosa Colorectal cancer Diverticulitis Inflammatory bowel disease

c-Met targeted therapy of cholangiocarcinoma

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World Journal of Gastroenterology 2008年第19期14卷 2990-2994页

作者： Matei P Socoteanu Frank Mott Gianfranco Alpini arthur E Frankel Scott & White Hospital and Clinics 5701 SAirport RdTemple

Cholangiocarcinoma continues to be a challenging disease to treat. Systemic therapy is used in unresectable disease, disease progression after surgery, and in the palliative setting. Unfortunately, results of multiple phase Ⅱ trials have rarely yielded positive results. As data on the molecular carcinogenesis of cholangiocarcinoma is developing, we are more able to understand the disease process and can use this understanding to create unique targeted therapies. We reviewed the role of c-Met/ hepatocyte growth factor (HGF) in the development of cholangiocarcinoma. Furthermore, we explored the use of the c-Met guided cascade as a target to treat cholangiocarcinoma. We reviewed the current use and options for future development of c-Met agents to treat this disease.

关键词： Cholangiocarcinoma c-Met Chemotherapy Target therapy

Influences and drivers of woody debris movement in urban watercourses

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Science China(Technological Sciences) 2014年第8期57卷 1512-1521页

作者： ALLEN Deonie arthur Scott HAYNES Heather WALLIS Stephen G WALLERSTEIN Nicholas Institute for Infrastructure and Environment Heriot-Watt University

It is recognised that the blockage of culverts by woody debris can result in an increased risk of infrastructure damage and *** date,debris transport analysis has focused on regional fluvial systems and large woody debris,both in flume and field *** the social and economic risk associated with urban flooding,and as urban drainage design shifts away from subsurface piped network reliance,there is an increasing need to understand debris movement in urban *** prediction of urban watercourse small woody debris(SWD)movement,both quantity and risk,has undergone only limited analysis predominantly due to lack of field *** paper describes the development of a methodology to enable the collection of accurate and meaningful SWD residency and transportation data from *** presented research examines the limitations and effective function of PIT tag technology to collect SWD transport data in the field appropriate for risk and prediction *** integrated transponder(PIT)technology provides a method to collect debris transport data within the urban *** this study,the tags are installed within small woody debris and released at known locations into a small urban natural watercourse enabling monitoring of movement and travel *** velocity and detention are collated with solute time of travel,watercourse and point flow characteristics to identify the relationships between these key *** work presented tests three hypotheses:firstly,that the potential for unobstructed or un-detained SWD movement increases with flow velocity and water ***,that SWD travel distance,and the resistance forces along this travel path,influence SWD transport ***,the relationship between SWD and channel dimensions is examined with the aim of advancing representative debris transport prediction modelling.

关键词： woody debris transport prediction urban flood risk blockage solute dye tracing

Contemporary meta-analysis of short-term probiotic consumption on gastrointestinal transit

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World Journal of Gastroenterology 2016年第21期22卷 5122-5131页

作者： Larry E Miller Angela K Zimmermann arthur C Ouwehand Miller Scientific Consulting Inc. Asheville NC 28803 United States DuPont Nutrition and Health FIN-02460 Kantvik Finland

AIM: To determine the efficacy of probiotic supplementation on intestinal transit time(ITT) in adults and to identify factors that influence these outcomes. METHODS: We conducted a systematic review of randomized controlled trials of probiotic supplementation that measured ITT in adults. Study quality was assessed using the Jadad scale. A random effects meta-analysis was performed with standardized mean difference(SMD) of ITT between probiotic and control groups as the primary outcome. Meta-regression and subgroup analyses examined the impact of moderator variables on SMD of ***: A total of 15 clinical trials with 17 treatment effects representing 675 subjects were included in this analysis. Probiotic supplementation was moderately efficacious in decreasing ITT compared to control, with an SMD of 0.38(95%CI: 0.23-0.53, P < 0.001). Subgroup analyses demonstrated statistically greater reductions in ITT with probiotics in subjects with vs without constipation(SMD: 0.57 vs 0.22, P < 0.01) and in studies with high vs low study quality(SMD: 0.45 vs 0.00, P = 0.01). Constipation(R^2 = 38%, P < 0.01), higher study quality(R^2 = 31%, P = 0.01), older age(R^2 = 27%, P = 0.02), higher percentage of female subjects(R^2 = 26%, P = 0.02), and fewer probiotic strains(R^2 = 20%, P < 0.05) were predictive of decreased ITT with probiotics in meta-regression. Medium to large treatment effects were identified with B. lactis HN019(SMD: 0.67, P < 0.001) and B. lactis DN-173 010(SMD: 0.54, P < 0.01) while other probiotic strains yielded negligible reductions in ITT relative to ***: Probiotic supplementation is moderately efficacious for reducing ITT in adults. Probiotics were most efficacious in constipated subjects, when evaluated in high-quality studies, and with certain probiotic strains.

关键词： Constipation Gastrointestinal Intestinal transit time Meta-analysis Probiotics

Modified malleable prosthesis with a fixed mesh:case series for the Ghattas technique

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Asian Journal of Andrology 2022年第2期24卷 167-170页

作者： Osama Ghattas Mohamed Fahmy Doheim Hossam Kotb arthur L Burnett Dar-elzokora Center of Andrology Alexandria 21500Egypt Alexandria Faculty of Medicine Alexandria UniversityAlexandria 21131Egypt Department of Urology Johns Hopkins University School of MedicineBaltimoreMD 21287USA

Penile prosthetic implantation represents a cornerstone for patients with organic erectile dysfunction(ED)that is refractory,unsatisfactory,or contra-indicated for other approved medical or mechanical *** this study,we introduce the“Ghattas technique,”wherein we constructed a polypropylene mesh sheath that surrounds and is fixed to a 13-mm malleable prosthesis cylinder,which can increase the cylinder diameter for cases that need a larger *** patients underwent preoperative evaluation and completed the five-item International Index of Erectile Function questionnaire(IIEF-5).Postoperative outcomes were evaluated by IIEF-5 and Erectile Dysfunction Inventory of Treatment Satisfaction(EDITS)questionnaires at final *** mean age of the 23 included patients was 57.9(standard deviation[s.d.]:11.4)years and the mean duration of ED was 8.5(s.d.:7.9)*** improvement was determined by comparing mean preoperative and postoperative IIEF-5 scores(8.3[s.d.:3.9]vs 24.6[s.d.:0.6],P<0.001).High treatment satisfaction was determined according to a mean EDITS score of 94.9(s.d.:9.9).The proposed Ghattas technique was safe and effective in our patients,and provides opportunity for cases that need a diameter larger than 13 *** studies are needed to confirm these results.

关键词： erectile dysfunction mesh penile prosthesis surgical technique

Influence of a probiotic mixture on antibiotic induced microbiota disturbances

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World Journal of Gastroenterology 2014年第33期20卷 11878-11885页

作者： Sofia Forssten Malkanthi Evans Dale Wilson arthur C Ouwehand Active Nutrition DuPont Nutrition & Health 02460 Kantvik Finland KGK Synergize London ONN6A 5R8 Canada

AIM: To study the effect of probiotic consumption on the faecal microbiota during and after antibiotic exposure.

关键词： Probiotic Antibiotic treatment Amoxicillin/ clavulanate Microbiota Beta-lactamases Lactobacillus acidophilus Bifidobacterium lactis