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Plasma and platelet serotonin levels in patients with liver cirrhosis

World Journal of Gastroenterology 2007年第43期13卷 5750-5753页

作者： ■or■e M ulafi duko S Mirkovi miodrag d vukevi Jelena S Rudi Clinic of Gastroenterology and Hepatology Institute of Digestive Diseases Institute of Medical Biochemistry Institute of Pulmonary diseases Clinical Center of Serbia Medical Faculty Belgrade

AIM: To analyze the relationship between plasma and platelet serotonin levels and the degree of liver insufficiency. METHOdS: The prospective study included 30 patients with liver cirrhosis and 30 healthy controls. The degree of liver failure was assessed according to the Child-Pugh classification. Platelet and platelet poor plasma serotonin levels were determined. RESULTS: The mean plasma serotonin level was higher in liver cirrhosis patients than in healthy subjects (215.0 ± 26.1 vs 63.1 ± 18.1 nmol/L; P different in patients with liver cirrhosis compared with healthy individuals (4.8 ± 0.6; 4.2 ± 0.3 nmol/platelet; P > 0.05). Plasma serotonin levels were significantly higher in Child- Pugh grade A/B than in grade C patients (246.8 ± 35.0 vs 132.3 ± 30.7 nmol/L; P different between Child-Pugh grade C and grade A/B (4.6 ± 0.7 vs 5.2 ± 0.8 nmol/platelet; P > 0.05). CONCLUSION: Plasma serotonin levels are significantly higher in patients with cirrhosis than in the controls and represent the degree of liver insufficiency. In addition, platelet poor plasma serotonin estimation is a better marker for liver insufficiency than platelet serotonin content.

关键词： Serotonin Plasma Platelet Liver cirrhosis

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Spontaneous gastrojejunal fistula is a complication of gastric ulcer

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World Journal of Gastroenterology 2007年第3期13卷 483-485页

作者： dorde M ulafi Olivera d Mateji Vladimir S duki miodrag d vukevi Mirko d Kerkez Clinic of Gastroenterology and Hepatology Institute of Digestive Diseases Clinical Center of Serbia Medical FacultyBelgradeSerbia Clinic of Surgery Institute of Digestive Diseases Clinical Center of SerbiaMedical FacultyBelgradeSerbia Institute of Pulmonary diseases Clinical Center of SerbiaMedical FacultyBelgradeSerbia

Spontaneous gastrojejunal fistula formation is an extremely rare complication of gastric ulcer disease. We report a 77-year old woman who presented with diffuse abdominal pain, weight loss, malaise, nausea, and occasional dark stools. Laboratory tests showed extreme hyposideremic anemia with inflammatory syndrome. In addition, biochemical parameters of malnourishment were presented. Upper endoscopy revealed the patent esophagus along the full length without any pathological changes. Large and deep ulceration with perforation in the small intestine was detected in the posterior gastric wall. The small intestine loop was reached by endoscope through spontaneously developed gastrojejunal fistula. Polytopic biopsies of described ulcerative change were carried out. Histopathologically reepithelialized ulcerous zone was seen in the gastric mucosa. Also, gastrojejunal fistula was visualized after wide opening of hepatogastric and gastrocolic ligament. Jejunal loop 25 cm from ligament of Treitz was attached to mesocolon and posterior gastric wall because of ulcer penetration. Postoperative course was uneventful, Per oral intake started on the 4^th postoperative day, and the patient was discharged on the 8^th postoperative day. In summary, this case indicates that persistent symptoms of peptic ulcer disease associated with nutritional disturbances may be caused by gastrojejunal fistula.

关键词： Gastric ulcer Spontaneous Gastrojejunal fistula

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A framework for efficient irregular wave simulations using Higher Order Spectral method coupled with viscous two phase model

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Journal of Ocean Engineering and Science 2017年第4期2卷 253-267页

作者： Inno Gatin vuko vukčević Hrvoje Jasak Faculty of Mechanical Engineering and Naval Architecture University of ZagrebIvana Lučića 5ZagrebCroatia Wikki Ltd. 459 Southbank HouseSE17SJ LondonUnited Kingdom

In this paper a framework for efficient irregular wave simulations using Higher Order Spectral method coupled with fully nonlinear viscous,two-phase Computational Fluid dynamics(CFd)model is *** model is based on solution decomposition via Spectral Wave Explicit Navier-Stokes Equation method,allowing efficient coupling with arbitrary potential flow *** Order Spectrum is a pseudo-spectral,potential flow method for solving nonlinear free surface boundary conditions up to an arbitrary order of *** is capable of efficient long time nonlinear propagation of arbitrary input wave spectra,which can be used to obtain realistic extreme *** facilitate the coupling strategy,Higher Order Spectrum method is implemented in foam-extend alongside the CFd *** of the Higher Order Spectrum method is performed on three test cases including monochromatic and irregular wave ***,the coupling between Higher Order Spectrum and CFd is validated on three hour irregular wave ***,a simulation of a 3d extreme wave encountering a full scale container ship is shown.

关键词： Higher Order Spectral method Irregular waves Extreme waves CFd Foam-extend

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