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化工设计 2007年第5期17卷 29-33页

作者：张民贞洛阳石油化工工程公司洛阳471003

通过对工程建设中管道支吊架设置的重要性论述,重点分析弹簧支吊架的应用场合、弹簧的选用方法以及弹簧失效的原因。

关键词：支吊架弹簧管道设计荷载变化率失效

中西医结合治疗小儿抗生素相关性腹泻39例临床观察

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中国民族民间医药 2018年第15期27卷 106-108页

作者：张敏珍山西省阳泉市中医医院儿科山西阳泉045000

目的:观察中西医结合治疗小儿抗生素相关性腹泻的临床疗效。方法:选取小儿抗生素相关性腹泻患儿78例,随机分为对照组和观察组,每组39例。对照组采用常规西药治疗,观察组在对照组基础上予健脾补肾固摄汤治疗,对两组腹泻频率、腹泻持续时... 详细信息

目的:观察中西医结合治疗小儿抗生素相关性腹泻的临床疗效。方法:选取小儿抗生素相关性腹泻患儿78例,随机分为对照组和观察组,每组39例。对照组采用常规西药治疗,观察组在对照组基础上予健脾补肾固摄汤治疗,对两组腹泻频率、腹泻持续时间及疗效进行比较。结果:观察组腹泻频率及持续时间均明显少于对照组,治疗总有效率较高,差异有统计学意义(P<0.05)。结论:中西医结合治疗可有效减轻小儿抗生素相关性腹泻,腹泻症状减轻缩短腹泻持续时间,提高治疗效果。

关键词：抗生素相关性腹泻小儿健脾补肾固摄汤

玉屏风口服液合人参五味子汤加减治疗支气管哮喘缓解期肺脾气虚证临床观察

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光明中医 2018年第17期33卷 2512-2514页

作者：张敏珍阳泉市中医医院儿科山西阳泉045000

目的探讨玉屏风口服液与人参五味子汤联合治疗支气管哮喘缓解期肺脾气虚证的疗效。方法选取我院2016年2月—2018年2月收治的支气管哮喘缓解期肺脾气虚患儿60例,根据随机数字表法分为对照组与观察组,各30例。对照组接受西药治疗,观察组... 详细信息

目的探讨玉屏风口服液与人参五味子汤联合治疗支气管哮喘缓解期肺脾气虚证的疗效。方法选取我院2016年2月—2018年2月收治的支气管哮喘缓解期肺脾气虚患儿60例,根据随机数字表法分为对照组与观察组,各30例。对照组接受西药治疗,观察组在对照组基础上联合使用玉屏风口服液与人参五味子汤,治疗3个月后对比2组临床症状缓解情况,、肺功能改善情况及不良反应发生率。结果治疗后,观察组症状改善情况优于对照组,肺功能各指标水平较对照组升高明显,差异有统计学意义(P<0.05);所有患者均无不良反应发生。结论支气管哮喘缓解期肺脾气虚者应用玉屏风口服液与人参五味子汤联合治疗,可促进临床症状更好更快缓解,肺功能显著改善,且无明显不良反应,安全有效。

关键词：支气管哮喘肺脾气虚证缓解期玉屏风口服液人参五味子汤中医药疗法

医用钛合金表面聚电解质层接枝酪蛋白磷酸肽复合薄膜的生物矿化评价

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材料导报 2014年第12期28卷 55-58,62页

作者：张民珍李明昕王富国刘斌张俊彦兰州大学口腔医学院兰州730000 中国科学院兰州化学物理研究所兰州730000

采用层层自组装的方法,在羟基化和硅烷偶联剂处理的医用钛合金表面交替组装海藻酸钠和壳聚糖,再通过酰胺化反应接枝酪蛋白磷酸肽,在医用钛合金表面形成具有仿生矿化能力的聚电解质复合薄膜。采用XPS、ATR-FTIR、FESEM以及XRD对样品表面... 详细信息

采用层层自组装的方法,在羟基化和硅烷偶联剂处理的医用钛合金表面交替组装海藻酸钠和壳聚糖,再通过酰胺化反应接枝酪蛋白磷酸肽,在医用钛合金表面形成具有仿生矿化能力的聚电解质复合薄膜。采用XPS、ATR-FTIR、FESEM以及XRD对样品表面进行表征,并将各组样品放入模拟体液中考察仿生矿化沉积能力。结果表明:在医用钛合金表面成功制备了聚电解质层接枝酪蛋白磷酸肽复合薄膜,经仿生矿化的各组样品表面均有羟基磷灰石沉积,聚电解质层组表面具有纳米多孔结构以及羧基和羟基活性基团,接枝酪蛋白磷酸肽后表面又具有磷酸活性基团,因此最终形成的复合薄膜羟基磷灰石沉积最为致密,表明其生物矿化能力明显增强。

关键词：钛合金表面改性羟基磷灰石生物矿化

噻托溴铵对慢性阻塞性肺疾病稳定期患者血清超敏C反应蛋白、肿瘤坏死因子-α水平及肺功能的影响

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中国医药导报 2014年第20期11卷 66-68页

作者：王中原张敏珍浙江省宁波市北仑区人民医院呼吸科浙江宁波315806

目的探讨噻托溴铵对慢性阻塞性肺疾病（COPD）稳定期患者血清超敏C反应蛋白（hs-CRP）和肿瘤坏死因子-α（TNF-α）水平及肺功能的影响。方法选取2012年8月～2013年9月宁波市北仑区人民医院呼吸科治疗的COPD稳定期患者70例,随机分为观... 详细信息

目的探讨噻托溴铵对慢性阻塞性肺疾病（COPD）稳定期患者血清超敏C反应蛋白（hs-CRP）和肿瘤坏死因子-α（TNF-α）水平及肺功能的影响。方法选取2012年8月～2013年9月宁波市北仑区人民医院呼吸科治疗的COPD稳定期患者70例,随机分为观察组（n=35）和对照组（n=35）。对照组患者予以茶碱缓释片口服,0.1 g/次,2次/d,连用16周。观察组患者予以噻托溴铵干粉剂1粒/次,1次/d,睡前吸入,连用16周。观察两组治疗前和治疗16周后血清hs-CRP、TNF-α及肺功能的变化。结果治疗16周后,观察组与对照组患者血清hs-CRP、TNF-α水平[（1.07±0.23）mg/L,（1.45±0.27）ng/mL;（1.42±0.31）mg/L,（2.16±0.45）ng/mL]均较前[（2.05±0.46）mg/L,（2.92±0.52）ng/mL;（1.97±0.45）mg/L,（2.87±0.57）ng/mL]明显下降（t=3.02、3.17、2.39、2.31,P〈0.01或P〈0.05）,且观察组下降幅度明显大于对照组（t=2.27、2.45,P〈0.05）;同时观察组与对照组患者治疗后用力肺活量（FVC）、第1秒用力呼气量（FEV1）和FEV1/FVC[（1.77±0.34）L,（1.21±0.25）L,（0.70±0.19）;（1.58±0.32）L,（0.99±0.23）L,（0.63±0.15）]均较前[（1.41±0.24）L,（0.80±0.15）L,（0.57±0.12）;（1.42±0.26）L,（0.79±0.18）L,（0.56±0.13）]明显提高（t=2.45、2.89、2.44、2.16、2.41、2.18,P〈0.05或P〈0.01）,且观察组提高幅度明显大于对照组（t=2.18、2.37、2.15,P〈0.05）。结论噻托溴铵吸入治疗COPD稳定期具有较好的效果,能明显改善患者的肺功能,其作用机制与其能降低血清炎症因子hs-CRP、TNF-α水平,抑制慢性炎性反应过程密切相关。

关键词：慢性阻塞性肺疾病噻托溴铵超敏C反应蛋白肿瘤坏死因子-α

Determination of Double Beta Decay Half-Life of 136Xe with the PandaX-4T Natural Xenon Detector

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Research 2023年第2期2022卷 33-41页

作者： Lin Si Zhaokan Cheng Abdusalam Abdukerim Zihao Bo Wei Chen Xun Chen Yunhua Chen Chen Cheng Yunshan Cheng Xiangyi Cui Yingjie Fan Deqing Fang Changbo Fu Mengting Fu Lisheng Geng Karl Giboni Linhui Gu Xuyuan Guo Ke Han Changda He Jinrong He Di Huang Yanlin Huang Zhou Huang Ruquan Hou Xiangdong Ji Yonglin Ju Chenxiang Li Jiafu Li Mingchuan Li Shu Li Shuaijie Li Qing Lin Jianglai Liu Xiaoying Lu Lingyin Luo Yunyang Luo Wenbo Ma Yugang Ma Yujun Mao Yue Meng Nasir Shaheed Xiaofeng Shang Xuyang Ning Ningchun Qi Zhicheng Qian Xiangxiang Ren Changsong Shang Guofang Shen Wenliang Sun Andi Tan Yi Tao Anqing Wang Meng Wang Qiuhong Wang Shaobo Wang Siguang Wang Wei Wang Xiuli Wang Zhou Wang Yuehuan Wei Mengmeng Wu Weihao Wu Jingkai Xia Mengjiao Xiao Xiang Xiao Pengwei Xie Binbin Yan Xiyu Yan Yong Yang Chunxu Yu Jumin Yuan Ying Yuan Zhe Yuan Dan zhang minzhen zhang Peng zhang Shibo zhang Shu zhang Tao zhang Li Zhao Qibin Zheng Jifang Zhou Ning Zhou Xiaopeng Zhou Yong Zhou IMOE Key Laboratory for Particle Astrophysics and Cosmology Shanghai Key Laboratory for Particle Physics and Cosmology School of Physics and AstronomyShanghai Jiao Tong UniversityShanghai 200240China Sino-French Institute of Nuclear Engineering and Technology Sun Yat-sen UniversityZhuhai 519082China Sichuan Research Institute Shanghai Jiao Tong UniversityChengdu 610213China Yalong River Hydropower Development Company Ltd.288 Shuanglin RoadChengdu 610051China School of Physics Sun Yat-sen UniversityGuangzhou 510275China Research Center for Particle Science and Technology Institute of Frontier and Interdisciplinary ScienceShandong UniversityQingdao266237 ShandongChina Key Laboratory of Particle Physics and Particle Irradiation of Ministry of Education Shandong UniversityQingdao266237 ShandongChina Tsung-Dao Lee Institute Shanghai Jiao Tong UniversityShanghai 200240China School of Physics Nankai UniversityTianjin 300071China Key Laboratory NuclearPyics and Ionampplication(MOE)Instituteof ModenPysics Fun Universty Shanghai 200433China School of Physics Peking UniversityBeijing 100871China Schol of Physics Beihang UniversityBejing 100191China International Research Center for Nuclei and Particles in the Cosmos Beijing key Laboratory of Advanced Nuclear Materials and Physics Beihang UniversityBeijing 100191China School of Medical Instrument and Food Engineering University of Shanghai for Science and TechnologyShanghai200093China Department of Physics University of MarylandCollge ParkMaryland 20742USA School of Mechanical Engineering Shanghai Jiao Tong UniversityShanghai 200240China State Key Laboratoryof Particle Detetion and Electronics University of Scienceand Technology of ChinaHefei230026China Department of Modern Physics University of Science and Technology of ChinaHefei230026China SJTU ParisElite Instute of Technology Shanghai Jiao Tong UniversityShanghai 200240China

Precise measurement of two-neutrino double beta decay(DBD)half-life is an important step for the searches of Majorana neutrinos with neutrinoless double beta *** report the measurement of DBD half-life of 136xe using the Pandax-4T dual-phase Time Projection Chamber(TPC)with 3.7-tonne natural xenon and the first 94.9-day physics data release.

关键词： decay double Determination

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巴戟天多糖对大鼠骨质疏松的作用机制研究

陕西中医 2024年第3期45卷 302-307页

作者：张民珍罗文杨黎艳邝慧芳海南医学院第一附属医院海南海口570102

目的:探讨巴戟天多糖对大鼠骨质疏松的疗效。方法:通过将30只大鼠分为正常组、模型组和不同剂量的巴戟天多糖组,进行相关实验研究。结果:与正常组相比,模型组大鼠血清中TNF-α、IL-6水平升高,骨小梁分离度增加,并且骨密度、骨钙、骨磷、... 详细信息

目的:探讨巴戟天多糖对大鼠骨质疏松的疗效。方法:通过将30只大鼠分为正常组、模型组和不同剂量的巴戟天多糖组,进行相关实验研究。结果:与正常组相比,模型组大鼠血清中TNF-α、IL-6水平升高,骨小梁分离度增加,并且骨密度、骨钙、骨磷、ALP含量、废用残根骨体积分数、骨小梁厚度和数量、最大载荷、最大桡度、弹性载荷、刚性系数、CaBp-D9k和CaBp-D28k蛋白表达降低。与模型组相比,巴戟天多糖组的血清TNF-α、IL-6水平降低,骨小梁分离度减少,且骨密度、骨钙、骨磷、ALP含量、废用残根骨体积分数、骨小梁厚度和数量、最大载荷、最大桡度、弹性载荷、刚性系数、CaBp-D9k和CaBp-D28k蛋白表达增加。结论:巴戟天多糖能提高骨密度、骨钙、骨磷和ALP含量,抑制炎症因子分泌,增加CaBp-D9k蛋白表达,改善废用残根咀嚼功能,且对骨质疏松的改善具有积极作用。

关键词：骨质疏松巴戟天多糖咀嚼功能骨生物力学钙结合蛋白-D9k

头孢呋辛联合甲泼尼龙治疗老年慢性阻塞性肺疾病合并肺气肿的疗效观察

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中国基层医药 2017年第10期24卷 1515-1519页

作者：张勇华陈水芳张敏珍陈世元宁波市北仑区人民医院呼吸科浙江省宁波315800

目的观察老年慢性阻塞性肺疾病（COPD）合并肺气肿患者接受头孢呋辛联合甲泼尼龙治疗的疗效.方法选取92例老年慢性阻塞性肺气肿患者为研究对象,按照数字表法随机分为观察组和对照组,每组46例.对照组采用抗生素治疗,观察组采用头孢呋... 详细信息

目的观察老年慢性阻塞性肺疾病（COPD）合并肺气肿患者接受头孢呋辛联合甲泼尼龙治疗的疗效.方法选取92例老年慢性阻塞性肺气肿患者为研究对象,按照数字表法随机分为观察组和对照组,每组46例.对照组采用抗生素治疗,观察组采用头孢呋辛联合甲泼尼龙治疗,比较两组临床治疗效果、肺功能指标、血气指标及不良反应发生情况.结果观察组总有效率为91.30%,明显高于对照组的76.09%（χ^2=8.476,P〈0.05）;观察组用力肺活量占预计值百分比（FVC%）、第一秒钟用力呼气容积（FEV1）、第一秒用力呼气容积占预计值百分比（FEV1%）、最大分钟通气量（MVV）均高于对照组（t=2.657、3.610、2.413、2.359,均P〈0.05）;观察组PaO2水平[（80.3±2.8）mmHg]较对照组[（74.1±3.8）mmHg]更高,PaCO2水平[（34.0±1.1）mmHg]明显低于对照组[（40.2±2.2）mmHg],差异均有统计学意义（t=3.021 1、3.952,均P〈0.05）;观察组不良反应发生率为6.52%,与对照组的10.87%比较差异无统计学意义（χ^2=1.363,P〉0.05）.结论针对老年慢性阻塞性肺疾病合并肺气肿患者,采用抗生素与糖皮质激素联合治疗,可有效缓解临床症状,改善血气指标和肺功能,不良反应少,安全性高,具有较高的临床应用价值.

关键词：肺疾病,慢性阻塞性肺气肿抗生素糖皮质激素老年人

Measurement of solar pp neutrino flux using electron recoil data from PandaX-4T commissioning run

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Chinese Physics C 2024年第9期48卷 1-7,300页

作者： Xiaoying Lu Abdusalam Abdukerim Zihao Bo Wei Chen Xun Chen Yunhua Chen Chen Cheng Zhaokan Cheng Xiangyi Cui Yingjie Fan Deqing Fang Lisheng Geng Karl Giboni Xuyuan Guo Chencheng Han Ke Han Changda He Jinrong He Di Huang Junting Huang Zhou Huang Ruquan Hou Yu Hou Xiangdong Ji Yonglin Ju Chenxiang Li Jiafu Li Mingchuan Li Shuaijie Li Tao Li Qing Lin Jianglai Liu Congcong Lu Lingyin Luo Yunyang Luo Wenbo Ma Yugang Ma Yajun Mao Yue Meng Xuyang Ning Binyu Pang Ningchun Qi Zhicheng Qian Xiangxiang Ren Nasir Shaheed Xiaofeng Shang Xiyuan Shao Guofang Shen Manbin Shen Lin Si Wenliang Sun Yi Tao Anqing Wang Meng Wang Qiuhong Wang Shaobo Wang Siguang Wang Wei Wang Xiuli Wang Xu Wang Zhou Wang Yuehuan Wei Mengmeng Wu Weihao Wu Yuan Wu Mengjiao Xiao Xiang Xiao Kaizhi Xiong Binbin Yan Xiyu Yan Yong Yang Chunxu Yu Ying Yuan Zhe Yuan Youhui Yun Xinning Zeng minzhen zhang Peng zhang Shibo zhang Shu zhang Tao zhang Wei zhang Yang zhang Yingxin zhang Yuanyuan zhang Li Zhao Jifang Zhou Ning Zhou Xiaopeng Zhou Yubo Zhou Zhizhen Zhou Research Center for Particle Science and Technology Institute of Frontier and Interdisciplinary ScienceShandong UniversityQingdao 266237China Key Laboratory of Particle Physics and Particle Irradiation of Ministry of Education Shandong UniversityQingdao 266237China School of Physics and Astronomy Shanghai Jiao Tong UniversityKey Laboratory for Particle Astrophysics and Cosmology(MoE)Shanghai Key Laboratory for Particle Physics and CosmologyShanghai 200240China New Cornerstone Science Laboratory Tsung-Dao Lee InstituteShanghai Jiao Tong UniversityShanghai 200240China Shanghai Jiao Tong University Sichuan Research Institute Chengdu 610213China Jinping Deep Underground Frontier Science and Dark Matter Key Laboratory of Sichuan Province Liangshan 615000China Yalong River Hydropower Development Company Ltd.288 Shuanglin RoadChengdu 610051China School of Physics Sun Yat-Sen UniversityGuangzhou 510275China Sino-French Institute of Nuclear Engineering and Technology Sun Yat-Sen UniversityZhuhai 519082China Department of Physics Yantai UniversityYantai 264005China Key Laboratory of Nuclear Physics and Ion-beam Application(MOE) Institute of Modern PhysicsFudan UniversityShanghai 200433China School of Physics Beihang UniversityBeijing 102206China Beijing Key Laboratory of Advanced Nuclear Materials and Physics Beihang UniversityBeijing 102206China Peng Huanwu Collaborative Center for Research and Education Beihang UniversityBeijing 100191China Southern Center for Nuclear-Science Theory(SCNT) Institute of Modern PhysicsChinese Academy of SciencesHuizhou 516000China School of Mechanical Engineering Shanghai Jiao Tong UniversityShanghai 200240China Department of Physics University of MarylandCollege ParkMaryland 20742USA State Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026China Department of Modern Physics University of Science and Technology of ChinaHefei 230026China School of Physics Peking UniversityBeijing 100871Ch

The proton-proton(pp)fusion chain dominates the neutrino production in the *** uncertainty of the predicted pp neutrino flux is at the sub-percent level,whereas that of the best measurement is O(10%).In this study,for the first time,we measure solar pp neutrinos in the electron recoil energy range from 24 to 144 keV using the PandaX-4T commissioning data with 0.63 tonne×year *** pp neutrino flux is determined as(8.0±3.9(stat)±10.0(syst))×1010 s^(-1)cm^(-2),which is consistent with the Standard Solar Model and existing measurements,corresponding to an upper flux limit of 23.3×10^(10)s^(-1)cm^(-2)at 90%C.L..

关键词： solar pp neutrino flux PandaX-4T electron recoil spectrum

Glucocorticoid receptor signaling in the brain and its involvement in cognitive function

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Neural Regeneration Research 2025年第9期20卷 2520-2537页

作者： Chonglin Su Taiqi Huang Meiyu zhang Yanyu zhang Yan Zeng Xingxing Chen Brain Science and Advanced Technology Institute Hubei Province Key Laboratory of Occupational Hazard Identification and ControlSchool of MedicineWuhan University of Science and TechnologyWuhanHubei ProvinceChina

The hypothalamic-pituitary-adrenal axis regulates the secretion of glucoco rticoids in response to environmental *** the brain,a nuclear receptor transcription fa ctor,the glucocorticoid recepto r,is an important component of the hypothalamicpituitary-a d renal axis's negative feedback loop and plays a key role in regulating cognitive equilibrium and *** glucoco rticoid receptor influences cognitive processes,including glutamate neurotransmission,calcium signaling,and the activation of brain-derived neurotrophic factor-mediated pathways,through a combination of genomic and non-genomic *** interactions within the central nervous system can alter the expression and activity of the glucocorticoid receptor,there by affecting the hypothalamic-pituitary-a d renal axis and stress-related cognitive *** appropriate level of glucocorticoid receptor expression can improve cognitive function,while excessive glucocorticoid receptors or long-term exposure to glucoco rticoids may lead to cognitive *** with cognitive impairment-associated diseases,such as Alzheimer's disease,aging,depression,Parkinson's disease,Huntington's disease,stroke,and addiction,often present with dysregulation of the hypothalamic-pituitary-adrenal axis and glucocorticoid receptor *** review provides a comprehensive overview of the functions of the glucoco rticoid receptor in the hypothalamic-pituitary-a d renal axis and cognitive *** emphasizes that appropriate glucocorticoid receptor signaling fa cilitates learning and memory,while its dysregulation can lead to cognitive *** provides clues about how glucocorticoid receptor signaling can be targeted to ove rcome cognitive disability-related disorders.

关键词： brain-derived neurotrophic factor calcium signaling glucocorticoid receptor glucocorticoid glutamate transmission hypothalamic-pituitary-adrenal axis long-term potentiation neurocognitive disorders neuroplasticity stress