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Biomechanical and biological responses of periodontium in orthodontic tooth movement:up-date in a new decade

International Journal of Oral Science 2021年第2期13卷 129-147页

作者： Yuan Li Qi Zhan minyue bao Jianru Yi Yu Li State Key Laboratory of Oral Diseases&National Clinical Research Center for Oral Diseases&Department of Orthodontics West China Hospital of StomatologySichuan UniversityChengduChina

Nowadays,orthodontic treatment has become increasingly ***,the biological mechanisms of orthodontic tooth movement(OTM)have not been fully *** were aiming to summarize the evidences regarding the mechanisms of ***,we introduced the research models as a basis for further discussion of ***,we proposed a new hypothesis regarding the primary roles of periodontal ligament cells(PDLCs)and osteocytes involved in OTM mechanisms and summarized the biomechanical and biological responses of the periodontium in OTM through four steps,basically in OTM temporal sequences,as follows:(1)Extracellular mechanobiology of periodontium:biological,mechanical,and material changes of acellular components in periodontium under orthodontic forces were introduced.(2)Cell strain:the sensing,transduction,and regulation of mechanical stimuli in PDLCs and osteocytes.(3)Cell activation and differentiation:the activation and differentiation mechanisms of osteoblast and osteoclast,the force-induced sterile inflammation,and the communication networks consisting of sensors and effectors.(4)Tissue remodeling:the remodeling of bone and periodontal ligament(PDL)in the compression side and tension side responding to mechanical stimuli and root ***,we talked about the clinical implications of the updated OTM mechanisms,regarding optimal orthodontic force(OOF),acceleration of OTM,and prevention of root resorption.

关键词： period prevention inflammation

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Biomineralization inspired 3D printed bioactive glass nanocomposite scaffolds orchestrate diabetic bone regeneration by remodeling micromilieu

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Bioactive Materials 2023年第7期25卷 239-255页

作者： Zeqian Xu Xuanyu Qi minyue bao Tian Zhou Junfeng Shi Zhiyan Xu Mingliang Zhou Aldo R.Boccaccini Kai Zheng Xinquan Jiang Department of Prosthodontics Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineNo.639 Zhizaoju RoadShanghai200011People’s Republic of China College of Stomatology Shanghai Jiao Tong UniversityNo.639 Zhizaoju RoadShanghai200011People’s Republic of China National Center for Stomatology No.639 Zhizaoju RoadShanghai200011People’s Republic of China National Clinical Research Center for Oral Diseases No.639 Zhizaoju RoadShanghai200011People’s Republic of China Shanghai Key Laboratory of Stomatology No.639 Zhizaoju RoadShanghai200011People’s Republic of China Shanghai Engineering Research Center of Advanced Dental Technology and Materials No.639 Zhizaoju RoadShanghai200011People’s Republic of China Department of Oral Maxillofacial-Head and Neck Oncology Shanghai Ninth People’s HospitalCollege of StomatologyShanghai Jiao Tong University School of MedicineShanghai200023People’s Republic of China Institute of Biomaterials University of Erlangen-NurembergCauerstrasse 691058ErlangenGermany Jiangsu Province Engineering Research Center of Stomatological Translational Medicine Nanjing Medical UniversityNanjing210029People’s Republic of China Jiangsu Key Laboratory of Oral Diseases Nanjing Medical UniversityNanjing210029People’s Republic of China

TypeⅡdiabetes mellitus(TIIDM)remains a challenging clinical issue for both dentists and *** virtue of persistent hyperglycemia and altered host metabolism,the pathologic diabetic micromilieu with chronic inflammation,advanced glycation end products accumulation,and attenuated biomineralization severely impairs bone regeneration *** to“remodel”the pathologic diabetic micromilieu,we 3D-printed bioscaffolds composed of Sr-containing mesoporous bioactive glass nanoparticles(Sr-MBGNs)and gelatin methacrylate(GelMA).Sr-MBGNs act as a biomineralization precursor embedded in the GelMA-simulated extracellular matrix and release Sr,Ca,and Si ions enhancing osteogenic,angiogenic,and immunomodulatory *** addition to angiogenic and anti-inflammatory outcomes,this innovative design reveals that the nanocomposites can modulate extracellular matrix reconstruction and simulate biomineralization by activating lysyl oxidase to form healthy enzymatic crosslinked collagen,promoting cell focal adhesion,modulating osteoblast differentiation,and boosting the release of OCN,the noncollagenous proteins(intrafibrillar mineralization dependent),and thus orchestrating osteogenesis through the Kindlin-2/PTH1R/OCN *** 3D-printed bioscaffold provides a multifunctional biomineralization-inspired system that remodels the“barren”diabetic microenvironment and sheds light on the new bone regeneration approaches for TIIDM.

关键词： Biomineralization TypeⅡDiabetes mellitus 3D printing Sr-containing mesoporous bioactive glass nanoparticles Enzymatic cross-links

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稻谷在锦江黄牛瘤胃降解率测定

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饲料工业 2014年第11期35卷 58-60页

作者：包淋斌刘敏跃瞿明仁江西农业大学江西省动物营养重点实验室江西南昌330045 辽宁省农牧业机械研究所有限公司辽宁沈阳110036

试验旨在研究稻谷在锦江黄牛瘤胃中的降解规律,为肉牛饲料配制提供依据。研究选用3头装有永久性瘤胃瘘管的健康成年锦江黄牛测定稻谷干物质、有机物质、粗蛋白、中性洗涤纤维和酸性洗涤纤维的降解率。结果表明:稻谷干物质、有机物质、... 详细信息

试验旨在研究稻谷在锦江黄牛瘤胃中的降解规律,为肉牛饲料配制提供依据。研究选用3头装有永久性瘤胃瘘管的健康成年锦江黄牛测定稻谷干物质、有机物质、粗蛋白、中性洗涤纤维和酸性洗涤纤维的降解率。结果表明:稻谷干物质、有机物质、粗蛋白、中性洗涤纤维、酸性洗涤纤维含量分别为87.71%、83.87%、7.16%、31.51%、26.90%,其在锦江黄牛瘤胃中有效降解率率分别为:75.34%、79.72%、39.49%、39.55%、48.58%,说明稻谷在瘤胃中能很好地被消化,具有较高的饲用价值。

关键词：稻谷锦江黄牛瘤胃降解率

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