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电针预处理对输尿管软镜下钬激光碎石术老年患者术后认知功能的影响

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上海针灸杂志 2023年第1期42卷 12-16页

作者：万义芹周民涛南阳市第一人民医院(河南大学附属医院) 南阳473010

目的观察电针(electroacupuncture,EA)预处理对全身麻醉(general anesthesia,GA)下行输尿管软镜(flexible ureteroscope,FURS)下钬激光碎石术老年患者术后认知功能的影响。方法将择期GA下行FURS下钬激光碎石术老年患者60例随机分为观察... 详细信息

目的观察电针(electroacupuncture,EA)预处理对全身麻醉(general anesthesia,GA)下行输尿管软镜(flexible ureteroscope,FURS)下钬激光碎石术老年患者术后认知功能的影响。方法将择期GA下行FURS下钬激光碎石术老年患者60例随机分为观察组和对照组,每组30例。麻醉诱导前30 min,观察组采用电针(EA)治疗;对照组不予EA治疗。观察两组EA刺激前(T_(0))、麻醉诱导后3 min(Ta_(1))、气管插管后1 min(Ta_(2))、手术开始时(Ta_(3))、气管导管拔出时(Ta_(4))和拔管后5 min(Ta_(5))的心率(heart rate,HR)与平均动脉压(mean arterial pressure,MAP);观察两组EA T_(0)、术后1 d(Tb_(1))、术后3 d(Tb_(2))和术后7 d(Tb_(3))的简易智力状态量表(mini-mental state examination,MMSE)评分及血浆神经元特异性烯醇化酶(neuron-specific enolase,NSE)、S100β蛋白和白细胞介素-6(interleukin-6,IL-6)的含量;并比较两组术后认知功能障碍(postoperative cognitive dysfunction,POCD)发生率。结果与T_(0)比较,两组Ta1MAP和HR降低(P<0.05),对照组MAP和HR在Ta_(2)和Ta_(4)升高(P<0.05);与对照组比较,观察组Ta_(2)和Ta_(4)MAP和HR降低(P<0.05)。与T_(0)比较,对照组MMSE评分在Tb_(1)和Tb_(2)降低(P<0.05);与对照组比较,观察组Tb_(1)和Tb_(2)MMSE评分明显升高(P<0.05)。与T_(0)比较,两组Tb_(1)、Tb_(2)血浆S100β蛋白与NSE升高(P<0.05);与对照组比较,观察组Tb_(1)、Tb_(2)血浆S100β蛋白与NSE降低(P<0.05)。与T_(0)比较,对照组Tb_(1)血浆IL-6升高(P<0.05);与对照组比较,观察组Tb_(1)血浆IL-6降低(P<0.05)。与对照组比较,观察组Tb_(1)和Tb_(2)POCD发生率明显降低(P<0.05)。结论EA能降低GA下行FURS下钬激光碎石术的老年患者POCD的发生率,其机制可能与术中维持稳定的血流动力学和降低手术创伤引起IL-6的过度表达有关。

关键词：电针术后并发症的认知障碍输尿管软镜碎石术激光血流动力学白细胞介素-6

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汽水分离再热器安全阀维修标定试验研究

中国特种设备安全 2019年第4期35卷 20-24页

作者：解永超贾仁东万民涛中核集团中国中原对外工程有限公司

分析了新型卧式汽水分离再热器安全阀首次维修标定过程中的维修要点和热、冷态试验结果与影响因素,给出了冷态标定起跳压力范围,并从结构方面提出了改进建议,对该机组后续安全阀的维修标定具有一定指导意义。

关键词：汽水分离再热器安全阀维修标定

TIR enzymatic functions:signaling molecules and receptor mechanisms

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aBIOTECH 2023年第2期4卷 172-175页

作者： Li wan National Key Laboratory of Plant Molecular Genetics CAS Center for Excellence in Molecular Plant SciencesInstitute of Plant Physiology and EcologyChinese Academy of SciencesShanghai200032China

The evolutionarily conserved Toll/Interleukin-1 Receptor(TIR)domains across kingdoms of prokaryotes,plants,and animals play critical roles in innate immunity.Recent studies have revealed the enzymatic functions of TIRs,the structural bases of TIRs as holoenzymes,and the identity of TIR-generated small signaling molecules and their receptors,which significantly advanced our understanding on TIR-mediated immune signaling pathways.We reviewed the most up-to-date findings in TIR enzymatic functions from the perspectives of signaling molecules and receptor mechanisms.

关键词： NLR immune receptors TIR domains Signaling molecules Cell death

Protecting People from Tobacco Smoke in China: Current Status and Challenges

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China CDC weekly 2022年第21期4卷 460-464页

作者： Xia wan Institute of Basic Medical Sciences Chinese Academy of Medical Sciences and School of Basic MedicinePeking Union Medical CollegeBeijingChina

Over the past two years,many people have encountered difficulties because of the advent of coronavirus disease 2019(COVID-19).The COVID-19 pandemic has unleashed many concerns,such as social isolation and loneliness,drastic changes to lifestyles,uncertainty for the future,and financial pressure.Some people reported smoking more than usual to reduce stress or loneliness(1),which made more people vulnerable to be exposed to second-hand tobacco smoke(SHS).As we know there is no safe level of exposure to SHS,and even brief exposure can cause harm(2).Under this circumstance,it is quite meaningful to reiterate the topic of protecting people from the harms of SHS.

关键词： smoke meaningful exposure

Light people:Prof.Evelyn Hu's adventure:from semiconductors to quantum-from industry to academia

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光:科学与应用(英文版) 2023年第8期12卷 1459-1466页

作者： Yating wan Chenzi Guo Integrated Photonics lab King Abdullah University of Science and TechnologyThuwalMakkah ProvinceSaudi Arabia Changchun Institute of Optics Fine Mechanics and PhysicsChinese Academy of SciencesChangchunChina

Editorial As part of our Light People series,we are delighted to have invited Prof.Evelyn Hu,a highly accomplished scientist from Harvard University,to share with us her personal journey.Prof.Hu's remarkable contributions in both academia and industry have taken her from industry giants to academia's most prestigious institutions,traversing various research frontiers that have played a critical role in the ongoing digital revolution.Through this interview,we aim to offer the Light community valuable insights into nanophotonics,quantum engineering,and Prof.Hu's research methodology and life philosophy,while also celebrating her outstanding achievements as a female role model.Ultimately,our goal is to inspire more women to pursue careers in this important and rapidly expanding field,which has a profound impact on all sectors of society.The following is a summary of an interview with Professor Evelyn Hu,available in the Supplementary Information.

关键词： interview frontier industry

Light People:Prof.John Bowers spoke about silicon photonics

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Light(Science & Applications) 2022年第12期11卷 2843-2848页

作者： Chenzi Guo Yating wan Changchun Institute of Optics Fine Mechanics and PhysicsChinese Academy of SciencesChangchunChina Integrated Photonics lab King Abdullah University of Science and TechnologyThuwalMakkah

Editorial Silicon photonics is advancing rapidly with many scientific and engineering advances and many new applications for photonics.To highlight the topic,Light:Science&Applications invited John Bowers,director of the Institute for Energy Efficiency and distinguished professor from the University of California,Santa Barbara,to talk about the fundamentals and industries,and give a future perspective of silicon photonics.The below is summarized from the video interview of Prof.Bowers.The original interview can be accessed in Supplementary video.

关键词： Efficiency interview photonics

Evaluating changes in business distribution within urban rail transit hubs in Beijing via Point of Interest (POI) data analysis (2008-2020)

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Frontiers of Architectural Research 2024年第2期13卷 305-318页

作者： Bo wan Dongyang wan Qiang Sheng School of Architecture and Design Beijing Jiaotong UniversityBeijing 100044China

This paper,set against the backdrop of expanding urban rail networks and dynamic urban development,focuses on the distribution and evolution of commercial Points of Interests(POIs)within the central urban rail transit areas of Beijing.The study examines data from four different years-2008,2013,2017,and 2020-to observe the temporal evolution of commercial entities.It identifies stable explanatory variables affecting the distribution and evolution of commercial POIs,which include rail transit accessibility,characteristics of the working and residential population distribution around stations,and the construction intensity in the vicinity of station areas.Through statistical analysis and model building,relatively stable linear regression equations were established,with R2 values generally maintained above 0.5(except for 2017).The study advances our understanding of the influence of rail transit on urban commercial spaces and how this influence shifts with temporal and urban developmental changes.It elucidates the correlation between changes in the number of businesses and spatial configuration,offering insights and information for urban planners and policy makers.This research also serves as a model for exploring the interplay between urban rail transit and commercial spaces in other major cities.

关键词： Urbanrail transit areas Spatial configuration Distributionand evolution of commercial POls

Light People:Prof.Kei May Lau,newly elected US NAE member in Hong Kong,talks about future of photonics and women in science

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Light(Science & Applications) 2024年第4期13卷 602-608页

作者： Yating wan Chenzi Guo Electrical and Computer Engineering the ComputerElectrical and Mathematical Sciences and Engineering DivisionKing Abdullah University of Science and Technology23955-6900 ThuwalSaudi Arabia Changchun Institute of Optics Fine Mechanics and PhysicsChinese Academy of SciencesChangchunChina

Editorial Photonics technology remains a driving force in today’s scientific landscape,marked by continuous innovation and crossdisciplinary relevance.In an enlighting conversation with Light:Science&Applications,Prof.Kei May Lau,a pioneer in photonics research,shares her deep insights on the evolution of technologies of LEDs,lasers,challenges of hetero-epitaxy,and the future of micro-LEDs and quantum dot lasers.Recently honored as a member of the US National Academy of Engineering(NAE)for her significant contributions to photonics and electronics using III-V semiconductors on silicon,Prof.Lau stands out as the sole Hong Kong scholar inducted into the NAE this year,joining 114 new and 21 international members.In this exclusive Light People interview,Prof.Lau shares her journey as a pioneering woman in engineering,her commitment to mentorship and academia,and her perspective on advancing female representation in science.The summary provided is distilled from Prof.Lau’s thoughtful responses during the interview.For a deeper exploration of Prof.Lau’s experiences and advice,the full interview is available in the Supplementary material.

关键词： interview lighting driving

Unveiling the future of chemistry:the 2023 emerging investigator issue of Science China Chemistry

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Science China Chemistry 2023年第12期66卷 3323-3330页

作者： Li-Jun wan Institute of Chemistry Chinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China

In the dynamic realm of scientific discovery,it is imperative to acknowledge and support the innovative perspectives and groundbreaking research emanating from the next generation of leaders in our field.To this end,S... 详细信息

关键词： breaking field chemistry