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Targeting the Warburg effect:A revisited perspective from molecular mechanisms to traditional and innovative therapeutic strategies in cancer

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Acta Pharmaceutica Sinica B 2024年第3期14卷 953-1008页

作者： minru liao Dahong Yao Lifeng Wu Chaodan Luo Zhiwen Wang Jin Zhang Bo Liu Department of Biotherapy Cancer Center and State Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengdu 610041China School of Pharmaceutical Sciences Shenzhen Technology UniversityShenzhen 518118China School of Pharmacy Shenzhen University Medical SchoolShenzhen UniversityShenzhen 518055China Department of Psychology University of Southern CaliforniaLos AngelesCA 90089USA

Cancer reprogramming is an important facilitator of cancer development and survival,with tumor cells exhibiting a preference for aerobic glycolysis beyond oxidative phosphorylation,even under sufficient oxygen supply *** metabolic alteration,known as the Warburg effect,serves as a significant indicator of malignant tumor *** Warburg effect primarily impacts cancer occurrence by influencing the aerobic glycolysis pathway in cancer *** enzymes involved in this process include glucose transporters(GLUTs),HKs,PFKs,LDHs,and ***,the expression of transcriptional regulatory factors and proteins,such as FOXM1,p53,NF-κB,HIF1a,and c-Myc,can also influence cancer ***,lncRNAs,miRNAs,and circular RNAs play a vital role in directly regulating the Warburg ***,gene mutations,tumor microenvironment remodeling,and immune system interactions are closely associated with the Warburg ***,the development of drugs targeting the Warburg effect has exhibited promising potential in tumor *** comprehensive review presents novel directions and approaches for the early diagnosis and treatment of cancer patients by conducting in-depth research and summarizing the bright prospects of targeting the Warburg effect in cancer.

关键词： Warburg effect Cancer Regulatory factor LncRNAs miRNAs Traditional Chinese medicine Small-molecule drug Drug resistance

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Regulated cell death(RCD)in cancer:key pathways and targeted therapies

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Signal Transduction and Targeted Therapy 2022年第9期7卷 3283-3348页

作者： Fu Peng minru liao Rui Qin Shiou Zhu Cheng Peng Leilei Fu Yi Chen Bo Han West China School of Pharmacy State Key Laboratory of Biotherapy and Cancer CenterDepartment of Gastrointestinal SurgeryWest China HospitalSichuan UniversityChengdu 610041China State Key Laboratory of Southwestern Chinese Medicine Resources Hospital of Chengdu University of Traditional Chinese MedicineSchool of PharmacyChengdu University of Traditional Chinese MedicineChengdu 611137China Sichuan Engineering Research Center for Biomimetic Synthesis of Natural Drugs School of Life Scienceand EngineeringSouthwest Jiaotong UniversityChengdu610031China

Regulated cell death(RCD),also well-known as programmed cell death(PCD),refers to the form of cell death that can be regulated by a variety of biomacromolecules,which is distinctive from accidental cell death(ACD).Accumulating evidence has revealed that RCD subroutines are the key features of tumorigenesis,which may ultimately lead to the establishment of different potential therapeutic ***,targeting the subroutines of RCD with pharmacological small-molecule compounds has been emerging as a promising therapeutic avenue,which has rapidly progressed in many types of human ***,in this review,we focus on summarizing not only the key apoptotic and autophagy-dependent cell death signaling pathways,but the crucial pathways of other RCD subroutines,including necroptosis,pyroptosis,ferroptosis,parthanatos,entosis,NETosis and lysosomedependent cell death(LCD)in ***,we further discuss the current situation of several small-molecule compounds targeting the different RCD subroutines to improve cancer treatment,such as single-target,dual or multiple-target small-molecule compounds,drug combinations,and some new emerging therapeutic strategies that would together shed new light on future directions to attack cancer cell vulnerabilities with small-molecule drugs targeting RCD for therapeutic purposes.

关键词： routine death cancer

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Autophagy and beyond:Unraveling the complexity of UNC-51-like kinase 1(ULK1)from biological functions to therapeutic implications

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Acta Pharmaceutica Sinica B 2022年第10期12卷 3743-3782页

作者： Ling Zou minru liao Yongqi Zhen Shiou Zhu Xiya Chen Jin Zhang Yue Hao Bo Liu School of Pharmaceutical Sciences Health Science CenterShenzhen UniversityShenzhen 518060China State Key Laboratory of Biotherapy and Cancer Center West China HospitalSichuan UniversityChengdu 610041China

UNC-51-like kinase 1(ULK1),as a serine/threonine kinase,is an autophagic initiator in mammals and a homologous protein of autophagy related protein(Atg)1 in yeast and of UNC-51 in Caenorhabditis ***1 is well-known for autophagy activation,which is evolutionarily conserved in protein transport and indispensable to maintain cell *** the direct target of energy and nutrition-sensing kinase,ULK1 may contribute to the distribution and utilization of cellular resources in response to metabolism and is closely associated with multiple pathophysiological ***,ULK1 has been widely reported to play a crucial role in human diseases,including cancer,neurodegenerative diseases,cardiovascular disease,and infections,and subsequently targeted small-molecule inhibitors or activators are also ***,the non-autophagy function of ULK1 has been emerging,indicating that non-autophagy-relevant ULK1 signaling network is also linked with diseases under some specific ***,in this review,we summarized the structure and functions of ULK1 as an autophagic initiator,with a focus on some new approaches,and further elucidated the key roles of ULK1 in autophagy and ***,we also discussed the relationships between ULK1 and human diseases,as well as illustrated a rapid progress for better understanding of the discovery of more candidate small-molecule drugs targeting ULK1,which will provide a clue on novel ULK1-targeted therapeutics in the future.

关键词： UNC-51-like kinase 1(ULK1) Autophagy Non-autophagy Biological function Small-molecule drug ULK1-targeted therapy Human diseases

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2-APQC,a small-molecule activator of Sirtuin-3(SIRT3),alleviates myocardial hypertrophy and fibrosis by regulating mitochondrial homeostasis

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Signal Transduction and Targeted Therapy 2024年第6期9卷 2748-2764页

作者： Fu Peng minru liao Wenke Jin Wei Liu Zixiang Li Zhichao Fan Ling Zou Siwei Chen Lingjuan Zhu Qian Zhao Gu Zhan Liang Ouyang Cheng Peng Bo Han Jin Zhang Leilei Fu West China School of Pharmacy and Department of Biotherapy Cancer Center and State Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengdu 610041China Sichuan Engineering Research Center for Biomimetic Synthesis of Natural Drugs School of Life Science and EngineeringSouthwest Jiaotong UniversityChengdu 610031China State Key Laboratory of Southwestern Chinese Medicine Resources Hospital of Chengdu University of Traditional Chinese MedicineSchool of PharmacyChengdu University of Traditional Chinese MedicineChengdu 611137China School of Pharmaceutical Sciences Health Science CenterShenzhen UniversityShenzhen 518060China School of Traditional Chinese Materia Medica Key Laboratory of Structure-Based Drug Design&Discovery of Ministry of EducationShenyang Pharmaceutical UniversityShenyang 110016China

Sirtuin 3(SIRT3)is well known as a conserved nicotinamide adenine dinucleotide^(+)(NAD^(+))-dependent deacetylase located in the mitochondria that may regulate oxidative stress,catabolism and ATP *** evidence has recently revealed that SIRT3 plays its critical roles in cardiac fibrosis,myocardial fibrosis and even heart failure(HF),through its deacetylation ***,discovery of SIRT3 activators and elucidating their underlying mechanisms of HF should be urgently ***,we identified a new small-molecule activator of SIRT3(named 2-APQC)by the structure-based drug designing strategy.2-APQC was shown to alleviate isoproterenol(ISO)-induced cardiac hypertrophy and myocardial fibrosis in vitro and in vivo rat ***,in SIRT3 knockout mice,2-APQC could not relieve HF,suggesting that 2-APQC is dependent on SIRT3 for its protective ***,2-APQC was found to inhibit the mammalian target of rapamycin(mTOR)-p70 ribosomal protein S6 kinase(p70S6K),c-jun N-terminal kinase(JNK)and transforming growth factor-β(TGF-β)/small mother against decapentaplegic 3(Smad3)pathways to improve ISO-induced cardiac hypertrophy and myocardial *** upon RNA-seq analyses,we demonstrated that SIRT3-pyrroline-5-carboxylate reductase 1(PYCR1)axis was closely assoiated with *** activating PYCR1,2-APQC was shown to enhance mitochondrial proline metabolism,inhibited reactive oxygen species(ROS)-p38 mitogen activated protein kinase(p38MAPK)pathway and thereby protecting against ISO-induced mitochondrialoxidative ***,activation of SIRT3 by 2-APQC could facilitate AMP-activated protein kinase(AMPK)-Parkin axis to inhibit ISO-induced ***,our results demonstrate that 2-APQC is a targeted SIRT3 activator that alleviates myocardial hypertrophy and fibrosis by regulating mitochondrial homeostasis,which may provide a new clue on exploiting a promising drug candidate for the future HF therapeutics.

关键词： SIRT3 homeostasis metabolism

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人性化护理对骨折患者不良情绪的影响

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临床医学工程 2012年第6期19卷 982-984页

作者：曹惠萍叶小惠廖敏如广东省深圳市宝安区松岗人民医院广东深圳518105

目的探讨人性化护理对改善骨折患者不良情绪的影响。方法选取骨折患者244例,并随机分为观察组和对照组,每组各122例,对照组采用骨科常规护理方法,观察组则在对照组护理基础上加强人性化护理,观察并分析两组患者不良情绪的改善情况。结... 详细信息

目的探讨人性化护理对改善骨折患者不良情绪的影响。方法选取骨折患者244例,并随机分为观察组和对照组,每组各122例,对照组采用骨科常规护理方法,观察组则在对照组护理基础上加强人性化护理,观察并分析两组患者不良情绪的改善情况。结果干预后观察组的疼痛、焦虑、抑郁的改善均优于对照组,治疗依从性好于对照组,患者的满意度高于对照组,差异有统计学意义(P<0.05)。结论在骨折患者治疗的过程中实施人性化护理,可有效地改善患者的不良情绪,提高患者在住院期间的生活质量,加速身体康复,值得临床推广应用。

关键词：骨折人性化护理不良情绪改善

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口腔鳞癌中预后相关miRNA的生物信息学分析及实验验证

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现代肿瘤医学 2023年第16期31卷 2988-2995页

作者：苟秋童谢强靳文珂廖敏茹李自祥黄海霞西南医科大学附属口腔医院修复科四川泸州646000 口颌面修复重建和再生泸州市重点实验室四川泸州646000 西南医科大学口腔医学研究所四川泸州646000 四川大学华西医院生物治疗与癌症中心国家重点实验室四川成都610031 西南交通大学生命科学与工程学院四川省天然药物仿生合成工程研究中心四川成都610031

目的:通过生物信息学筛选与口腔鳞癌(oral squamous cell carcinoma,OSCC)预后显著相关的miRNA,并通过体外实验进行验证。方法:从癌症基因组图谱(The Cancer Genome Atlas,TCGA)下载OSCC患者数据。通过R分析差异表达的miRNA。使用回归... 详细信息

目的:通过生物信息学筛选与口腔鳞癌(oral squamous cell carcinoma,OSCC)预后显著相关的miRNA,并通过体外实验进行验证。方法:从癌症基因组图谱(The Cancer Genome Atlas,TCGA)下载OSCC患者数据。通过R分析差异表达的miRNA。使用回归分析建立风险模型。通过Kaplan-Meier生存分析预测OSCC患者预后。通过受试者操作特征(receiver operating characteristic,ROC)曲线及回归分析验证风险模型可靠性。使用GO和KEGG分析预测预后相关miRNA的生物学功能。通过qRT-PCR及Western blot对生物信息学结果进行体外验证。结果:20个miRNA在OSCC中差异表达;miR-204-5p及miR-503-3p与OSCC预后显著相关;本研究构建的风险模型能有效预测OSCC预后;GO分析显示miR-204-5p与细胞凋亡、增殖及迁徙相关,而miR-503-3p与细胞分化、细胞周期及GTP结合有关;KEGG分析显示miR-204-5p与PI3K/Akt/mTOR通路及自噬通路相关,而miR-503-3p与Ras通路及HIF-1通路相关;qRT-PCR显示OSCC细胞中miR-204-5p表达量下降(P<0.05),瞬时转染miR-204-5p mimic后OSCC细胞中miR-204-5p表达量明显升高(P<0.05);Western blot显示升高miR-204-5p后OSCC细胞中PIK3CB表达量明显下降(P<0.05)。结论:miR-204-5p及miR-503-3p是OSCC中有效的预后生物标志物。miR-204-5p及miR-503-3p构建的风险模型能有效预测OSCC患者预后。miR-204-5p在OSCC细胞中低表达,升高miR-204-5p后OSCC细胞中PIK3CB的表达量下降。

关键词：口腔鳞癌 miRNA 生物信息学预后生物标志物风险模型 PIK3CB

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Step-edge controlled fast growth of wafer-scale MoSe_(2)films by MOCVD

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Nano Research 2023年第7期16卷 9577-9583页

作者： Rui Ji Jing liao Lintao Li Rongji Wen Mengjie Liu Yifeng Ren Jianghua Wu Yunrui Song minru Qi Zhixing Qiao Liwei Liu Chengbing Qin Yu Deng Yongtao Tian Suotang Jia Yufeng Hao Key Laboratory of Material Physics of Ministry of Education School of Physics and MicroelectronicsZhengzhou UniversityZhengzhou 450052China National Laboratory of Solid State Microstructures College of Engineering and Applied SciencesJiangsu Key Laboratory of Artificial Functional Materialsand Collaborative Innovation Center of Advanced MicrostructuresNanjing UniversityNanjing 210023China State Key Laboratory of Quantum Optics and Quantum Optics Devices Institute of Laser SpectroscopyShanxi UniversityTaiyuan 030006China Collaborative Innovation Center of Extreme Optics Shanxi UniversityTaiyuan 030006China College of Medical Imaging Shanxi Medical UniversityTaiyuan 030001China MIIT Key Laboratory for Low-Dimensional Quantum Structure and Devices School of Integrated Circuits and ElectronicsBeijing Institute of TechnologyBeijing 100081China

Two-dimensional(2D)transition metal dichalcogenides(TMDCs),due to their unique physical properties,have a wide range of applications in the next generation of electronics,optoelectronics,and ***-scale preparation of high-quality TMDCs films is critical to realize these potential *** we report a study on metal-organic chemical vapor deposition(MOCVD)growth of wafer-scale MoSe_(2)films guided by the crystalline step edges of miscut sapphire *** established that the nucleation density and growth rate of MoSe_(2)films were positively correlated with the step-edge density and negatively with the growth *** a certain temperature,the MoSe_(2)domains on the substrate with high step-edge density grow faster than that with low *** a result,wafer-scale and continuous MoSe_(2)films can be formed in a short duration(30 min).The MoSe_(2)films are of high crystalline quality,as confirmed by systematic Raman and photoluminescence(PL)*** results provide an important methodology for the rapid growth of wafer-scale TMDCs,which may promote the application of 2D semiconductors.

关键词： MoSe_(2) nucleation density transition metal dichalcogenides metal-organic chemical vapor deposition(MOCVD) waferscale two-dimensional(2D)semiconductor

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微生物介导的表没食子儿茶素没食子酸酯生物转化及其代谢物活性研究进展

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食品科学 2020年第9期41卷 204-210页

作者：杜敏如房倩安廖振林方祥王洁华南农业大学食品学院广东广州510642

表没食子儿茶素没食子酸酯(epigallocatechin gallate,EGCG)是从茶叶中分离的多酚类黄酮化合物,具有抗氧化、抗菌、抗肿瘤、降低胆固醇、减肥等生物学功能;但EGCG不稳定的结构及较低的生物利用度限制了其生理功效的发挥。据报道,EGCG经... 详细信息

表没食子儿茶素没食子酸酯(epigallocatechin gallate,EGCG)是从茶叶中分离的多酚类黄酮化合物,具有抗氧化、抗菌、抗肿瘤、降低胆固醇、减肥等生物学功能;但EGCG不稳定的结构及较低的生物利用度限制了其生理功效的发挥。据报道,EGCG经过微生物代谢后,其稳定性、生物利用度明显提高,且大部分代谢产物保留了EGCG原有的生理活性,其中某些生理活性甚至要高于EGCG本身。本文将对微生物介导的EGCG生物转化及其代谢物活性进行综述,重点阐述EGCG代谢产物、代谢途径及代谢物活性,以期为开发EGCG相关的高值化产品及微生物介导多酚转化促进人体健康的深入研究提供理论依据。

关键词：表没食子儿茶素没食子酸酯生物转化微生物代谢途径生物活性

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虚轴机床结构误差的间接测量

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中国机械工程 1999年第10期10卷 1126-1128页

作者：黄敏如廖启征周晓光梁崇高北京邮电大学

对虚轴机床的结构误差进行分析和测量，并用软件进行补偿是提高机床精度的重要方法。提出一种间接测量和补偿的方法。在虚轴机床的动台体上固定７根测量杆，用来间接测量动台体的位置和姿态。当动台体到达某一位置和姿态时，如果机床... 详细信息

对虚轴机床的结构误差进行分析和测量，并用软件进行补偿是提高机床精度的重要方法。提出一种间接测量和补偿的方法。在虚轴机床的动台体上固定７根测量杆，用来间接测量动台体的位置和姿态。当动台体到达某一位置和姿态时，如果机床本身没有结构误差，则各测量杆的测量值应该与理论值相同，但由于机床实际上是有结构误差的，因此各测量杆的测量值与理论值必定存在一定的偏差。利用若干个位置和姿态下的偏差值，间接计算出机床的结构误差，然后进行软件补偿。采用计算机仿真方法，对该方法进行验证。仿真计算结果十分理想。从而证明方法的正确性。该方法简单易行，是对虚轴机床误差进行补偿提高机床精度的一种有益的探索。

关键词：虚轴机床结构误差误差测量误差修正间接测量

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单轴应变Si纳米NMOSFET电特性优化

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电子科技 2018年第7期31卷 46-50页

作者：廖晨光郝敏如西安电子科技大学微电子学院陕西西安710071

针对小尺寸器件二级物理效应对集成电路正常工作的影响,同时为了进一步提高集成电路的性能,本文提出了利用Sentaurus TCAD软件仿真进行小尺寸单轴应变Si n型金属氧化物半导体场效应晶体管(NMOSFET)器件参数优化的方法。首先利用Sentauru... 详细信息

针对小尺寸器件二级物理效应对集成电路正常工作的影响,同时为了进一步提高集成电路的性能,本文提出了利用Sentaurus TCAD软件仿真进行小尺寸单轴应变Si n型金属氧化物半导体场效应晶体管(NMOSFET)器件参数优化的方法。首先利用Sentaurus TCAD软件,对氧化物半导体场效应晶体管(MOSFET)源、栅、漏上淀积氮化硅薄膜(SiN)来分析沟道中应力的变化得出沟道中产生应力的必要条件是沟道上方具有一层薄栅氧化层,其次进行了单轴应变Si NMOSFET的电性能随沟道应力以及沟道长度的变化仿真分析,接着利用软件仿真分析栅氧化层厚度、SiN膜淀积次数和厚度等因素对沟道应力的影响得出优化参数,最后利用优化后的参数对小尺寸单轴应变Si NMOSFET与常规器件的驱动电流进行了对比,结果显示模拟90 nm、65 nm、45 nm单轴应变Si NMOS器件相对常规器件分别提升了26.8%、27.8%和29.9%。因此利用Sentaurus TCAD软件仿真的方法为小尺寸单轴应变Si NMOSFET器件制造工艺提供了有效参考。

关键词：应变Si NMOSFET 氮化硅薄膜(SiN) 沟道应力参数优化

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