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Dipeptidyl peptidase-4: A key player in chronic liver disease

World Journal of Gastroenterology 2013年第15期19卷 2298-2306页

作者： minoru itou Takumi Kawaguchi Eitaro Taniguchi Michio Sata Division of Gastroenterology Department of MedicineKurume University School of MedicineKurume 830-0011Japan Division of Gastroenterology Department of Medicine and Department of Digestive Disease Information and ResearchKurume University School of MedicineKurume 830-0011Japan

Dipeptidyl peptidase-4 (DPP-4) is a membrane-associated peptidase, also known as CD26. DPP-4 has widespread organ distribution throughout the body and exerts pleiotropic effects via its peptidase activity. A representative target peptide is glucagon-like peptide-1, and inactivation of glucagon-like peptide-1 results in the development of glucose intolerance/diabetes mellitus and hepatic steatosis. In addition to its peptidase activity, DPP-4 is known to be associated with immune stimulation, binding to and degradation of extracellular matrix, resistance to anti-cancer agents, and lipid accumulation. The liver expresses DPP-4 to a high degree, and recent accumulating data suggest that DPP-4 is involved in the development of various chronic liver diseases such as hepatitis C virus infection, non-alcoholic fatty liver disease, and hepatocellular carcinoma. Furthermore, DPP-4 occurs in hepatic stem cells and plays a crucial role in hepatic regeneration. In this review, we described the tissue distribution and various biological effects of DPP-4. Then, we discussed the impact of DPP-4 in chronic liver disease and the possible therapeutic effects of a DPP-4 inhibitor.

关键词： Incretin Viral hepatitis Insulin resistance Steatohepatitis Cancer Sitagliptin Vildagliptin Alogliptin Teneligliptin Linagliptin

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Insulin resistance and chronic liver disease

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World Journal of Hepatology 2011年第5期3卷 99-107页

作者： Takumi Kawaguchi Eitaro Taniguchi minoru itou Masahiro Sakata Shuji Sumie Michio Sata Department of Disease Information & Research Kurume University School of MedicineKurume 830-0011Japan Department of Medicine Kurume University School of MedicineKurume 830-0011Japan

Increased insulin resistance is frequently associated with chronic liver disease and is a pathophysiological feature of hepatogenous *** factors including hepatic parenchymal cell damage,portalsystemic shunting and hepatitis C virus are responsible for the development of hepatogenous insulin resistance/*** it remains unclear whether insulin secretion from pancreatic beta cells is impaired as it is in type 2 diabetes,retinopathic and cardiovascular risk is low and major causes of death in cirrhotic patients with diabetes are liver failure,hepatocellular carcinoma and gastrointestinal *** A1c is an inaccurate marker for the assessment and management of hepatogenous ***,exogenous insulin or sulfonylureas may be harmful because these agents may promote ***,pathogenesis,cause of death,assessment and therapeutic strategy for hepatogenous insulin resistance/diabetes differ from those for lifestyle-related type 2 *** this article,we review features of insulin resistance in relationship to chronic liver *** also discuss the impact of anti-diabetic agents on interferon treatment and hepatocarcinogenesis.

关键词： Viral hepatitis Hyperinsulinemia Hypoglycemic drug Hepatoma

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