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Proposal of ZigBee Systems for the Provision of Location Information and Transmission of Sensor Data in Medical Welfare

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E-Health Telecommunication Systems and Networks 2015年第3期4卷 45-55页

作者： Takefumi Hiraguri minoru aoyagi Yoshiaki Morino Toshinari Akimoto Kentaro Nishimori Tomomi Hiraguri Faculty of Engineering Nippon Institute of Technology Miyashiro-machi Saitama Japan Faculty of Engineering Niigata University Nishi-ku Niigata Japan Faculty of Health Sciences Tokoha University Aoi-ku Shizuoka-shi Japan

This paper proposes a scheme to obtain location and vital health information using ZigBee system. ZigBee systems are wireless communication systems defined by IEEE 802.154. In the proposed scheme, location information is obtained using the Link Quality Indication (LQI) function of a ZigBee system, which represents the received signal strength. And, the vital health information are collected from the electrocardiogram monitor, the pulse and blood pressure device, attached to the patient’s body. This information is then transmitted to an outside network by ZigBee systems. In this way, vital health information can be transmitted as ZigBee sensor data while patients with the ZigBee terminal are moving. In the experiments using actual ZigBee devices, the proposed scheme could obtain accurate location and vital health information from the sensor data. Moreover, to achieve high reliability in the actual service, the collected amount of sensor data was confirmed by the theoretic calculation, when a ZigBee terminal passed through ZigBee routers. These results indicate that the proposed scheme can be used to detect the accurate location of the ZigBee terminal. And over 99% of the sensor data on vital health information was obtained when the ZigBee terminal passed through approximately four ZigBee routers.

关键词： ZigBee Medical Welfare Location Information Sensor Data

Shear wave velocity is a useful marker for managing nonalcoholic steatohepatitis

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World Journal of Gastroenterology 2010年第23期16卷 2918-2925页

作者： Akihiko Osaki Tomoyuki Kubota Takeshi Suda Masato Igarashi Keisuke Nagasaki Atsunori Tsuchiya Masahiko Yano Yasushi Tamura Masaaki Takamura Hirokazu Kawai Satoshi Yamagiwa Toru Kikuchi minoru Nomoto Yutaka aoyagi Department of Gastroenterology and Hepatology Graduate School of Medical and Dental SciencesNiigata University Department of Homeostatic Regulation and Development Graduate School of Medical and Dental SciencesNiigata University Department of Laboratory Medicine Niigata University Medical and Dental Hospital

AIM:To investigate whether a noninvasive measurement of tissue strain has a potential usefulness for management of nonalcoholic steatohepatitis(NASH).METHODS:In total 26 patients,23 NASHs and 3 normal controls were enrolled in this *** was staged based on Brunt *** a region of interest(ROI),a shear wave was evoked by implementing an acoustic radiation force impulse(ARFI),and the propagation velocity was quantif ***:Shear wave velocity(SWV) could be reproducibly quantified at all ROIs in all subjects except for 4 NASH cases,in which a reliable SWV value was not calculated at several *** average SWV of 1.34 ± 0.26 m/s in fibrous stage 0-1 was significantly slower than 2.20 ± 0.74 m/s and 2.90 ± 1.01 m/s in stages 3 and 4,respectively,but was not significantly different from 1.79 ± 0.78 m/s in stage *** a cutoff value was set at 1.47 m/s,receiver operating characteristic analysis showed significance to dissociate stages 3 and 4 from stage 0-1(P=0.0092) with sensitivity,specificity and area under curve of 100%,75% and 94.2%,*** addition,the correlation between SWV and hyaluronic acid was significant(P<0.0001),while a tendency toward negative correlation was observed with serum albumin(P=0.053).CONCLUSION:The clinical implementation of ARFI provides noninvasive repeated evaluations of liver stiffness at an arbitrary position,which has the potential to shed new light on NASH management.

关键词： Nonalcoholic steatohepatitis Ultrasound Liver stiffness measurement Shear wave velocity Acoustic radiation force impulse

Advances in understanding and treating liver diseases during pregnancy:A review

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World Journal of Gastroenterology 2015年第17期21卷 5183-5190页

作者： Kenya Kamimura Hiroyuki Abe Hirokazu Kawai Hiroteru Kamimura Yuji Kobayashi minoru Nomoto Yutaka aoyagi Shuji Terai Division of Gastroenterology and Hepatology Graduate School of Medical and Dental SciencesNiigata UniversityNiigata 951-8510Japan

Liver disease in pregnancy is rare but pregnancyrelated liver diseases may cause threat to fetal and maternal *** includes pre-eclampsia;eclampsia;haemolysis,elevated liver enzymes,and low platelets syndrome;acute fatty liver of pregnancy;hyperemesis gravidarum;and intrahepatic cholestasis of *** basic researches have shown the various etiologies involved in this disease *** these advances,rapid diagnosis is essential for severe cases since the decision of immediate delivery is important for maternal and fetal *** other therapeutic options have also been shown in recent reports based on the clinical trials and cooperation and information sharing between hepatologist and gynecologist is important for timely therapeutic ***,correct understandings of diseases and differential diagnosis from the pre-existing and co-incidental liver diseases during the pregnancy will help to achieve better ***,here we review and summarized recent advances in understanding the etiologies,clinical courses and management of liver disease in *** information will contribute to physicians for diagnosis of disease and optimum management of patients.

关键词： Pregnancy Liver injury Low platelets Haemolysis elevated liver enzymes Acute fatty liverof pregnancy Hyperemesis gravidarum Intrahepaticcholestasis of pregnancy

Multicentric occurrence of hepatocellular carcinoma with nonalcoholic steatohepatitis

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World Journal of Hepatology 2011年第1期3卷 15-23页

作者： Hirokazu Kawai minoru Nomoto Takeshi Suda Kenya Kamimura Atsunori Tsuchiya Yasushi Tamura Masahiko Yano Masaaki Takamura Masato Igarashi Toshifumi Wakai Satoshi Yamagiwa Yasunobu Matsuda Shogo Ohkoshi Isao Kurosaki Yoshio Shirai Masahiko Okada Yutaka aoyagi Department of Clinical Laboratory Niigata University Medical and Dental Hospital Division of Gastroenterology and Hepatology Niigata University Graduate School of Medical and Dental Sciences Division of Digestive and General Surgery Niigata University Graduate School of Medical and Dental Sciences Department of Medical Technology Niigata University Graduate School of Health Sciences Division of Preventive Medicine Niigata University Graduate School of Medical and Dental Sciences

AIM:To reveal the manner of hepatocellular carcinoma (HCC) development in patients with nonalcoholic steatohepatitis(NASH) focusing on multicentric occurrence (MO) of ***:We compared clinicopathological characteristics between patients with and without MO of HCC arising from NASH *** clinical features were implicated with reference to the literature ***:MO of HCC was identified with histological proof in 4 out of 12 patients with NASH-related HCC(2 males and 2 females).One patient had synchronous MO;an advanced HCC,two well-differentiated HCCs and a dysplastic nodule,followed by the development of metachronous MO of *** other three patients had multiple advanced HCCs accompanied by a well-differentiated HCC or a dysplastic *** these three patients,one had synchronous MO,one had metachronous MO and the other had both synchronous and metachronous *** were no obvious differences between the patients with or without MO in terms of liver function tests,tumor markers and anatomical extent of *** the other hand,all four patients with MO of HCC were older than 70 years old and had the comorbidities of obesity,type 2 diabetes mellitus(T2DM),hypertension and *** these conditions were not limited to MO of HCC,all the conditions were met in only one of eight patients without MO of ***,concurrence of these conditions may be a predisposing situation to synchronous MO of *** particular,old age,T2DM and cirrhosis were suggested to be prerequisite for MO because these factors were depicted in common among two other cases with MO of HCC under NASH in the ***:The putative predisposing factors and necessary preconditions for synchronous MO of HCC in NASH were suggested in this *** investigations are required to clarify the accurate prevalence and predictors of MO to establish better strategies for treatment and prevention leading to the prognostic improvement in NASH.

关键词： Nonalcoholic steatohepatitis Hepatocellular carcinoma Multicentric occurrence

Active treatments are a rational approach for hepatocellular carcinoma in elderly patients

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World Journal of Gastroenterology 2013年第24期19卷 3831-3840页

作者： Takeshi Suda Aiko Nagashima Shyunsaku Takahash Tsutomu Kanefuji Kenya Kamimura Yasushi Tamura Ma-saaki Takamura Masato Igarashi Hirokazu Kawai Satoshi Yamagiwa minoru Nomoto Yutaka aoyagi Division of Gastroenterology and Hepatology Graduate School of Medical and Dental Sciences Niigata University

AIM: To determine whether an active intervention is beneficial for the survival of elderly patients with hepa-tocellular carcinoma (HCC). METHODS: The survival of 740 patients who received various treatments for HCC between 1983 and 2011 was compared among different age groups using Cox regression analysis. Therapeutic options were principal-ly selected according to the clinical practice guidelines for HCC from the Japanese Society of Hepatology. The treatment most likely to achieve regional control capa-bility was chosen, as far as possible, in the following order: resection, radiofrequency ablation, percutaneous ethanol injection, transcatheter arterial chemoembo-lization, transarterial oily chemoembolization, hepatic arterial infusion chemotherapy, systemic chemotherapy including molecular targeting, or best supportive *** treatment was used alone, or in combination, with a clinical goal of striking the best balance be-tween functional hepatic reserve and the volume of the targeted area, irrespective of their age. The percent survival to life expectancy was calculated based on a Japanese national population survey. RESULTS: The median ages of the subjects during each 5-year period from 1986 were 61, 64, 67, 68 and 71 years and increased significantly with time (P<0.0001). The Child-Pugh score was comparable among younger (59 years of age or younger), middle-aged (60-79 years of age), and older (80 years of age or older) groups (P=0.34), whereas the tumor-node-metastasis stage tended to be more advanced in the younger group (P=0.060). Advanced disease was significantly more frequent in the younger group compared with the middle-aged group (P=0.010), whereas there was no difference between the middle-aged and elderly groups (P=0.75). The median sur-vival times were 2593, 2011, 1643, 1278 and 1195 d for 49 years of age or younger, 50-59 years of age, 60-69 years of age, 70-79 years of age, or 80 years of age or older age groups, respectively, whereas the me-di

关键词： Hepatocellular carcinoma Population ag-ing Survival Life expectancy Active intervention