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Epstein–Barr virus-associated hemophagocytic syndrome in a patient with ulcerative colitis during treatment with azathioprine: A case report and review of literature

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World Journal of Clinical Cases 2018年第14期6卷 776-780页

作者： Kazuya Miyaguchi minoru Yamaoka Yoshikazu Tsuzuki Keigo Ashitani Hideki Ohgo Yoshitaka Miyagawa Keisuke Ishizawa Hidekazu Kayano Hidetomo Nakamoto Hiroyuki Imaeda Department of General Internal Medicine Saitama Medical University Department of Gastroenterology Saitama Medical University Department of Pathology Saitama Medical University

A 19-year-old female was diagnosed with ulcerative colitis when she presented with persistent melena, and has been treated with 5-aminosalicylic acid for 4 years, with additional azathioprine for 2 years at our hospital. The patient experienced high-grade fevers, chills, and cough fve d prior to presenting to the outpatient unit. At frst, the patient was suspected to have developed neutropenic fever; however, she was diagnosed with Epstein-Barr virus-associated hemophagocytic syndr-ome （EB-VAHS） upon fulfilling the diagnostic criteria after bone marrow aspiration. When patients withinflammatory bowel disease treated with immunomo-dulators, such as thiopurine preparations, develop fever, EB-VAHS should be considered in the differential diagnosis.

关键词： Infammatory bowel disease Azathioprine Virus-associated hemophagocytic syndrome Ulcerative colitis Case report

Clinical analysis of high serum IgE in autoimmune pancreatitis

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World Journal of Gastroenterology 2010年第41期16卷 5241-5246页

作者： Kenji Hirano minoru Tada Hiroyuki Isayama Kazumichi Kawakubo Hiroshi Yagioka Takashi Sasaki Hirofumi Kogure Yousuke Nakai Naoki Sasahira Takeshi Tsujino Nobuo Toda Kazuhiko Koike Department of Gastroenterology University of Tokyo 7-3-1 HongoBunkyo-ku Tokyo 113-8655 Japan De-partment of Gastroenterology University of Tokyo 7-3-1 HongoBunkyo-ku Tokyo 113-8655 Japan Department of Gastroenterology JR Tokyo General Hospital Tokyo 151-8528 Japan Department of Gastroenterology Mitsui Memo-rial Hospital Tokyo 101-8643 Japan

AIM: To clarify the clinical significance of high serum IgE in autoimmune pancreatitis (AIP). METHODS: Forty-two AIP patients, whose IgE was measured before steroid treatment, were analyzed. To evaluate the relationship between IgE levels and the disease activity of AIP, we examined (1) Frequency of high IgE (> 170 IU/mL) and concomitant allergic dis-eases requiring treatment; (2) Correlations between IgG, IgG4, and IgE; (3) Relationship between the presence of extrapancreatic lesions and IgE; (4) Re-lationship between clinical relapse and IgE in patients treated with steroids, and (5) Transition of IgE before and after steroid treatment. RESULTS: IgE was elevated in 36/42 (86%) *** allergic disease was observed in seven patients (allergic rhinitis in three, bronchial asthma in three, and urticaria in one). There were no signifi-cant correlations between IgG, IgG4, and IgE (r = -0.168 for IgG, and r = -0.188 for IgG4). There was no significant difference in IgE in the patients with and without extrapancreatic lesions (526 ± 531 IU/mL vs 819 ± 768 IU/mL, P = 0.163), with and without clini-cal relapse (457 ± 346 IU/mL vs 784 ± 786 IU/mL, P = 0.374). There was no significant difference in IgE between before and after steroid treatment (723 ± 744 IU/mL vs 673 ± 660 IU/mL, P = 0.633). CONCLUSION: Although IgE does not necessarily reflect the disease activity, IgE might be useful for the diagnosis of AIP in an inactive stage.

关键词： IgE IgG4 IgG Autoimmune pancreatitis

Impact Properties of Austempered Spheroidal Graphite Cast Irons

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Materials Sciences and Applications 2017年第13期8卷 948-958页

作者： Tohru Nobuki minoru Hatate Toshio Shiota Faculty of Engineering Kindai University Hiroshima Japan Kindai University Higashiosaka Japan

This study aims to clarify the influence of external notch on impact characteristics of high toughness ductile cast irons prepared by austempering heat treatment. We produced ductile cast irons samples with various matrix microstructure tested by Charpy impact within five kinds of external notches whose stress concentration factors (α), with values taken from 1.0 (Un-notched) to 4.8. In addition, to clarify the initiation process of impact characteristics, we observed the evolution of microstructure surface during bending tests with a slow loading speed for the un-notched and the notched impact samples. The results showed that the impact fracture energy decreases strongly in the range of α from 1 to 2.3 but decreases slightly for α larger than 3. Moreover, the impact value of samples with austempered microstructure is sensitive to the external notch shape. The impact transition temperature increases with increasing the stress concentration factor. The fracture energy is decreasing with the external notch from the impact test since the crack initiation energy is directly affected by this later. This work contributes to get a better understanding in the basic theories of external notch effect on impact characteristics of austempered spheroidal graphite cast irons (ADI).

关键词： Spheroidal Graphite Cast Irons Austempering Impact Characteristics Charpy Impact Value High Toughness

Novel Concept of Self-organized Bifunctional Catalyst Systems for Traditional Olefin Polymerization Catalysts

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华东理工大学学报（自然科学版） 2009年第6期35卷 941-941页

作者： minoru TERANO School of Materials Science Japan Advanced Institute of Science and Technology 1-1 Asahidai Nomi Ishileawa 923 1292 Japan

Pre-hepatectomy type Ⅳ collagen 7S predicts post-hepatectomy liver failure and recovery

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World Journal of Gastroenterology 2020年第7期26卷 725-739页

作者： Masatsugu Ishii Osamu Itano Masahiro Shinoda minoru Kitago Yuta Abe Taizo Hibi Hiroshi Yagi Ayano Takeuchi Hanako Tsujikawa Tokiya Abe Yuko Kitagawa Department of Surgery Keio University School of MedicineTokyo 160-8582Japan Department of Hepato-Biliary-Pancreatic and Gastrointestinal Surgery International University of Health and Welfare School of MedicineChiba 286-8686Japan Department of Pediatric Surgery and Transplantation Kumamoto UniversityKumamoto 860-8556Japan Department of Public Health Keio University School of MedicineTokyo 160-8582Japan Department of Pathology Keio University School of MedicineTokyo 160-8582Japan

BACKGROUND Liver resection is an effective treatment for benign and malignant liver ***,a method for preoperative evaluation of hepatic reserve has not yet been *** reported assessments of preoperative hepatic reserve focused only on liver failure in the early postoperative period and did not consider the long-term recovery of hepatic *** determining eligibility for hepatectomy,the underlying pathophysiology needs to be considered to determine if the functional hepatic reserve can withstand both surgery and any postoperative *** To identify pre-hepatectomy factors associated with both early postoperative liver failure and long-term postoperative liver function *** This study was a retrospective cohort *** retrospectively investigated 215 patients who underwent hepatectomy at our hospital between May 2013 and December *** post-hepatectomy liver failure(PHLF)was defined using the International Study Group of Liver Surgery’s definition of ***-term postoperative recovery of liver function was defined as the time taken for serum total bilirubin and albumin levels to return to levels of2.8 g/dL,respectively,and the time taken for Child-Pugh score to return to Child-Pugh class *** Preoperative type IV collagen 7S was identified as a significant independent factor associated with both PHLF and postoperative long-term recovery of liver *** analysis revealed that the time taken for the recovery of Child-Pugh scores and serum total bilirubin and albumin levels was significantly shorter in patients with type IV collagen 7S≤6 ng/mL than in those with type IV collagen 7S>6 ng/*** additional analyses,similar results were observed in patients without chronic viral hepatitis associated with *** Preoperative type IV collagen 7S is a preoperative predictor of PHLF and longterm postoperative liver function *** can also be used in patients without chron

关键词： Hepatectomy Liver failure Type Ⅳ collagen 7S Liver fibrosis Postoperative complications Long-term postoperative liver function recovery

Does Embankment Improve Quality of a River? A Case Study in To Lich River Inner City Hanoi, with Special Reference to Heavy Metals

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Journal of Environmental Protection 2013年第4期4卷 361-370页

作者： Nguyen Thi Thuong minoru Yoneda Yasuto Matsui Lab of Environmental Risk Analysis Department of Environmental Engineering Graduate School of Engineering Kyoto University Kyoto Japan

To Lich River (TLR) system receives wastewaters from a population of nearly two million people and 100 manufactories of five industrial zones in inner city Hanoi, Vietnam. To improve quality of TLR, the embankment was carried out in 1998 and finished in 2002, resulted in width of 20 - 45 m, depth of 2 - 4 m, and maximum water flow capacity of 30 m3/s. Water and sediment quality indices based on heavy metal concentrations were used to evaluate current river environment compared to that of pre-embankment. Mass balance model was employed to estimate total metal loads for specific river reaches, which corresponds to various types of wastewater discharged along the river. The results indicated that currently there is about284,000 m3sediment accumulated in TLR bed, which is under high contamination of Cr, Mn, Fe, Ni Cu, Zn, As, Cd, and Pb with a total of 7347 tons of all concerned metals. Domestic-discharged river reaches received much lower metal loads, roughly 8% - 28% compared to river reaches of both domestic and industrial inputs. Total load of all nine concerned metals at the end of TLR is161.7 kg/day, which is finally discharged to Nhue River at South Hanoi. Water quality was improved much right after finishing embankment, then it gradually deteriorated. Meanwhile, sediment quality became even much worse after embankment. Relative river quality index as equal weight for both water and sediment quality indices indicated that quality of TLR was not much improved after the embankment. It even became worse due to the urbanization in recent years.

关键词： Industrial Discharge Mass Balance Metal Load River Quality Index Sediment Accumulation

Virtual Reality Driving Simulation for Measuring Driver Behavior and Characteristics

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Journal of Transportation Technologies 2017年第2期7卷 123-132页

作者： Seyyed Meisam Taheri Kojiro Matsushita minoru Sasaki Department of Human and Information Systems Engineering Gifu University Gifu Japan

This article provides new insights regarding driver behavior, techniques and adaptability. This study has been done because: 1) driving a vehicle is critical and one of the most common daily tasks;2) simulators are used for the purpose of training and researching driver behavior and characteristics;3) the article addresses driver experience by involving new virtual reality technologies. A simulator has been used to assist novice drivers to learn how to drive in a very safe environment, and researching and collecting data for researchers has become easier due to this secure and user-friendly environment. The theoretical framework of this driving simulation has been designed by using the Unity3D game engine (5.4.f3 version) and was programmed with the C# programming language. To make the driving environment more realistic we, in addition, utilized the HTC Vive Virtual reality headset which is powered by Steamvr. We used Unity Game Engine to design our scenarios and maps because by doing this we are able to be more flexible with designing. In this study, we asked 10 people ranging from ages 19 - 37 to participate in this experiment. Four Japanese divers and six non-Japanese drivers engaged in this study, some of which do not have a driver’s license in Japan. A few Japanese drivers have a license and car, while others have a license but no car. In order to analyze the results of this experiment we are used MatlabR2016b to analyze the gathered data. The result of this research indicates that individual’s behavior and characteristics such as controlling the speed, remaining calm and relaxed when driving, driving at appropriate speeds depending on changes in road structures and etc. can affect their driving performance.

关键词： Driver Behavior Game Driving Unity3D Virtual Reality Simulation HTC

Calculate Target Position of Object in 3-Dimensional Area Based on the Perceived Locations Using EOG Signals

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Journal of Computer and Communications 2014年第11期2卷 53-60页

作者： Muhammad Ilhamdi Rusydi minoru Sasaki Satoshi Ito Department of Mechanical Engineering Gifu University 1-1 Yanagido Gifu City 501-1193 Japan Department of Electrical Engineering Andalas University Limau Manis Padang City 25163 Indonesia

EOG is a biosignal which occurs during eye activities such as eye movement and blink. EOG has a linear relationship with gaze distance. Detection object position in 3-dimensional area using gaze motion was proposed in this research. To calculate the distance of gaze motion in pixel unit, affine transform method was developed. The homogeneous matrix from five geometry processes: transformation-1, rotation, transformation-2, shear, and dilatation was determined. To give tracking ability in 3-dimensional area, two cameras were attached each in front of and top side of object. The cameras were accessed by voluntary blink. The EOG characteristic of blink eye was determined based on the absolute ratio between positive peak and negative peak which was greater than 1. Every blink toggled the active camera. The position of object was given by the perceived locations from the two cameras. Every movement in pixel coordinate was converted into centimeter unit. Then, the perceived location was used to calculate to the base coordinate. The result shows that the blink method successfully accessed the camera. Both of the cameras could show the location of object from their side. Calculating the gaze distance using affine transform also gave a satisfied result. Using this method controlling a machine in 3-dimensional area by EOG could be developed.

关键词： Gaze Motion Blink Affine Transform Perceived Location Camera

Evaluating Hazard Response Behavior of a Driver Using Physiological Signals and Car-Handling Indicators in a Simulated Driving Environment

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Journal of Transportation Technologies 2019年第4期9卷 439-449页

作者： Joseph Kamau Muguro minoru Sasaki Kojiro Matsushita Department of Mechanical Engineering Gifu University Gifu Japan

Road traffic accidents are a major cause of casualties and costly implications to all the stakeholders. Research focusing on the driver as one of the causal agent of accidents has been studied for centuries and with the advent of modernized driver assistance technologies. This paper sought to evaluate response of a driver using active-driving performance indicators like reaction time and physiological signal response (surface electromyogram), to understand hazard response behavior. Simulation of driving scenes was done using Unity3D engine and VR Head mounted display. The driver was presented with stimulus (collision objects) of different size and distance. From the results, an event scene that the driver considered hazardous was marked with increased electromyography response distinct from non-event scenes. From the results, we noted an increase in pedal misapplication during hazard response. The proposed approach is applicable in a real time driving analysis for on-road risk level classification.

关键词： SEMG Driver Response Behavior 3D-VR Hazard Response