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Inhibitory Actions of Tetrandrine on Tumor Necrosis Factor α-Induced NF-κB Activation in Neovascularization of Cultured Choroidal Explants

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Chinese Medicine 2010年第3期1卷 75-83页

作者： minoru kikuchi Shusuke Kamimura Masaaki Nomura Tatsuo Takahashi Nobuyoshi Hagino Shinjiro Kobayashi 不详

Tetrandrine (1 μM), a bis-benzylisoquinoline alkaloid isolated from Stephania tetrandra S Moore, signifi-cantly decreased tumor necrosis factor alpha (TNFα;10 ng/ml)-induced increase in the number of micro vessels that budded from cultured rat choroidal explants. Tetrandrine also decreased the TNFα-induced in-crease in the number of cells composing the microvessels. Ammonium pyrrolidine dithiocarbamate (APDC;0.1-0.3 μM), an inhibitor of nuclear factor-κB (NF-κB), decreased the TNFα-induced increase in the number of microvessels in a concentration-dependent manner. TNFα increased the phosphorylation and degradation of inhibitor of NF-κB (IκBα), as well as increasing the DNA-binding activity of NF-κB in choroidal explants. TNF? induced an increase of vascular endothelial growth factor (VEGF)-A mRNA, but not VEGF-C mRNA or VEGF-D mRNA. TNFα-induced angiogenic action was inhibited by treatment of VEGF-A antibody in cultured choroidal capillaries. Tetrandrine inhibited the TNFα-induced increases of phosphorylation and degradation of IκBα, and reduced the TNFα-induced increase of DNA-binding activity of NF-κB in chor-oidal explants. In conclusion, tetrandrine inhibits TNFα-induced activation of NF-κB in the choroidal capil-laries via inhibition of TNFα-induced phosphorylation of IκBα.

关键词： Choroidal Neovascularization Anti-angiogenesis Tetrandrine Tumor Necrosis Factor α NF-κB Activity Phosphorylation of IκBα

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Shear wave velocity is a useful marker for managing nonalcoholic steatohepatitis

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World Journal of Gastroenterology 2010年第23期16卷 2918-2925页

作者： Akihiko Osaki Tomoyuki Kubota Takeshi Suda Masato Igarashi Keisuke Nagasaki Atsunori Tsuchiya Masahiko Yano Yasushi Tamura Masaaki Takamura Hirokazu Kawai Satoshi Yamagiwa Toru kikuchi minoru Nomoto Yutaka Aoyagi Department of Gastroenterology and Hepatology Graduate School of Medical and Dental SciencesNiigata University Department of Homeostatic Regulation and Development Graduate School of Medical and Dental SciencesNiigata University Department of Laboratory Medicine Niigata University Medical and Dental Hospital

AIM:To investigate whether a noninvasive measurement of tissue strain has a potential usefulness for management of nonalcoholic steatohepatitis(NASH).METHODS:In total 26 patients,23 NASHs and 3 normal controls were enrolled in this *** was staged based on Brunt *** a region of interest(ROI),a shear wave was evoked by implementing an acoustic radiation force impulse(ARFI),and the propagation velocity was quantif ***:Shear wave velocity(SWV) could be reproducibly quantified at all ROIs in all subjects except for 4 NASH cases,in which a reliable SWV value was not calculated at several *** average SWV of 1.34 ± 0.26 m/s in fibrous stage 0-1 was significantly slower than 2.20 ± 0.74 m/s and 2.90 ± 1.01 m/s in stages 3 and 4,respectively,but was not significantly different from 1.79 ± 0.78 m/s in stage *** a cutoff value was set at 1.47 m/s,receiver operating characteristic analysis showed significance to dissociate stages 3 and 4 from stage 0-1(P=0.0092) with sensitivity,specificity and area under curve of 100%,75% and 94.2%,*** addition,the correlation between SWV and hyaluronic acid was significant(P<0.0001),while a tendency toward negative correlation was observed with serum albumin(P=0.053).CONCLUSION:The clinical implementation of ARFI provides noninvasive repeated evaluations of liver stiffness at an arbitrary position,which has the potential to shed new light on NASH management.

关键词： Nonalcoholic steatohepatitis Ultrasound Liver stiffness measurement Shear wave velocity Acoustic radiation force impulse

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New acetogenin katsuurallene from Laurencia saitoi collected from Katsuura, Japan

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Natural Products and Bioprospecting 2022年第1期12卷 121-127页

作者： Yu Minamida Hiroshi Matsuura Takahiro Ishii Miyu Miyagi Yuto Shinjo Kosuke Sato Takashi Kamada Yoshihiro Mihara Iwao Togashi Keisuke Sugimoto Tsuyoshi Abe Norio kikuchi minoru Suzuki Advanced Course of Applied Chemistry National Institute of TechnologyAsahikawa CollegeShunkodai 2-2-1-6AsahikawaHokkaido 071-8142Japan Department of Materials Chemistry National Institute of TechnologyAsahikawa CollageShunkodai 2-2-1-6AsahikawaHokkaido 071-8142Japan Department of Biosciences and Biotechnology Faculty of AgricultureUniversity of the Ryukyus1 SenbaruNishiharaOkinawa 903-0213Japan Department of Materials and Life Science Faculty of Science and TechnologyShizuoka Institute of Science and Technology2200-2 ToyosawaFukuroiShizuoka 437-8555Japan Department of Medicinal Chemistry Faculty of Pharmaceutical SciencesHokkaido University of ScienceMaeda 715-4-1Teine-kuSapporoHokkaido 006-8590Japan The Hokkaido University Museum Hokkaido UniversityN10 W8Kita-kuSapporoHokkaido 060-0810Japan Coastal Branch of Natural History Museum and Institute Chiba123 YoshioKatsuuraChiba 299-5242Japan Department of Life Science Graduate School of Engineering ScienceAkita University1-1 Tegatagakuen-machiAkita 010-8502Japan

We examined the chemical constitution of the red alga Laurencia saitoi Perestenko,collected from Katsuura,Boso Peninsula,Chiba Prefecture,*** specimen produced a new polyhalogenated acetogenin,named katsuural-lene(1),which structure was determined by the spectral methods,along with known diterpene,deoxyparguerol(2)and triterpene,thyrsiferol(3).In this paper we describe the structural elucidation of katsuurallene together with some biological activities.

关键词： Laurencia Rhodomelaceae Acetogenin Triterpene Diterpene Biological activity

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尼可地尔降低非心脏手术过程中或术后心脏事件的发生率

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首都食品与医药 2015年第24期22卷 143-143页

作者： Satoshi Kashimoto Makoto Seki Toshihiko Ishiguro Hitoshi Yoshioka Osamu Nagata Kinya Nishimura Toshihiro kikuchi Tatsuya Yamada Motoyo Iwade Akibumi Omi Osamu Honda Atsuhiro Sakamoto Yukihiko Ogihara Keiko Fujimoto Yasushi Nakaigawa Jitsu Kato Akio Watanabe minoru Nomura Junzo Takeda 王青北京四环科宝制药有限公司 100079

（接11月下）组间无显著性差异。心脏事件的频率在附表2中显示,手术过程中心脏事件的每个风险因素的优势比在附表3中显示。在通过逐步回归分析得到的风险因素中,与尼可地尔联系最紧密的因素的优势比是0.15（95%置信区间,0.03~0.76;

关键词：尼可地尔心脏事件非心脏手术优势比逐步回归分析无显著性差异置信区间心肌衰竭患者例数心肌缺血患者

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尼可地尔降低非心脏手术过程中或术后心脏事件的发生率

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首都食品与医药 2015年第22期22卷 151-151页

作者： Satoshi Kashimoto Makoto Seki Toshihiko Ishiguro Hitoshi Yoshioka Osamu Nagata Kinya Nishimura Toshihiro kikuchi Tatsuya Yamada Motoyo Iwade Akibumi Omi Osamu Honda Atsuhiro Sakamoto Yukihiko Ogihara Keiko Fujimoto Nakaigawa Jitsu Kato Akio Watanabe minoru Nomura Junzo Takeda 王青北京四环科宝制药有限公司 100079

目的评估尼可地尔是否能减少危险手术进行过程中或术后心脏事件的发生。方案多中心研究。试验点日本的13家医院。患者通过心绞痛、心肌梗死病史、心脏衰竭、糖尿病和心电图异常等风险因素来评定的中危患者。给药方案在手术过程中给予这... 详细信息

目的评估尼可地尔是否能减少危险手术进行过程中或术后心脏事件的发生。方案多中心研究。试验点日本的13家医院。患者通过心绞痛、心肌梗死病史、心脏衰竭、糖尿病和心电图异常等风险因素来评定的中危患者。给药方案在手术过程中给予这些患者尼可地尔。试验方法和主要结果术中和术后连续5天监控心脏事件,比较尼可地尔治疗组患者与非治疗组患者心脏事件的发生率。其中,尼可地尔治疗组患者84例,常规治疗组患者237例。与常规治疗相比,术中和术后给予尼可地尔治疗的患者心脏事件发生率均显著降低（术中给予尼可地尔：比值比0.15;95%置信区间,0.03～0.76;P=0.02;术后给予尼可地尔：比值比0.24;95%置信区间,0.06～0.90;P=0.04）。结论在非心脏手术术中或术后给予尼可地尔,均能降低心脏事件的发生率。

关键词：心脏手术过程尼可地尔心脏事件发生率术后试验方法置信区间多中心研究

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