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世界核心医学期刊文摘（儿科学分册） 2005年第11期1卷 34-35页

作者： minodier p. Robert S. Nel G. 贺文龙 Urgences p.diatriques CHU Nord Chemin des Bourrelly 13915 Marseille Cedex 20 France

Aims of the study. -First, to describe lip.somal amp.otericin B (AmBisome) use as first line treatment of p.diatric visceral leishmaniasis and secondly, to evaluate the incidence of the disease in southern France (p.ovence -Alp.s -Cte d’Azur -Corse). Material and methods. -Re-trosp.ctive chart review of children referred for visceral leishmaniasis from 1996 to 2003. Results. -Thirty-two children under 15 years of age and suffering from visceral leishmaniasis were treated with lip.somal amp.otericin B as first line treatment. Clinical and biological features were usual: age p.een enlargement and fever, cytop.nia. In this p.p.lation, treatment effectiveness was evaluated to 97%(one relap.e). Under treatment, p.tients quickly imp.oved. Drug regimens varied from 18 to 24 mg/kg (day 1 to 5, and day 10). Four other children were not treated with first-line lip.somal amp.otericin B during the p.riod. Thus, the incidence of p.diatric visceral leishmaniasis was evaluated to be 0.61/100,000 children p.s-Maritimes dep.rtment, French Riviera, and 0.6 in the Bouches-du-Rhne dep.rtment, Marseilles area). Conclusion. -Lip.somal am-p.otericin B treatment is usual for children referred for visceral leishmaniasis in this region. This treatment may be ap.roved regarding the high level of effectiveness and the low number of adverse events. A two days drug regimen with 20 mg/kg should be evaluated. Moreover, the incidence of the p.diatric visceral leishmaniasis in southern France is decreasing, but local variations may be observed.

关键词：利什曼病两性霉素法国南部血细胞减少用药量免疫缺陷脾大生物学特征度假旅游

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甲氟喹(MFQ)和盐酸氯菲醇(HFT)治疗儿童急性单纯性恶性疟疾(AUFM)的疗效比较

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世界核心医学期刊文摘（儿科学分册） 2005年第11期1卷 32-32页

作者： minodier p. No■l G. Salles M. 贺文龙 Urgences p.diatriques CHU Nord chemin des Bourrelly 13915 Marseille Cedex 20 France

Aim of the study. -To evaluate mefloquine versus halofantrine in children suffering from acute uncomp.icated falcip.rum malaria. Material and methods. -p.osp.ctive non randomized study in hosp.talized children during one year. Acute falcip.mm malaria was defined by fever and a p.sitive thin and/or thick smear. Malaria was p.esumed to have been contracted in Comoros archip.lago and/or Madagascar 6 months p.eviously. p.tients were excluded, when quinine had to be used, according to World Health Organization’s severity criteria. Results. -Forty-nine children were included: 29 were treated with halofantrine and 20 with mefioquine. p.tients features in the two group. of treatment were identical, with excep.ion for the mean time between first clinical signs and diagnosis (shorter in mefloquine group.. Fever’s and hosp.talization’s durations under treatment were similar. An increase in QTc interval was frequently observed in p.tients treated with halofantrine (56 versus 0%), although p.tients with mefloquine exp.rienced vomiting (45 versus 0%). Relap.es seemed to bemore frequent with halofantrine (14 versus 0%). Discussion. -Halofantrine and mefloquine are efficient for falcip.rum malaria treatment in our p.diatric series, desp.te a high rate of adverse events. Mefloquine’s tolerance may p.obably be imp.oved with changes in regimen and dose. Relap.es are more frequent with a single first treatment of halofantrine, than with mefloquine. Unfortunately, features of a second halofantrine treatment are not defined.

关键词：恶性疟疾 AUFM HFT MFQ 甲氟喹科摩罗群岛程度标准住院儿童随机研究马达加斯加岛

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甲型流感季节性暴发的儿科特点及其在儿科急诊室和儿科病房的费用负担

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世界核心医学期刊文摘（儿科学分册） 2006年第5期2卷 19-20页

作者： Blanc p. No■l G. Dubus J.C. p. minodier 俞晓梅 Urgences p.diatriques CHU Nord chemin des Bourrelly 13915 Marseille Cedex 20 France

Aim of the study. -To describe ep.demiological features of an outbreak of flu A in hosp.talized children and to evaluate the flu’s burden in p.diatric and p.ediatric emergencies dep.rtments. p.p.lation and methods. -Multicenter p.osp.ct ive study in 2 p.diatric university hosp.tals, in Marseille, France. Nasal swabs for flu A were p.rformed in all the febrile children admitted during winter 200 3-2004. p.e and p.stoutbreak admissions in p.diatric and p.diatric emergencies dep.rtments were comp.red too. Results. -During the outbreak, 941 children were admitted and 605 were tested for flu A. Nasal swabs were p.sitive in 111. Attac k’s rate was 11.8%. In these children, infants under 2 years were 66%. Resp.r atory forms were uncommon, although febrile seizures and digestive troubles were much frequent. The mean hosp.talization duration was almost 4 days. Flu A outbr eak finally increased the p.diatric and p.diatric emergencies dep.rtments rates of admission, of 48%and 37%resp.ctively. Conclusion. -Flu is frequently under estimated in children, esp.cially in infants. Clinical forms are various. Child ’s vaccination is questionable in France.

关键词：甲型流感病毒儿科病房急诊室暴发负担费用季节性多中心前瞻性研究流行病学特征住院治疗

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