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Analysis of particle dispersion in a turbulent flow considering particle rotation

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Chinese Journal of Chemical Engineering 2023年第6期58卷 29-39页

作者： Wenshi Huang Yang Zhang Yuxin Wu Jingyu Wang minmin zhou Department of Energy and Power Engineering International Joint Laboratory on Low Carbon Clean Energy InnovationTsinghua UniversityBeijing 100084China Department of Chemical Engineering University of UtahUT 84108USA

Non-spherical particles exist widely in natural and industrial fluid systems and the motions of nonspherical particles are significantly different from that of spherical *** this paper,a simplified model of non-spherical particles considering particle drag correction,lift,and rotation was *** on the Eulerian-Lagrangian simulation,the dispersion characteristics of spherical and nonspherical particles with different Stokes numbers in a high-speed turbulent jet were analyzed and compared considering the effect of particle *** results show that,the differences in particle dispersion and radial velocity fluctuation between non-spherical particles and spherical particles in the jet are significant,especially when Stokes number is ***,the effects of different type of forces on the dispersion of non-spherical particles and spherical particles were compared in detail,which revealed that the change of the Magnus force caused by the increase in the angular velocity of non-spherical particles plays a dominant role in the differences of particle dispersion.

关键词： Dispersion Particle Particle-laden flows Particle rotation Turbulent flow

Characterizing the Lassa Virus Envelope Glycoprotein Membrane Proximal External Region for Its Role in Fusogenicity

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Virologica Sinica 2021年第2期36卷 273-280页

作者： Junyuan Cao Guangshun Zhang minmin zhou Yang Liu Gengfu Xiao Wei Wang State Key Laboratory of Virology Wuhan Institute of VirologyCenter for Biosafety Mega-ScienceChinese Academy of SciencesWuhan 430071China University of the Chinese Academy of Sciences Beijing 100049China College of Life Sciences Nankai UniversityTianjin 300353China

The membrane-proximal external region(MPER)of Lassa virus(LASV)glycoprotein complex(GPC)is critical in modulating its *** now,the high-resolution structure of the intact GPC,including MPER is not *** this study,we used alanine substitution to scan all 16 residues located in LASV *** blotting and quantification fusion assay showed that the residues located at the C terminus of the HR2(M414 and L415)and N terminus of the MPER(K417 and Y419)are critical for GPC-mediated membrane fusion ***,cell surface biotinylation experiments revealed that M414 A,K417 A and Y419 A expressed similar levels as WT,whereas L415 A mutant led to a reduction of mature GPC on the cell ***,substitution of these residues with the similar residue such as M414 L,L415 I,K417 R and Y419 F would partly compensate the loss of the fusion activity caused by the alanine mutant in these *** from this study showed that several key residues in the MPER region are indispensable to promote the conformational changes that drive fusion events and shed light on the structure analysis of LASV GPC and anti-LASV therapeutics.

关键词： Lassa virus(LASV) Arenavirus Glycoprotein complex(GPC) Membrane-proximal external region(MPER) Membrane fusion

An Integration Testing Framework and Evaluation Metric for Vulnerability Mining Methods

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China Communications 2018年第2期15卷 190-208页

作者： Jin Li Jinfu Chen Minhuan Huang minmin zhou Wanggen Xie Zhifeng Zeng Shujie Chen Zufa Zhang National key laboratory of science and technology on information system security Beijing institute of system engineering School of Computer Science and Communication Engineering Jiangsu University

Software an important way to vulnerability mining is detect whether there are some loopholes existing in the software, and also is an important way to ensure the secu- rity of information systems. With the rapid development of information technology and software industry, most of the software has not been rigorously tested before being put in use, so that the hidden vulnerabilities in software will be exploited by the attackers. Therefore, it is of great significance for us to actively de- tect the software vulnerabilities in the security maintenance of information systems. In this paper, we firstly studied some of the common- ly used vulnerability detection methods and detection tools, and analyzed the advantages and disadvantages of each method in different scenarios. Secondly, we designed a set of eval- uation criteria for different mining methods in the loopholes evaluation. Thirdly, we also proposed and designed an integration testing framework, on which we can test the typical static analysis methods and dynamic mining methods as well as make the comparison, so that we can obtain an intuitive comparative analysis for the experimental results. Final- ly, we reported the experimental analysis to verify the feasibility and effectiveness of the proposed evaluation method and the testingframework, with the results showing that the final test results will serve as a form of guid- ance to aid the selection of the most appropri- ate and effective method or tools in vulnera- bility detection activity.

关键词： software vulnerability detection loopholes information security evaluationmethod testing framework

Toward a K-means clustering approach to adaptive random testing for object-oriented software

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Science China(Information Sciences) 2019年第11期62卷 204-205页

作者： Jinfu CHEN minmin zhou T H TSE Tsong Yueh CHEN Yuchi GUO Rubing HUANG Chengying MAO School of Computer Science and Communication Engineering Jiangsu University Jiangsu Key Laboratory of Security Technology for Industrial Cyberspace Jiangsu University Department of Computer Science The University of Hong Kong Department of Computer Science and Software Engineering Swinburne University of Technology School of Software and Communication Engineering Jiangxi University of Finance and Economics

Dear editor,Testing and debugging are mainstream methods for software quality assurance. In particular,random testing (RT, also known as fuzz testing) and partition testing (PT) are most widely adopted. Classical stud... 详细信息

关键词： Toward a K-means clustering approach to adaptive random testing for object-oriented software OO

Deletion of the first glycosylation site promotes Lassa virus glycoprotein-mediated membrane fusion

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Virologica Sinica 2023年第3期38卷 380-386页

作者： Siqi Dong Wenting Mao Yang Liu Xiaoying Jia Yueli Zhang minmin zhou Yuxia Hou Gengfu Xiao Wei Wang State Key Laboratory of Virology Wuhan Institute of VirologyCenter for Biosafety Mega-ScienceChinese Academy of SciencesWuhan430207China University of the Chinese Academy of Sciences Beijing100049China College of Pharmacy and State Key Laboratory of Medicinal Chemical Biology Nankai UniversityTianjin300071China

The Lassa virus(LASV)is endemic in West Africa and causes severe hemorrhagic Lassa fever in *** glycoprotein complex(GPC)of LASV is highly glycosylation-modified,with 11 N-glycosylation *** 11 N-linked glycan chains play critical roles in GPC cleavage,folding,receptor binding,membrane fusion,and immune *** this study,we focused on the first glycosylation site because its deletion mutant(N79Q)results in an unexpected enhanced membrane fusion,whereas it exerts little effect on GPC expression,cleavage,and receptor ***,the pseudotype virus bearing GPC_(N79Q)was more sensitive to the neutralizing antibody 37.7H and was attenuated in *** the biological functions of the key glycosylation site on LASV GPC will help elucidate the mechanism of LASV infection and provide strategies for the development of attenuated vaccines against LASV infection.

关键词： Lassa virus(LASV) Glycoprotein complex(GPC) Glycosylation site Membrane fusion

A Vulnerability Model Construction Method Based on Chemical Abstract Machine

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Wuhan University Journal of Natural Sciences 2018年第2期23卷 150-162页

作者： LI Xiang CHEN Jinfu LIN Zhechao ZHANG Lin WANG Zibin zhou minmin XIE Wanggen National Key Laboratory of Science and Technology onInformation System Security Beijing 100101 China Beijing Institute of System Engineering Beijing 100101China School of Computer Science and Communication Engineering Jiangsu University Zhenjiang 212013 Jiangsu China

It is difficult to formalize the causes of vulnerability, and there is no effective model to reveal the causes and characteristics of vulnerability. In this paper, a vulnerability model construction method is proposed to realize the description of vulnerability attribute and the construction of a vulnerability model. A vulnerability model based on chemical abstract machine（CHAM） is constructed to realize the CHAM description of vulnerability model, and the framework of vulnerability model is also discussed. Case study is carried out to verify the feasibility and effectiveness of the proposed model. In addition, a prototype system is also designed and implemented based on the proposed vulnerability model. Experimental results show that the proposed model is more effective than other methods in the detection of software vulnerabilities.

关键词： software security, vulnerability detection vulner-ability analysis vulnerability model chemical abstract machine

A Method for Software Vulnerability Detection Based on Improved Control Flow Graph

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Wuhan University Journal of Natural Sciences 2019年第2期24卷 149-160页

作者： zhou minmin CHEN Jinfu LIU Yisong ACKAH-ARTHUR Hilary CHEN Shujie ZHANG Qingchen ZENG Zhifeng School of Computer Science and Communication Engineering Jiangsu University

With the rapid development of software technology, software vulnerability has become a major threat to computer security. The timely detection and repair of potential vulnerabilities in software, are of great significance in reducing system crashes and maintaining system security and integrity. This paper focuses on detecting three common types of vulnerabilities: Unused_Variable, Use_of_Uninitialized_Variable, and Use_After_ Free. We propose a method for software vulnerability detection based on an improved control flow graph(ICFG) and several predicates of vulnerability properties for each type of vulnerability. We also define a set of grammar rules for analyzing and deriving the three mentioned types of vulnerabilities, and design three vulnerability detection algorithms to guide the process of vulnerability detection. In addition, we conduct cases studies of the three mentioned types of vulnerabilities with real vulnerability program segments from Common Weakness Enumeration(CWE). The results of the studies show that the proposed method can detect the vulnerability in the tested program segments. Finally, we conduct manual analysis and experiments on detecting the three types of vulnerability program segments(30 examples for each type) from CWE, to compare the vulnerability detection effectiveness of the proposed method with that of the existing detection tool Cpp Check. The results show that the proposed method performs better. In summary, the method proposed in this paper has certain feasibility and effectiveness in detecting the three mentioned types of vulnerabilities, and it will also have guiding significance for the detection of other common vulnerabilities.

关键词： software security software vulnerability improved control flow graph vulnerability detection algorithm

Global Analysis of an SEIR Epidemic Model with Infectious Force under Intervention Strategies

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Journal of Applied Mathematics and Physics 2019年第8期7卷 1706-1717页

作者： minmin zhou Tiansi Zhang College of Science University of Shanghai for Science and Technology Shanghai China

In this paper, we investigate the global stability of an SEIR (Susceptible-Exposed-Infected-Remove) epidemic model with infectious force under intervention strategies. To address this issue, we prove that the basic reproduction number R0 plays an essential role in determining whether the disease extincts or persists. If , there is a unique disease-free equilibrium point of the model which is globally asymptotically stable and the disease dies out, and if , there exists a unique endemic equilibrium point which is globally asymptotically stable and the disease persists.

关键词： SEIR Epidemic Model Intervention Strategies Basic Reproduction Number Global Stability

Large eddy simulation of a 660 MW utility boiler under variable load conditions

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Frontiers in Energy 2021年第1期15卷 124-131页

作者： Haoshu SHEN Yuxin WU minmin zhou Hai ZHANG Guangxi YUE Junfu LYU Department of Energy and Power Engineering Tsinghua UniversityBeijing 100084China Department of Chemical Engineering University of UtahSalt Lake City 84112USA

Large eddy simulation (LES) has become a promising tool for pulverized coal combustion with the development of computational fluid dynamics (CFD) technologies in recent years. LES can better capture the unsteady features and turbulent structures of coal jet flame than Reynolds averaged Navier Stokes (RANS). The coal-fired power plants in China are now required to be operated in a wide load range and quickly respond to the electric grid. The boiler performance of variable loads should be evaluated in terms of flow, heat transfer, and combustion processes. In this paper, LES was applied to simulate a 660 MW ultra-supercritical boiler under BMCR (boiler maximum continue rate), 75%THA-100, and 50%THA-100 conditions. The predicted gas velocities agree well with the thermal calculation and the temperature error is less than 130 K. The simulation results show that the operation load has significant effects on the boiler performance. It is also proved that LES can provide guidance for the design and operation of advanced coal-fired boilers.

关键词： large eddy simulation ultra-supercritical boiler operation load