检索结果-南通市图书馆

Genes & Diseases 2024年第2期11卷 701-710页

作者： minjie wu Heng Dong Chao Xu Mengqing Sun Haojin Gao Fangtian Bu Jianxiang Chen College of Pharmacy and Department of Hepatology Institute of Hepatology and Metabolic DiseasesThe Affiliated Hospital of Hangzhou Normal UniversityHangzhou Normal UniversityHangzhouZhejiang 311121China Laboratory of Cancer Genomics Division of Cellular and Molecular ResearchNational Cancer CentreSingapore 169610Singapore Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines Engineering Laboratory of Development and Application of Traditional Chinese MedicinesCollaborative Innovation Center of Traditional Chinese Medicines of Zhejiang ProvinceHangzhou Normal UniversityHangzhouZhejiang 311121China

B-cell CLL/lymphoma 9(BCL9)is considered a key developmental regulator and a well-established oncogenic driver in multiple cancer types,mainly through potentiating the Wnt/β-catenin signaling.However,increasing evidences indicate that BCL9 also plays multiple Wnt-independent roles.Herein,we summarized the updates of the canonical and non-canonical functions of BCL9 in cellular,physiological,or pathological processes.Moreover,we also concluded that the targeted inhibitors disrupt the interaction ofβ-catenin with BCL9 reported recently.

关键词： BCL9 Development Immunity Multifaceted functions Therapeutic target Tumorigenesis

LONP1 ameliorates liver injury and improves gluconeogenesis dysfunction in acute-on-chronic liver failure

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Medical Journal 2024年第2期137卷 190-199页

作者： Muchen wu Jing wu Kai Liu minjie Jiang Fang Xie Xuehong Yin Jushan wu Qinghua Meng Department of Liver Disease Beijing You-An HospitalCapital Medical UniversityBeijing 100069China Beijing Institute of Hepatology Beijing You-An HospitalCapital Medical UniversityBeijing 100069China Department of General Surgery Beijing You-An HospitalCapital Medical UniversityBeijing 100069China

Background:Acute-on-chronic liver failure(ACLF)is a severe liver disease with complex pathogenesis.Clinical hypoglycemia is common in patients with ACLF and often predicts a worse prognosis.Accumulating evidence suggests that glucose metabolic disturbance,especially gluconeogenesis dysfunction,plays a critical role in the disease progression of ACLF.Lon protease-1(LONP1)is a novel mediator of energy and glucose metabolism.However,whether gluconeogenesis is a potential mechanism through which LONP1 modulates ACLF remains unknown.Methods:In this study,we collected liver tissues from ACLF patients,established an ACLF mouse model with carbon tetrachloride(CCl 4),lipopolysaccharide(LPS),and D-galactose(D-gal),and constructed an in vitro hypoxia and hyperammonemia-triggered hepatocyte injury model.LONP1 overexpression and knockdown adenovirus were used to assess the protective effect of LONP1 on liver injury and gluconeogenesis regulation.Liver histopathology,biochemical index,mitochondrial morphology,cell viability and apoptosis,and the expression and activity of key gluconeogenic enzymes were detected to explore the underlying protective mechanisms of LONP1 in ACLF.Results:We found that LONP1 and the expressions of gluconeogenic enzymes were downregulated in clinical ACLF liver tissues.Furthermore,LONP1 overexpression remarkably attenuated liver injury,which was characterized by improved liver histopathological lesions and decreased serum alanine aminotransferase(ALT)and aspartate aminotransferase(AST)in ACLF mice.Moreover,mitochondrial morphology was improved upon overexpression of LONP1.Meanwhile,the expression and activity of the key gluconeogenic enzymes were restored by LONP1 overexpression.Similarly,the hepatoprotective effect was also observed in the hepatocyte injury model,as evidenced by improved cell viability,reduced cell apoptosis,and improved gluconeogenesis level and activity,while LONP1 knockdown worsened liver injury and gluconeogenesis disorders.Conclusion:We demonstrated that gluconeogenesis dysfunc

关键词： Acute-on-chronic liver failure Lon protease-1 Gluconeogenesis disturbance Mitochondrial dysfunction Metabolism

Application of Global Leadership Initiative on Malnutrition criteria in patients with liver cirrhosis

在线全文

学校读者我要写书评

暂无评论

Chinese Medical Journal 2024年第1期137卷 97-104页

作者： minjie Jiang Juan Chen Muchen wu Jing wu Xiaotong Xu Juan Li Can Liu Yaping Zhao Xin Hua Qinghua Meng Department of Hepatology Beijing You-An HospitalCapital Medical UniversityBeijing 100069China Beijing Institute of Hepatology Beijing 100069China Department of Medical Oncology Beijing You-An HospitalCapital Medical UniversityBeijing 100069China Department of Nutrition Beijing You-An HospitalCapital Medical UniversityBeijing 100069China

Background:The Global Leadership Initiative on Malnutrition(GLIM)criteria were published to build a global consensus on nutritional diagnosis.Reduced muscle mass is a phenotypic criterion with strong evidence to support its inclusion in the GLIM consensus criteria.However,there is no consensus regarding how to accurately measure and define reduced muscle mass in clinical settings.This study aimed to investigate the optimal reference values of skeletal muscle mass index for diagnosing sarcopenia and GLIM-defined malnutrition,as well as the prevalence of GLIM-defined malnutrition in hospitalized cirrhotic patients.Methods:This retrospective study was conducted on 1002 adult patients with liver cirrhosis between January 1,2018,and February 28,2022,at Beijing You-An Hospital,Capital Medical University.Adult patients with a clinical diagnosis of liver cirrhosis and who underwent an abdominal computed tomography(CT)examination during hospitalization were included in the study.These patients were randomly divided into a modeling group(cohort 1,667 patients)and a validation group(cohort 2,335 patients).In cohort 1,optimal cut-off values of skeletal muscle index at the third lumbar skeletal muscle index(L3-SMI)were determined using receiver operating characteristic analyses against in-hospital mortality in different gender groups.Next,patients in cohort 2 were screened for nutritional risk using the Nutritional Risk Screening 2002(NRS-2002),and malnutrition was diagnosed by GLIM criteria.Additionally,the reference values of reduced muscle mass in GLIM criteria were derived from the L3-SMI values from cohort 1.Multivariate logistic regression analysis was used to analyze the association between GLIM-defined malnutrition and clinical outcomes.Results:The optimal cut-off values of L3-SMI were 39.50 cm 2/m 2 for male patients and 33.06 cm 2/m 2 for female patients.Based on the cut-off values,31.63%(68/215)of the male patients and 23.3%(28/120)of the female patients had CT-determined sarcopenia in cohort 2.The prevalence of GL

关键词： Malnutrition Liver cirrhosis Sarcopenia Clinical outcomes GLIM criteria

Interface engineering of Zn meal anodes using electrochemically inert Al_(2)O_(3)protective nanocoatings

在线全文

学校读者我要写书评

暂无评论

Nano Research 2022年第8期15卷 7227-7233页

作者： Rui Wang Qiongfei wu minjie wu Jiaxian Zheng Jian Cui Qi Kang Zhengbing Qi JiDong Ma Zhoucheng Wang Hanfeng Liang State Key Laboratory of Physical Chemistry of Solid Surfaces College of Chemistry and Chemical EngineeringXiamen UniversityXiamen 361005China Key Laboratory of Functional Materials and Applications of Fujian Province School of Materials Science and EngineeringXiamen University of TechnologyXiamen 361024China Department of Polymer Science and Engineering Shanghai Key Laboratory of Electrical Insulation and Thermal AgeingShanghai Jiao Tong UniversityShanghai 200240China

Aqueous rechargeable Zn-ion batteries are regarded as a promising alternative to lithium-ion batteries owing to their high energy density,low cost,and high safety.However,their commercialization is severely restricted by the Zn dendrite formation and side reactions.Herein,we propose that these issues can be minimized by modifying the interfacial properties through introducing electrochemically inert Al_(2)O_(3)nanocoatings on Zn meal anodes(Al_(2)O_(3)@Zn).The Al_(2)O_(3)nanocoatings can effectively suppress both the dendrite growth and side reactions.As a result,the Al_(2)O_(3)@Zn symmetric cells show excellent electrochemical performance with a long lifespan of more than 4,000 h at 1 mA·cm^(−2)and 1 mAh·cm^(−2).Meanwhile,the assembled Al_(2)O_(3)@Zn//V_(2)O_(5)full cells can deliver a high capacity(236.2 mAh·g^(−1))and long lifespan with a capacity retention of 76.11%after 1,000 cycles at 4 A·g^(−1).

关键词： aqueous Zn-ion batteries Zn dendrites side reactions Al2O3 protective nanocoatings interface engineering

Choice for graphene as conductive additive for cathode of lithium-ion batteries

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Energy Chemistry 2019年第3期28卷 19-26页

作者： Ying Shi Lei Wen Songfeng Pei minjie wu Feng Li Shenyang National Laboratory for Materials Science Institute of Metal Research Chinese Academy of Sciences

Graphene is a promising conductive additive for the lithium-ion batteries(LIBs) and shows great potential especially with its fast development of the large scale fabrication technology. This work has explored the influence of the incorporation of graphenes prepared by three typical methods on the electrochemical performance of the LiCoO_2-based cathode focusing on the choice for the effective graphene as conductive additive for the cathode of LIBs. Through the comparison of the intrinsic characteristics of graphenes and the electrochemical performance of electrodes with graphene, it is found that graphene with low disorder degree and large size is not suitable for LiCoO_2 cathodes as conductive additive. Conversely, the graphene with oxygen functional groups, relatively low surface area and proper size displays much better electrochemical performance when it is used as conductive additive. This work also demonstrates the transmission mechanism for different graphenes as conductive additives in the LiCoO_2 materials, and further reveals that the conductivity of graphene is not the only factor as conductive additives, surface chemistry and sheet size of the graphene are also essential factors which greatly influence the electrochemical performance of electrode. In addition, when combined with Super P, only 1% graphene is enough to construct an efficient conductive network in the electrode. This study also gives a new sight on the practical application of graphene as conductive additive for high performance LIBs.

关键词： Graphene Conductive additive Lithium-ion batteries LiCoO2 cathode

在线全文

学校读者我要写书评

暂无评论

新一代基于云架构信号系统建设方案

城市轨道交通研究 2024年第2期27卷 255-259页

作者：刘敏杰吴刚常州地铁集团有限公司常州213010 广州地铁设计研究院股份有限公司广州510010

[目的]以推进城市轨道交通信息化、发展智能系统、建设“智慧城轨”为主题,构建高度集成的城市轨道交通云平台是新时代技术发展方向,信号系统与云平台融合属于信号系统的一个重要发展趋势,需对如何构建高效、可靠、经济的基于云架构的... 详细信息

[目的]以推进城市轨道交通信息化、发展智能系统、建设“智慧城轨”为主题,构建高度集成的城市轨道交通云平台是新时代技术发展方向,信号系统与云平台融合属于信号系统的一个重要发展趋势,需对如何构建高效、可靠、经济的基于云架构的信号系统进行深入研究。[方法]结合常州地铁新一轮城市轨道交通建设方案的需求,根据现有云平台技术特点和信号系统技术现状,对信号系统云化可行性及建设方案进行分析、论证;重点研究线网统一的ATS(列车自动监控)建设方案、信号系统云化范围、云平台架构的选择、云化后信号系统ATS互联互通方案等内容。[结果及结论]明确了信号系统云化的定义,论证了信号系统ATS云化的可行性;根据信号系统云化后能否通过SIL2(安全、完整性等级2)评估,确定了ATS云化的具体设备清单;提出了新一代基于云架构的信号系统建设方案,建议承载ATS的城市轨道交通云平台架构可逐步从模式一向模式三过渡,并应具备更新迭代的能力。信号系统设备融入云平台后能够提升信号系统的处理能力,减少硬件设备数量,并有利于实现线网资源信息互通,促进调度智能化的发展。

关键词：城市轨道交通信号系统云平台建设方案

WiFi CSI Gesture Recognition Based on Parallel LSTM-FCN Deep Space-Time Neural Network

在线全文

学校读者我要写书评

暂无评论

China Communications 2021年第3期18卷 205-215页

作者： Zhiling Tang Qianqian Liu minjie wu Wenjing Chen Jingwen Huang Guangxi Key Laboratory of Wireless Broadband Communication and Signal Processing Guilin University of Electronic TechnologyGuilin 541004China

In this study,we developed a system based on deep space–time neural networks for gesture recognition.When users change or the number of gesture categories increases,the accuracy of gesture recognition decreases considerably because most gesture recognition systems cannot accommodate both user differentiation and gesture diversity.To overcome the limitations of existing methods,we designed a onedimensional parallel long short-term memory–fully convolutional network(LSTM–FCN)model to extract gesture features of different dimensions.LSTM can learn complex time dynamic information,whereas FCN can predict gestures efficiently by extracting the deep,abstract features of gestures in the spatial dimension.In the experiment,50 types of gestures of five users were collected and evaluated.The experimental results demonstrate the effectiveness of this system and robustness to various gestures and individual changes.Statistical analysis of the recognition results indicated that an average accuracy of approximately 98.9% was achieved.

关键词： signal and information processing parallel LSTM-FCN neural network deep learning gesture recognition wireless channel state information

Involvement of C2H2 zinc finger proteins in the regulation of epidermal cell fate determination in Arabidopsis

在线全文

学校读者我要写书评

暂无评论

Journal of Integrative Plant Biology 2014年第12期56卷 1112-1117页

作者： An Yan minjie wu Yongqin Zhao Aidong Zhang Bohan Liu John Schiefelbein Yinbo Gan Department of Agronomy College of Agriculture and Biotechnology Zhejiang University Department of Molecular Cellular and Developmental Biology University of Michigan Ann Arbor Michigan 48109 USA

Cell fate determination is a basic developmental process during the growth of multicellular organisms.Trichomes and root hairs of Arabidopsis are both readily accessible structures originating from the epidermal cells of the aerial tissues and roots respectively, and they serve as excellent models for understanding the molecular mechanisms controlling cell fate determination and cell morphogenesis. The regulation of trichome and root hair formationis a complex program that consists of the integration of hormonal signals with a large number of transcriptional factors, including MYB and b HLH transcriptional factors.Studies during recent years have uncovered an important role of C2H2 type zinc finger proteins in the regulation of epidermal cell fate determination. Here in this minireview we briefly summarize the involvement of C2H2 zinc finger proteins in the control of trichome and root hair formation in Arabidopsis.

关键词： C2H2 cell fate determination root hair trichome zinc finger protein

胎儿肺动脉瓣狭窄的超声心动图特征及生后管理分析

在线全文

学校读者我要写书评

暂无评论

中华儿科杂志 2024年第2期62卷 138-144页

作者：梁永州赵莉晴张敏杰陈笋孙锟武育蓉上海交通大学医学院附属新华医院儿童心脏中心上海200092

目的探讨胎儿不同程度肺动脉瓣狭窄(PS)的超声心动图特征、胎儿期与生后诊断一致性及生后结局。方法回顾性队列研究。选择2012年11月至2023年2月于上海交通大学医学院附属新华医院行胎儿期诊断并生后随访的108例PS胎儿为研究对象。收集P... 详细信息

目的探讨胎儿不同程度肺动脉瓣狭窄(PS)的超声心动图特征、胎儿期与生后诊断一致性及生后结局。方法回顾性队列研究。选择2012年11月至2023年2月于上海交通大学医学院附属新华医院行胎儿期诊断并生后随访的108例PS胎儿为研究对象。收集PS胎儿形态学及血流动力学等超声心动图特征,且所有胎儿至少随访至生后6月龄。采用单因素方差分析和Kruskal-Wallis检验等比较不同程度PS胎儿的超声心动图特征差异。采用McNemar检验分析胎儿期与生后诊断一致性。应用Logistic回归分析中度PS胎儿需新生儿期干预的危险因素,并利用受试者工作特征(ROC)曲线探索连续变量的最佳截断值。结果108例胎儿首诊时孕母年龄(30.8±4.0)岁,胎龄26.5(24.6,30.0)周。根据首诊超声心动图特征将胎儿PS分为轻度(17例)、中度(49例)和危重型(42例)。轻度PS胎儿超声心动图特征包括瓣膜增厚、回声增强伴流速增快或MPA扩张,中度PS同时伴瓣膜开放活动受限,瓣口呈五彩血流。中度和危重型PS胎儿过瓣流速明显快于轻度组[(2.66±0.86)和(2.77±1.30)比(1.43±0.59)m/s,F=14.52,P<0.001]。危重型PS均为动脉导管血流逆灌注,其右心室偏小比例明显高于轻度和中度组[42.9%(18/42)比0和2.0%(1/49),χ^(2)=31.73,P<0.001],且重度三尖瓣反流的比例也更高[35.7%(15/42)比0和10.2%(5/49),χ^(2)=36.94,P<0.001]。与轻度和危重型PS胎儿相比,中度PS胎儿期与生后诊断一致率更低[40.8%(20/49)比13/17和83.3%(35/42),χ^(2)=12.45,P=0.006]。过瓣流速是中度PS胎儿生后需新生儿期干预的独立危险因素(OR=7.21,95%CI 2.11~24.62),且胎儿中期过瓣流速≥2.18 m/s、胎儿晚期过瓣流速≥3.15 m/s提示中度PS胎儿需新生儿期干预。108例胎儿生后68例接受手术治疗后均存活,39例定期随访,1例未手术死亡,生后6个月存活率为99.1%(107/108)。结论不同程度的胎儿PS在超声心动图中表现出特征性的形态学和血流动力学改变。生后严重程度与胎儿期差异较大,应对胎儿PS行定期随访。胎儿PS的整体预后较好。

关键词：肺动脉瓣狭窄胎儿超声心动描记术

大中小学一体化思政课意蕴价值、困囿和建设策略的研究

在线全文

学校读者我要写书评

暂无评论

科教文汇 2024年第5期 45-48页

作者：吴敏洁合肥职业技术学院安徽合肥230012

思想政治教育课是立德树人的重要一环,开展大中小学一体化思政课是一项重要工作,可以很大程度上解决不同学段的差异性问题,提升思想政治教育的实际效果。该文从新时代大中小学一体化思政课的内涵和规律入手,分析当下大中小学一体化思政... 详细信息

思想政治教育课是立德树人的重要一环,开展大中小学一体化思政课是一项重要工作,可以很大程度上解决不同学段的差异性问题,提升思想政治教育的实际效果。该文从新时代大中小学一体化思政课的内涵和规律入手,分析当下大中小学一体化思政课建设可能存在的弊端,再从课程目标、编纂教材、师资管理、课程评价等多个方面提出优化对策,以期推动大中小学一体化思政课更加合理有效地开展。

关键词：大中小学一体化思想政治课程教材体系教学督导教师协同