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LONP1 ameliorates liver injury and improves gluconeogenesis dysfunction in acute-on-chronic liver failure

Chinese Medical Journal 2024年第2期137卷 190-199页

作者： Muchen Wu Jing Wu Kai Liu minjie jiang Fang Xie Xuehong Yin Jushan Wu Qinghua Meng Department of Liver Disease Beijing You-An HospitalCapital Medical UniversityBeijing 100069China Beijing Institute of Hepatology Beijing You-An HospitalCapital Medical UniversityBeijing 100069China Department of General Surgery Beijing You-An HospitalCapital Medical UniversityBeijing 100069China

Background:Acute-on-chronic liver failure(ACLF)is a severe liver disease with complex *** hypoglycemia is common in patients with ACLF and often predicts a worse *** evidence suggests that glucose metabolic disturbance,especially gluconeogenesis dysfunction,plays a critical role in the disease progression of *** protease-1(LONP1)is a novel mediator of energy and glucose ***,whether gluconeogenesis is a potential mechanism through which LONP1 modulates ACLF remains ***:In this study,we collected liver tissues from ACLF patients,established an ACLF mouse model with carbon tetrachloride(CCl 4),lipopolysaccharide(LPS),and D-galactose(D-gal),and constructed an in vitro hypoxia and hyperammonemia-triggered hepatocyte injury ***1 overexpression and knockdown adenovirus were used to assess the protective effect of LONP1 on liver injury and gluconeogenesis *** histopathology,biochemical index,mitochondrial morphology,cell viability and apoptosis,and the expression and activity of key gluconeogenic enzymes were detected to explore the underlying protective mechanisms of LONP1 in ***:We found that LONP1 and the expressions of gluconeogenic enzymes were downregulated in clinical ACLF liver ***,LONP1 overexpression remarkably attenuated liver injury,which was characterized by improved liver histopathological lesions and decreased serum alanine aminotransferase(ALT)and aspartate aminotransferase(AST)in ACLF ***,mitochondrial morphology was improved upon overexpression of ***,the expression and activity of the key gluconeogenic enzymes were restored by LONP1 ***,the hepatoprotective effect was also observed in the hepatocyte injury model,as evidenced by improved cell viability,reduced cell apoptosis,and improved gluconeogenesis level and activity,while LONP1 knockdown worsened liver injury and gluconeogenesis ***

关键词： Acute-on-chronic liver failure Lon protease-1 Gluconeogenesis disturbance Mitochondrial dysfunction Metabolism

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Application of Global Leadership Initiative on Malnutrition criteria in patients with liver cirrhosis

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Chinese Medical Journal 2024年第1期137卷 97-104页

作者： minjie jiang Juan Chen Muchen Wu Jing Wu Xiaotong Xu Juan Li Can Liu Yaping Zhao Xin Hua Qinghua Meng Department of Hepatology Beijing You-An HospitalCapital Medical UniversityBeijing 100069China Beijing Institute of Hepatology Beijing 100069China Department of Medical Oncology Beijing You-An HospitalCapital Medical UniversityBeijing 100069China Department of Nutrition Beijing You-An HospitalCapital Medical UniversityBeijing 100069China

Background:The Global Leadership Initiative on Malnutrition(GLIM)criteria were published to build a global consensus on nutritional *** muscle mass is a phenotypic criterion with strong evidence to support its inclusion in the GLIM consensus ***,there is no consensus regarding how to accurately measure and define reduced muscle mass in clinical *** study aimed to investigate the optimal reference values of skeletal muscle mass index for diagnosing sarcopenia and GLIM-defined malnutrition,as well as the prevalence of GLIM-defined malnutrition in hospitalized cirrhotic ***:This retrospective study was conducted on 1002 adult patients with liver cirrhosis between January 1,2018,and February 28,2022,at Beijing You-An Hospital,Capital Medical *** patients with a clinical diagnosis of liver cirrhosis and who underwent an abdominal computed tomography(CT)examination during hospitalization were included in the *** patients were randomly divided into a modeling group(cohort 1,667 patients)and a validation group(cohort 2,335 patients).In cohort 1,optimal cut-off values of skeletal muscle index at the third lumbar skeletal muscle index(L3-SMI)were determined using receiver operating characteristic analyses against in-hospital mortality in different gender ***,patients in cohort 2 were screened for nutritional risk using the Nutritional Risk Screening 2002(NRS-2002),and malnutrition was diagnosed by GLIM ***,the reference values of reduced muscle mass in GLIM criteria were derived from the L3-SMI values from cohort *** logistic regression analysis was used to analyze the association between GLIM-defined malnutrition and clinical ***:The optimal cut-off values of L3-SMI were 39.50 cm 2/m 2 for male patients and 33.06 cm 2/m 2 for female *** on the cut-off values,31.63%(68/215)of the male patients and 23.3%(28/120)of the female patients had CT-determ

关键词： Malnutrition Liver cirrhosis Sarcopenia Clinical outcomes GLIM criteria

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Photo-induced 1,2-aryl migration of 2-chloro-1-arylpropanone under batch and flow conditions:Rapid,scalable and sustainable approach to 2-arylpropionic acids

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Chinese Chemical Letters 2024年第2期35卷 366-369页

作者： Qiao Li minjie Liu Meifen jiang Li Wan Yingtang Ning Fen-Er Chen College of Chemical Engineering Zhejiang University of TechnologyHangzhou 310014China Engineering Center of Catalysis and Synthesis for Chiral Molecules Fudan UniversityShanghai 200433China Shanghai Engineering Center of Industrial Catalysis for Chiral Drugs Shanghai 200433China Institute of Pharmaceutical Science and Technology Zhejiang University of TechnologyHangzhou 310014China

We report the photo-mediated 1,2-aryl migration of 2‑chloro-1-arylpropanones to 2-arylpropionic acids using HCOONa as an acid *** pragmatically focused study obviates the multiple-step sequence in the industrially employed,ZnO-promoted rearrangement strategy,and offers rapid access to various 2-arylpropionic acids under environmentally friendly ***,the successful transfer of this batch photochemistry to a continuous flow platform led to improved scalability and enabled the gram-scale synthesis of loxoprofen.

关键词： Green chemistry Flow chemistry 2-Arylpropionic acids Photo-Favorskii reaction

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八步连续流全合成维生素B_(1)工艺研究

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Engineering 2024年第1期32卷 226-232页

作者： Meifen jiang minjie Liu Weijian Li Yingqi Xia Fen-Er Chen Engineering Center of Catalysis and Synthesis for Chiral Molecules Department of ChemistryFudan UniversityShanghai 200433China Shanghai Engineering Research Center of Industrial Asymmetric Catalysis of Chiral Drugs Shanghai 200433China School of Science Harbin Institute of Technology(Shenzhen)Shenzhen 518055China

Vitamin B_(1) is widely applied in the healthcare and food industry as an antineuritic and antioxidant to maintain the normal functioning of nerve conduction,the heart,and the gastrointestinal *** study reports on an integrated eight-step continuous-flow synthesis of vitamin B_(1) from commercially available *** proposed continuous-flow process is based on advances in chemistry,engineering,and equipment design,and affords improved performance and safety compared with batch-mode *** challenges were precisely investigated and controlled,including mixing,unexpected clogging,solvent switches,an exothermic reaction,and the prevention of side reactions,using various micro-channel flow reactors,mixers,separators,and continuous *** B_(1) was produced with a separated yield of 47.7% and high purity,with a total residence time of about 3.5 *** eight-step continuous-flow protocol enables technology involving up to six of the key principles of green ***,the application of flow technology is of paramount importance for improving security,reducing waste,and,in particular,improving the efficiency of batch operations that require several days for manufacturing.

关键词： Vitamin B_(1) Continuous-flow synthesis Micro-reactor Continuous manufacturing

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Analysis of DNA Methylation of Gracilariopsis lemaneiformis Under Temperature Stress Using the Methylation Sensitive Amplification Polymorphism(MSAP) Technique

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Journal of Ocean University of China 2018年第3期17卷 623-631页

作者： PENG Chong SUI Zhenghong ZHOU Wei HU Yiyi MI Ping jiang minjie LI Xiaodong RUAN Xudong Key Laboratory of Marine Genetics and Breeding of Ministry of Education Ocean University of China

Gracilariopsis lemaneiformis is an economically important agarophyte, which contains high quality gel and shows a high growth rate. Wild population of G. lemaneiformis displayed resident divergence, though with a low genetic diversity as was revealed by amplified fragment length polymorphism(AFLP) and simple sequence repeat(SSR) analyses. In addition, different strains of G. lemaneiformis are diverse in morphology. The highly inconsistence between genetic background and physiological characteristics recommends strongly to the regulation at epigenetic level. In this study, the DNA methylation change in G. lemaneiformis among different generation branches and under different temperature stresses was assessed using methylation sensitive amplified polymorphism(MSAP) technique. It was shown that DNA methylation level among different generation branches was diverse. The full and total methylated DNA level was the lowest in the second generation branch and the highest in the third generation. The total methylation level was 61.11%, 60.88% and 64.12% at 15℃, 22℃ and 26℃, respectively. Compared with the control group(22℃), the fully methylated and totally methylated ratios were increased in both experiment groups(15℃ and 26℃). All of the cytosine methylation/demethylation transform(CMDT) was further analyzed. High temperature treatment could induce more CMDT than low temperature treatment did.

关键词： DNA 多型性温度应力敏感技术基因差异温度处理温度压力

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Application of Nuclear rDNA Phylogeny in Coniferopsida and Taxaceae

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Agricultural Science & Technology 2016年第8期17卷 1978-1981页

作者： Qian ZHOU minjie jiang Bida GAO Department of Bioinformatics Hunan Agricultural University

Due to differences in morphology, ecology and biology, the phylogenesis of Coniferopsida and Taxaceae remains controversial, and the phylogenetic relationship of Pseudotaxus is yet to be confirmed. Three rDNA regions, ITS1, 5.8S rDNA, and ITS2, were prepared for 77 species belonging to seven families of Coniferopsida, including Taxaceae. Maximum parsimony(MP)and Neighbor-joining(NJ) analyses were performed. Results showed that:(1) the Coniferopsida species formed three branches:(Taxaceae, Cephalotaxaceae, Cupressaceae, Taxodiaceae),(Araucariaceae, Podocarpaceae), and(Pinaceae);(2) Taxaceae included Taxus, Pseudotaxus, Amentotaxus, and Torreya; and(3) Pseudotaxus belonged to Taxaceae, with a support rate of 97%in MP analyses and 99% in NJ analyses.

关键词： rDNA序列系统发育红豆杉科应用白豆杉属最大简约法亲缘关系 ITS1

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对欧洲临床营养与代谢学会微量营养素指南(2022)的解读

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中华临床营养杂志 2022年第6期30卷 379-384页

作者：徐晓桐姜敏杰孟庆华首都医科大学附属北京佑安医院肿瘤内科 100069

在许多急、慢性疾病中均存在微量营养素(micronutrient, MN)的缺乏, 应对MN进行监测和管理。2022年2月, 欧洲临床营养与代谢学会发布了MN指南。该指南旨在指导日常临床营养实践中对MN的评估、监测和治疗, 同时对易混淆的词汇进行规范。... 详细信息

在许多急、慢性疾病中均存在微量营养素(micronutrient, MN)的缺乏, 应对MN进行监测和管理。2022年2月, 欧洲临床营养与代谢学会发布了MN指南。该指南旨在指导日常临床营养实践中对MN的评估、监测和治疗, 同时对易混淆的词汇进行规范。通过在Medline、PubMed、Cochrane、Google Scholar和CINAHL数据库中检索文献, 最终从MN的主要功能、最佳检测方法、炎症对其影响、潜在毒性以及肠内或肠外营养补充剂量方面, 对每种MN进行总结。为解决高危疾病中MN的缺乏状态, 提供有关MN补充及监测的实用建议。该文根据指南内容, 针对重要内容进行解读。

关键词：微量营养素微量元素维生素

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红外偏振辐射模型对铬和铜元素的优化识别

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哈尔滨工程大学学报 2024年第3期45卷 615-621页

作者：徐将姚明印王晓万敏杰江西农业大学工学院江西南昌330045 江西农业大学江西省生物光电及应用重点实验室江西南昌330045 南京理工大学电子工程与光电技术学院江苏南京210094

针对优化激光诱导击穿光谱技术识别铬和铜元素的问题,本文提出了一种结合红外偏振检测理论的方法。利用菲涅尔反射定律和基尔霍夫理论分析了红外偏振产生机理,根据能量守恒定律验证了目标红外自发热辐射的偏振特性;利用红外偏振辐射传... 详细信息

针对优化激光诱导击穿光谱技术识别铬和铜元素的问题,本文提出了一种结合红外偏振检测理论的方法。利用菲涅尔反射定律和基尔霍夫理论分析了红外偏振产生机理,根据能量守恒定律验证了目标红外自发热辐射的偏振特性;利用红外偏振辐射传输模型及菲涅尔反射穆勒矩阵,结合温度的麦克斯韦-玻尔兹曼分布特性,推导出了等离子体红外偏振辐射信号模型,用于识别各激发能量下的重金属元素;利用5种不同能量的脉冲激光验证了模型的精准性。结果表明:在相同的激光能量下,红外偏振辐射光谱可以收集到更多的特征信号峰;在低能量激励下,红外偏振辐射光谱的优势更为突出。红外偏振辐射模型的构建是科学有效的,可用于优化重金属元素的快速检测。

关键词：红外偏振辐射模型重金属特征信号激光诱导击穿光谱菲涅尔反射定律脉冲激光穆勒矩阵

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肝硬化肌肉减少症的评估及临床管理

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国际流行病学传染病学杂志 2023年第1期50卷 8-13页

作者：姜敏杰孟庆华首都医科大学附属北京佑安医院肿瘤内科北京100069

肝硬化时患者体内蛋白质及脂质氧化率高,碳水化合物氧化率低,这种体内供能方式发生改变使得肝硬化患者容易发生蛋白质-能量营养不良。肌肉减少症作为营养不良的重要组成部分,在肝硬化患者中多见并且与患者预后不良相关。目前还没有肝硬... 详细信息

肝硬化时患者体内蛋白质及脂质氧化率高,碳水化合物氧化率低,这种体内供能方式发生改变使得肝硬化患者容易发生蛋白质-能量营养不良。肌肉减少症作为营养不良的重要组成部分,在肝硬化患者中多见并且与患者预后不良相关。目前还没有肝硬化患者肌肉减少症诊断的统一标准,关于肝硬化患者肌肉减少症的发生机制研究也较少。本文就该类患者的评估及临床管理加以阐述,旨在为相关临床问题的研究提供参考。

关键词：肌减少症肝硬化发病机制诊断与治疗评估

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热处理对热轧7075铝合金组织和力学性能的影响

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精密成形工程 2024年第7期16卷 163-172页

作者：孔令波姜巨福黄敏杰王迎鞠英男哈尔滨工业大学材料科学与工程学院哈尔滨150001 哈尔滨工业大学机电工程学院哈尔滨150001

目的探究T6、T73和RRA热处理对不同道次压下量的热轧7075铝合金板材微观组织和力学性能的影响,确定不同道次压下量的热轧7075铝合金板材最优热处理工艺。方法分别将11%和16%道次压下量的热轧7075铝合金进行T6、T73和RRA热处理,并对热处... 详细信息

目的探究T6、T73和RRA热处理对不同道次压下量的热轧7075铝合金板材微观组织和力学性能的影响,确定不同道次压下量的热轧7075铝合金板材最优热处理工艺。方法分别将11%和16%道次压下量的热轧7075铝合金进行T6、T73和RRA热处理,并对热处理后的试样进行微观组织表征和力学性能测试。结果3种方式热处理后,11%道次压下量的热轧板材微观组织以拉长晶粒为主,伴随有等轴再结晶晶粒的生成,而对于16%道次压下量的热轧板材,等轴晶数量增多,故经3种方式热处理后,16%道次压下量热轧板材的屈服强度和抗拉强度均高于11%道次压下量热轧板材的相应强度。RRA热处理有效提升了16%道次压下量热轧板材的延伸率,而对于11%道次压下量热轧板材,RRA的预时效等过程会造成其晶粒粗化,从而降低延伸率,与T6和RRA热处理相比,T73热处理对力学性能的提升不显著。对于2种不同道次压下量的板材,T6热处理为最优热处理工艺。经过T6处理后,11%道次压下量的热轧板材抗拉强度达到589.8 MPa,屈服强度达到560.7 MPa,延伸率达到16.6%,16%道次压下量的热轧板材抗拉强度达到607.5 MPa、屈服强度达到580.9 MPa、延伸率达到13.6%。T6热处理后,方向的织构占主导,原始板材内部存在较多的小角度晶界,热处理后大角度晶界含量增多且有静态再结晶出现。3种热处理后的拉伸试样断口形貌没有太大区别,存在大量韧窝和撕裂棱特征,说明热处理后板材塑性较好。结论热处理能调控再结晶行为,优化亚晶等微观结构,与其他7系铝合金热处理后的力学性能相比,本文的7075热轧铝合金在16%道次压下量和T6热处理条件下获得了较为优异的力学性能,说明热处理工艺设计合理。

关键词： 7075铝合金热处理微观组织再结晶力学性能

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