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基于改进DSET的电力视频终端网络安全评估

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哈尔滨理工大学学报 2024年第3期29卷 60-70页

作者：杨敏杰林静何良圆夏飞国网上海市电力公司嘉定供电公司上海201800 上海电力大学自动化工程学院上海200090

提出一种改进证据理论(dempster-shafer evidence theory,DSET)的物联网智能终端网络安全评估方法。通过k-means方法得到不同识别框架的聚类中心,作为数据驱动曲线的中线值,改进了数据驱动法的信息源基本概率分配(basic probability all... 详细信息

提出一种改进证据理论(dempster-shafer evidence theory,DSET)的物联网智能终端网络安全评估方法。通过k-means方法得到不同识别框架的聚类中心,作为数据驱动曲线的中线值,改进了数据驱动法的信息源基本概率分配(basic probability allocation,BPA),特别是避免了焦元支持率为1的冲突证据生成。进一步为了分配证据间的冲突,基于所有证据源计算关键证据,引入相似度权重冲突分配规则进行融合,从而得到评估结果。为了验证本文提出的方法,搭建视频终端实验网络,采用设备应用控制器(device application controller,DAC)设备探查设备运行资产,以视频终端网络要素层安全评估为例,比较了不同方法得到的要素层运行资产BPA在融合评估中的结果,以及针对冲突证据融合时不同融合规则得到的融合结果。实验结果表明,相比其他改进方法,本文提出的改进DSET方法能在避免生成冲突极大的证据同时合理分配冲突,并且保证了较高的物联网终端网络安全评估正确率。

关键词：证据理论聚类物联网智能终端网络安全

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《经桡动脉入路外周介入中国专家共识》解读

中国临床医学 2024年第1期31卷 56-59页

作者：杨敏捷颜志平复旦大学附属中山医院介入放射科上海200032 国家放射与治疗临床医学研究中心上海200032 上海市影像医学研究所上海200032

2023年,中国抗癌协会肿瘤介入学专业委员会组织全国范围内的介入专家制定了首个《经桡动脉入路外周介入中国专家共识》。本文将对共识中经桡动脉入路(transradial access, TRA)外周介入的应用现状、优势及局限性、桡动脉解剖学特征、患... 详细信息

2023年,中国抗癌协会肿瘤介入学专业委员会组织全国范围内的介入专家制定了首个《经桡动脉入路外周介入中国专家共识》。本文将对共识中经桡动脉入路(transradial access, TRA)外周介入的应用现状、优势及局限性、桡动脉解剖学特征、患者选择、操作规范、常见并发症预防与处理、辐射剂量及学习曲线7大方面的主要观点以及共识出台的背景进行解读。

关键词：桡动脉入路股动脉入路外周介入桡动脉闭塞专家共识

经皮椎弓根螺钉手术对脊柱创伤患者术后恢复时间、术中出血量的影响

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中国医学创新 2024年第15期21卷 55-59页

作者：杨敏捷杨永华罗素梅九江市第一人民医院骨三科江西九江332000 九江市第一人民医院肿瘤科江西九江332000

目的:分析对脊柱创伤患者采取经皮椎弓根螺钉手术治疗对其术后恢复时间、术中出血量及安全性的影响。方法:将九江市第一人民医院2020年1月—2022年12月收治的脊柱创伤患者共64例患者作为研究对象,以随机数字表法分组,观察组32例采取经... 详细信息

目的:分析对脊柱创伤患者采取经皮椎弓根螺钉手术治疗对其术后恢复时间、术中出血量及安全性的影响。方法:将九江市第一人民医院2020年1月—2022年12月收治的脊柱创伤患者共64例患者作为研究对象,以随机数字表法分组,观察组32例采取经皮椎弓根螺钉手术治疗,对照组32例采取常规手术治疗,比较两组治疗后临床疗效、并发症发生率(切口感染、神经受损、内固定移位)、手术指标(术中出血量、切口长度、术后引流量)、恢复时间(首次下床时间、首次排便时间、住院时间),比较两组治疗前后视觉模拟评分法(visual analogue scale,VAS)评分、日本骨科学会(Japanese orthopaedic association,JOA)评分、腰椎功能(椎体前缘高度、Cobb角)。结果:观察组治疗后临床总有效率高于对照组,术中出血量及术后引流量均少于对照组,切口长度短于对照组,并发症发生率低于对照组,恢复时间均短于对照组,两组对比差异均有统计学意义(P0.05),治疗后,观察组VAS评分、Cobb角均低于对照组,JOA评分、椎体前缘高度均高于对照组,两组对比差异均有统计学意义(P<0.05)。结论:对脊柱创伤者采取经皮椎弓根螺钉手术可提高临床疗效,术中出血量少,切口短,可改善腰椎功能,减轻术后疼痛程度,缩短术后恢复时间,较常规手术治疗更有利于降低术后并发症发生率,提高治疗安全性。

关键词：经皮椎弓根螺钉术脊柱创伤安全性出血量腰椎功能

水平井段连续管多形态流域可溶桥塞碎屑运移规律

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石油机械 2024年第3期52卷 25-31页

作者：王龙徐燕东王锁男吴春洪任海冰张磊杨敏杰中国石油化工股份有限公司西北油田分公司中国石油化工集团公司碳酸盐岩缝洞型油藏提高采收率重点实验室长江大学机械工程学院中国石油集团西部钻探工程有限公司井下作业公司

随着油田大规模的开发,连续管钻磨桥塞技术得到广泛应用。然而该技术在现场应用中会由于桥塞碎屑的堆积而造成钻磨时效低、井下故障频发等一系列工程难题。为此,探究在水平井眼多形态流域桥塞碎屑的运移规律很有必要。运用CFD数值模拟方... 详细信息

随着油田大规模的开发,连续管钻磨桥塞技术得到广泛应用。然而该技术在现场应用中会由于桥塞碎屑的堆积而造成钻磨时效低、井下故障频发等一系列工程难题。为此,探究在水平井眼多形态流域桥塞碎屑的运移规律很有必要。运用CFD数值模拟方法,对水平井段连续管不同形态时的桥塞碎屑进行运移规律研究,探究当边界条件不同(钻磨液黏度、钻磨液流量、固相初始体积分数)时各个截面上桥塞碎屑的体积分数的变化规律。研究结果表明:钻磨液黏度的增加、钻磨液流量的减少、固相初始体积分数的降低都有利于桥塞碎屑的运移;并且当连续管在中心时出口处的桥塞碎屑体积分数比连续管螺旋屈曲时的要高26.5%;碎屑初始体积分数对碎屑运移的影响最大。所得结论可有效预防井下卡钻等风险。

关键词：水平井碎屑运移连续管钻磨桥塞数值模拟

贝伐珠单抗联合化疗治疗转移性结直肠癌的效果研究

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中国医学创新 2024年第24期21卷 37-40页

作者：罗素梅熊超曾灵芝杨敏捷九江市第一人民医院肿瘤科江西九江332000 九江市第一人民医院骨三科江西九江332000

目的:研究贝伐珠单抗联合化疗治疗对转移性结直肠癌(MCRC)患者的肿瘤标志物及机体免疫的影响。方法:选取2021年3月—2022年12月经九江市第一人民医院确诊为MCRC的患者78例,按随机数字表法分组,每组39例。对照组仅接受FOLFOX-6方案化疗,... 详细信息

目的:研究贝伐珠单抗联合化疗治疗对转移性结直肠癌(MCRC)患者的肿瘤标志物及机体免疫的影响。方法:选取2021年3月—2022年12月经九江市第一人民医院确诊为MCRC的患者78例,按随机数字表法分组,每组39例。对照组仅接受FOLFOX-6方案化疗,观察组基于对照组化疗条件施加贝伐珠单抗靶向治疗,比较两组方案近期疗效、治疗前后肿瘤标志物[癌胚抗原(CEA)、糖类抗原19-9(CA19-9)、生殖细胞特异性蛋白DDX4(DDX4)]和机体免疫状况[CD3^(+)、CD4^(+)、自然杀伤细胞(NK)]。结果:观察组客观有效率、疾病控制率均高于对照组(P<0.05)。治疗后,观察组3项肿瘤标志物(CEA、CA19-9及DDX4)检测值均低于对照组(P<0.05)。治疗后,观察组3项机体免疫指标(CD3^(+)、CD4^(+)及NK)检测值均高于对照组(P<0.05)。结论:贝伐珠单抗联合化疗治疗能够提升MCRC患者的近期治疗效果,降低肿瘤标志物水平,或与其可调节机体免疫状况有关。

关键词：转移性结直肠癌贝伐珠单抗靶向治疗肿瘤标志物机体免疫

Development of a Novel Endovascular Brachytherapy Stent:A Proof-of-concept Study

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Journal of Clinical and Translational Hepatology 2021年第5期9卷 711-718页

作者： Nan Du Jingqin Ma Zihan Zhang Yongjie Zhou minjie yang Wen Zhang Jianjun Luo Zhiping Yan Department of Interventional Radiology Zhongshan HospitalFudan UniversityShanghaiChina Shanghai Institution of Medical Imaging ShanghaiChina

Background and Aims:Endovascular implantation of iodine-125(125I)seeds strand combined with stent is an effective method of treatment for portal vein tumor *** aim of this study was to develop a novel endovascular brachytherapy stent(EVB-Stent)and to evaluate its feasibility of ***:An EVB-Stent was implanted into the main portal vein(MPV)in a live porcine model via the percutaneous transhepatic *** samples were collected and tested before and after operation,as well as before ***-photon emission computed tomography(SPECT)combined with CT(SPECT/CT)scan were performed directly after operation and CT scan was performed 2 months after *** the CT scan was performed,all animals were euthanized and histologically ***:The novel stent was successfully positioned in all six *** deterioration of liver function was observed during the 2-month follow-up ***/CT revealed the uniform distribution of radiation around the seeds strand,and the hottest spot was near the center of the *** patency of the stented MPV was confirmed using CT *** tissue-accumulated absorbed dose was 31,822.11 mGy at 10 mm transversely away from the midpoint of the 125I seeds strand,with a half-life of 59.4 *** examination results showed no significant atrophy or inflammation of adjunct liver tissue,and no obvious intima thickening or thrombosis were detected in the stented ***:A liver porcine model was used to demonstrate that the transhepatic placement of a novel endovascular brachytherapy stent,EVB-Stent,is both technically feasible and safe.

关键词： Portal vein tumor Tumor thrombus Brachytherapy Stent Iodine-125 seeds strand

Unraveling the serial glycosylation in the biosynthesis of steroidal saponins in the medicinal plant Paris polyphylla and their antifungal action

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Acta Pharmaceutica Sinica B 2023年第11期13卷 4638-4654页

作者： Yuegui Chen Qin Yan Yunheng Ji Xue Bai Desen Li Rongfang Mu Kai Guo minjie yang yang Tao Jonathan Gershenzon Yan Liu Shenghong Li State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of BotanyChinese Academy of SciencesKunming 650201China State Key Laboratory of Southwestern Chinese Medicine Resources Innovative Institute of Chinese Medicine and PharmacyChengdu University of Traditional Chinese MedicineChengdu 611137China Key Laboratory for Plant Diversity and Biogeography of East Asia Kunming Institute of BotanyChinese Academy of SciencesKunming 650201China Max Planck Institute for Chemical Ecology Jena D-07745Germany University of Chinese Academy of Sciences Beijing 100049China

Sugar-sugar glycosyltransferases play important roles in constructing complex and bioactive ***,we characterized a series of UDP-glycosyltransferases responsible for biosynthesizing the branched sugar chain of bioactive steroidal saponins from a widely known medicinal plant Paris polyphylla *** them,a 2'-O-rhamnosyltransferase and three 6'-O-glucosyltrasferases catalyzed a cascade of glycosylation to produce steroidal diglycosides and triglycosides,*** UDP-glycosyltransferases showed astonishing substrate promiscuity,resulting in the generation of a panel of 24 terpenoid glycosides including 15 previously undescribed compounds.A mutant library containing 44 variants was constructed based on the identification of critical residues by molecular docking simulations and protein model alignments,and a mutant UGT91AH1^(Y187A)with increased catalytic efficiency was *** steroidal saponins exhibited remarkable antifungal activity against four widespread strains of human pathogenic fungi attributed to ergosterol-dependent damage of fungal cell membranes,and 2'-O-rhamnosylation appeared to correlate with strong antifungal *** findings elucidated the biosynthetic machinery for their production of steroidal saponins and revealed their potential as new antifungal agents.

关键词： Paris polyphylla var.yunnanensis Steroidal saponins Glycosyltransferases Sugar chain elongation Antifungal activity

Characterization of two chimeric sesterterpene synthases from a fungal symbiont isolated from a sesterterpenoid-producing Lamiaceae plant Leucosceptrum canum

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Chinese Chemical Letters 2023年第1期34卷 279-283页

作者： Desen Li minjie yang Rongfang Mu Shihong Luo Yuegui Chen Wenyuan Li An Wang Kai Guo Yan Liu Shenghong Li State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of BotanyChinese Academy of SciencesKunming 650201China State Key Laboratory of Southwestern Chinese Medicine Resources and Innovative Institute of Chinese Medicine and PharmacyChengdu University of Traditional Chinese MedicineChengdu 611137China College of Bioscience and Biotechnology Shenyang Agricultural UniversityShenyang 110866China University of Chinese Academy of Sciences Beijing 100049China

Two chimeric sesterterpene synthases(Aa TPS1 and Aa TPS2)were functionally characterized from Alternaria alternata MB-30 isolated from the leaves of a sesterterpenoid-producing Lamiaceae plant Leucosceptrum *** TPS1 generated a 5/8/6/5 tetracyclic sesteraltererol(1)and its absolute stereochemistry was determined by X-ray crystallographic analysis of its derivative 10,11-epoxysesteraltererol(2),which enabled revision of the absolute configuration of C7 of sesterfisherol produced by Nf SS and PTTS014 characterized previously and its derivative 10,*** TPS2 produced a 5/15 bicyclic preterpestacin I(3).Site-directed mutagenesis suggested that F192 in Aa TPS1 was likely involved in controlling of the hydroxylation of C12,and eight amino acids were important for the enzyme activity of Aa TPS1 and Aa *** engineered Escherichia coli and Saccharomyces cerevisiae strains were constructed for the productions of compounds 1 and 3,and the highest titer of compound 1 reached 62.3 mg/L in shake-flask *** compounds 1 and 2 showed anti-adipogenic activity.

关键词： Sesterterpenoids Chimeric sesterterpene synthases Plant symbiotic fungi Alternaria alternata Leucosceptrum canum Anti-adipogenic activity

Bronchial artery embolization for hemoptysis:A systematic review and meta-analysis

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Journal of Interventional Medicine 2021年第4期4卷 172-180页

作者： Zhiyuan Zheng Zhiquan Zhuang minjie yang Jianjun Luo Wen Zhang Zhiping Yan Xiaolin Wang Department of Interventional Radiology Zhongshan HospitalFudan University180 Fenglin RoadShanghai200032China Shanghai Institute of Medical Imaging ShanghaiChina

Objective:To assess the safety and efficacy of bronchial artery embolization(BAE)for *** and materials:Databases with articles published in English,including Pubmed,Embase,Web of science and Chochrane library,were comprehensively searched to get accurate,up-to-date and sufficient literature about BAE for hemoptysis until March *** technical success rates,immediate control rates,recurrence rates,mortality rates,and total complication rates(minor and major complication rates)extracted from the articles were pooled to estimate and assess the efficacy and safety of BAE using random-effect and fixed-effect ***:21 articles published between 2008 and 2019,which include a total of 2511 patients,were studied to evaluate the safety and efficacy of *** technical success and immediate control rates are 99.9%(95%CI:99%-100%)and 99.5%(95%CI:97.8%-99.2%),*** study showed hemoptysis recurrence in 23.7%(95%CI:18.5%-28.9%)with a mortality rate of 2%(95%CI:0-3%).Additionally,the assessment of complications revealed a total complication rate of 13.4%(95%CI:7.6-19.2%),in which 0.2%(95%CI:0.2-0.4%)were major complications and 10%(95%CI:4.7-9.6%)were minor ***:BAE is an effective,safe,and feasible procedure with a low complication rate for hemoptysis ***,recurrence of hemoptysis is still at high risk after BAE due to different underlying diseases.

关键词： BAE Hemoptysis Efficacy Safety