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Studies on the properties of surface and edges of N-layer graphenes

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Science China(Physics,Mechanics & Astronomy) 2011年第10期54卷 1729-1738页

作者： chen minjiang ZHOU HaiQing QIU CaiYu YANG HuaiChao YU Fang SUN LianFeng National Center for Nanoscience and Technology Beijing 100190 China Graduate University of Chinese Academy of Sciences Beijing 100049 China Tsinghua University Beijing 100084 China peking University Beijing 100871 China

Graphene, a new two-dimensional carbon material, is a rising star of physics, chemistry and materials science. In this work, we report the recent experimental researches on the Raman spectra and the temperature-dependent features of graphenes and car- bon nanoscrolls, which are evolved from graphene and have an open tubular structure. The layer-dependent Raman enhancing characteristics of n-layer graphenes for crystal violet, and the thickness-dependent morphologies of gold on n-layer graphenes are also systematically investigated. Meanwhile, the aggregations of ferromagnetic and paramagnetic atoms at edges of gra- phenes and graphite are observed and the mechanisms are discussed.

关键词： N-layer graphene Raman spectroscopy edge ferromagnetism

Case report of neurofibromatosis type 1 combined with primary ciliary dyskinesia

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Frontiers of Medicine 2021年第6期15卷 933-937页

作者： Chun Bian Xinyue Zhao Yaping Liu minjiang chen Shuying Zheng Xinlun Tian Kai-Feng Xu Department of Internal Medicine State Key Laboratory of Complex Severe and Rare DiseasesPeking Union Medical College HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing100730China McKusick-Zhang Center for Genetic Medicine State Key Laboratory of Medical Molecular BiologyInstitute of Basic Medical SciencesChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing100730China Department of Pulmonary and Critical Care Medicine State Key Laboratory of Complex Severe and Rare DiseasesPeking Union Medical College HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing100730China Department of Electron Microscope Laboratory Peking University People’s HospitalBeijing100034China

Neurofibromatosis(NF)is a genetic disease in which the lungs are rarely ***,in NF cases with lung involvement,chest computed tomography may show bilateral basal reticulations,apical bullae,and cysts without ***,we report a patient diagnosed with NF on the basis of the results of genetic testing who presented with early-onset wet cough and *** the differential diagnosis of bronchiectasis combined with his early-onset wet cough,sinusitis,and sperm quality decline,we considered the possibility of primary ciliary dyskinesia(PCD).Further electron microscopy analysis of cilia and identification of homozygous mutations in the RSPH4A gene confirmed the diagnosis of ***,for patients with NF,when an image change exists in the lungs that does not correspond to NF,the possibility of other diagnoses,including PCD,must be considered.

关键词： primary ciliary dyskinesia neurofibromatosis bronchiectasis transmission electron microscopy genetic sequencing

Fucoidan-based dual-targeting mesoporous polydopamine for enhanced MRI-guided chemo-photothermal therapy of HCC via P-selectin-mediated drug delivery

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Asian Journal of Pharmaceutical Sciences 2022年第6期17卷 908-923页

作者： Gaofeng Shu Lin Shen Jiayi Ding Junchao Yu Xiaoxiao chen Xiaoju Guo Enqi Qiao Yaning chen chenying Lu Zhongwei Zhao Yongzhong Du minjiang chen Jiansong Ji Key Laboratory of Imaging Diagnosis and Minimally Invasive Intervention Research Institute of Imaging Diagnosis and Minimally Invasive Intervention ResearchThe Fifth Affiliated Hospital of Wenzhou Medical UniversityLishui 323000China Department of radiology Lishui Hospital of Zhejiang UniversitySchool of MedicineLishui 323000China Institute of Pharmaceutics College of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China Shaoxing University School of Medcine Shaoxing 312000China

The development of novel theranostic agents with outstanding diagnostic and therapeutic performances is still strongly desired in the treatment of hepatocellular carcinoma(HCC).Here,a fucoidan-modified mesoporous polydopamine nanoparticle dual-loaded with gadolinium iron and doxorubicin(FMPDA/Gd^(3+)/DOX)was prepared as an effective theranostic agent for magnetic resonance imaging(MRI)-guided chemo-photothermal therapy of *** was found that FMPDA/Gd^(3+)/DOX had a high photothermal conversion efficiency of 33.4%and excellent T1-MRI performance with a longitudinal relaxivity(r1)value of 14.966 m M^(-1)·s^(-1).Moreover,the results suggested that FMPDA/Gd^(3+)/DOX could effectively accumulate into the tumor foci by dual-targeting the tumor-infiltrated platelets and HCC cells,which resulted from the specific interaction between fucoidan and overexpressed p-selectin *** excellent tumor-homing ability and MRI-guided chemo-photothermal therapy therefore endowed FMPDA/Gd^(3+)/DOX with a strongest ability to inhibit tumor growth than the respective single treatment ***,our study demonstrated that FMPDA/Gd^(3+)/DOX could be applied as a potential nanoplatform for safe and effective cancer theranostics.

关键词： Mesoporous polydopamine Fucoidan P-selectin target Platelets bridge Cancer theranostics

Thickness-dependent morphologies of Ag on n-layer MoS2 and its surface-enhanced Raman scattering

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Nano Research 2016年第6期9卷 1682-1688页

作者： Ya Deng minjiang chen Jian Zhang Zihao Wang Wenbin Huang Yun Zhao Jean PierreNshimiyimana Xiao Hu Xiannian Chi Gu Hou ,Xueyao Zhang Yanjun Guo Lianfeng Sun CAS Key Laboratory of Nanosystem and Hierarchical Fabrication CAS Center for Excellence in Nanoscience National Center for Nanoscience and Technology 8eijing 100190 China School of Physics Shandong University Jinan 250100 China Chinese Academy of Sciences Beijing 100049 China

The size and density of Ag nanoparticles on n-layer MoS2 exhibit thickness- dependent behavior. The size and density of these particles increased and decreased, respectively, with increasing layer number （n） of n-layer MoS2. Furthermore, the surface-enhanced Raman scattering （SERS） of Ag on this substrate was observed. The enhancement factor of this scattering varied with the thickness of MoS2. The mechanisms governing the aforementioned thickness dependences are proposed and discussed.

关键词： MoS2 nanoparticle thickness-dependent surface-enhanced Ramanscattering (SERS)

Acidic/hypoxia dual-alleviated nanoregulators for enhanced treatment of tumor chemo-immunotherapy

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Asian Journal of Pharmaceutical Sciences 2024年第2期19卷 136-152页

作者： Xiaoju Guo Xiaoxiao chen Jiayi Ding Feng Zhang Shunyang chen Xin Hu Shiji Fang Lin Shen chenying Lu Zhongwei Zhao Jianfei Tu Gaofeng Shu minjiang chen Jiansong Ji Lishui Central Hospital Shaoxing UniversityShaoxing 312000China Zhejiang Key Laboratory of Imaging and Interventional Medicine Imaging Diagnosis and Interventional Minimally Invasive InstituteThe Fifth Affiliated Hospital of Wenzhou Medical UniversityLishui 323000China Clinical College of The Affiliated Central Hospital School of MedicineLishui UniversityLishui 323000China Key Laboratory of Precision Medicine of Lishui Lishui 323000China

Chemotherapy plays a crucial role in triple-negative breast cancer (TNBC) treatment as it not only directly kills cancer cells but also induces immunogenic cell death. However, the chemotherapeutic efficacy was strongly restricted by the acidic and hypoxic tumor environment. Herein, we have successfully formulated PLGA-based nanoparticles concurrently loaded with doxorubicin (DOX), hemoglobin (Hb) and CaCO3 by a CaCO3-assisted emulsion method, aiming at the effective treatment of TNBC. We found that the obtained nanomedicine (DHCaNPs) exhibited effective drug encapsulation and pH-responsive drug release behavior. Moreover, DHCaNPs demonstrated robust capabilities in neutralizing protons and oxygen transport. Consequently, DHCaNPs could not only serve as oxygen nanoshuttles to attenuate tumor hypoxia but also neutralize the acidic tumor microenvironment (TME) by depleting lactic acid, thereby effectively overcoming the resistance to chemotherapy. Furthermore, DHCaNPs demonstrated a notable ability to enhance antitumor immune responses by increasing the frequency of tumor-infiltrating effector lymphocytes and reducing the frequency of various immune-suppressive cells, therefore exhibiting a superior efficacy in suppressing tumor growth and metastasis when combined with anti-PD-L1 (αPD-L1) immunotherapy. In summary, this study highlights that DHCaNPs could effectively attenuate the acidic and hypoxic TME, offering a promising strategy to figure out an enhanced chemo-immunotherapy to benefit TNBC patients.

关键词： CaCO3-based nanoparticles Hypoxia attenuation Acidity neutralization Reversal of chemotherapy resistance Enhanced chemo-immunotherapy

Manganese molybdate nanodots with dual amplification of STING activation for“cycle”treatment of metalloimmunotherapy

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Bioactive Materials 2024年第1期31卷 53-62页

作者： Huali Lei Quguang Li Guangqiang Li Tianyi Wang Xinjing Lv Zifan Pei Xiang Gao Nailin Yang Fei Gong Yuqi Yang Guanghui Hou minjiang chen Jiansong Ji Zhuang Liu Liang cheng Institute of Functional Nano&Soft Materials(FUNSOM) Jiangsu Key Laboratory for Carbon-Based Functional Materials and DevicesSoochow UniversitySuzhou215123China Department of Neurosurgery The First Affiliated Hospital of Soochow UniversitySuzhou215000China Children’s Hospital of Soochow University Pediatric Research Institute of Soochow UniversitySuzhou215123China Department of Orthopedics The Second Affiliated Hospital of Soochow UniversitySuzhouJiangsu215004China Key Laboratory of Imaging Diagnosis and Minimally Invasive Intervention Research Fifth Affiliated Hospital of Wenzhou Medical UniversityLishui323000ZhejiangChina

Certain types of cationic metal ions,such as Mn^(2+)are able to activate immune functions via the stimulator of interferon genes(STING)pathway,showing potential applications in eliciting antitumor *** anionic ions interact with immune cells remains largely ***,selecting from a range of cationic and anionic ions,we were excited to discover that MoO_(4)^(2-)could act as a cGAS-STING agonist and further confirmed the capability of Mn^(2+)to activate the cGAS-STING *** by such findings,we synthesized manganese molybdate nanoparticles with polyethylene glycol modification(MMP NDs)for cancer ***,MMP NDs could consume glutathione(GSH)over-expressed in tumors and induce ferroptosis owing to high-valence Mo and Mn to elicit tumor-specific immune responses,which was further amplified by MMP-triggered the cGAS-STING *** turn,activated CD8+T cells to secrete high levels of interferonγ(IFN-γ)and reduced GPX4 expression in tumor cells to trigger ferroptosis-specific lipid peroxidation,which constituted a“cycle”of *** a result,the metalloimmunotherapy with systemic administration of MMP NDs offered a remarkable tumor inhibition effect for a variety of tumor *** work for the first time discovered the ability of anionic metal ions to activate the immune system and rationally designed bimetallic oxide nanostructures as a multifunctional therapeutic nanoplatform for tumor immunotherapy.

关键词： Metalloimmunotherapy Manganese molybdate nanoparticles cGAS-STING pathway DCs maturation Ferroptosis

Prediction of major adverse cardiac events is the first critical task in the management of immune checkpoint inhibitor-associated myocarditis

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Cancer Communications 2022年第9期42卷 902-905页

作者： Yan Xu Yanjun Song Xiaoyan Liu Yuequan Shi Yingxian Liu Hao Qian Xiaoxing Gao minjiang chen Ruili Pan Jing Zhao Wei Zhong Wei Wu Mengzhao Wang Department of Respiratory and Critical Care Medicine Peking Union Medical College HospitalChinese Academy of Medical Science&Peking Union Medical CollegeBeijing 100730P.R.China Department of Cardiology Peking Union Medical College HospitalChinese Academy of Medical Science&Peking Union Medical CollegeBeijing 100730P.R.China

Dear Editor,The application of immune checkpoint inhibitors(ICIs),anti-tumor immunotherapy unleashing the host immune system to eradicate tumor cells,has revolutionized the treatment of various advanced cancers and showed remarkable anti-tumor effects[1].However,emphasis must be placed on fatal immune-related adverse events(irAEs),especially some fulminant irAEs like ICI-related cardiovascular AEs[2,3].However,due to the low rate of cardiovascular AEs,little is known about the effective methods for evaluating the risk of catastrophic cardiac events in ICI-associated myocarditis and its management[4,5].

关键词： cardiac myocarditis cardiovascular

Precision interventional radiology

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Journal of Interventional Medicine 2021年第4期4卷 155-158页

作者： Jiansong Ji Shiji Fang minjiang chen Liyun zheng Weiqian chen Zhongwei Zhao Yongde cheng Key Laboratory of Imaging Diagnosis and Minimally Invasive Intervention Research Lishui Hospital of Zhejiang UniversityFifth Affiliated Hospital of Wenzhou Medical UniversityLishui323000China Magazine of the Journal of Interventional Medicine Shanghai200052China

The recent interest in precision medicine among interventionists has led to the establishment of the concept of precision interventional radiology(PIR).This concept focuses not only on the accuracy of interventional operations using traditional image-guided techniques,but also on the comprehensive evaluation of *** invisible features extracted from CT,MRI,or US improve the accuracy and specificity of *** integration of multi-omics and molecule imaging provides more information for interventional *** development and application of drugs,embolic materials,and devices broaden the concept of *** medicine and engineering brings new image-guided techniques that increase the efficacy of interventional operations while reducing the complications of interventional *** all,PIR,an important part of precision medicine,emphasizing the whole disease management process,including precision diagnosis,comprehensive evaluation,and interventional therapy,maximizes the benefits of patients with limited damage.

关键词： Precision interventional radiology Anatomical location Comprehensive evaluation Interventional therapy Precision diagnosis

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基于负荷模糊聚类的电压稳定概率评估

电力系统自动化 2007年第4期31卷 23-27页

作者：吴蓓张焰陈闽江上海交通大学电气工程系上海市200240

在对研究时段内多个负荷水平进行模糊C均值聚类的基础上,采用多维正态分布抽样技术,提出了一种同时计及节点负荷相关性和负荷预测不确定性的电压稳定概率评估方法。通过对负荷样本多次抽样后进行连续潮流计算及模态分析,可以获得系统功... 详细信息

在对研究时段内多个负荷水平进行模糊C均值聚类的基础上,采用多维正态分布抽样技术,提出了一种同时计及节点负荷相关性和负荷预测不确定性的电压稳定概率评估方法。通过对负荷样本多次抽样后进行连续潮流计算及模态分析,可以获得系统功率极值、母线与支路参与因子的统计信息,以及系统在给定负荷水平下电压失稳的概率,从概率角度指出具有潜在电压稳定问题的区域,实现对系统电压稳定性的概率评估。通过对IEEE57节点系统进行分析计算,验证了算法的可行性和有效性,并就模糊聚类数、负荷预测不确定性和节点负荷相关性对电压稳定评估结果的影响进行了比较和分析。

关键词：模糊聚类电压稳定概率评估节点负荷相关性负荷不确定性