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Network pharmacology and molecular dynamics study of the effect of the Astragalus-Coptis drug pair on diabetic kidney disease

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World Journal of Diabetes 2024年第7期15卷 1562-1588页

作者： mo-Yan Zhang Shu-Qin Zheng Liaoning University of Traditional Chinese Medicine Liaoning University of Traditional Chinese MedicineShenyang 110847Liaoning ProvinceChina Department of Endocrinology The Affiliated Hospital of Liaoning University of Traditional Chinese MedicineShenyang 110032Liaoning ProvinceChina

BACKGROUND Diabetic kidney disease(DKD)is the primary cause of end-stage renal *** Astragalus-Coptis drug pair is frequently employed in the management of ***,the precise molecular mechanism underlying its therapeutic effect remains *** To investigate the synergistic effects of multiple active ingredients in the Astragalus-Coptis drug pair on DKD through multiple targets and *** The ingredients of the Astragalus-Coptis drug pair were collected and screened using the TCMSP database and the SwissADME *** targets were predicted using the SwissTargetPrediction database,while the DKD differential gene expression analysis was obtained from the Gene Expression Omnibus *** targets were acquired from the GeneCards,Online Mendelian Inheritance in Man database,and DisGeNET databases,with common targets identified through the Venny *** protein-protein interaction network and the“disease-active ingredient-target”network of the common targets were constructed utilizing the STRING database and Cytoscape software,followed by the analysis of the interaction relationships and further screening of key targets and core active *** Ontology(GO)function and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway enrichments were performed using the DAVID *** tissue and organ distributions of key targets were *** and AutoDock software validate the molecular docking between the core ingredients and key ***,molecular dynamics(MD)simulations were conducted to simulate the optimal complex formed by interactions between core ingredients and key target *** A total of 27 active ingredients and 512 potential targets of the Astragalus-Coptis drug pair were *** were 273 common targets between DKD and the Astragalus-Coptis drug *** protein-protein interaction network topology analysis,we identified 9 core active ingredients and 10 key *** and KEGG pathwa

关键词： Astragalus membranaceus Coptis chinensis Franch Diabetic kidney disease Network pharmacology molecular docking molecular dynamics simulation

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Automatic SOC Equalization Strategy of Energy Storage Units with DC Microgrid Bus Voltage Support

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Energy Engineering 2024年第2期121卷 439-459页

作者： Jingjing Tian Shenglin mo Feng Zhao Xiaoqiang Chen School of Automation&Electrical Engineering Lanzhou Jiaotong UniversityLanzhou730070China Key Laboratory of Opto-Technology and Intelligent Control(Lanzhou Jiaotong University) Ministry of EducationLanzhou730070China

In this paper,an improved sag control strategy based on automatic SOC equalization is proposed to solve the problems of slow SOC equalization and excessive bus voltage fluctuation amplitude and offset caused by load and PV power variations in a stand-alone DC *** strategy includes primary and secondary *** them,the primary control suppresses the DC microgrid voltage fluctuation through the I and II section control,and the secondary control aims to correct the P-U curve of the energy storage system and the PV system,thus reducing the steady-state bus voltage *** simulation results demonstrate that the proposed control strategy effectively achieves SOC balancing and enhances the immunity of bus *** proposed strategy improves the voltage fluctuation suppression ability by approximately 39.4%and 43.1%under the PV power and load power fluctuation conditions,***,the steady-state deviation of the bus voltage,△U_(dc) is only 0.01–0.1 V,ensuring stable operation of the DC microgrid in fluctuating power environments.

关键词： Automatic equalization independent DC microgrid improve droop control secondary control state of charge

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Attention-based network embedding with higher-order weights and node attributes

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CAAI Transactions on Intelligence Technology 2024年第2期9卷 440-451页

作者： Xian mo Binyuan Wan Rui Tang Junkai Ding Guangdi Liu School of Information Engineering Ningxia UniversityYinchuanChina School of Cyber Science and Engineering Sichuan UniversityChengduChina Computer Science and Information Technology University of MalayaKuala LumpurMalaysia Academy of Medical Sciences Zhengzhou UniversityZhengzhouChina

Network embedding aspires to learn a low-dimensional vector of each node in networks,which can apply to diverse data mining *** real-life,many networks include rich attributes and temporal ***,most existing embedding approaches ignore either temporal information or network attributes.A self-attention based architecture using higher-order weights and node attributes for both static and temporal attributed network embedding is presented in this article.A random walk sampling algorithm based on higher-order weights and node attributes to capture network topological features is *** static attributed networks,the algorithm incorporates first-order to k-order weights,and node attribute similarities into one weighted graph to preserve topological features of *** temporal attribute networks,the algorithm incorporates previous snapshots of networks containing first-order to k-order weights,and nodes attribute similarities into one weighted *** addition,the algorithm utilises a damping factor to ensure that the more recent snapshots allocate a greater *** features are then incorporated into topological ***,the authors adopt the most advanced architecture,Self-Attention Networks,to learn node *** results on node classification of static attributed networks and link prediction of temporal attributed networks reveal that our proposed approach is competitive against diverse state-of-the-art baseline approaches.

关键词： data mining deep neural networks social network

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Effects of weaning on intestinal longitudinal muscle-myenteric plexus function in piglets

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Science China(Life Sciences) 2024年第2期67卷 379-390页

作者： Jing Li Fenfen Liu Kaibin mo Hengjia Ni Yulong Yin Key Laboratory of Agro-Ecological Processes in Subtropical Region Hunan Provincial Key Laboratory of Animal Nutritional Physiology and Metabolic ProcessHunan Research Center of Livestock and Poultry SciencesSouth Central Experimental Station of Animal Nutrition and Feed Science in the Ministry of AgricultureInstitute of Subtropical AgricultureChinese Academy of SciencesChangsha 410125China University of Chinese Academy of Sciences Beijing 100008China Guangdong Key Laboratory for Veterinary Drug Development and Safety Evaluation College of Veterinary MedicineSouth China Agricultural UniversityGuangzhou 510642China

Weaning piglets usually suffer from severe diarrhea(commonly known as postweaning diarrhea,PWD)along with intestinal motility *** peristalsis is mainly regulated by the longitudinal muscle-myenteric plexus(LM-MP).To understand the relationship between intestinal LM-MP function and the development of PWD,we compared the intestinal electrical activity,and the transcriptional profile of the LM-MP between 21-day-old piglets(just weaned,n=7)and 24-day-old piglets(suffered the most severe weaning stress,n=7).The results showed that 24-day-old piglets exhibited different degrees of diarrhea.A significant increase in the slow-wave frequency in the ileum and colon was observed in 24-day-old piglets,while c-kit expression in the intestinal LM-MPs was significantly decreased,indicating that PWD caused by elevated slow-wave frequency may be associated with loss of *** real-time quantitative PCR(RT-q PCR)and enzyme-linked immunosorbent assay(ELISA)showed that intestinal LM-MPs in 24-day-old piglets may undergo inflammation and oxidative *** increases in 8-hydroxy-2′-deoxyguanosine and decreases in thioredoxin suggest that weaning may lead to DNA damage in the LM-MP of 24-day-old *** addition,activating transcription factor 3 was significantly upregulated,indicating nerve damage in the LM-MP of 24-day-old *** transcriptomic results showed that most of the differentially expressed genes in the ileal LM-MP after weaning were downregulated and closely related to the cell cycle *** RT-q PCR analysis showed that the relative expression of p21 was upregulated,while the expression of cyclin A2,cyclin B1,and proliferating cell nuclear antigen was downregulated in the ileal and colonic LM-MP of 24-day-old piglets,suggesting that weaning may inhibit cell proliferation and cause G1/S cell cycle arrest in ileal and colonic *** conclusion,weaning may lead to cell cycle arrest by causing DNA damage in the LM-MP,impairing i

关键词： weaning piglets diarrhea longitudinal muscle-myenteric plexus

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Rheological properties and concentration evolution of thickened tailings under the coupling effect of compression and shear

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International Journal of Minerals,Metallurgy and Materials 2024年第5期31卷 862-876页

作者： Aixiang Wu Zhenqi Wang Zhuen Ruan Raimund Bürger Shaoyong Wang Yi mo Key Laboratory of the Ministry of Education of China for High-efficient Mining and Safety of Metal Mines University of Science and Technology BeijingBeijing 100083China Shunde Innovation School University of Science and Technology BeijingFoshan 528399China CI2MA and Departamento de Ingeniería Matemática Facultad de Ciencias Físicas y MatemáticasUniversidad de ConcepciónCasilla 160-CConcepciónChile School of Civil and Resource Engineering University of Science and Technology BeijingBeijing 100083China China Railway Construction Tongguan Investment Co. Ltd.Tongling 244000China

Cemented paste backfill(CPB)is a key technology for green mining in metal mines,in which tailings thickening comprises the primary link of CPB ***,difficult flocculation and substandard concentrations of thickened tailings often *** rheological properties and concentration evolution in the thickened tailings remain ***,traditional indoor thickening experiments have yet to quantitatively characterize their rheological *** experiment of flocculation condition optimization based on the Box-Behnken design(BBD)was performed in the study,and the two response values were investigated:concentration and the mean weighted chord length(MWCL)of ***,optimal flocculation conditions were *** addition,the rheological properties and concentration evolution of different flocculant dosages and ultrafine tailing contents under shear,compression,and compression-shear coupling experimental conditions were tested and *** results show that the shear yield stress under compression and compression-shear coupling increases with the growth of compressive yield stress,while the shear yield stress increases slightly under *** order of shear yield stress from low to high under different thickening conditions is shear,compression,and compression-shear *** compression and compression-shear coupling,the concentration first rapidly increases with the growth of compressive yield stress and then slowly increases,while concentration increases slightly under *** order of concentration from low to high under different thickening conditions is shear,compression,and compression-shear ***,the evolution mechanism of the flocs and drainage channels during the thickening of the thickened tailings under different experimental conditions was revealed.

关键词： thickened tailings compression-shear coupling compressive yield stress shear yield stress concentration

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Recent advancements in continuously scalable conversion-ratio switched-capacitor converter

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Journal of Semiconductors 2024年第4期45卷 8-11页

作者： mo Huang Yuanfei Wang Rui P.Martins Yan Lu State Key Laboratory of Analog and Mixed-Signal VLSI Institute of MicroelectronicsUniversity of MacaoMacaoChina

Switched-capacitor(SC)DC-DC converter[1]is an impor-tant alternative to inductive DC-DC converter,in terms of removing the bulky power ***,it is widely used in low-profile,low-power applications,such as the internet of things(IoT)sensor nodes and energy harvesting[2].Mean-while,considering that capacitor has a much higher energy density than inductor,high-power applications.

关键词： converter switched removing

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Regulated polarization degree of upconversion luminescence and multiple anti-counterfeit applications

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Rare Metals 2024年第5期43卷 2172-2183页

作者： Dong-Ping Wen Ping Chen Yi Liang Xiao-Ming mo Cao-Feng Pan Center On Nanoenergy Research Guangxi Key Laboratory for Relativistic AstrophysicsSchool of Physical Science and TechnologyGuangxi UniversityNanning 530004China Key Laboratory of Micronano Energy and Sensor CAS Center for Excellence in NanoscienceBeijing Institute of Nanoenergy and NanosystemsChinese Academy of SciencesBeijing 100140China

Polarization upconversion luminescence(PUCL)of lanthanide ions(Ln^(3+))has been widely used in single particle tracking,microfluidics detection,three-dimensional displays,and so ***,no effective strategy has been developed for modulating *** we report a strategy to regulate PUCL in Ho^(3+)-doped NaYF4single nanorods based on the number of upconversion *** constructing a multiphoton upconversion system for Ho^(3+),we regulate the degree of polarization(DOP)of PUCL from 0.590 for two-photon luminescence to 0.929 for three-photon upconversion luminescence(UCL).Furthermore,our strategy is verified from cross-relaxation between Ho^(3+)and Yb^(3+),excitation wavelength,excitation power density,and local site *** this regulation strategy of PUCL has also been achieved in Tm^(3+),with the DOP ranging from 0.233 for two-photon luminescence to 0.925 for four-photon UCL Besides,multi-dimensional anti-counterfeiting display has been explored with *** work provides an effective strategy for regulating PUCL and also provides more opportunities for the development of polarization display optical encoding,anti-counterfeiting,and integrated optical devices.

关键词： Polarization upconversion luminescence Degree of polarization Population density of excited state Number of upconversion photons Polarization anti-counterfeitingdisplay

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Unveiling field-coupled nanocomputing:Leaning molecules to shape readable bits

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Nano Research 2024年第9期17卷 8447-8454页

作者： Yuri Ardesi Giuliana Beretta Fabrizio mo Chiara Elfi Spano Gianluca Piccinini Mariagrazia Graziano Corso Duca degli Abruzzi Department of Electronics and TelecommunicationsPolitecnico di TorinoTurin 10129Italy Corso Duca degli Abruzzi Department of Applied Science and TechnologyPolitecnico di TorinoTurin 10129Italy

molecular field-coupled nanocomputing(molFCN)encodes information in the molecule charge distribution and elaborates it through electrostatic *** the advantageous sub-nanometric size and low-power dissipation,only a few attempts have been made to validate the technology *** of the obstacles is the difficulty in measuring molecule charges to validate information encoding or integrate molFCN with complementary-metal-oxide-semiconductor(CmoS).In this work,we propose a paradigm preserving the advantages of molFCN,which exploits the position of waiving molecules to augment the information *** validate the paradigm,named bend-boosted molFCN,with density functional theory using 6-(ferrocenyl)hexanethiol *** demonstrate that the encoded information can be electrically read by constituting a molecular *** paradigm is compatible with the charge-based molFCN,thus acting as a readout *** obtained results favor the experimental assessment of the molFCN principle through scanning probe microscopy techniques and the design of molFCN-CmoS heterogeneous circuits.

关键词： nanoelectronics molecular electronics field-coupled nanocomputing electronics beyond-complementary-metal-oxidesemiconductor(CmoS)

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Thirty-eight spider species (Arachnida: Araneae) from China, Indonesia, Japan and Vietnam

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Zoological Systematics 2024年第1期49卷 4-98页

作者： Yejie Lin Shuqiang Li Haolin mo Xihao Wang Institute of Zoology Chinese Academy of SciencesBeijing 100101China Key Laboratory of Wildlife Evolution and Conservation in mountain Ecosystem of Guangxi Nanning Normal UniversityNanning 530001China Jinan Licheng No.2 High School Jinan 250109China

Four new genera in three spider families are reported, namely Langlibaitiao Lin &Li, gen. nov., of Dictynidae O. Pickard-Cambridge, 1871, with Lathys inaffecta Li, 2017(♂♀,China: Guangxi) as the type species;Huoyanluo Lin & Li, gen. nov., of Macrobunidae Petrunkevitch, 1928, with Huoyanluo ruanxiaoqi Lin & Li, sp. nov.(♂, China: Yunnan) as the type species and Gushangzao Lin & Li, gen. nov. and Gyro Lin & Li, gen. nov., of Theridiidae Sundevall, 1833, with Gushangzao shiqian Lin & Li, sp. nov.(♂♀, China: Xizang) and Gyro zeppeli Lin & Li, sp. nov.(♀, China: Yunnan) as the type species, respectively. Further 31 new species in 19 spider families are reported, including Agelenidae C.L. Koch, 1837:Troglocoelotes doul Lin & Li, sp. nov.(♀, China: Guangxi) and T. ruanxiaowu Lin & Li, ***.(♀, China: Guangxi);Dictynidae: Langlibaitiao zhangshun Lin & Li, sp. nov.(♂, China:Hainan);Hahniidae Bertkau, 1878: Hahnia zhuyifani Lin & Li, sp. nov.(♀, China: Yunnan);Liocranidae Simon, 1897: Platnick xintongi Lin & Li, sp. nov.(♂♀, China: Xizang);Macrobunidae: Funny yanqing Lin & Li, sp. nov.(♂♀, China: Xizang) and Huoyanluo zhangzezhongi Lin & Li, sp. nov.(♂, China: Yunnan);Mysmenidae Petrunkevitch, 1928:Phricotelus yangxiong Lin & Li, sp. nov.(♂♀, China: Chongqing);Nemesiidae Simon, 1889:Raveniola shixiu Lin, Wang & Li, sp. nov.(♀, China: Guangxi) and R. xiezhen Lin, Wang & Li,sp. nov.(♂♀, China: Yunnan);Nesticidae Simon,1894: Speleoticus sicet Lin & Li, sp. nov.(♂♀,China: Sichuan);Ochyroceratidae Fage, 1912: Speocera yiduoi Lin & Li, sp. nov.(♂, China:Guangdong);Oecobiidae Blackwall, 1862: Uroctea chenyui Lin & Li, sp. nov.(♂♀, China:Guangxi);Oonopidae Simon, 1890: Orchestina xiebao Lin & Li, sp. nov.(♀, China:Chongqing);Philodromidae Thorell, 1869: Apollophanes lujiani Lin & Li, sp. nov.(♂♀, China:Guangxi) and Psellonus dawanqu Lin & Li, sp. nov.(♂♀, China: Guangdong);Salticidae Blackwall, 1841: Coccorchestes spark Lin & Li, sp. nov.(♂♀, Indonesia, West Papua),Onomastus zhuwu

关键词： Diagnosis new combination new genus new species Asia.

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A weakly-solvated ether-based electrolyte for fast-charging graphite anode

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Chinese Chemical Letters 2024年第8期35卷 526-532页

作者： Xiao Zhu Yanbing mo Jiawei Chen Gaopan Liu Yonggang Wang Xiaoli Dong Department of Chemistry and Shanghai Key Laboratory of molecular Catalysis and Innovative Materials Institute of New EnergyiChEM(Collaborative Innovation Center of Chemistry for Energy Materials)Fudan UniversityShanghai 200433China

Weakly-solvated electrolytes(WSEs)utilizing solvents with weak coordination ability offer advantages for low-potential graphite anode owing to their facile desolvation process and anions-derived inorganic-rich solid electrolyte interphase(SEI)***,these electrolytes face challenges in achieving a balance between the weak solvation affinity and high ionic conductivity,as well as between rigid inorganic-rich SEI and flexible SEI for long-term ***,we introduce 1,3-dioxolane(DOL)and lithium bis(trifluoromethanesulfonyl)-imide(LiTFSI)as functional additives into a WSE based on nonpolar cyclic ether(1,4-dioxane).The well-formulated WSE not only preserves the weakly solvated features and anion-dominated solvation sheath,but also utilizes DOL to contribute organic species for stabilizing the SEI *** from these merits,the optimized electrolyte enables graphite anode with excellent fast-charging performance(210 mAh/g at 5 C)and outstanding cycling stability(600 cycles with a capacity retention of 82.0%at room temperature and 400 cycles with a capacity retention of 80.4%at high temper-ature).Furthermore,the fabricated LiNi_(0.8)Co_(0.1)Mn_(0.1)O_(2)||graphite full cells demonstrate stable operation for 140 cycles with high capacity retention of 80.3%.This work highlights the potential of tailoring solvation sheath and interphase properties in WSEs for advanced electrolyte design in graphite-based lithium-ion batteries.

关键词： Weakly-solvated solvent Bisalt ether-based electrolyte Graphite anode NCM||graphite battery Interfacial optimization

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