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Ultrastable in-situ silver nanoparticle dressing for effective prevention and treatment of wound infection in emergency

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Engineered Regeneration 2024年第1期5卷 111-123页

作者： Wei Wang Ziwei Hu Wanying mo Min Ouyang Shihao Lin Xiang Li Chengxinqiao Wang Feng Yu Yupeng Wang Dongfang Zhou Key Laboratory of Mental Health of the Ministry of Education NMPA Key Laboratory for Research and Evaluation of Drug Metabolism&Guangdong Provincial Key Laboratory of New Drug ScreeningSchool of Pharmaceutical SciencesSouthern Medical UniversityGuangzhou 510515China Institute of Otolaryngology Head and neck surgery Guangzhou Red Croee Hospital of Jinan UniversityGuangzhou 510282China c Department of Orthopaedics and Traumatology Zhujiang HospitalSouthern Medical UniversityGuangzhou 510282China

The use of antibacterial dressings is crucial in the prevention and treatment of wound infection in emergency ***,the efficacy of dressings is compromised by long-term storage or exposure to harsh ***,an ultrastable in-situ silver nanoparticle dressing(AgSNP@CD)was prepared for effective prevention and treatment of wound infection in *** fabrication process of AgSNP@CD is simple,suitable for large-scale *** to the strong interaction between the in-situ synthesized AgNPs and the cotton fabric,AgSNP@CD owned remarkable stability,thus retaining its antimicrobial efficacy even after long-term storage(up to 2 years)and under extreme conditions(damp heat,low temperatures,low-oxygen,water immersion,acid-alkali erosion).Both in vitro and in vivo results demonstrated the extraordinary antibacterial efficacy and stability of AgSNP@CD,facilitating infection prevention and wound healing in extreme *** particular,AgSNP@CD exhibited a superior treatment effect on severe bacteria-infected trauma and can prevent the occur-rence of sepsis *** exceptional stability and antibacterial efficacy of AgSNP@CD under complex and extreme conditions make it a well-suited dressing strategy for the prevention and treatment of wound infection in emergency.

关键词： Bacteria-infected wounds Silver nanoparticle dressing Ultra stability Infection prevention In emergency

Environmental Change and Human Occupation during Late Pleistocene in Hunan Province， South China

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Journal of Earth Science 2024年

作者： Aipeng Guo Longjiang Mao Yiyuan Li Haicheng Lai Jiafu Zhang Duowen mo School of Marine Science， Nanjing University of Information Science and Technology Hunan Institute of Archaeology Institute of Scientific and Technical History， Nanjing University of Information Science and Technology College of Urban and Environmental Sciences， Peking University

The Paleolithic sites in South China have caused controversy regarding human behaviors in response to the rapidly shifting environment of the late Pleistocene. However， chronometric and high-resolution proxies are absent from interpreting the paleoenvironmental evolution. Here we present the chronology， grain size parameters， and geochemical elements records from the Hejialing (HJL) site in South China to reveal the crucial aspects of environmental evolution， and human occupation. The geochemical record shows that during MIS 5e–5a， northern Hunan experienced the influence of summer monsoon and maintained a warm and humid climate. The laterite layer began to develop. During MIS 4， the climate transitioned to dry and cold state， leading to the attraction of hominins to the HJL area due to the abundant water and lithic raw material resources， resulting in their establishment of a short-term camp. The HJL site was primarily inhabited by hunter-gatherer societies within a forested environment. From MIS 4 to MIS 2， Hunan experienced a prolonged period of dry and cold climatic conditions， with a brief rainfall recovery occurring in late MIS 3. Diminished vegetation and resource availability compelled human populations to broaden their activities and undertake migrations. The HJL site was abandoned amid the arid phase of MIS 2. The HJL area gradually became buried beneath eolian dust deposition (EM1) from distant sources and riverine dust from nearby sources (EM2)， and the site was informed. In MIS 1， During MIS 1， the climate shifted to a warm and humid state， marking the emergence of early agricultural practices. As an essential part of South China， the environmental evolution process and diverse survival strategies employed by hominins in Hunan are vital for explaining how the paleoenvironment drove human occupation during the Late Pleistocene.

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Transforming organic chemistry research paradigms:moving from manual efforts to the intersection of automation and artificial intelligence

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National Science Open 2024年第2期3卷 98-127页

作者： Chengchun Liu Yuntian Chen Fanyang mo School of Materials Science and Engineering Peking UniversityBeijing 100871China Ningbo Institute of Digital Twin Eastern Institute of TechnologyNingbo 315000China AI for Science(AI4S)-Preferred Program Peking University Shenzhen Graduate SchoolShenzhen 518055China

Organic chemistry is undergoing a major paradigm shift,moving from a labor-intensive approach to a new era dominated by automation and artificial intelligence(AI).This transformative shift is being driven by technological advances,the ever-increasing demand for greater research efficiency and accuracy,and the burgeoning growth of interdisciplinary *** models,supported by computational power and algorithms,are drastically reshaping synthetic planning and introducing groundbreaking ways to tackle complex molecular *** addition,autonomous robotic systems are rapidly accelerating the pace of discovery by performing tedious tasks with unprecedented speed and *** article examines the multiple opportunities and challenges presented by this paradigm shift and explores its far-reaching *** provides valuable insights into the future trajectory of organic chemistry research,which is increasingly defined by the synergistic interaction of automation and AI.

关键词： organic chemistry automation platform artificial intelligence algorithms

In situ photoelectric biosensing based on ultranarrowband near-infrared plasmonic hot electron photodetection

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Advanced Photonics 2024年第2期6卷 81-89页

作者： Xianghong Nan Wenduo Lai Jie Peng Haiquan Wang Bojun Chen Huifan He Zekang mo Zikun Xia Ning Tan Zhong Liu Long Wen Dan Gao Qin Chen Jinan University College of Physics & Optoelectronic Engineering Institute of Nanophotonics Guangdong Provincial Key Laboratory of Nanophotonic Manipulation Tsinghua University Shenzhen International Graduate School State Key Laboratory of Chemical Oncogenomics Jinan University College of Life Science and Technology

Narrowband photodetection is an important measurement technique for material analysis and sensing, for example, nondispersive infrared sensing technique. Both photoactive material engineering and nanophotonic filtering schemes have been explored to realize wavelength-selective photodetection,while most devices have a responsive bandwidth larger than 2% of the operating wavelength, limiting sensing performance. Near-infrared photodetection with a bandwidth of less than 0.2% of the operating wavelength was demonstrated experimentally in Au/Si Schottky nanojunctions. A minimum linewidth of photoelectric response down to 2.6 nm was obtained at a wavelength of 1550 nm by carefully tailing the absorptive and radiative loss in the nanostructures. Multiple functions were achieved on chip with the corrugated Au film, including narrowband resonance, light harvesting for sensing and photodetection, and electrodes for hot electron emission. Benefiting from such a unity integration with in situ photoelectric conversion of the optical sensing signal and the ultranarrowband resonance, self-contained on-chip biosensing via simple intensity interrogation was demonstrated with a limit of detection down to 0.0047%in concentration for glucose solution and 150 ng∕m L for rabbit IgG. Promising potential of this technique is expected for the applications in on-site sensing, spectroscopy, spectral imaging, etc.

关键词： Photodetectors Plasmonics Biosensing Optical gratings Gold Absorption spectrum Acoustooptic tunable filters Absorption Sensors In situ remote sensing

Optical secret sharing by multi-step liquid crystal planar doublet panning and coupling

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CHINESE OPTICS LETTERS 2024年第8期22卷 080502-080502页

作者： mo, Zhichang Chen, Yi Zhu, Xiangyu Zhang, Zhouhao Li, Dawei Shao, Jianda Zhao, Yuanan Wang, Jianguo Chinese Acad Sci Shanghai Inst Opt & Fine Mech Lab Thin Film Opt Shanghai 201800 Peoples R China Univ Chinese Acad Sci Ctr Mat Sci & Optoelect Engn Beijing 100049 Peoples R China Chinese Acad Sci Key Lab Mat High Power Laser Shanghai 201800 Peoples R China Henan Normal Univ Sch Phys Henan Key Lab Infrared Mat & Spectrum Measures & A Xinxiang 453007 Peoples R China Univ Chinese Acad Sci Hangzhou Inst Adv Study Hangzhou 310024 Peoples R China

The hologram, which is formed by phases coupled through cascade devices for secret information sharing, still carries a cracking risk. We propose a liquid crystal planar doublet as the information carrier, and new holograms generated by the new coupled phases when the relative displacements of the different liquid crystal layers change. The designed geometrical phases are generated by an optimized iterative restoration algorithm, and each holographic image formed by these phases is readable. This scheme achieves an increase in the capacity of the stored secret information and provides more misdirection, which is expected to have potential value in optical steganography and storage.

关键词： liquid crystal holography optical steganography displacement coupled geometrical phase PHASE FABRICATION

RARRES2 regulates lipid metabolic reprogramming to mediate the development of brain metastasis in triple negative breast cancer

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Military Medical Research 2024年第1期11卷 34-49页

作者： Yi-Qun Li Fang-Zhou Sun Chun-Xiao Li Hong-Nan mo Yan-Tong Zhou Dan Lv Jing-Tong Zhai Hai-Li Qian Fei Ma Department of Medical Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China State Key Laboratory of molecular Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China

Background Triple negative breast cancer(TNBC),the most aggressive subtype of breast cancer,is characterized by a high incidence of brain metastasis(BrM)and a poor *** the most lethal form of breast cancer,BrM remains a major clinical challenge due to its rising incidence and lack of effective treatment *** evidence suggested a potential role of lipid metabolic reprogramming in breast cancer brain metastasis(BCBrM),but the underlying mechanisms are far from being fully *** Through analysis of BCBrM transcriptome data from mice and patients,and immunohistochemical validation on patient tissues,we identified and verified the specific down-regulation of retinoic acid receptor responder 2(RARRES2),a multifunctional adipokine and chemokine,in BrM of *** investigated the effect of aberrant RARRES2 expression of BrM in both in vitro and in vivo *** signaling pathway components were evaluated using multi-omics *** were performed to elucidate the regulation of lipid metabolic reprogramming of *** We found that downregulation of RARRES2 is specifically associated with BCBrM,and that RARRES2 deficiency promoted BCBrM through lipid metabolic ***,reduced expression of RARRES2 in brain metastatic potential TNBC cells resulted in increased levels of glycerophospholipid and decreased levels of triacylglycerols by regulating phosphatase and tensin homologue(PTEN)-mammalian target of rapamycin(mTOR)-sterol regulatory element-binding protein 1(SREBP1)signaling pathway to facilitate the survival of breast cancer cells in the unique brain *** Our work uncovers an essential role of RARRES2 in linking lipid metabolic reprogramming and the development of ***2-dependent metabolic functions may serve as potential biomarkers or therapeutic targets for BCBrM.

关键词： RARRES2 Lipid metabolic reprogramming Brain metastasis(BrM) Breast cancer

Multimorbidity and mortality among older patients with coronary heart disease in Shenzhen,China

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Journal of Geriatric Cardiology 2024年第1期21卷 81-89页

作者： Fu-Rong LI Shuang WANG Xia LI Zhi-Yuan CHENG Cheng JIN Chun-Bao mo Jing ZHENG Feng-Chao LIANG Dong-Feng GU Shenzhen Key Laboratory of Cardiovascular Health and Precision Medicine Southern University of Science and TechnologyShenzhenGuangdongChina School of Public Health and Emergency Management Southern University of Science and TechnologyShenzhenGuangdongChina Shenzhen Health Development Research and Data Management Center ShenzhenChina School of Medicine Southern University of Science and TechnologyShenzhenGuangdongChina

BACKGROUND The current understanding of the magnitude and consequences of multimorbidity in Chinese older adults with coronary heart disease(CHD)is *** aimed to assess the association and population-attributable fractions(PAFs)between multimorbidity and mortality among hospitalized older patients who were diagnosed with CHD in Shenzhen,*** We conducted a retrospective cohort study of older Chinese patients(aged≥65 years)who were diagnosed with *** proportional hazards models were used to estimate the associations between multimorbidity and all-cause and cardiovascular disease(CVD)*** also calculated the *** The study comprised 76,455 older hospitalized patients who were diagnosed with CHD between January 1,2016,and August 31,*** them,70,217(91.9%)had multimorbidity,defined as the presence of at least one of the predefined 14 chronic *** with cancer,hemorrhagic stroke and chronic liver disease had the worst overall death risk,with adjusted HRs(95%CIs)of 4.05(3.77,4.38),2.22(1.94,2.53),and 1.85(1.63,2.11),*** CVD mortality,the highest risk was observed for hemorrhagic stroke,ischemic stroke,and chronic kidney disease;the corresponding adjusted HRs(95%CIs)were 3.24(2.77,3.79),1.91(1.79,2.04),and 1.81(1.64,1.99),***-cause mortality was mostly attributable to cancer,heart failure and ischemic stroke,with PAFs of 11.8,10.2,and 9.1,*** for CVD mortality,the leading PAFs were heart failure,ischemic stroke and diabetes;the corresponding PAFs were 18.0,15.7,and 6.1,*** Multimorbidity was common and had a significant impact on mortality among older patients with CHD in Shenzhen,***,heart failure,ischemic stroke and diabetes are the primary contributors to ***,prioritizing improved treatment and management of these comorbidities is essential for the survival prognosis of CHD patients from a holistic public health perspective.

关键词： patients morbidity mortality

Galvanostatic method assembled ZIFs nanostructure as novel nanozyme for the glucose oxidation and biosensing

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Chinese Chemical Letters 2024年第9期35卷 279-283页

作者： Erzhuo Cheng Yunyi Li Wei Yuan Wei Gong Yanjun Cai Yuan Gu Yong Jiang Yu Chen Jingxi Zhang Guangquan mo Bin Yang The Fourth Affiliated Hospital of Guangzhou Medical University School of Biomedical EngineeringGuangzhou Medical UniversityGuangzhou 511436China Department of Nephrology First Affiliated Hospital of Jinan UniversityGuangzhou 510630China Department of Oncology Xiangyang Central Hospital of Hubei University of Arts and ScienceXiangyang 441000China

Recently,the composite of soft conductive substrates,such as carbon fiber(CF),with metal-organic frameworks(moFs)has been employed in a myriad of *** composite material has demonstrated exceptional potential in the realm of electrochemical sensing ***,the rapid growth of moFs on the surface of CF remains a ***,we propose a simple galvanostatic method as an effective strategy for rapidly growing zeolitic imidazolate frameworks(ZIFs)on CF,and obtain nanocaltrop-like ZIFs modified CF(NC-ZIFs/CF)glucose(Glu)sensor platform with distinctive *** prepared NC-ZIFs/CF demonstrated significant electrocatalytic activity towards the oxidation of Glu in alkaline media,characterized by a pronounced augmentation in oxidation current *** an applied potential of 0.4 V,NC-ZIFs/CF exhibited a remarkably broad detection range(3–30,000μmol/L)and demonstrated outstanding selectivity,repeatability and ***,the NC-ZIFs/CF was efficaciously employed for the detection of blood Glu levels in the serum of both normoglycemic and hyperglycemic patients,obtaining highly reliable *** work demonstrates the feasibility of using galvanostatic method assembly to induce the growth of moFs on conductive substrates,providing new ideas for electrocatalysis sensors and other electrochemical applications.

关键词： Sensor moFs Electrocatalytic oxidation Electrochemical assembly Glucose

Regioselective cation exchange reaction for photoelectrochemical water splitting

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Rare Metals 2024年第7期43卷 3400-3407页

作者： mo-Yan Chen Tai-Song Zhang Zhi Yan Jiang-Nan Lv Xiao-Ting Sun Rui-Xia Yang Mark TSwihart Xiao-Hong Xu Yang Liu Research Institute of Materials Science of Shanxi Normal University&Key Laboratory of Magnetic molecules and Magnetic Information Materials of Ministry of Education Taiyuan 030031China Department of Chemical and Biological Engineering University at Buffalo(SUNY)NY 14260USA Department of Materials Science Fudan UniversityShanghai 200433China

Engineering copper sulfide-based heterostructures via cation exchange(CE)is an appealing approach,as it allows selective combination of distinct compositions and functions of metal *** heterostructures can play a significant role in photoelectrochemical applications,but the effect of the ratio between two or more domains in such heterostructures on the photoresponse has not been well explored.

关键词： exchange sulfide splitting